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Research paper thumbnail of Pregnant Mare's Serum Gonadotropin. IV. Induction of Premature Labor by Pregnant Mare's Serum Gonadotropin and its Prevention by using Clomiphene or Indomethacin**Supported by a grant from the Indian Council of Medical Research; Grant M76.18 from The Population Council, New York; and grants from ...

Fertility and Sterility, 1978

The administration of pregnant mare's serum gonadotropin (PMSG), 30 IU on day 18 of pregn... more The administration of pregnant mare's serum gonadotropin (PMSG), 30 IU on day 18 of pregnancy, resulted in premature labor in rats. However, this abortifacient efficacy of PMSG was not demonstrable when a simultaneous injection of progesterone, clomiphene, or indomethacin was scheduled, thus suggesting that the action of PMSG is medicated by the estrogen-stimulated release of prostaglandin. The termination of pseudopregnancy in bilaterally hysterectomized rats by PMSG and its reversal by indomethacin revealed that the inhibition of luteal function by PMSG does not require the presence of a uterus.

Research paper thumbnail of Pregnant Mare’s Serum gonadotropin. III. Hemispaying and the Reversal of the Antifertility Faculty of Pregnant Mare’s Serum Gonadotropin**Supported by a research grant from the Indian Council of Medical Research, University Grants Commission, New Delhi (to T. G.); Grant M 76.18 from The Populatio...

Fertility and Sterility, 1977

A single injection of 10 IU of pregnant mare's serum gonadotropin (PMSG) on day 5 of preg... more A single injection of 10 IU of pregnant mare's serum gonadotropin (PMSG) on day 5 of pregancy caused wastage of the fetoplacental unit by day 16 of pregnancy. Semispaying, which seems to subtract approximately 50% of the ovarian steroid contribution, at 24, 48, and 72 hours following the PMSG schedule prevented the antifertility faculty of the hormone preparation. However, hemicastration at 96 hours following the gonadotropin regimen was found to be ineffective, and 100% of the test animals showed complete termination of pregnancy. Experimental data collectively tempt us to propose that an estrogen excess, particularly of follicular origin in both ovaries, is essential for more than 72 hours following gonadotropin sensitization before the antifertility faculty of PMSG can be demonstrated.

Research paper thumbnail of Pregnant Mare's Serum Gonadotrophin. I

European Journal of Endocrinology, 1976

A single consistent Iuteolytic dose of 10 IU PMSG given on day 5 of pregnancy caused complete res... more A single consistent Iuteolytic dose of 10 IU PMSG given on day 5 of pregnancy caused complete resorption of foetuses and placentae associated with a polyfollicular ovarian state in rats. Concomitant treatment with progesterone or prolactin given concurrently with PMSG was found to overcome the antifertility efficacy of PMSG and maintained the endocrine balance favouring pregnancy maintenance. It was postulated that the PMSG-induced ovarian polyfolliculogenesis might be responsible for luteolysis of the corpus luteum gravidarum.

Research paper thumbnail of Role of Ascorbic Acid in the Inhibition of Estrous Cycle in Alloxan Diabetes

Research paper thumbnail of The possible mode of action of prostaglandins: XIV. Evidence of an involvement of progesterone in the initiation of prostaglandin F2a-induced premature labor in rats

Research paper thumbnail of Cyproterone acetate: II. Failure to reduce sperm fertility in the surgically separated epididymis of rat

Contraception, 1977

Cyproterone acetate, an antiandrogen, reduced the weight of the surgically separated epididymis. ... more Cyproterone acetate, an antiandrogen, reduced the weight of the surgically separated epididymis. However, fertility of the epididymal spermatozoa remained unchanged following a short-or long-term exposure to microquantities of cyproterone acetate. It appears that ...

Research paper thumbnail of Prostaglandin E2 and its differential effects in intact and castrated pregnant rats

Contraception, 1977

An injection of prostaglandin E 2 (PGE 2 ) at a dose level of 10 mg/kg bw on day 3 or day 5 of pr... more An injection of prostaglandin E 2 (PGE 2 ) at a dose level of 10 mg/kg bw on day 3 or day 5 of pregnancy, was found to cause pregnancy wastage in 25% of the test animals. However, progesterone given concurrently with PGE 2 maintained pregnancy in all animals so far tested. An ...

Research paper thumbnail of Estrogen and female fertility. II. Indomethacin and the reversal of the luteolytic efficacy of estradiol cyclopentylpropionate

Contraception, 1978

A subcutaneous injection of 10 μg estradiol cyclopentylpropionate (ECP) on day 5 of pregnancy or ... more A subcutaneous injection of 10 μg estradiol cyclopentylpropionate (ECP) on day 5 of pregnancy or pseudopregnancy in hysterectomized rats caused luteolysis as well as termination of pregnancy or pseudopregnancy. Addition of indomethacin concurrently with ECP in either of the ...

Research paper thumbnail of Pregnant mare's serum gonadotrophin: II. Reversal of the antifertility faculty of pregnant mare's serum gonadotrophin by using clomiphene citrate or reserpine in rats

Contraception, 1977

An injection of 10 IU pregnant mare's serum gaondotrophin (PMSG) on day 5 of pregnancy resul... more An injection of 10 IU pregnant mare's serum gaondotrophin (PMSG) on day 5 of pregnancy resulted in complete wastage of pregnancy on day 16 as the consequence of luteolysis. Concomitant treatment of clomiphene citrate of 0.3 mg/kg or reserpine of 0.5 mg/kg bw concurrently ...

Research paper thumbnail of Role of Ascorbic Acid on the Uterotrophic Activity of Estrogen

Cells Tissues Organs, 1964

... 56, No. 4, 1964 Article (PDF 462 KB) Paper. ROLE OF ASCORBIC ACID ON THE UTEROTROPHIC ACTIVIT... more ... 56, No. 4, 1964 Article (PDF 462 KB) Paper. ROLE OF ASCORBIC ACID ON THE UTEROTROPHIC ACTIVITY OF ESTROGEN Amar Chatterjee, Chandicharan Deb Department of Physiology, University College of Science, Calcutta, India. Address of Corresponding Author. ...

Research paper thumbnail of Effect of carbon tetrachloride on gonadal physiology in female rats

Cells Tissues Organs, 1968

Materials and methods The experiments were carried out on a total of 20 four to five-day cyclic a... more Materials and methods The experiments were carried out on a total of 20 four to five-day cyclic albino rats averaging 125 ⅛ 5 g body weight. Regularity of estrous rhythm of the animals was confirmed prior to experimentation. During an early diestrous phase of the cycle, 15 of them received an injection of CC14 and coconut oil mixture (1: 1) through an intraperitoneal route. The dose of the mixture used was 0.3 ml/l00 g rat weight. The remaining five received an equal volume of coconut oil as controls. The animals were ...

Research paper thumbnail of Pregnant Mare's Serum Gonadotropin. IV. Induction of Premature Labor by Pregnant Mare's Serum Gonadotropin and its Prevention by using Clomiphene or Indomethacin**Supported by a grant from the Indian Council of Medical Research; Grant M76.18 from The Population Council, New York; and grants from ...

Fertility and Sterility, 1978

The administration of pregnant mare's serum gonadotropin (PMSG), 30 IU on day 18 of pregn... more The administration of pregnant mare's serum gonadotropin (PMSG), 30 IU on day 18 of pregnancy, resulted in premature labor in rats. However, this abortifacient efficacy of PMSG was not demonstrable when a simultaneous injection of progesterone, clomiphene, or indomethacin was scheduled, thus suggesting that the action of PMSG is medicated by the estrogen-stimulated release of prostaglandin. The termination of pseudopregnancy in bilaterally hysterectomized rats by PMSG and its reversal by indomethacin revealed that the inhibition of luteal function by PMSG does not require the presence of a uterus.

Research paper thumbnail of Pregnant Mare’s Serum gonadotropin. III. Hemispaying and the Reversal of the Antifertility Faculty of Pregnant Mare’s Serum Gonadotropin**Supported by a research grant from the Indian Council of Medical Research, University Grants Commission, New Delhi (to T. G.); Grant M 76.18 from The Populatio...

Fertility and Sterility, 1977

A single injection of 10 IU of pregnant mare's serum gonadotropin (PMSG) on day 5 of preg... more A single injection of 10 IU of pregnant mare's serum gonadotropin (PMSG) on day 5 of pregancy caused wastage of the fetoplacental unit by day 16 of pregnancy. Semispaying, which seems to subtract approximately 50% of the ovarian steroid contribution, at 24, 48, and 72 hours following the PMSG schedule prevented the antifertility faculty of the hormone preparation. However, hemicastration at 96 hours following the gonadotropin regimen was found to be ineffective, and 100% of the test animals showed complete termination of pregnancy. Experimental data collectively tempt us to propose that an estrogen excess, particularly of follicular origin in both ovaries, is essential for more than 72 hours following gonadotropin sensitization before the antifertility faculty of PMSG can be demonstrated.

Research paper thumbnail of Pregnant Mare's Serum Gonadotrophin. I

European Journal of Endocrinology, 1976

A single consistent Iuteolytic dose of 10 IU PMSG given on day 5 of pregnancy caused complete res... more A single consistent Iuteolytic dose of 10 IU PMSG given on day 5 of pregnancy caused complete resorption of foetuses and placentae associated with a polyfollicular ovarian state in rats. Concomitant treatment with progesterone or prolactin given concurrently with PMSG was found to overcome the antifertility efficacy of PMSG and maintained the endocrine balance favouring pregnancy maintenance. It was postulated that the PMSG-induced ovarian polyfolliculogenesis might be responsible for luteolysis of the corpus luteum gravidarum.

Research paper thumbnail of Role of Ascorbic Acid in the Inhibition of Estrous Cycle in Alloxan Diabetes

Research paper thumbnail of The possible mode of action of prostaglandins: XIV. Evidence of an involvement of progesterone in the initiation of prostaglandin F2a-induced premature labor in rats

Research paper thumbnail of Cyproterone acetate: II. Failure to reduce sperm fertility in the surgically separated epididymis of rat

Contraception, 1977

Cyproterone acetate, an antiandrogen, reduced the weight of the surgically separated epididymis. ... more Cyproterone acetate, an antiandrogen, reduced the weight of the surgically separated epididymis. However, fertility of the epididymal spermatozoa remained unchanged following a short-or long-term exposure to microquantities of cyproterone acetate. It appears that ...

Research paper thumbnail of Prostaglandin E2 and its differential effects in intact and castrated pregnant rats

Contraception, 1977

An injection of prostaglandin E 2 (PGE 2 ) at a dose level of 10 mg/kg bw on day 3 or day 5 of pr... more An injection of prostaglandin E 2 (PGE 2 ) at a dose level of 10 mg/kg bw on day 3 or day 5 of pregnancy, was found to cause pregnancy wastage in 25% of the test animals. However, progesterone given concurrently with PGE 2 maintained pregnancy in all animals so far tested. An ...

Research paper thumbnail of Estrogen and female fertility. II. Indomethacin and the reversal of the luteolytic efficacy of estradiol cyclopentylpropionate

Contraception, 1978

A subcutaneous injection of 10 μg estradiol cyclopentylpropionate (ECP) on day 5 of pregnancy or ... more A subcutaneous injection of 10 μg estradiol cyclopentylpropionate (ECP) on day 5 of pregnancy or pseudopregnancy in hysterectomized rats caused luteolysis as well as termination of pregnancy or pseudopregnancy. Addition of indomethacin concurrently with ECP in either of the ...

Research paper thumbnail of Pregnant mare's serum gonadotrophin: II. Reversal of the antifertility faculty of pregnant mare's serum gonadotrophin by using clomiphene citrate or reserpine in rats

Contraception, 1977

An injection of 10 IU pregnant mare's serum gaondotrophin (PMSG) on day 5 of pregnancy resul... more An injection of 10 IU pregnant mare's serum gaondotrophin (PMSG) on day 5 of pregnancy resulted in complete wastage of pregnancy on day 16 as the consequence of luteolysis. Concomitant treatment of clomiphene citrate of 0.3 mg/kg or reserpine of 0.5 mg/kg bw concurrently ...

Research paper thumbnail of Role of Ascorbic Acid on the Uterotrophic Activity of Estrogen

Cells Tissues Organs, 1964

... 56, No. 4, 1964 Article (PDF 462 KB) Paper. ROLE OF ASCORBIC ACID ON THE UTEROTROPHIC ACTIVIT... more ... 56, No. 4, 1964 Article (PDF 462 KB) Paper. ROLE OF ASCORBIC ACID ON THE UTEROTROPHIC ACTIVITY OF ESTROGEN Amar Chatterjee, Chandicharan Deb Department of Physiology, University College of Science, Calcutta, India. Address of Corresponding Author. ...

Research paper thumbnail of Effect of carbon tetrachloride on gonadal physiology in female rats

Cells Tissues Organs, 1968

Materials and methods The experiments were carried out on a total of 20 four to five-day cyclic a... more Materials and methods The experiments were carried out on a total of 20 four to five-day cyclic albino rats averaging 125 ⅛ 5 g body weight. Regularity of estrous rhythm of the animals was confirmed prior to experimentation. During an early diestrous phase of the cycle, 15 of them received an injection of CC14 and coconut oil mixture (1: 1) through an intraperitoneal route. The dose of the mixture used was 0.3 ml/l00 g rat weight. The remaining five received an equal volume of coconut oil as controls. The animals were ...