Chauhan Hitesh - Academia.edu (original) (raw)
Papers by Chauhan Hitesh
International Journal of Biomedical and Advance Research, Jun 30, 2014
International Journal of Biomedical and Advance Research, 2013
International Journal of Biomedical and Advance Research, 2013
Background & objectives: Prostate carcinoma is the second leading cause of cancer death in men ab... more Background & objectives: Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years worldwide. More than 80% of the cancers concomitantly arise with Benign prostate hyperplasia. Prostate carcinoma is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in Prostate carcinoma patients and to make a comparison with other study. Methods: In present study 05 cases of prostate carcinoma were taken on the basis of clinical diagnosis from the Gujarat Cancer Research Institute (GCRI), Ahmedabad, Gujarat, India, during the period of March 2011 to October 2011. The patients were analyzed for chromosomal aberrations using cultured peripheral blood lymphocytes with their pre-informed written consent. Results: In the present study, all 5 cases were > 60 years of age. 3(60%) cases of prostate carcinoma have elevated PSA level (>4 ng/ml). In adenocarcinoma of prostate gain, deletion, and translocation of 7q22-q31 is common. In present study, Karyotype analysis reveal 01 prostate carcinoma patient had 46,XY,del(7)(q31). In present study 2 cases shows evidence of metastasis. Conclusion: Prostate carcinoma is found in > 60 years of age. Chromosome 1, 2, 3, 6, 7, 9, 16, 22, X and many more chromosomes were affected in prostate carcinoma patients, Common chromosomal aberration is 46,XY,del(7)(q31). Patients with prostate carcinoma have elevated PSA level (>4 ng/ml). Prostate carcinoma associated with metastasis have poor prognosis.
Gallbladder is one of the organs having a wide spectrum of diseases ranging from congenital anoma... more Gallbladder is one of the organs having a wide spectrum of diseases ranging from congenital anomalies, calculi and its complications, non-inflammatory, inflammatory to the neoplastic lesions. Gallstones are one of the major causes of morbidity and mortality all over the world affecting 10% of adult population. While Gallbladder cancer is a disease of the elderly; it affects patients in their 70s, with a female to male ratio 5:1. The aim was to study the distribution with respect to age and sex and the usefulness of histological evaluation of gallbladder. Methods: This is a retrospective study of 100 cases of gallbladder lesions during the period of April 2010 to October 2011. Results: Lesions of gallbladder were more common seen in females with a male to female ratio of 1:2.3. Gallbladder lesions were more commonly found in 4 th & 5 th decades of the patients. Out of 100 cases, Non-neoplastic lesions found in 95 cases (95%) and Neoplastic lesion found in 5 cases (5%) with the ratio being 19:1. The commonest histological observation found was chronic calculous cholecystitis in 46 cases (46%) followed by acute calculous cholecystitis in 9 cases (9%). Conclusion: Female in their 4 th decade are common sufferer of Gallbladder diseases. Gallstones and their consequences are the major factors for histomorphological changes of cholecystitis. Histological examination help where adjuvent treatment is depend up on grade, severity & Extent of invasion and also to rule out suspicion about malignancy.
Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years world... more Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years worldwide. More than 80% of the cancers concomitantly arise with Benign prostate hyperplasia. Prostate carcinoma is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in Prostate carcinoma patients and to make a comparison with other study.
International Journal of Biomedical and Advance Research, Jun 30, 2014
International Journal of Biomedical and Advance Research, 2013
International Journal of Biomedical and Advance Research, 2013
Background & objectives: Prostate carcinoma is the second leading cause of cancer death in men ab... more Background & objectives: Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years worldwide. More than 80% of the cancers concomitantly arise with Benign prostate hyperplasia. Prostate carcinoma is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in Prostate carcinoma patients and to make a comparison with other study. Methods: In present study 05 cases of prostate carcinoma were taken on the basis of clinical diagnosis from the Gujarat Cancer Research Institute (GCRI), Ahmedabad, Gujarat, India, during the period of March 2011 to October 2011. The patients were analyzed for chromosomal aberrations using cultured peripheral blood lymphocytes with their pre-informed written consent. Results: In the present study, all 5 cases were > 60 years of age. 3(60%) cases of prostate carcinoma have elevated PSA level (>4 ng/ml). In adenocarcinoma of prostate gain, deletion, and translocation of 7q22-q31 is common. In present study, Karyotype analysis reveal 01 prostate carcinoma patient had 46,XY,del(7)(q31). In present study 2 cases shows evidence of metastasis. Conclusion: Prostate carcinoma is found in > 60 years of age. Chromosome 1, 2, 3, 6, 7, 9, 16, 22, X and many more chromosomes were affected in prostate carcinoma patients, Common chromosomal aberration is 46,XY,del(7)(q31). Patients with prostate carcinoma have elevated PSA level (>4 ng/ml). Prostate carcinoma associated with metastasis have poor prognosis.
Gallbladder is one of the organs having a wide spectrum of diseases ranging from congenital anoma... more Gallbladder is one of the organs having a wide spectrum of diseases ranging from congenital anomalies, calculi and its complications, non-inflammatory, inflammatory to the neoplastic lesions. Gallstones are one of the major causes of morbidity and mortality all over the world affecting 10% of adult population. While Gallbladder cancer is a disease of the elderly; it affects patients in their 70s, with a female to male ratio 5:1. The aim was to study the distribution with respect to age and sex and the usefulness of histological evaluation of gallbladder. Methods: This is a retrospective study of 100 cases of gallbladder lesions during the period of April 2010 to October 2011. Results: Lesions of gallbladder were more common seen in females with a male to female ratio of 1:2.3. Gallbladder lesions were more commonly found in 4 th & 5 th decades of the patients. Out of 100 cases, Non-neoplastic lesions found in 95 cases (95%) and Neoplastic lesion found in 5 cases (5%) with the ratio being 19:1. The commonest histological observation found was chronic calculous cholecystitis in 46 cases (46%) followed by acute calculous cholecystitis in 9 cases (9%). Conclusion: Female in their 4 th decade are common sufferer of Gallbladder diseases. Gallstones and their consequences are the major factors for histomorphological changes of cholecystitis. Histological examination help where adjuvent treatment is depend up on grade, severity & Extent of invasion and also to rule out suspicion about malignancy.
Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years world... more Prostate carcinoma is the second leading cause of cancer death in men above age of 60 years worldwide. More than 80% of the cancers concomitantly arise with Benign prostate hyperplasia. Prostate carcinoma is associated with various lower urinary tract symptoms, which affect their day to day life. The aim of the present investigation was to find out the major chromosomal aberrations present in Prostate carcinoma patients and to make a comparison with other study.