Cheuk Fung Lau - Academia.edu (original) (raw)

FIELD: organic chemistry, biochemistry, enzymes. SUBSTANCE: invention relates to compounds repres... more FIELD: organic chemistry, biochemistry, enzymes. SUBSTANCE: invention relates to compounds represented by the formula: wherein values of substitutes are given in the invention description. Also, invention relates to pharmaceutically acceptable salts of the compound that can be used in treatment and/or prophylaxis of cathepsin-dependent states or diseases of mammals. Proposed compound are useful in treatment of diseases wherein bone resorption inhibition is desired, such as osteoporosis, increased mineral density of bone and reducing risk of fractures. Proposed claimed compounds are designated for preparing a drug possessing the inhibitory activity with respect to cathepsin. EFFECT: valuable medicinal and biochemical properties of compounds. 24 cl, 13 sch, 4 tbl, 15 ex