Chiara Insacco - Academia.edu (original) (raw)
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Papers by Chiara Insacco
The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
Neuropsychobiology, 2006
was associated with low novelty-seeking scores (p = 0.006) and genotypes containing the DRD4 long... more was associated with low novelty-seeking scores (p = 0.006) and genotypes containing the DRD4 long allele were marginally associated with low harm avoidance (p = 0.05). Finally, the long MAO-A allele was associated with decreased persistence scores among females (p = 0.006). Our observation of a pattern of infl uence on temperamental dimension exerted by serotonergic and dopaminergic genes suggests that the contribution of these polymorphisms to the clinical presentation of mood disorders could be mediated by an infl uence on personality differences.
NeuroImage, 2010
Background: Morphological and functional studies suggested involvement of several cortical and su... more Background: Morphological and functional studies suggested involvement of several cortical and subcortical circuitries in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to investigate networks involved in OCD pathophysiology, using power (coupling of EEG bands, low-resolution electromagnetic tomography-LORETA) and coherence analysis in drug naïve patients. Method: EEG was obtained from 37 drug-naïve patients with OCD and 37 age-and sex-matched controls. Resting EEG was recorded from 29 scalp channels. Coupling (ratio and correlation) between low and high frequencies was analyzed on Fz. For each frequency band, LORETA current density distribution, intrahemispheric and inter-hemispheric coherence analysis were computed. Results: OCD had increased current density for delta in the insula and for beta in frontal, parietal and limbic lobes. OCD also had decreased inter-hemispheric coherence and reduced coupling between delta and beta frequencies.
The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
Neuropsychobiology, 2006
was associated with low novelty-seeking scores (p = 0.006) and genotypes containing the DRD4 long... more was associated with low novelty-seeking scores (p = 0.006) and genotypes containing the DRD4 long allele were marginally associated with low harm avoidance (p = 0.05). Finally, the long MAO-A allele was associated with decreased persistence scores among females (p = 0.006). Our observation of a pattern of infl uence on temperamental dimension exerted by serotonergic and dopaminergic genes suggests that the contribution of these polymorphisms to the clinical presentation of mood disorders could be mediated by an infl uence on personality differences.
NeuroImage, 2010
Background: Morphological and functional studies suggested involvement of several cortical and su... more Background: Morphological and functional studies suggested involvement of several cortical and subcortical circuitries in patients with obsessive-compulsive disorder (OCD). The aim of the present study was to investigate networks involved in OCD pathophysiology, using power (coupling of EEG bands, low-resolution electromagnetic tomography-LORETA) and coherence analysis in drug naïve patients. Method: EEG was obtained from 37 drug-naïve patients with OCD and 37 age-and sex-matched controls. Resting EEG was recorded from 29 scalp channels. Coupling (ratio and correlation) between low and high frequencies was analyzed on Fz. For each frequency band, LORETA current density distribution, intrahemispheric and inter-hemispheric coherence analysis were computed. Results: OCD had increased current density for delta in the insula and for beta in frontal, parietal and limbic lobes. OCD also had decreased inter-hemispheric coherence and reduced coupling between delta and beta frequencies.