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Papers by Chinyere V Patrick Onyeaka

Research paper thumbnail of A subtle sign of aortic outflow obstruction in an infected 29 year old Starr-Edward's valve

Heart, 2001

Background-Raised plasma homocysteine is a risk factor for coronary artery disease. Patients with... more Background-Raised plasma homocysteine is a risk factor for coronary artery disease. Patients with myocardial infarction or unstable angina show greater activation of coagulation, greater troponin release, and a worse outcome. Objective-To examine variations in plasma homocysteine concentration in relation to C reactive protein (CRP) in patients presenting with acute coronary syndromes. Methods-Consecutive patients presenting with acute myocardial infarction (22) and unstable angina pectoris (12) were studied. Plasma samples were obtained on admission (before clinical intervention), on days 2, 7, and 28, and again six months after admission. Plasma homocysteine, assayed by high performance liquid chromatography, and CRP were both determined at the same time points. Changes were assessed by analysis of variance. Results-CRP concentrations showed a classical rise on day 2, followed by a gradual decline to normal values taken at six months from admission in both myocardial infarction (p < 0.0001) and unstable angina (p = 0.02). Homocysteine concentrations in myocardial infarction (median, 25th to 75th interquartile range) were: 11.9 (10.7 to 12.6), 11.5 (9.1 to 13.4), 12.1 (11.4 to 14.1), 12.4 (11.1 to 14.4), and 12.1 (11.2 to 14.0) µmol/l, for days 1, 2, 7, 28, and 180, respectively (p = 0.02). Significant diVerences were observed only between day 2 and day 7 (p < 0.05). The final homocysteine measurement was not diVerent from the admission level. Homocysteine concentrations in unstable angina did not diVer between admission and convalescence (12.5 (9.1 to 14.5) µmol/l and 12.3 (7.7 to 14.9) µmol/l, respectively). Conclusions-Plasma homocysteine concentrations are minimally influenced by acute phase variations with reliable measurements obtained on admission in patients with myocardial infarction and unstable angina.

Research paper thumbnail of O-16 Early thoracoscopic excision is the best treatment of an indeterminate solitary pulmonary nodule

Research paper thumbnail of Surgery-induced Thyroiditis: Fact or Fiction?

Ear, Nose & Throat Journal, 2002

Research paper thumbnail of Experience with video-assisted surgery for suspected mediastinal tumours

European Journal of Surgical Oncology

Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the ... more Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the excision of suspected mediastinal tumours. Methods. The case notes of 24 consecutive patients referred to a single surgeon between 1997 and 2002 for excision of suspected mediastinal tumours were reviewed. The operative, post-operative and pathological characteristics of patients treated thoracoscopically and by open procedure were analysed. Results. Thirteen of 24 patients underwent thoracoscopic excision. The mean age of the two groups was similar as was the mean operating time and duration of chest drainage. However, patients in the thoracoscopic group had less chest drainage, less pain and a shorter hospital stay. Conclusions. Video-assisted thoracoscopic excision of mediastinal tumours is a safe and technically feasible procedure and may offer significant post-operative advantages over open procedures.

Research paper thumbnail of Experience with video-assisted surgery for suspected mediastinal tumours

European journal of …, 2004

Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the ... more Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the excision of suspected mediastinal tumours. Methods. The case notes of 24 consecutive patients referred to a single surgeon between 1997 and 2002 for excision of suspected mediastinal tumours were reviewed. The operative, post-operative and pathological characteristics of patients treated thoracoscopically and by open procedure were analysed. Results. Thirteen of 24 patients underwent thoracoscopic excision. The mean age of the two groups was similar as was the mean operating time and duration of chest drainage. However, patients in the thoracoscopic group had less chest drainage, less pain and a shorter hospital stay. Conclusions. Video-assisted thoracoscopic excision of mediastinal tumours is a safe and technically feasible procedure and may offer significant post-operative advantages over open procedures.

Research paper thumbnail of A subtle sign of aortic outflow obstruction in an infected 29 year old Starr-Edward's valve

Heart, 2001

Background-Raised plasma homocysteine is a risk factor for coronary artery disease. Patients with... more Background-Raised plasma homocysteine is a risk factor for coronary artery disease. Patients with myocardial infarction or unstable angina show greater activation of coagulation, greater troponin release, and a worse outcome. Objective-To examine variations in plasma homocysteine concentration in relation to C reactive protein (CRP) in patients presenting with acute coronary syndromes. Methods-Consecutive patients presenting with acute myocardial infarction (22) and unstable angina pectoris (12) were studied. Plasma samples were obtained on admission (before clinical intervention), on days 2, 7, and 28, and again six months after admission. Plasma homocysteine, assayed by high performance liquid chromatography, and CRP were both determined at the same time points. Changes were assessed by analysis of variance. Results-CRP concentrations showed a classical rise on day 2, followed by a gradual decline to normal values taken at six months from admission in both myocardial infarction (p < 0.0001) and unstable angina (p = 0.02). Homocysteine concentrations in myocardial infarction (median, 25th to 75th interquartile range) were: 11.9 (10.7 to 12.6), 11.5 (9.1 to 13.4), 12.1 (11.4 to 14.1), 12.4 (11.1 to 14.4), and 12.1 (11.2 to 14.0) µmol/l, for days 1, 2, 7, 28, and 180, respectively (p = 0.02). Significant diVerences were observed only between day 2 and day 7 (p < 0.05). The final homocysteine measurement was not diVerent from the admission level. Homocysteine concentrations in unstable angina did not diVer between admission and convalescence (12.5 (9.1 to 14.5) µmol/l and 12.3 (7.7 to 14.9) µmol/l, respectively). Conclusions-Plasma homocysteine concentrations are minimally influenced by acute phase variations with reliable measurements obtained on admission in patients with myocardial infarction and unstable angina.

Research paper thumbnail of O-16 Early thoracoscopic excision is the best treatment of an indeterminate solitary pulmonary nodule

Research paper thumbnail of Surgery-induced Thyroiditis: Fact or Fiction?

Ear, Nose & Throat Journal, 2002

Research paper thumbnail of Experience with video-assisted surgery for suspected mediastinal tumours

European Journal of Surgical Oncology

Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the ... more Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the excision of suspected mediastinal tumours. Methods. The case notes of 24 consecutive patients referred to a single surgeon between 1997 and 2002 for excision of suspected mediastinal tumours were reviewed. The operative, post-operative and pathological characteristics of patients treated thoracoscopically and by open procedure were analysed. Results. Thirteen of 24 patients underwent thoracoscopic excision. The mean age of the two groups was similar as was the mean operating time and duration of chest drainage. However, patients in the thoracoscopic group had less chest drainage, less pain and a shorter hospital stay. Conclusions. Video-assisted thoracoscopic excision of mediastinal tumours is a safe and technically feasible procedure and may offer significant post-operative advantages over open procedures.

Research paper thumbnail of Experience with video-assisted surgery for suspected mediastinal tumours

European journal of …, 2004

Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the ... more Aim. To assess the therapeutic feasibility of video-assisted thoracoscopic surgery (VATS) in the excision of suspected mediastinal tumours. Methods. The case notes of 24 consecutive patients referred to a single surgeon between 1997 and 2002 for excision of suspected mediastinal tumours were reviewed. The operative, post-operative and pathological characteristics of patients treated thoracoscopically and by open procedure were analysed. Results. Thirteen of 24 patients underwent thoracoscopic excision. The mean age of the two groups was similar as was the mean operating time and duration of chest drainage. However, patients in the thoracoscopic group had less chest drainage, less pain and a shorter hospital stay. Conclusions. Video-assisted thoracoscopic excision of mediastinal tumours is a safe and technically feasible procedure and may offer significant post-operative advantages over open procedures.