Emanuele Chisari - Academia.edu (original) (raw)

Uploads

Papers by Emanuele Chisari

Research paper thumbnail of A Crossover Randomized Trial of Visual Abstracts Versus Plain-Text Tweets for Disseminating Orthopedics Research

The Journal of Arthroplasty

Research paper thumbnail of A Crossover Randomized Trial of Visual Abstracts Versus Plain-Text Tweets for Disseminating Orthopedics Research

The Journal of Arthroplasty

Research paper thumbnail of African American Patients Have Improved Functional Gains and Comparable Clinical Outcomes to Caucasian Patients After Total Hip and Knee Arthroplasty

The Journal of Arthroplasty

Research paper thumbnail of Residency Program Reputation Influences the American Association of Hip and Knee Surgeons Match Results

The Journal of Arthroplasty

Research paper thumbnail of Prevention of Infection and Disruption of the Pathogen Transfer Chain in Elective Surgery

The Journal of Arthroplasty

Research paper thumbnail of High Bundled Payment Costs Following Total Hip and Knee Arthroplasty in African Americans

The Journal of Arthroplasty

Research paper thumbnail of Cancelled Total Joint Arthroplasty: Who, What, When and Why?

The Journal of Arthroplasty

Research paper thumbnail of Is There a Role for Spacer Exchange in Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection?

Journal of Clinical Medicine

Periprosthetic joint infection (PJI) continues to be one of the most serious complications after ... more Periprosthetic joint infection (PJI) continues to be one of the most serious complications after hip and knee arthroplasty. The choice of surgical treatment depends on a multitude of factors like chronicity of infection, host factors, and institutional or surgeon experience. Two-stage exchange remains one of the most commonly used technique for chronic PJI in the United States of America. The intended two-stage revision may involve an additional interim procedure where the initial antibiotic cement spacer is removed and a new spacer is inserted. Mostly, the rationale behind spacer exchange is an additional load of local antibiotics before proceeding to reimplantation. There is no conclusive evidence whether a spacer exchange confers additional benefits, yet it delays reimplantation and exposes already fragile patients to the risks and morbidity of an additional surgery.

Research paper thumbnail of Accuracy of blood-tests and synovial fluid-tests in the diagnosis of periprosthetic joint infections

Expert Review of Anti-infective Therapy

Research paper thumbnail of Obesity Increases the Risk of Tendinopathy, Tendon Tear and Rupture, and Postoperative Complications

Clinical Orthopaedics and Related Research

Research paper thumbnail of The role of the immune system in tendon healing: a systematic review

British Medical Bulletin

Introduction The role of the immune system in tendon healing relies on polymorphonucleocytes, mas... more Introduction The role of the immune system in tendon healing relies on polymorphonucleocytes, mast cells, macrophages and lymphocytes, the ‘immune cells’ and their cytokine production. This systematic review reports how the immune system affects tendon healing. Sources of data We registered our protocol (registration number: CRD42019141838). After searching PubMed, Embase and Cochrane Library databases, we included studies of any level of evidence published in peer-reviewed journals reporting clinical or preclinical results. The PRISMA guidelines were applied, and risk of bias and the methodological quality of the included studies were assessed. We excluded all the articles with high risk of bias and/or low quality after the assessment. We included 62 articles assessed as medium or high quality. Areas of agreement Macrophages are major actors in the promotion of proper wound healing as well as the resolution of inflammation in response to pathogenic challenge or tissue damage. The i...

Research paper thumbnail of Analyse de la perte de réduction en tant que facteur de risque de déplacement secondaire supplémentaire après traitement orthopédique chez l’enfant des fractures distales du radius déplacées

Revue de Chirurgie Orthopédique et Traumatologique

Research paper thumbnail of Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects

Materials

Chondral knee defects have a limited ability to be repaired. Current surgical interventions have ... more Chondral knee defects have a limited ability to be repaired. Current surgical interventions have been unable to regenerate articular cartilage with the mechanical properties of native hyaline cartilage. The use of a scaffold-based approach is a potential solution. Scaffolds are often implanted with cells to stimulate cartilage regeneration, but cell-based therapies are associated with additional regulatory restrictions, an additional surgical procedure for cell harvest, time for cell expansion, and the associated costs. To overcome these disadvantages, cell-free scaffolds can be used in isolation allowing native cells to attach over time. This review discusses the optimal properties of scaffolds used for chondral defects, and the evidence for the use of hydrogel scaffolds and hydrogel–synthetic polymer hybrid scaffolds. Preclinical and clinical studies have shown that cell-free scaffolds can support articular cartilage regeneration and have the potential to treat chondral defects. H...

Research paper thumbnail of Integration of ultrasound in medical School: Effects on Physical Examination Skills of Undergraduates

Medical Science Educator

Introduction Ultrasound (US) imaging has rapidly increased its application in almost every medica... more Introduction Ultrasound (US) imaging has rapidly increased its application in almost every medical field. Many universities worldwide provide teaching of US for undergraduates in their curricula. Emerging evidence is supporting the use of ultrasonography to improve also non-US skills and knowledge of medical students. Objectives The purpose of this review is to understand if the integration of US lessons into medical students' curriculum improves their learning of physical examination and enhances their skills when performing it. Methods We performed a systematic review of literature by searching three electronic medical databases. We included studies of any level of evidence published in peer-reviewed journals. Evaluated data were extracted using the PICO framework and critically analyzed. PRISMA guidelines were applied; we excluded all the articles evaluated with serious risk of bias and/or low methodological quality. Results We included 15 articles, accounting for more than 1643 medical students involved from five different countries and 14 various academical institutions. Eight out of nine studies (88.9%) reported an improvement of practical physical examination scores by students exposed to ultrasound lectures. Eleven out of eleven studies (100%), which administered self-assessment questionnaires, reported strong agreement among students that ultrasound lectures helped them learning and understanding the physical exam and improved their confidence and skills. Conclusions Increasing evidence shows that incorporating ultrasound in medical students' curriculum might improve their ability and confidence when learning and performing a physical exam. This significant tendency needs to be corroborated at a deeper level by further studies.

Research paper thumbnail of Analysis of loss of reduction as risk factor for additional secondary displacement in children with displaced distal radius fractures treated conservatively

Orthopaedics & Traumatology: Surgery & Research

Research paper thumbnail of The Effects of TNF-alpha Inhibition on Cartilage: a Systematic Review of preclinical studies

Osteoarthritis and Cartilage

Research paper thumbnail of Single-Stage Revision Surgery in Infected Total Knee Arthroplasty: A PRISMA Systematic Review

Journal of Clinical Medicine

Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a... more Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a common reason for revision surgery. The current standard of care is two-stage revision surgery. There is however increasing evidence to support the use of single-stage revision surgery. We conducted a PRISMA systematic review of the current evidence on the use of single-stage revision for infected total knee arthroplasty. Four databases (PubMed, Embase, Science Direct, and Cochrane Library) were systematically screened for eligible studies. The risk bias of each study was identified using ROBINS-I tool, and the quality of evidence was assessed using the GRADE criteria. Sixteen articles were retained after applying the inclusion and exclusion criteria that evaluated 3645 knee single-stage revision surgeries. Our review reveals satisfactory outcomes for single-stage revision in the management of infected total knee arthroplasty. The reinfection rates in the studies included in our review ...

Research paper thumbnail of Perioperative management of renal transplant patients undergoing total joint arthroplasty

Journal of Perioperative Practice

The success of renal transplantation depends on lifelong immunosuppression. This can lead to a hi... more The success of renal transplantation depends on lifelong immunosuppression. This can lead to a high incidence of avascular necrosis of major joints in the body for which arthroplasty is the treatment of choice. The risk of surgical complications is high in these patients, and there is no current set of cohesive perioperative management guidelines. In this review, we discuss the perioperative management of renal transplant patients undergoing elective total joint arthroplasty.

Research paper thumbnail of Polyphenol-rich foods and Osteoporosis

Current Pharmaceutical Design

Background: Osteoporosis is a metabolic disease affecting the bone mineral density able to compro... more Background: Osteoporosis is a metabolic disease affecting the bone mineral density able to compromise is architecture and strength. Disease prevention through diet is object of study and discussion. Among the several nutrients investigated, the intake of phenols seems to influence bone mineral density by acting as free radical scavengers, preventing oxidation-induced damage to bone cells. In addition, the growing understanding of the bone remodelling process supports the theory that inflammation significantly contributes to the etiopathogenesis of osteoporosis. Methods: To provide an overview of current evidence on polyphenol-rich foods and osteoporosis prevention we made a comprehensive review of the literature focusing on the state of art of the topic Results: Some polyphenol-rich foods, including olive oil, fruit and vegetable, tea and soy, seem to be beneficial for osteoporosis disease and progression prevention. The mechanism is still partly unknowns and may be involving differ...

Research paper thumbnail of The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

BioMed Research International

Introduction. Osteoarthritis (OA) is a degenerative joint disease characterized by articular cart... more Introduction. Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). Methods. A review of the literature was performed on the PubMed database based on the following inclusion criteria: article written in English language in the last 20 years and dealing with (1) the role of Wnt-β catenin pathway in the pathogenesis of osteoarthritis and (2) pharmacologic or biologic strategies modulati...

Research paper thumbnail of A Crossover Randomized Trial of Visual Abstracts Versus Plain-Text Tweets for Disseminating Orthopedics Research

The Journal of Arthroplasty

Research paper thumbnail of A Crossover Randomized Trial of Visual Abstracts Versus Plain-Text Tweets for Disseminating Orthopedics Research

The Journal of Arthroplasty

Research paper thumbnail of African American Patients Have Improved Functional Gains and Comparable Clinical Outcomes to Caucasian Patients After Total Hip and Knee Arthroplasty

The Journal of Arthroplasty

Research paper thumbnail of Residency Program Reputation Influences the American Association of Hip and Knee Surgeons Match Results

The Journal of Arthroplasty

Research paper thumbnail of Prevention of Infection and Disruption of the Pathogen Transfer Chain in Elective Surgery

The Journal of Arthroplasty

Research paper thumbnail of High Bundled Payment Costs Following Total Hip and Knee Arthroplasty in African Americans

The Journal of Arthroplasty

Research paper thumbnail of Cancelled Total Joint Arthroplasty: Who, What, When and Why?

The Journal of Arthroplasty

Research paper thumbnail of Is There a Role for Spacer Exchange in Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection?

Journal of Clinical Medicine

Periprosthetic joint infection (PJI) continues to be one of the most serious complications after ... more Periprosthetic joint infection (PJI) continues to be one of the most serious complications after hip and knee arthroplasty. The choice of surgical treatment depends on a multitude of factors like chronicity of infection, host factors, and institutional or surgeon experience. Two-stage exchange remains one of the most commonly used technique for chronic PJI in the United States of America. The intended two-stage revision may involve an additional interim procedure where the initial antibiotic cement spacer is removed and a new spacer is inserted. Mostly, the rationale behind spacer exchange is an additional load of local antibiotics before proceeding to reimplantation. There is no conclusive evidence whether a spacer exchange confers additional benefits, yet it delays reimplantation and exposes already fragile patients to the risks and morbidity of an additional surgery.

Research paper thumbnail of Accuracy of blood-tests and synovial fluid-tests in the diagnosis of periprosthetic joint infections

Expert Review of Anti-infective Therapy

Research paper thumbnail of Obesity Increases the Risk of Tendinopathy, Tendon Tear and Rupture, and Postoperative Complications

Clinical Orthopaedics and Related Research

Research paper thumbnail of The role of the immune system in tendon healing: a systematic review

British Medical Bulletin

Introduction The role of the immune system in tendon healing relies on polymorphonucleocytes, mas... more Introduction The role of the immune system in tendon healing relies on polymorphonucleocytes, mast cells, macrophages and lymphocytes, the ‘immune cells’ and their cytokine production. This systematic review reports how the immune system affects tendon healing. Sources of data We registered our protocol (registration number: CRD42019141838). After searching PubMed, Embase and Cochrane Library databases, we included studies of any level of evidence published in peer-reviewed journals reporting clinical or preclinical results. The PRISMA guidelines were applied, and risk of bias and the methodological quality of the included studies were assessed. We excluded all the articles with high risk of bias and/or low quality after the assessment. We included 62 articles assessed as medium or high quality. Areas of agreement Macrophages are major actors in the promotion of proper wound healing as well as the resolution of inflammation in response to pathogenic challenge or tissue damage. The i...

Research paper thumbnail of Analyse de la perte de réduction en tant que facteur de risque de déplacement secondaire supplémentaire après traitement orthopédique chez l’enfant des fractures distales du radius déplacées

Revue de Chirurgie Orthopédique et Traumatologique

Research paper thumbnail of Cell-Free Scaffolds as a Monotherapy for Focal Chondral Knee Defects

Materials

Chondral knee defects have a limited ability to be repaired. Current surgical interventions have ... more Chondral knee defects have a limited ability to be repaired. Current surgical interventions have been unable to regenerate articular cartilage with the mechanical properties of native hyaline cartilage. The use of a scaffold-based approach is a potential solution. Scaffolds are often implanted with cells to stimulate cartilage regeneration, but cell-based therapies are associated with additional regulatory restrictions, an additional surgical procedure for cell harvest, time for cell expansion, and the associated costs. To overcome these disadvantages, cell-free scaffolds can be used in isolation allowing native cells to attach over time. This review discusses the optimal properties of scaffolds used for chondral defects, and the evidence for the use of hydrogel scaffolds and hydrogel–synthetic polymer hybrid scaffolds. Preclinical and clinical studies have shown that cell-free scaffolds can support articular cartilage regeneration and have the potential to treat chondral defects. H...

Research paper thumbnail of Integration of ultrasound in medical School: Effects on Physical Examination Skills of Undergraduates

Medical Science Educator

Introduction Ultrasound (US) imaging has rapidly increased its application in almost every medica... more Introduction Ultrasound (US) imaging has rapidly increased its application in almost every medical field. Many universities worldwide provide teaching of US for undergraduates in their curricula. Emerging evidence is supporting the use of ultrasonography to improve also non-US skills and knowledge of medical students. Objectives The purpose of this review is to understand if the integration of US lessons into medical students' curriculum improves their learning of physical examination and enhances their skills when performing it. Methods We performed a systematic review of literature by searching three electronic medical databases. We included studies of any level of evidence published in peer-reviewed journals. Evaluated data were extracted using the PICO framework and critically analyzed. PRISMA guidelines were applied; we excluded all the articles evaluated with serious risk of bias and/or low methodological quality. Results We included 15 articles, accounting for more than 1643 medical students involved from five different countries and 14 various academical institutions. Eight out of nine studies (88.9%) reported an improvement of practical physical examination scores by students exposed to ultrasound lectures. Eleven out of eleven studies (100%), which administered self-assessment questionnaires, reported strong agreement among students that ultrasound lectures helped them learning and understanding the physical exam and improved their confidence and skills. Conclusions Increasing evidence shows that incorporating ultrasound in medical students' curriculum might improve their ability and confidence when learning and performing a physical exam. This significant tendency needs to be corroborated at a deeper level by further studies.

Research paper thumbnail of Analysis of loss of reduction as risk factor for additional secondary displacement in children with displaced distal radius fractures treated conservatively

Orthopaedics & Traumatology: Surgery & Research

Research paper thumbnail of The Effects of TNF-alpha Inhibition on Cartilage: a Systematic Review of preclinical studies

Osteoarthritis and Cartilage

Research paper thumbnail of Single-Stage Revision Surgery in Infected Total Knee Arthroplasty: A PRISMA Systematic Review

Journal of Clinical Medicine

Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a... more Periprosthetic joint infection in total knee arthroplasty is a significant complication that is a common reason for revision surgery. The current standard of care is two-stage revision surgery. There is however increasing evidence to support the use of single-stage revision surgery. We conducted a PRISMA systematic review of the current evidence on the use of single-stage revision for infected total knee arthroplasty. Four databases (PubMed, Embase, Science Direct, and Cochrane Library) were systematically screened for eligible studies. The risk bias of each study was identified using ROBINS-I tool, and the quality of evidence was assessed using the GRADE criteria. Sixteen articles were retained after applying the inclusion and exclusion criteria that evaluated 3645 knee single-stage revision surgeries. Our review reveals satisfactory outcomes for single-stage revision in the management of infected total knee arthroplasty. The reinfection rates in the studies included in our review ...

Research paper thumbnail of Perioperative management of renal transplant patients undergoing total joint arthroplasty

Journal of Perioperative Practice

The success of renal transplantation depends on lifelong immunosuppression. This can lead to a hi... more The success of renal transplantation depends on lifelong immunosuppression. This can lead to a high incidence of avascular necrosis of major joints in the body for which arthroplasty is the treatment of choice. The risk of surgical complications is high in these patients, and there is no current set of cohesive perioperative management guidelines. In this review, we discuss the perioperative management of renal transplant patients undergoing elective total joint arthroplasty.

Research paper thumbnail of Polyphenol-rich foods and Osteoporosis

Current Pharmaceutical Design

Background: Osteoporosis is a metabolic disease affecting the bone mineral density able to compro... more Background: Osteoporosis is a metabolic disease affecting the bone mineral density able to compromise is architecture and strength. Disease prevention through diet is object of study and discussion. Among the several nutrients investigated, the intake of phenols seems to influence bone mineral density by acting as free radical scavengers, preventing oxidation-induced damage to bone cells. In addition, the growing understanding of the bone remodelling process supports the theory that inflammation significantly contributes to the etiopathogenesis of osteoporosis. Methods: To provide an overview of current evidence on polyphenol-rich foods and osteoporosis prevention we made a comprehensive review of the literature focusing on the state of art of the topic Results: Some polyphenol-rich foods, including olive oil, fruit and vegetable, tea and soy, seem to be beneficial for osteoporosis disease and progression prevention. The mechanism is still partly unknowns and may be involving differ...

Research paper thumbnail of The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

BioMed Research International

Introduction. Osteoarthritis (OA) is a degenerative joint disease characterized by articular cart... more Introduction. Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, subchondral damage, and bone remodelling, affecting most commonly weight-bearing joints, such as the knee and hip. The loss of cartilage leads to joint space narrowing, pain, and loss of function which could ultimately require total joint replacement. The Wnt/β catenin pathway is involved in the pathophysiology of OA and has been proposed as a therapeutic target. Endogenous and pharmacological inhibitors of this pathway were recently investigated within innovative therapies including the use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). Methods. A review of the literature was performed on the PubMed database based on the following inclusion criteria: article written in English language in the last 20 years and dealing with (1) the role of Wnt-β catenin pathway in the pathogenesis of osteoarthritis and (2) pharmacologic or biologic strategies modulati...