Christian Chaussy - Academia.edu (original) (raw)
Papers by Christian Chaussy
Current Urology Reports, Jun 17, 2015
Although shock wave lithotripsy (SWL) remains an excellent non-invasive method for active removal... more Although shock wave lithotripsy (SWL) remains an excellent non-invasive method for active removal of stones from the ureter and kidney, its popularity has decreased during recent years and the arguments for choosing endoscopic procedures rather than the only non-invasive surgical procedure are usually based on the opinion that SWL results are inferior to those obtained with endoscopic methods. It is considered that slow technical progress has not sufficiently met the requirements of disintegration, reduced need of repeated treatments, shorter treatment duration and less negative effects on tissues. This article summarises some recently published articles that address these problems and have the aim of improving the function of lithotripters. Modification of the shock wave geometry, elimination or control of cavitation bubbles, and different techniques of disintegration studied in in vitro and in animal experiments suggest several possible future directions that might provide a basis for development of a new "gold standard" lithotripter.
Nuklearmedizin, 1974
ZusammenfassungMittels quantitativer Kamera-Funktionsszintigraphie und gleichzeitiger seitengetre... more ZusammenfassungMittels quantitativer Kamera-Funktionsszintigraphie und gleichzeitiger seitengetrennter Clearance-Bestimmung mit 131J-Hippuran und 169Yb-EDTA wurde die Nierenfunktion nach einer neuen organschonenden Operationsmethode, der insitu-Perfusion und Kühlung von Nieren im Tierexperiment und am Patienten gemessen. Während im Tierexperiment (Bastardhunde, mittleres Körpergewicht 15 kg) eine Kontrollgruppe (N = 5) nach 1 stündiger normothermer Ischämie eine postoperative Verzögerung des intrarenalen 131J-Hippuran-Transportes mit Einschränkung der 131J-Hippuran- und 169Yb-EDTA-Clearance aufwies, war nach 1 stündiger (N = 5) und 2stündiger (N = 5) hypothermer Ischämie die Nierenfunktion am 1. postoperativen Tag normalisiert. Bei der klinischen Anwendung an Patienten (N = 9) mit hypothermer in-situ-Perfusion zwischen 40 und 92 Minuten-Dauer zeigte sich nach vorübergehender postoperativer Verzögerung des intrarenalen 131J-Hippuran-Transportes und Einschränkung der 131J-Hippuran-Cle...
Der Urologe. Ausg. A, 1982
The only efficient way to obtain adequate numbers of kidneys for transplantation is to perfect th... more The only efficient way to obtain adequate numbers of kidneys for transplantation is to perfect the technical and organisational method or organ harvesting. Careful attention to the details of organ procurement is as essential to the outcome of the transplantation as the procedure itself. To obtain optimal results, an effective collaboration between the central and peripheral hospital is necessary. A mobile medical and surgical team, coming from the central hospital for donor procurement was found to be most effective. Success in a major transplantation program requires continued improvement in the relationship between peripheral hospital physicians and the central transplant unit.
Comparaison de la clairance du 131 I-hipparan avant et jusqu'a 6,6 ans apres la lithiotripsie... more Comparaison de la clairance du 131 I-hipparan avant et jusqu'a 6,6 ans apres la lithiotripsie. Aucune deterioration de la fonction renale
20. bis 23. Oktober 1982, Hamburg, 1983
Wie schon die vorausgegangenen Mitteilungen zeigten, rechtfertigen die mit der Nierentransplantat... more Wie schon die vorausgegangenen Mitteilungen zeigten, rechtfertigen die mit der Nierentransplantation bei Kindern erzielten Resultate die Indikation zu diesem Eingriff.
Archivos españoles de urología, 1992
The Journal of Urology, 2007
Journal of Endourology, 2000
The results of the standard treatment for prostate cancer-radical prostatectomy-are not entirely ... more The results of the standard treatment for prostate cancer-radical prostatectomy-are not entirely satisfactory. A new local therapy, transrectal high-intensive focused ultrasound (HIFU), has been developed. We reviewed our experience with HIFU for palliation of localized prostate cancer. Our series included 65 men with confirmed prostate cancer without detectable metastases who were not suitable candidates for radical prostatectomy. After prophylactic suprapubic cystostomy, the patients were treated using the Ablatherm version 2.32 under spinal anesthesia. The effects were monitored by serum prostate specific antigen assays, digital rectal examination, and biopsy. The mean follow-up is 10 months (range 1-18 months). There were no intraoperative or postoperative deaths, and there have been no deaths from prostate cancer. Residual cancer was detected in 35% of the patients in whom only biopsy-positive portions of the prostate were treated and 17% of those in whom the entire gland was treated. Retreatment was performed 1 month after the first session in these patients. The prostate volume increased an average of 30% after treatment, but by 3 months, the gland was 10% to 20% smaller than its original size. Three patients suffered complications secondary to overheating of the rectal wall or treatment too close to the external urethral sphincter. The low morbidity, minimal invasiveness, avoidance of systemic side effects, and potentially curative effect make HIFU a potentially useful option for the treatment of localized prostate cancer.
Journal of Endourology, 2008
Developments in the technology applied to the field of minimally invasive surgery have led to the... more Developments in the technology applied to the field of minimally invasive surgery have led to the exploration of high-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer. Extensive research and continuous evolution have resulted in two commercially available HIFU devices: the Ablatherm and the Sonablate500. These devices are conceptually the same; however, specific technical differences exist. This paper reviews the clinical outcomes obtained with these devices, evaluates the quality of the evidence from the individual trials, and provides the results of a head-to-head comparison in terms of oncologic outcomes and complication rates.
Journal of Endourology, 2003
To describe the safety and efficacy of high-intensity focused ultrasound (HIFU) for the treatment... more To describe the safety and efficacy of high-intensity focused ultrasound (HIFU) for the treatment of prostate cancer as assessed in a Phase II/III prospective multicentric clinical trial. Patients (N = 402) presenting with localized (stage T(1-2)N(0-x)M(0)) prostate cancer between 1995 and 1999 at six European sites who were not candidates for radical prostatectomy were treated with HIFU under general or spinal anesthesia. Their mean age was 69.3 +/- 7.1 (SD) years, the mean prostate volume 28.0 +/- 13.8 cc, and the mean serum prostate specific antigen (PSA) concentration 10.9 +/- 8.7 ng/mL. Nearly all (92.2%) of the patients had one to four positive biopsy samples at baseline. The Gleason scores were 2 to 4 for 13.2% of the patients, 5 to 7 for 77.5%, and 8 to 10 for 9.3%. During the follow-up, random sextant biopsies and serum PSA measurements were performed. Any positive sample in biopsies performed after the last treatment session resulted in a "HIFU failure" classification. The patients received a mean of 1.4 HIFU sessions. The mean follow-up duration was 407 days (quartile 1 135 days, median 321 days, quartile 3 598 days). The negative biopsy rate observed in the T1-2 primary-care population was 87.2%. These results were also stratified according to the usual disease-related risk classification, and as much as a 92.1% negative biopsy rate was observed in low-risk patients. Nadir PSA results correlated with prostate size and the clinical procedure. These short-term results obtained on a large cohort confirm that HIFU is an option to be considered for the primary treatment of localized prostate cancer.
Journal of Endourology, 2009
Journal of Endourology, 2010
In one-third of patients, prostate cancer (PCa) is monofocal. These patients can undergo focal hi... more In one-third of patients, prostate cancer (PCa) is monofocal. These patients can undergo focal high-intensity focused ultrasound (HIFU) therapy of the tumor without damage to surrounding structures and not compromising uro-oncologic safety. Robot-assisted HIFU coagulates the entire targeted volume within the prostate transrectally, in one session, without direct tumor contact and without adjuvant endourologic therapy. It is performed with the patient receiving spinal anesthesia and without blood loss; negative immunologic influence can be excluded. Heat-destroyed cancer cells that act as tumor vaccination are discussed. Right now, the limitation of focal therapy is caused by the lack of diagnostic accuracy to determine multifocal stages of PCa reliably. Discussions of tumor development, triggering primary lesion monotherapy, do not overcome skepticism about leaving invisible tumor foci untreated. This explains why PCa therapy today treats always the entire gland. Furthermore, the thought that the problem could be solved "radically, once forever," ignores the fact that in all PCa therapies, local recurrence rates are between 10% and 50%. Considering the longer survival of men in industrialized countries, a structured multimodal therapy concept should be created and evaluated in studies and should replace the competition between classic therapies. Focal therapy in most cases should be the first approach in cancer therapy because it is noninvasive, has low side effects, and is a single-session therapy. It does not exclude but may delay other, more invasive therapies in cases of cancer recurrence. Focal therapy should not be misunderstood as substitution for existing classic therapies but as a therapeutic first choice in monofocal, low-aggressive PCa cases.
Journal of Endourology, 1996
The side effects of high-energy shockwaves (HESW) from two different sources on kidney parenchyma... more The side effects of high-energy shockwaves (HESW) from two different sources on kidney parenchyma obtained from 10 patients treated by radical nephrectomy for renal cell carcinoma were examined. Immediately after nephrectomy, the kidneys were perfused with cold HTK solution and kept in hypothermia (8 degrees C) for a maximum of 4 hours. In five cases, the tumor-free parenchyma was treated at the upper or lower renal pole with 2000 shocks, energy output 21 kV, in an experimental electromagnetic shockwave system (Siemens Co., Erlangen). In the other five cases, the upper or lower poles were treated with 2000 shocks, energy output 24 kV, in an electrohydraulic spark gap system (MFL 5000; Dornier Medizintechnik, Germering). The resulting tissue defects were analyzed by histologic examinations. Changes after treatment with the electromagnetic system were found mainly in the tubules and midsized blood vessels in a well-defined focal area. Treatment with the electrohydraulic system was followed by tubular and glomerular lesions combined with vessel defects in a patchy pattern. The model is able to define the side effects of HESW in the human kidney and to test the side effects of different lithotripters.
Journal of Endourology, 1995
This article reviews the first experience using the Siemens Lithostar Multiline lithotripter in 3... more This article reviews the first experience using the Siemens Lithostar Multiline lithotripter in 372 consecutive treatments of ureteric and kidney stones. The disintegration rate was 97.7%, and a stone-free rate of 87% was achieved at the end of 3 months. Auxillary procedures were required in only 11% of the patients. No medication was required for pain management in 60.4% of the patients. The results were especially impressive in the management of ureteric stones, with a success rate of 91%, these patients being stone free after 1 week using the new booster technique. Analysis of the data indicates that the Siemens Lithostar Multiline is a safe, effective, and economically sound device to treat patients with ureteric and renal stones.
Journal of Endourology, 1987
... Extracorporeal Shock Wave Lithotripsy of Distal-Ureteral Calculi: Is It Worthwhile? CHRISTIAN... more ... Extracorporeal Shock Wave Lithotripsy of Distal-Ureteral Calculi: Is It Worthwhile? CHRISTIAN G. CHAUSSY, MD and GERHARD J. FUCHS, MD ABSTRACT ... 1 Page 2. CHAUSSY AND FUCHS Table 1. Current Differential Indications for Ureteral Stone-Removal Techniques ...
Journal of Endourology, 1988
Page 1. JOURNAL OF ENDOUROLOGY Volume 2, Number 2, 1988 Mary Ann Liebert, Inc., Publishers ESWL: ... more Page 1. JOURNAL OF ENDOUROLOGY Volume 2, Number 2, 1988 Mary Ann Liebert, Inc., Publishers ESWL: Past, Present, and Future CHRISTIAN G. CHAUSSY, MD INTRODUCTION EXTRACORPOREALshock wave LITHOTRIPSY ...
Journal of Endourology, 1988
... 1. Lutfi Tunc, Bora Kupeli, Cagri Senocak, Turgut Alkibay, Sinan Sözen, Ustunol Karaoglan,Ibr... more ... 1. Lutfi Tunc, Bora Kupeli, Cagri Senocak, Turgut Alkibay, Sinan Sözen, Ustunol Karaoglan,Ibrahim Bozkirli. 2007. ... Korean Journal of Urology 47:6, 625. [CrossRef] 3. Sinan Sözen , Bora Küpeli , Lütfi Tunc , Çağri Şenocak , Turgut Alkibay , Üstünol Karaoğlan , İbrahim Bozkirli . ...
Journal of Endourology, 1989
Journal of Endourology, 2011
The application of a water-jet dissector for mucosal elevation was shown to improve resection of ... more The application of a water-jet dissector for mucosal elevation was shown to improve resection of lesions of the gastrointestinal tract. We present the first prospective clinical trial on the application of a combined water-jet dissector and needle-knife (HybridKnife) in transurethral dissection (TUD) of urothelial carcinoma of the bladder (UCB). Thirty separate urothelial tumors of the bladder in 17 unselected patients were elevated and dissected with the HybridKnife. The goal was to determine the safety, effectiveness of resection, and overall applicability of the HybridKnife. No perforation or other complication was seen. All tumors could be dissected from the bladder wall en bloc. TUD of UCB by using the HybridKnife is technically feasible and safe in the resection of papillary and solid tumors. The application of the HybridKnife in TUD of UCB appears to be a feasibly safe and applicable for en-bloc dissection technique potentially following principles of oncologic surgery in transurethral removal of UCB. It seems to facilitate histopathologic assessment. A possibly improved oncologic outcome has to be addressed in further studies.
Current Urology Reports, Jun 17, 2015
Although shock wave lithotripsy (SWL) remains an excellent non-invasive method for active removal... more Although shock wave lithotripsy (SWL) remains an excellent non-invasive method for active removal of stones from the ureter and kidney, its popularity has decreased during recent years and the arguments for choosing endoscopic procedures rather than the only non-invasive surgical procedure are usually based on the opinion that SWL results are inferior to those obtained with endoscopic methods. It is considered that slow technical progress has not sufficiently met the requirements of disintegration, reduced need of repeated treatments, shorter treatment duration and less negative effects on tissues. This article summarises some recently published articles that address these problems and have the aim of improving the function of lithotripters. Modification of the shock wave geometry, elimination or control of cavitation bubbles, and different techniques of disintegration studied in in vitro and in animal experiments suggest several possible future directions that might provide a basis for development of a new "gold standard" lithotripter.
Nuklearmedizin, 1974
ZusammenfassungMittels quantitativer Kamera-Funktionsszintigraphie und gleichzeitiger seitengetre... more ZusammenfassungMittels quantitativer Kamera-Funktionsszintigraphie und gleichzeitiger seitengetrennter Clearance-Bestimmung mit 131J-Hippuran und 169Yb-EDTA wurde die Nierenfunktion nach einer neuen organschonenden Operationsmethode, der insitu-Perfusion und Kühlung von Nieren im Tierexperiment und am Patienten gemessen. Während im Tierexperiment (Bastardhunde, mittleres Körpergewicht 15 kg) eine Kontrollgruppe (N = 5) nach 1 stündiger normothermer Ischämie eine postoperative Verzögerung des intrarenalen 131J-Hippuran-Transportes mit Einschränkung der 131J-Hippuran- und 169Yb-EDTA-Clearance aufwies, war nach 1 stündiger (N = 5) und 2stündiger (N = 5) hypothermer Ischämie die Nierenfunktion am 1. postoperativen Tag normalisiert. Bei der klinischen Anwendung an Patienten (N = 9) mit hypothermer in-situ-Perfusion zwischen 40 und 92 Minuten-Dauer zeigte sich nach vorübergehender postoperativer Verzögerung des intrarenalen 131J-Hippuran-Transportes und Einschränkung der 131J-Hippuran-Cle...
Der Urologe. Ausg. A, 1982
The only efficient way to obtain adequate numbers of kidneys for transplantation is to perfect th... more The only efficient way to obtain adequate numbers of kidneys for transplantation is to perfect the technical and organisational method or organ harvesting. Careful attention to the details of organ procurement is as essential to the outcome of the transplantation as the procedure itself. To obtain optimal results, an effective collaboration between the central and peripheral hospital is necessary. A mobile medical and surgical team, coming from the central hospital for donor procurement was found to be most effective. Success in a major transplantation program requires continued improvement in the relationship between peripheral hospital physicians and the central transplant unit.
Comparaison de la clairance du 131 I-hipparan avant et jusqu'a 6,6 ans apres la lithiotripsie... more Comparaison de la clairance du 131 I-hipparan avant et jusqu'a 6,6 ans apres la lithiotripsie. Aucune deterioration de la fonction renale
20. bis 23. Oktober 1982, Hamburg, 1983
Wie schon die vorausgegangenen Mitteilungen zeigten, rechtfertigen die mit der Nierentransplantat... more Wie schon die vorausgegangenen Mitteilungen zeigten, rechtfertigen die mit der Nierentransplantation bei Kindern erzielten Resultate die Indikation zu diesem Eingriff.
Archivos españoles de urología, 1992
The Journal of Urology, 2007
Journal of Endourology, 2000
The results of the standard treatment for prostate cancer-radical prostatectomy-are not entirely ... more The results of the standard treatment for prostate cancer-radical prostatectomy-are not entirely satisfactory. A new local therapy, transrectal high-intensive focused ultrasound (HIFU), has been developed. We reviewed our experience with HIFU for palliation of localized prostate cancer. Our series included 65 men with confirmed prostate cancer without detectable metastases who were not suitable candidates for radical prostatectomy. After prophylactic suprapubic cystostomy, the patients were treated using the Ablatherm version 2.32 under spinal anesthesia. The effects were monitored by serum prostate specific antigen assays, digital rectal examination, and biopsy. The mean follow-up is 10 months (range 1-18 months). There were no intraoperative or postoperative deaths, and there have been no deaths from prostate cancer. Residual cancer was detected in 35% of the patients in whom only biopsy-positive portions of the prostate were treated and 17% of those in whom the entire gland was treated. Retreatment was performed 1 month after the first session in these patients. The prostate volume increased an average of 30% after treatment, but by 3 months, the gland was 10% to 20% smaller than its original size. Three patients suffered complications secondary to overheating of the rectal wall or treatment too close to the external urethral sphincter. The low morbidity, minimal invasiveness, avoidance of systemic side effects, and potentially curative effect make HIFU a potentially useful option for the treatment of localized prostate cancer.
Journal of Endourology, 2008
Developments in the technology applied to the field of minimally invasive surgery have led to the... more Developments in the technology applied to the field of minimally invasive surgery have led to the exploration of high-intensity focused ultrasound (HIFU) for the treatment of localized prostate cancer. Extensive research and continuous evolution have resulted in two commercially available HIFU devices: the Ablatherm and the Sonablate500. These devices are conceptually the same; however, specific technical differences exist. This paper reviews the clinical outcomes obtained with these devices, evaluates the quality of the evidence from the individual trials, and provides the results of a head-to-head comparison in terms of oncologic outcomes and complication rates.
Journal of Endourology, 2003
To describe the safety and efficacy of high-intensity focused ultrasound (HIFU) for the treatment... more To describe the safety and efficacy of high-intensity focused ultrasound (HIFU) for the treatment of prostate cancer as assessed in a Phase II/III prospective multicentric clinical trial. Patients (N = 402) presenting with localized (stage T(1-2)N(0-x)M(0)) prostate cancer between 1995 and 1999 at six European sites who were not candidates for radical prostatectomy were treated with HIFU under general or spinal anesthesia. Their mean age was 69.3 +/- 7.1 (SD) years, the mean prostate volume 28.0 +/- 13.8 cc, and the mean serum prostate specific antigen (PSA) concentration 10.9 +/- 8.7 ng/mL. Nearly all (92.2%) of the patients had one to four positive biopsy samples at baseline. The Gleason scores were 2 to 4 for 13.2% of the patients, 5 to 7 for 77.5%, and 8 to 10 for 9.3%. During the follow-up, random sextant biopsies and serum PSA measurements were performed. Any positive sample in biopsies performed after the last treatment session resulted in a "HIFU failure" classification. The patients received a mean of 1.4 HIFU sessions. The mean follow-up duration was 407 days (quartile 1 135 days, median 321 days, quartile 3 598 days). The negative biopsy rate observed in the T1-2 primary-care population was 87.2%. These results were also stratified according to the usual disease-related risk classification, and as much as a 92.1% negative biopsy rate was observed in low-risk patients. Nadir PSA results correlated with prostate size and the clinical procedure. These short-term results obtained on a large cohort confirm that HIFU is an option to be considered for the primary treatment of localized prostate cancer.
Journal of Endourology, 2009
Journal of Endourology, 2010
In one-third of patients, prostate cancer (PCa) is monofocal. These patients can undergo focal hi... more In one-third of patients, prostate cancer (PCa) is monofocal. These patients can undergo focal high-intensity focused ultrasound (HIFU) therapy of the tumor without damage to surrounding structures and not compromising uro-oncologic safety. Robot-assisted HIFU coagulates the entire targeted volume within the prostate transrectally, in one session, without direct tumor contact and without adjuvant endourologic therapy. It is performed with the patient receiving spinal anesthesia and without blood loss; negative immunologic influence can be excluded. Heat-destroyed cancer cells that act as tumor vaccination are discussed. Right now, the limitation of focal therapy is caused by the lack of diagnostic accuracy to determine multifocal stages of PCa reliably. Discussions of tumor development, triggering primary lesion monotherapy, do not overcome skepticism about leaving invisible tumor foci untreated. This explains why PCa therapy today treats always the entire gland. Furthermore, the thought that the problem could be solved "radically, once forever," ignores the fact that in all PCa therapies, local recurrence rates are between 10% and 50%. Considering the longer survival of men in industrialized countries, a structured multimodal therapy concept should be created and evaluated in studies and should replace the competition between classic therapies. Focal therapy in most cases should be the first approach in cancer therapy because it is noninvasive, has low side effects, and is a single-session therapy. It does not exclude but may delay other, more invasive therapies in cases of cancer recurrence. Focal therapy should not be misunderstood as substitution for existing classic therapies but as a therapeutic first choice in monofocal, low-aggressive PCa cases.
Journal of Endourology, 1996
The side effects of high-energy shockwaves (HESW) from two different sources on kidney parenchyma... more The side effects of high-energy shockwaves (HESW) from two different sources on kidney parenchyma obtained from 10 patients treated by radical nephrectomy for renal cell carcinoma were examined. Immediately after nephrectomy, the kidneys were perfused with cold HTK solution and kept in hypothermia (8 degrees C) for a maximum of 4 hours. In five cases, the tumor-free parenchyma was treated at the upper or lower renal pole with 2000 shocks, energy output 21 kV, in an experimental electromagnetic shockwave system (Siemens Co., Erlangen). In the other five cases, the upper or lower poles were treated with 2000 shocks, energy output 24 kV, in an electrohydraulic spark gap system (MFL 5000; Dornier Medizintechnik, Germering). The resulting tissue defects were analyzed by histologic examinations. Changes after treatment with the electromagnetic system were found mainly in the tubules and midsized blood vessels in a well-defined focal area. Treatment with the electrohydraulic system was followed by tubular and glomerular lesions combined with vessel defects in a patchy pattern. The model is able to define the side effects of HESW in the human kidney and to test the side effects of different lithotripters.
Journal of Endourology, 1995
This article reviews the first experience using the Siemens Lithostar Multiline lithotripter in 3... more This article reviews the first experience using the Siemens Lithostar Multiline lithotripter in 372 consecutive treatments of ureteric and kidney stones. The disintegration rate was 97.7%, and a stone-free rate of 87% was achieved at the end of 3 months. Auxillary procedures were required in only 11% of the patients. No medication was required for pain management in 60.4% of the patients. The results were especially impressive in the management of ureteric stones, with a success rate of 91%, these patients being stone free after 1 week using the new booster technique. Analysis of the data indicates that the Siemens Lithostar Multiline is a safe, effective, and economically sound device to treat patients with ureteric and renal stones.
Journal of Endourology, 1987
... Extracorporeal Shock Wave Lithotripsy of Distal-Ureteral Calculi: Is It Worthwhile? CHRISTIAN... more ... Extracorporeal Shock Wave Lithotripsy of Distal-Ureteral Calculi: Is It Worthwhile? CHRISTIAN G. CHAUSSY, MD and GERHARD J. FUCHS, MD ABSTRACT ... 1 Page 2. CHAUSSY AND FUCHS Table 1. Current Differential Indications for Ureteral Stone-Removal Techniques ...
Journal of Endourology, 1988
Page 1. JOURNAL OF ENDOUROLOGY Volume 2, Number 2, 1988 Mary Ann Liebert, Inc., Publishers ESWL: ... more Page 1. JOURNAL OF ENDOUROLOGY Volume 2, Number 2, 1988 Mary Ann Liebert, Inc., Publishers ESWL: Past, Present, and Future CHRISTIAN G. CHAUSSY, MD INTRODUCTION EXTRACORPOREALshock wave LITHOTRIPSY ...
Journal of Endourology, 1988
... 1. Lutfi Tunc, Bora Kupeli, Cagri Senocak, Turgut Alkibay, Sinan Sözen, Ustunol Karaoglan,Ibr... more ... 1. Lutfi Tunc, Bora Kupeli, Cagri Senocak, Turgut Alkibay, Sinan Sözen, Ustunol Karaoglan,Ibrahim Bozkirli. 2007. ... Korean Journal of Urology 47:6, 625. [CrossRef] 3. Sinan Sözen , Bora Küpeli , Lütfi Tunc , Çağri Şenocak , Turgut Alkibay , Üstünol Karaoğlan , İbrahim Bozkirli . ...
Journal of Endourology, 1989
Journal of Endourology, 2011
The application of a water-jet dissector for mucosal elevation was shown to improve resection of ... more The application of a water-jet dissector for mucosal elevation was shown to improve resection of lesions of the gastrointestinal tract. We present the first prospective clinical trial on the application of a combined water-jet dissector and needle-knife (HybridKnife) in transurethral dissection (TUD) of urothelial carcinoma of the bladder (UCB). Thirty separate urothelial tumors of the bladder in 17 unselected patients were elevated and dissected with the HybridKnife. The goal was to determine the safety, effectiveness of resection, and overall applicability of the HybridKnife. No perforation or other complication was seen. All tumors could be dissected from the bladder wall en bloc. TUD of UCB by using the HybridKnife is technically feasible and safe in the resection of papillary and solid tumors. The application of the HybridKnife in TUD of UCB appears to be a feasibly safe and applicable for en-bloc dissection technique potentially following principles of oncologic surgery in transurethral removal of UCB. It seems to facilitate histopathologic assessment. A possibly improved oncologic outcome has to be addressed in further studies.