Christian Dobel - Academia.edu (original) (raw)

Papers by Christian Dobel

Research paper thumbnail of The Jena Voice Learning and Memory Test (JVLMT): A standardized tool for assessing the ability to learn and recognize voices

The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low e... more The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low end and super recognition at the high end. Yet there is no standardized test to measure an individual’s ability of learning and recognizing newly-learnt voices with samples of speech-like phonetic variability. We have developed the Jena Voice Learning and Memory Test (JVLMT), a 22min-test based on item response theory and applicable across languages. The JVLMT consists of three phases in which participants first become familiarized with eight speakers and then perform a three-alternative forced choice recognition task, using pseudo sentences devoid of semantics. Acoustic (dis)similarity analyses were used to create items with different levels of difficulty. Test scores are based on 22 Rasch-conform items. Items were selected based on 232 and validated based on 454 participants in an online study. Mean accuracy is 0.51 with an SD of .18. The JVLMT showed high and moderate correlations with...

Research paper thumbnail of Ratings of Emotional Expressions in Static and Dynamic Facial Recordings Before and After Upper Face Botulinum Injections—An Observational Prospective Study

Aesthetic Surgery Journal

Background Botulinum toxin A (BTX), a neurotoxin widely used for facial aesthetics, causes dose-d... more Background Botulinum toxin A (BTX), a neurotoxin widely used for facial aesthetics, causes dose-dependent muscle paralysis. It was hypothesized that treatment of mimic muscles with BTX might have a positive impact on emotional expression in static images (photographs), but a negative impact in dynamic recordings (videos). Objectives The aim of this study was to compare of emotional expression recorded in photographs and videos before and after treatment with BTX. Methods Twenty healthy women (mean age, 45 years) received a dose of 19 mouse units of XEOMIN (Merz, Frankfurt am Main, Germany) into the procerus, occipitofrontalis, and orbicularis oculi muscles. Photographs and videos of the participants’ faces with neutral and happy expressions were recorded before treatment and 2 weeks later. Recordings were rated by naive raters blind to the conditions and in balanced order. Results Videos were generally rated as more pleasant, arousing, attractive, and genuine than photographs (all P...

Research paper thumbnail of Maladaptive alterations of resting state cortical network in Tinnitus: A directed functional connectivity analysis of a larger MEG data set

Scientific Reports

The present study used resting state MEG whole-head recordings to identify how chronic tonal tinn... more The present study used resting state MEG whole-head recordings to identify how chronic tonal tinnitus relates to altered functional connectivity of brain’s intrinsic cortical networks. Resting state MEG activity of 40 chronic tinnitus patients and 40 matched human controls was compared identifying significant alterations in intrinsic networks of the tinnitus population. Directed functional connectivity of the resting brain, at a whole cortex level, was estimated by means of a statistical comparison of the estimated phase Transfer Entropy (pTE) between the time-series of cortical activations, as reconstructed by LORETA. As pTE identifies the direction of the information flow, a detailed analysis of the connectivity differences between tinnitus patients and controls was possible. Results indicate that the group of tinnitus patients show increased connectivity from right dorsal prefrontal to right medial temporal areas. Our results go beyond previous findings by indicating that the rol...

Research paper thumbnail of Choice of Test Stimulus matters for Pitch Matching Performance: Comparison between Pure Tone and Narrow Band Noise

Research paper thumbnail of Deaf signers outperform hearing non-signers in recognizing happy facial expressions

Research paper thumbnail of Seeing for speaking: Semantic and lexical information provided by briefly presented, naturalistic action scenes

PloS one, 2018

At the interface between scene perception and speech production, we investigated how rapidly acti... more At the interface between scene perception and speech production, we investigated how rapidly action scenes can activate semantic and lexical information. Experiment 1 examined how complex action-scene primes, presented for 150 ms, 100 ms, or 50 ms and subsequently masked, influenced the speed with which immediately following action-picture targets are named. Prime and target actions were either identical, showed the same action with different actors and environments, or were unrelated. Relative to unrelated primes, identical and same-action primes facilitated naming the target action, even when presented for 50 ms. In Experiment 2, neutral primes assessed the direction of effects. Identical and same-action scenes induced facilitation but unrelated actions induced interference. In Experiment 3, written verbs were used as targets for naming, preceded by action primes. When target verbs denoted the prime action, clear facilitation was obtained. In contrast, interference was observed wh...

Research paper thumbnail of Basic numerical processing, calculation, and working memory in children with dyscalculia and/or ADHD symptoms

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie

Deficits in basic numerical skills, calculation, and working memory have been found in children w... more Deficits in basic numerical skills, calculation, and working memory have been found in children with developmental dyscalculia (DD) as well as children with attention-deficit/hyperactivity disorder (ADHD). This paper investigates cognitive profiles of children with DD and/or ADHD symptoms (AS) in a double dissociation design to obtain a better understanding of the comorbidity of DD and ADHD. METHOD: Children with DD-only (N = 33), AS-only (N = 16), comorbid DD+AS (N = 20), and typically developing controls (TD, N = 40) were assessed on measures of basic numerical processing, calculation, working memory, processing speed, and neurocognitive measures of attention. RESULTS: Children with DD (DD, DD+AS) showed deficits in all basic numerical skills, calculation, working memory, and sustained attention. Children with AS (AS, DD+AS) displayed more selective difficulties in dot enumeration, subtraction, verbal working memory, and processing speed. Also, they generally performed more poorly in neurocognitive measures of attention, especially alertness. Children with DD+AS mostly showed an additive combination of the deficits associated with DD-only and A_Sonly, except for subtraction tasks, in which they were less impaired than expected.

Research paper thumbnail of Impairments of Speech Comprehension in Patients with Tinnitus—A Review

Frontiers in Aging Neuroscience

Tinnitus describes the subjective perception of a sound despite the absence of external stimulati... more Tinnitus describes the subjective perception of a sound despite the absence of external stimulation. Being a sensory symptom the majority of studies focusses on the auditory pathway. In the recent years, a series of studies suggested a crucial involvement of the limbic system in the manifestation and development of chronic tinnitus. Regarding cognitive symptoms, several reviews addressed the presence of cognitive impairments in tinnitus as well and concluded that attention and memory processes are affected. Despite the importance for social communication and the reliance on a highly functional auditory system, speech comprehension remains a largely neglected field in tinnitus research. This is why we review here the existing literature on speech and language functions in tinnitus patients. Reviewed studies suggest that speech comprehension is impaired in patients with tinnitus, especially in the presence of competing noise. This is even the case in tinnitus patients with normal hearing thresholds. Additionally, speech comprehension measures seem independent of other measures such as tinnitus severity and perceived tinnitus loudness. According to the majority of authors, the speech comprehension difficulties arise as a result of central processes or dysfunctional neuroplasticity.

Research paper thumbnail of Results of an Interdisciplinary Day Care Approach for Chronic Tinnitus Treatment: A Prospective Study Introducing the Jena Interdisciplinary Treatment for Tinnitus

Frontiers in Aging Neuroscience

Conclusion: The newly developed JITT represents a valuable treatment for chronic tinnitus patient... more Conclusion: The newly developed JITT represents a valuable treatment for chronic tinnitus patients with improvement remaining stable for at least 6 months after treatment. Using a large number of variables did not allow predicting treatment outcome which underlines the heterogeneity of tinnitus.

Research paper thumbnail of When Hearing Is Tricky: Speech Processing Strategies in Prelingually Deafened Children and Adolescents with Cochlear Implants Having Good and Poor Speech Performance

PLOS ONE

Cochlear implants provide individuals who are deaf with access to speech. Although substantial ad... more Cochlear implants provide individuals who are deaf with access to speech. Although substantial advancements have been made by novel technologies, there still is high variability in language development during childhood, depending on adaptation and neural plasticity. These factors have often been investigated in the auditory domain, with the mismatch negativity as an index for sensory and phonological processing. Several studies have demonstrated that the MMN is an electrophysiological correlate for hearing improvement with cochlear implants. In this study, two groups of cochlear implant users, both with very good basic hearing abilities but with non-overlapping speech performance (very good or very poor speech performance), were matched according to device experience and age at implantation. We tested the perception of phonemes in the context of specific other phonemes from which they were very hard to discriminate (e.g., the vowels in /bu/ vs. /bo/). The most difficult pair was individually determined for each participant. Using behavioral measures, both cochlear implants groups performed worse than matched controls, and the good performers performed better than the poor performers. Cochlear implant groups and controls did not differ during time intervals typically used for the mismatch negativity, but earlier: source analyses revealed increased activity in the region of the right supramarginal gyrus (220-260 ms) in good performers. Poor performers showed increased activity in the left occipital cortex (220-290 ms), which may be an index for cross-modal perception. The time course and the neural generators differ from data from our earlier studies, in which the same phonemes were assessed in an easy-to-discriminate context. The results demonstrate that the groups used different language processing strategies, depending on the success of language development and the particular language context. Overall, our data emphasize the role of neural plasticity and use of adaptive strategies for successful language development with cochlear implants.

Research paper thumbnail of Change of speech fundamental frequency explains the satisfaction with voice in response to testosterone therapy in female-to-male gender dysphoric individuals

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016

Previous studies demonstrated that there is a significant change in speaking fundamental frequenc... more Previous studies demonstrated that there is a significant change in speaking fundamental frequency after testosterone therapy in female-to-male gender dysphoric individuals. It is yet an open question how the satisfaction with voice alteration can be predicted because until now it is not clear whether a testosterone therapy is sufficiently effective. The aim of the current study was not only to measure satisfaction with voice, but additionally to detect factors that predict or explain satisfaction with voice after testosterone therapy. Therefore, nine female-to-male gender dysphoric individuals were examined during the first year of testosterone treatment at different points of time. The patients underwent several voice analyses within 1 year and had to fill out several questionnaires concerning their voice, depressive symptoms, quality of life and voice handicap index. Multiple regression analyses were performed to find the factors that explained satisfaction with altered voice aft...

Research paper thumbnail of Anxiety related personality traits and emotion regulation strategies predict number and integrity of probabilistically tracked pathways between the amygdala and prefrontal cortex regions

Research paper thumbnail of Ebenen der Sprachverarbeitung und ihre Beeinträchtigung bei der Aphasie: Evidenz von der topographischen Analyse ereigniskorrelierter Potentiale

Research paper thumbnail of DTD 5 ARTICLE IN PRESS Brief article Lexically-driven syntactic priming

Research paper thumbnail of Processing of existing, synonymous, and anomalous German derived adjectives: An MEG study

Neuroscience Letters, Jan 18, 2010

Neuronal activation as response to reading existing derived German adjectives (e.g., freundlich, ... more Neuronal activation as response to reading existing derived German adjectives (e.g., freundlich, friendly) was measured using MEG and compared to that evoked by non-existing, but semantically synonymous adjectives (*freundhaft) and to activation induced by non-existing, semantically and morphologically anomalous adjectives (*freundbar). By applying distributed source modeling we revealed a gradual increase of neuronal activity within areas of the left temporal lobe in the time range of the N400. Activity increased from existing over synonymous to anomalous adjectives. Underscoring the use of neurophysiological measures, these results demonstrate that morpho-semantic analysis take place for non-existing morphologically complex pseudowords even if not warranted by the current task. Furthermore, these data argue in favor of morphological decomposition.

Research paper thumbnail of Dyskalkulie vs. Rechenschwäche: Basisnumerische Verarbeitung in der Grundschule

Lernen Und Lernstorungen, Mar 3, 2015

Laut ICD-10 und DSM-IV-TR muss für die Diagnose einer Dyskalkulie eine Diskrepanz zwischen der al... more Laut ICD-10 und DSM-IV-TR muss für die Diagnose einer Dyskalkulie eine Diskrepanz zwischen der allgemeinen kognitiven Leistungsfähigkeit und der tatsächlichen oder vorhergesagten Leistung in einem Mathematiktest vorliegen. Diese Definition impliziert, dass sich rechenschwache Kinder, die diese Diskrepanz aufweisen, von rechenschwachen Kindern ohne Erfüllung des Diskrepanzkriteriums unterscheiden. Die vorliegende Arbeit hatte zum Ziel, mögliche Unterschiede zwischen dyskalkulischen und rechenschwachen Kindern sowie einer Kontrollgruppe in der basisnumerischen Verarbeitung zu prüfen. Zur Identifikation einer Dyskalkulie bzw. Rechenschwäche wurden entweder (a) ein Testverfahren mit basisnumerischem Schwerpunkt (ZAREKI-R) oder (b) Tests zur Erfassung von Rechenfertigkeiten (ZAREKI-R Kopfrechnen und Textaufgaben, HRT 1 – 4 Addition und Subtraktion, WISC-IV rechnerisches Denken) verwendet. Insgesamt bearbeiteten 68 Kinder (Dyskalkulie: Na = 27/Nb = 11, Rechenschwäche: Na = 21/Nb = 18, Kontrollgruppe: Na = 20/Nb = 39) eine Batterie von basisnumerischen Aufgaben: Simultanerfassung, Abzählen, Mengenvergleich, Transkodieren, Number sets und Zahlenstrahl (0 – 100). Zusätzlich wurde die Arbeitsgedächtniskapazität mit einer visuell-räumlichen Aufgabe (Matrixspanne) überprüft. Laut Klassifikation nach ZAREKI-R unterschieden sich rechenschwache und dyskalkulische Kinder in fast allen basisnumerischen Aufgaben klar von der Kontrollgruppe, jedoch nicht untereinander. Bei Klassifikation nach Rechenfertigkeiten konnten rechenschwache und dyskalkulische Kinder ebenfalls nicht differenziert werden, allerdings unterschieden sich nur rechenschwache Kinder von der Kontrollgruppe (bei den Aufgaben Simultanerfassung, Abzählen, symbolischer Mengenvergleich, Transkodieren, Zahlenstrahl). Die Befunde werden vor dem Hintergrund der Verwendung basisnumerischer Fertigkeiten für die Diagnose und Therapie von Dyskalkulie diskutiert.

Research paper thumbnail of Lobmaier+2010 ConfiguralFeaturalProcessingCongenitalProsopagnosia AdvancesCongitivePsychology

Research paper thumbnail of Song Perception by Professional Singers and Actors: An MEG Study

PloS one, 2016

The cortical correlates of speech and music perception are essentially overlapping, and the speci... more The cortical correlates of speech and music perception are essentially overlapping, and the specific effects of different types of training on these networks remain unknown. We compared two groups of vocally trained professionals for music and speech, singers and actors, using recited and sung rhyme sequences from German art songs with semantic and/ or prosodic/melodic violations (i.e. violations of pitch) of the last word, in order to measure the evoked activation in a magnetoencephalographic (MEG) experiment. MEG data confirmed the existence of intertwined networks for the sung and spoken modality in an early time window after word violation. In essence for this early response, higher activity was measured after melodic/prosodic than semantic violations in predominantly right temporal areas. For singers as well as for actors, modality-specific effects were evident in predominantly left-temporal lateralized activity after semantic expectancy violations in the spoken modality, and r...

Research paper thumbnail of Rapid apprehension of the coherence of action scenes

Psychonomic Bulletin & Review, 2016

Some information about complex naturalistic scenes, such as the scene's gist (a beach, a restaura... more Some information about complex naturalistic scenes, such as the scene's gist (a beach, a restaurant) or the category of an object depicted in a scene, can be extracted within a fraction of a second. The present study focused on the rapid apprehension of scene coherence in action scenes involving two actors. Coherence was manipulated by either varying global (body posture) or local (object details) actionscene properties. Scenes were presented for 20, 30, 50, or 100 ms, and subsequently masked. Viewers were able to determine scene coherence with only 30 ms presentation duration for global scene layout, but not even 100 ms sufficed for local object-action consistency. A second experiment ruled out that the difficulties in detecting local object-action consistency resulted from a strategic adaption by the participants. Overall, the results suggest that, as with scene gist, rapid extraction of coherence information from action scenes relies more on a scene's overall Gestalt than on detailed visual or even semantic representations.

Research paper thumbnail of Searching for the Oddball Response in the EEG and MEG

Research paper thumbnail of The Jena Voice Learning and Memory Test (JVLMT): A standardized tool for assessing the ability to learn and recognize voices

The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low e... more The ability to recognize someone’s voice exists on a broad spectrum with phonagnosia on the low end and super recognition at the high end. Yet there is no standardized test to measure an individual’s ability of learning and recognizing newly-learnt voices with samples of speech-like phonetic variability. We have developed the Jena Voice Learning and Memory Test (JVLMT), a 22min-test based on item response theory and applicable across languages. The JVLMT consists of three phases in which participants first become familiarized with eight speakers and then perform a three-alternative forced choice recognition task, using pseudo sentences devoid of semantics. Acoustic (dis)similarity analyses were used to create items with different levels of difficulty. Test scores are based on 22 Rasch-conform items. Items were selected based on 232 and validated based on 454 participants in an online study. Mean accuracy is 0.51 with an SD of .18. The JVLMT showed high and moderate correlations with...

Research paper thumbnail of Ratings of Emotional Expressions in Static and Dynamic Facial Recordings Before and After Upper Face Botulinum Injections—An Observational Prospective Study

Aesthetic Surgery Journal

Background Botulinum toxin A (BTX), a neurotoxin widely used for facial aesthetics, causes dose-d... more Background Botulinum toxin A (BTX), a neurotoxin widely used for facial aesthetics, causes dose-dependent muscle paralysis. It was hypothesized that treatment of mimic muscles with BTX might have a positive impact on emotional expression in static images (photographs), but a negative impact in dynamic recordings (videos). Objectives The aim of this study was to compare of emotional expression recorded in photographs and videos before and after treatment with BTX. Methods Twenty healthy women (mean age, 45 years) received a dose of 19 mouse units of XEOMIN (Merz, Frankfurt am Main, Germany) into the procerus, occipitofrontalis, and orbicularis oculi muscles. Photographs and videos of the participants’ faces with neutral and happy expressions were recorded before treatment and 2 weeks later. Recordings were rated by naive raters blind to the conditions and in balanced order. Results Videos were generally rated as more pleasant, arousing, attractive, and genuine than photographs (all P...

Research paper thumbnail of Maladaptive alterations of resting state cortical network in Tinnitus: A directed functional connectivity analysis of a larger MEG data set

Scientific Reports

The present study used resting state MEG whole-head recordings to identify how chronic tonal tinn... more The present study used resting state MEG whole-head recordings to identify how chronic tonal tinnitus relates to altered functional connectivity of brain’s intrinsic cortical networks. Resting state MEG activity of 40 chronic tinnitus patients and 40 matched human controls was compared identifying significant alterations in intrinsic networks of the tinnitus population. Directed functional connectivity of the resting brain, at a whole cortex level, was estimated by means of a statistical comparison of the estimated phase Transfer Entropy (pTE) between the time-series of cortical activations, as reconstructed by LORETA. As pTE identifies the direction of the information flow, a detailed analysis of the connectivity differences between tinnitus patients and controls was possible. Results indicate that the group of tinnitus patients show increased connectivity from right dorsal prefrontal to right medial temporal areas. Our results go beyond previous findings by indicating that the rol...

Research paper thumbnail of Choice of Test Stimulus matters for Pitch Matching Performance: Comparison between Pure Tone and Narrow Band Noise

Research paper thumbnail of Deaf signers outperform hearing non-signers in recognizing happy facial expressions

Research paper thumbnail of Seeing for speaking: Semantic and lexical information provided by briefly presented, naturalistic action scenes

PloS one, 2018

At the interface between scene perception and speech production, we investigated how rapidly acti... more At the interface between scene perception and speech production, we investigated how rapidly action scenes can activate semantic and lexical information. Experiment 1 examined how complex action-scene primes, presented for 150 ms, 100 ms, or 50 ms and subsequently masked, influenced the speed with which immediately following action-picture targets are named. Prime and target actions were either identical, showed the same action with different actors and environments, or were unrelated. Relative to unrelated primes, identical and same-action primes facilitated naming the target action, even when presented for 50 ms. In Experiment 2, neutral primes assessed the direction of effects. Identical and same-action scenes induced facilitation but unrelated actions induced interference. In Experiment 3, written verbs were used as targets for naming, preceded by action primes. When target verbs denoted the prime action, clear facilitation was obtained. In contrast, interference was observed wh...

Research paper thumbnail of Basic numerical processing, calculation, and working memory in children with dyscalculia and/or ADHD symptoms

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie

Deficits in basic numerical skills, calculation, and working memory have been found in children w... more Deficits in basic numerical skills, calculation, and working memory have been found in children with developmental dyscalculia (DD) as well as children with attention-deficit/hyperactivity disorder (ADHD). This paper investigates cognitive profiles of children with DD and/or ADHD symptoms (AS) in a double dissociation design to obtain a better understanding of the comorbidity of DD and ADHD. METHOD: Children with DD-only (N = 33), AS-only (N = 16), comorbid DD+AS (N = 20), and typically developing controls (TD, N = 40) were assessed on measures of basic numerical processing, calculation, working memory, processing speed, and neurocognitive measures of attention. RESULTS: Children with DD (DD, DD+AS) showed deficits in all basic numerical skills, calculation, working memory, and sustained attention. Children with AS (AS, DD+AS) displayed more selective difficulties in dot enumeration, subtraction, verbal working memory, and processing speed. Also, they generally performed more poorly in neurocognitive measures of attention, especially alertness. Children with DD+AS mostly showed an additive combination of the deficits associated with DD-only and A_Sonly, except for subtraction tasks, in which they were less impaired than expected.

Research paper thumbnail of Impairments of Speech Comprehension in Patients with Tinnitus—A Review

Frontiers in Aging Neuroscience

Tinnitus describes the subjective perception of a sound despite the absence of external stimulati... more Tinnitus describes the subjective perception of a sound despite the absence of external stimulation. Being a sensory symptom the majority of studies focusses on the auditory pathway. In the recent years, a series of studies suggested a crucial involvement of the limbic system in the manifestation and development of chronic tinnitus. Regarding cognitive symptoms, several reviews addressed the presence of cognitive impairments in tinnitus as well and concluded that attention and memory processes are affected. Despite the importance for social communication and the reliance on a highly functional auditory system, speech comprehension remains a largely neglected field in tinnitus research. This is why we review here the existing literature on speech and language functions in tinnitus patients. Reviewed studies suggest that speech comprehension is impaired in patients with tinnitus, especially in the presence of competing noise. This is even the case in tinnitus patients with normal hearing thresholds. Additionally, speech comprehension measures seem independent of other measures such as tinnitus severity and perceived tinnitus loudness. According to the majority of authors, the speech comprehension difficulties arise as a result of central processes or dysfunctional neuroplasticity.

Research paper thumbnail of Results of an Interdisciplinary Day Care Approach for Chronic Tinnitus Treatment: A Prospective Study Introducing the Jena Interdisciplinary Treatment for Tinnitus

Frontiers in Aging Neuroscience

Conclusion: The newly developed JITT represents a valuable treatment for chronic tinnitus patient... more Conclusion: The newly developed JITT represents a valuable treatment for chronic tinnitus patients with improvement remaining stable for at least 6 months after treatment. Using a large number of variables did not allow predicting treatment outcome which underlines the heterogeneity of tinnitus.

Research paper thumbnail of When Hearing Is Tricky: Speech Processing Strategies in Prelingually Deafened Children and Adolescents with Cochlear Implants Having Good and Poor Speech Performance

PLOS ONE

Cochlear implants provide individuals who are deaf with access to speech. Although substantial ad... more Cochlear implants provide individuals who are deaf with access to speech. Although substantial advancements have been made by novel technologies, there still is high variability in language development during childhood, depending on adaptation and neural plasticity. These factors have often been investigated in the auditory domain, with the mismatch negativity as an index for sensory and phonological processing. Several studies have demonstrated that the MMN is an electrophysiological correlate for hearing improvement with cochlear implants. In this study, two groups of cochlear implant users, both with very good basic hearing abilities but with non-overlapping speech performance (very good or very poor speech performance), were matched according to device experience and age at implantation. We tested the perception of phonemes in the context of specific other phonemes from which they were very hard to discriminate (e.g., the vowels in /bu/ vs. /bo/). The most difficult pair was individually determined for each participant. Using behavioral measures, both cochlear implants groups performed worse than matched controls, and the good performers performed better than the poor performers. Cochlear implant groups and controls did not differ during time intervals typically used for the mismatch negativity, but earlier: source analyses revealed increased activity in the region of the right supramarginal gyrus (220-260 ms) in good performers. Poor performers showed increased activity in the left occipital cortex (220-290 ms), which may be an index for cross-modal perception. The time course and the neural generators differ from data from our earlier studies, in which the same phonemes were assessed in an easy-to-discriminate context. The results demonstrate that the groups used different language processing strategies, depending on the success of language development and the particular language context. Overall, our data emphasize the role of neural plasticity and use of adaptive strategies for successful language development with cochlear implants.

Research paper thumbnail of Change of speech fundamental frequency explains the satisfaction with voice in response to testosterone therapy in female-to-male gender dysphoric individuals

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2016

Previous studies demonstrated that there is a significant change in speaking fundamental frequenc... more Previous studies demonstrated that there is a significant change in speaking fundamental frequency after testosterone therapy in female-to-male gender dysphoric individuals. It is yet an open question how the satisfaction with voice alteration can be predicted because until now it is not clear whether a testosterone therapy is sufficiently effective. The aim of the current study was not only to measure satisfaction with voice, but additionally to detect factors that predict or explain satisfaction with voice after testosterone therapy. Therefore, nine female-to-male gender dysphoric individuals were examined during the first year of testosterone treatment at different points of time. The patients underwent several voice analyses within 1 year and had to fill out several questionnaires concerning their voice, depressive symptoms, quality of life and voice handicap index. Multiple regression analyses were performed to find the factors that explained satisfaction with altered voice aft...

Research paper thumbnail of Anxiety related personality traits and emotion regulation strategies predict number and integrity of probabilistically tracked pathways between the amygdala and prefrontal cortex regions

Research paper thumbnail of Ebenen der Sprachverarbeitung und ihre Beeinträchtigung bei der Aphasie: Evidenz von der topographischen Analyse ereigniskorrelierter Potentiale

Research paper thumbnail of DTD 5 ARTICLE IN PRESS Brief article Lexically-driven syntactic priming

Research paper thumbnail of Processing of existing, synonymous, and anomalous German derived adjectives: An MEG study

Neuroscience Letters, Jan 18, 2010

Neuronal activation as response to reading existing derived German adjectives (e.g., freundlich, ... more Neuronal activation as response to reading existing derived German adjectives (e.g., freundlich, friendly) was measured using MEG and compared to that evoked by non-existing, but semantically synonymous adjectives (*freundhaft) and to activation induced by non-existing, semantically and morphologically anomalous adjectives (*freundbar). By applying distributed source modeling we revealed a gradual increase of neuronal activity within areas of the left temporal lobe in the time range of the N400. Activity increased from existing over synonymous to anomalous adjectives. Underscoring the use of neurophysiological measures, these results demonstrate that morpho-semantic analysis take place for non-existing morphologically complex pseudowords even if not warranted by the current task. Furthermore, these data argue in favor of morphological decomposition.

Research paper thumbnail of Dyskalkulie vs. Rechenschwäche: Basisnumerische Verarbeitung in der Grundschule

Lernen Und Lernstorungen, Mar 3, 2015

Laut ICD-10 und DSM-IV-TR muss für die Diagnose einer Dyskalkulie eine Diskrepanz zwischen der al... more Laut ICD-10 und DSM-IV-TR muss für die Diagnose einer Dyskalkulie eine Diskrepanz zwischen der allgemeinen kognitiven Leistungsfähigkeit und der tatsächlichen oder vorhergesagten Leistung in einem Mathematiktest vorliegen. Diese Definition impliziert, dass sich rechenschwache Kinder, die diese Diskrepanz aufweisen, von rechenschwachen Kindern ohne Erfüllung des Diskrepanzkriteriums unterscheiden. Die vorliegende Arbeit hatte zum Ziel, mögliche Unterschiede zwischen dyskalkulischen und rechenschwachen Kindern sowie einer Kontrollgruppe in der basisnumerischen Verarbeitung zu prüfen. Zur Identifikation einer Dyskalkulie bzw. Rechenschwäche wurden entweder (a) ein Testverfahren mit basisnumerischem Schwerpunkt (ZAREKI-R) oder (b) Tests zur Erfassung von Rechenfertigkeiten (ZAREKI-R Kopfrechnen und Textaufgaben, HRT 1 – 4 Addition und Subtraktion, WISC-IV rechnerisches Denken) verwendet. Insgesamt bearbeiteten 68 Kinder (Dyskalkulie: Na = 27/Nb = 11, Rechenschwäche: Na = 21/Nb = 18, Kontrollgruppe: Na = 20/Nb = 39) eine Batterie von basisnumerischen Aufgaben: Simultanerfassung, Abzählen, Mengenvergleich, Transkodieren, Number sets und Zahlenstrahl (0 – 100). Zusätzlich wurde die Arbeitsgedächtniskapazität mit einer visuell-räumlichen Aufgabe (Matrixspanne) überprüft. Laut Klassifikation nach ZAREKI-R unterschieden sich rechenschwache und dyskalkulische Kinder in fast allen basisnumerischen Aufgaben klar von der Kontrollgruppe, jedoch nicht untereinander. Bei Klassifikation nach Rechenfertigkeiten konnten rechenschwache und dyskalkulische Kinder ebenfalls nicht differenziert werden, allerdings unterschieden sich nur rechenschwache Kinder von der Kontrollgruppe (bei den Aufgaben Simultanerfassung, Abzählen, symbolischer Mengenvergleich, Transkodieren, Zahlenstrahl). Die Befunde werden vor dem Hintergrund der Verwendung basisnumerischer Fertigkeiten für die Diagnose und Therapie von Dyskalkulie diskutiert.

Research paper thumbnail of Lobmaier+2010 ConfiguralFeaturalProcessingCongenitalProsopagnosia AdvancesCongitivePsychology

Research paper thumbnail of Song Perception by Professional Singers and Actors: An MEG Study

PloS one, 2016

The cortical correlates of speech and music perception are essentially overlapping, and the speci... more The cortical correlates of speech and music perception are essentially overlapping, and the specific effects of different types of training on these networks remain unknown. We compared two groups of vocally trained professionals for music and speech, singers and actors, using recited and sung rhyme sequences from German art songs with semantic and/ or prosodic/melodic violations (i.e. violations of pitch) of the last word, in order to measure the evoked activation in a magnetoencephalographic (MEG) experiment. MEG data confirmed the existence of intertwined networks for the sung and spoken modality in an early time window after word violation. In essence for this early response, higher activity was measured after melodic/prosodic than semantic violations in predominantly right temporal areas. For singers as well as for actors, modality-specific effects were evident in predominantly left-temporal lateralized activity after semantic expectancy violations in the spoken modality, and r...

Research paper thumbnail of Rapid apprehension of the coherence of action scenes

Psychonomic Bulletin & Review, 2016

Some information about complex naturalistic scenes, such as the scene's gist (a beach, a restaura... more Some information about complex naturalistic scenes, such as the scene's gist (a beach, a restaurant) or the category of an object depicted in a scene, can be extracted within a fraction of a second. The present study focused on the rapid apprehension of scene coherence in action scenes involving two actors. Coherence was manipulated by either varying global (body posture) or local (object details) actionscene properties. Scenes were presented for 20, 30, 50, or 100 ms, and subsequently masked. Viewers were able to determine scene coherence with only 30 ms presentation duration for global scene layout, but not even 100 ms sufficed for local object-action consistency. A second experiment ruled out that the difficulties in detecting local object-action consistency resulted from a strategic adaption by the participants. Overall, the results suggest that, as with scene gist, rapid extraction of coherence information from action scenes relies more on a scene's overall Gestalt than on detailed visual or even semantic representations.

Research paper thumbnail of Searching for the Oddball Response in the EEG and MEG