Christoph Arens - Academia.edu (original) (raw)

Papers by Christoph Arens

European Archives of Oto-Rhino-Laryngology, 2012

Although recognized as a valuable diagnostic tool for more than 60 years, many laryngologists do ... more Although recognized as a valuable diagnostic tool for more than 60 years, many laryngologists do not routinely use laryngeal electromyography (LEMG). This may be due to a persisting lack of agreement on methodology, interpretation, validity, and clinical application of LEMG. To achieve consensus in these fields, a laryngeal electromyography working group of European neurolaryngologic experts was formed in order to (1) evaluate guidelines for LEMG performance and (2) identify issues requiring further clarification. To obtain an overview of existing knowledge and research, English-language literature about LEMG was identified using Medline.

Antimicrobial agents and chemotherapy, Jan 29, 2014

Echinocandins have become the agents of choice for early and specific antifungal treatment in cri... more Echinocandins have become the agents of choice for early and specific antifungal treatment in critically ill patients. In-vitro studies and clinical case reports revealed a possible impact of echinocandin treatment on cardiac function. The aim of our study was to evaluate echinocandin induced cardiac failure : Using an in-vivo rat model we assessed hemodynamic parameters and time to hemodynamic failure after central-venous application (Vena jugularis interna) of anidulafungin (low dose group 2.5 mg/kg bodyweight (BW), high dose group 25 mg/kg BW), caspofungin (low dose group 0.875 mg/kg BW, high dose group 8.75 mg/kg BW), micafungin (low dose group 3 mg/kg BW, high dose group 30mg/kg BW) and placebo (0.9% sodium chloride). Left ventricular heart tissue was collected to determine mitochondrial enzyme activity via spectrophotometric measurements. mRNA expression of transcriptional regulators and primary mitochondrial transcripts, mtDNA content, and citrate synthase activity were also ...

The Laryngoscope, 2015

Bilateral vocal fold paralysis (BVFP) is a rare but life-threatening condition mostly caused by i... more Bilateral vocal fold paralysis (BVFP) is a rare but life-threatening condition mostly caused by iatrogenic damage to the peripheral recurrent laryngeal nerve. Endoscopic enlargement techniques have been the standard treatment for decades. However, prospective studies using internationally accepted phoniatric and respiratory evaluation guidelines are rare. Prospective observational multicenter study. Twelve clinical centers screened 61 patients, of whom 36 were eligible according to the study protocol. Subjects were assessed with specific phoniatric and respiratory tests preoperatively and at 1 and 6 months postoperatively. Important respiratory parameters improved significantly 6 months postoperatively (peak expiratory and expiratory flow), confirming that a glottal enlargement effectively reduced the obstruction. Objective parameters dealing with voice quality worsened significantly (maximum phonation time, voice range profile, hoarseness), whereas subjective voice assessment (VHI-...

The Laryngoscope, 2015

Objectives/Hypothesis: To describe postoperative adverse events (AEs) and outcomes after transora... more Objectives/Hypothesis: To describe postoperative adverse events (AEs) and outcomes after transoral surgery for bilateral vocal fold paralysis (BVFP).

European Archives of Oto-Rhino-Laryngology, 2012

Although recognized as a valuable diagnostic tool for more than 60 years, many laryngologists do ... more Although recognized as a valuable diagnostic tool for more than 60 years, many laryngologists do not routinely use laryngeal electromyography (LEMG). This may be due to a persisting lack of agreement on methodology, interpretation, validity, and clinical application of LEMG. To achieve consensus in these fields, a laryngeal electromyography working group of European neurolaryngologic experts was formed in order to (1) evaluate guidelines for LEMG performance and (2) identify issues requiring further clarification. To obtain an overview of existing knowledge and research, English-language literature about LEMG was identified using Medline.

Antimicrobial agents and chemotherapy, Jan 29, 2014

Echinocandins have become the agents of choice for early and specific antifungal treatment in cri... more Echinocandins have become the agents of choice for early and specific antifungal treatment in critically ill patients. In-vitro studies and clinical case reports revealed a possible impact of echinocandin treatment on cardiac function. The aim of our study was to evaluate echinocandin induced cardiac failure : Using an in-vivo rat model we assessed hemodynamic parameters and time to hemodynamic failure after central-venous application (Vena jugularis interna) of anidulafungin (low dose group 2.5 mg/kg bodyweight (BW), high dose group 25 mg/kg BW), caspofungin (low dose group 0.875 mg/kg BW, high dose group 8.75 mg/kg BW), micafungin (low dose group 3 mg/kg BW, high dose group 30mg/kg BW) and placebo (0.9% sodium chloride). Left ventricular heart tissue was collected to determine mitochondrial enzyme activity via spectrophotometric measurements. mRNA expression of transcriptional regulators and primary mitochondrial transcripts, mtDNA content, and citrate synthase activity were also ...

The Laryngoscope, 2015

Bilateral vocal fold paralysis (BVFP) is a rare but life-threatening condition mostly caused by i... more Bilateral vocal fold paralysis (BVFP) is a rare but life-threatening condition mostly caused by iatrogenic damage to the peripheral recurrent laryngeal nerve. Endoscopic enlargement techniques have been the standard treatment for decades. However, prospective studies using internationally accepted phoniatric and respiratory evaluation guidelines are rare. Prospective observational multicenter study. Twelve clinical centers screened 61 patients, of whom 36 were eligible according to the study protocol. Subjects were assessed with specific phoniatric and respiratory tests preoperatively and at 1 and 6 months postoperatively. Important respiratory parameters improved significantly 6 months postoperatively (peak expiratory and expiratory flow), confirming that a glottal enlargement effectively reduced the obstruction. Objective parameters dealing with voice quality worsened significantly (maximum phonation time, voice range profile, hoarseness), whereas subjective voice assessment (VHI-...

The Laryngoscope, 2015

Objectives/Hypothesis: To describe postoperative adverse events (AEs) and outcomes after transora... more Objectives/Hypothesis: To describe postoperative adverse events (AEs) and outcomes after transoral surgery for bilateral vocal fold paralysis (BVFP).