Christoph Berliner - Academia.edu (original) (raw)

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Papers by Christoph Berliner

Ultraschall in der Medizin - European Journal of Ultrasound, 2013

A 79 yr.-old woman was admitted to our hospital because of amaurosis due to an obliteration of he... more A 79 yr.-old woman was admitted to our hospital because of amaurosis due to an obliteration of her left central artery and was treated with ASS. 4 days earlier she had had a car crash without any abdominal cutaneous marks.

Respiratory care, Jan 8, 2015

The value of computed tomography (CT) of the chest in the management of patients with ARDS is poo... more The value of computed tomography (CT) of the chest in the management of patients with ARDS is poorly defined. The aim of this study was to assess the clinical utility of thoracic CT scans in subjects with ARDS using the Berlin definition. This was a retrospective, observational study in a university hospital ARDS center on all subjects with ARDS in whom a CT scan of the chest was performed immediately before or during an ICU stay between January 1, 2007 and June 30, 2013. During the study period, a total of 1,781 thoracic CT scans were performed, of which 204 cases met inclusion criteria. The most common pathologic findings of the lung parenchyma were consolidations (94.1% of cases) and ground glass opacities (85.3%). Furthermore, CT scans showed pleural effusions (80.4%), mediastinal lymphadenopathy (66.7%), signs of right ventricular strain and pulmonary hypertension (53.9%), pericardial effusion (37.3%), emphysema of the chest wall (12.3%), pneumothorax (11.8%), emphysema of the ...

JACC. Cardiovascular imaging, Jan 30, 2015

Aims and objectives To measure the change of panceatic R2* relaxation rates in comparison to chan... more Aims and objectives To measure the change of panceatic R2* relaxation rates in comparison to changes of liver and cardiac R2* in patients with ß-thalassemia major (TM). Read more Methods and materials Eleven TM patients with iron overload due to blood transfusion received chelating therapy and were followed by multi-echo MRI-R2* over the course of up to 5 Years. Heart iron was assessed as transverse relaxation rate R2* by a mono-exponential fit. In-vivo liver iron concentration (LIC) was measured by SQUID biomagnetic liver susceptometry. The transverse relaxation rate R2* was assessed from ROI based signal intensities (head, body, and tail) of transverse slices (5.5mm) throughout the whole... Read more Results In 8/11 patients (82%) a decrease of pancreas R2* rates from median R2* =298 s-1 to R2* =175 s-1 was determined. In three patients an increase of R2*= 104 s-1 to 277 s-1 was determined despite the chelation therapy these patients had additionally increased serum ferritin value...

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2015

In den letzten Jahren hat sich die MRT als probates Mittel erwiesen, nicht invasiv die Organeisen... more In den letzten Jahren hat sich die MRT als probates Mittel erwiesen, nicht invasiv die Organeisenbeladung mittels R2-(T2) oder R2* -(T2*) Relaxometrie zu bestimmen. In dieser Studie wurde das Hypophyseneisen in einer Kohorte von ß-Thalassemia major (TM), Diamond Blackfan Anaemia (DBA) und anderen chronisch transfusionsbedürftigen Anämien im Vergleich zu einem Normalkollektiv bestimmt.

Tumor Biology, 2010

The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are small lip... more The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are small lipid molecules with a variety of physiological roles. Additionally, their involvement in the initiation and progression of malignant tumors has been increasingly recognized in recent years. However, the data on the expression of S1P and LPA receptors on different cancer cells are very few. Real-time polymerase chain reaction was used for the analysis of mRNA expression of five S1P (1-5) and three LPA (1-3) receptors on a large panel of 13 colon, breast, melanoma, and lung cancer cell lines. Furthermore, the modulation of S1P and LPA receptor mRNA expression was studied upon xenotransplantation of tumor cells into severe combined immunodeficient (SCID) mice. The S1P and LPA receptors were expressed to a variable degree on all tumor cell lines tested (with exception of colon cancer SW480). Most notably, tumor cell lines in vitro expressed S1P 2 mRNA that was down-regulated upon xenotransplan-tation, whereas LPA 2 receptor mRNA was strongly expressed both in vitro and in vivo (except by breast cancer cells). The latter was especially distinctive for small cell lung tumor cells. The S1P and LPA receptors are differentially expressed on tumor cell lines in vitro. Their expression is modulated upon xenografting into SCID mice in vivo.

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2013