Christoph Herrmann-Lingen - Academia.edu (original) (raw)

Papers by Christoph Herrmann-Lingen

Endocrine Abstracts, 2018

Journal of Clinical Medicine, 2022

Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong t... more Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients are scarce. Based on previous data, we hypothesized that anxiety would be associated with higher cortisol output and a more pronounced morning increase in moderately depressed CAD patients. 77 patients (60 y, 79% male) underwent saliva sampling (+0, +30, +45, +60 min after awakening, midday and late-night sample). Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS) and patients were grouped into anxious versus non anxious subjects based upon the recommended score (≥11). A repeated measures ANOVA yielded a significant time and quadratic time effect referring to the typical CAR. Anxious patients showed a significantly ...

(A) Luciferase reporter gene assay in U3A cells expressing the indicated STAT1 variants ... more (A) Luciferase reporter gene assay in U3A cells expressing the indicated STAT1 variants normalized to the expression of constitutively co-expressed β-galactosidase. The reporter constructs used in this experiment contained a triple GAS site from the Ly6E promoter (3xLy6E) in the luciferase gene. Cells were treated for 0 h (white columns), 2 h (bright grey), 4 h (dark grey) and 6 h (black) with 5 ng/ml IFNγ before, in whole cell extracts, luciferase luminescence and β-galactosidase activity were measured. The experiment was repeated at least three times in six independent transfections. (B) Endogenous gene induction by the STAT1 mutants was determined by real-time PCR assays. Histograms depict expression levels of the gbp1, irf1, mig1, ccl2 and for control stat1 gene before (grey columns) and after 6 h stimulation with 5 ng/ml IFNγ (black columns). Specific gene induction was normalized to the expression of the house-keeping gene gapdh. The data are presented as means and standard deviations from at least three independent experiments. Statistical significance between the groups of IFNγ-stimulated cells expressing the indicated STAT1 variants is marked by asterisks.</p

$Research paper thumbnail of Influence of baseline parameters on one‐year physical, mental, and health‐related quality of life in patients with heart failure and preserved ejection fraction$

ESC Heart Failure, 2021

To identify baseline parameters longitudinally influencing overall health‐related quality of life... more To identify baseline parameters longitudinally influencing overall health‐related quality of life (HRQoL), physical function and mental health 1 year later in patients with chronic heart failure and preserved ejection fraction (HFpEF).

PiD - Psychotherapie im Dialog, 2021

Die Erkenntnisse der psychokardiologischen Forschung sind in den letzten 20 Jahren verstärkt in m... more Die Erkenntnisse der psychokardiologischen Forschung sind in den letzten 20 Jahren verstärkt in medizinische Leitlinien einbezogen worden und haben zu wichtigen Weiterentwicklungen in der Patientenversorgung geführt. Diese sind allerdings noch nicht flächendeckend implementiert. Ausgehend von einem Patientenbeispiel werden im Folgenden Empfehlungen ausgewählter Leitlinien und Positionspapiere zur psychokardiologischen Behandlung dargestellt.

Psychotherapeut, 2017

Machbarkeit im Rahmen des deutschen Gesundheitssystems Entscheidend für einen positiven Verlauf d... more Machbarkeit im Rahmen des deutschen Gesundheitssystems Entscheidend für einen positiven Verlauf der koronaren Herzerkrankung (KHK) sind sowohl Verhaltensänderungen wie Steigerung der körperlichen Aktivität, Raucherentwöhnung, Verbesserung der Medikamentenadhärenz etc. als auch die Behandlung häufig komorbid auftretender Depression und psychosozialem Distress. Allerdings brauchen Patienten bei Veränderungen ihres Lebensstils professionelle Unterstützung über einen längeren Zeitraum, was von den behandelnden Ärzten meist nicht geleistet werden kann. Hier setzt das Team-Care-Modell an, in dem der Behandlungsassistent die parallele Behandlung von psychischen und somatischen Risikofaktoren sicherstellt.

Journal of Psychosomatic Research, 2018

Low socioeconomic status (SES) has been associated with an increased coronary risk in Western cou... more Low socioeconomic status (SES) has been associated with an increased coronary risk in Western countries. All stress experiences are more pronounced in low SES patients with stress emanating from problems with family, job, or money. The SPIRR-CAD study offered an excellent opportunity to examine these risk factors in German speaking mildly and medium depressed patients. In the SPIRR CAD study, a German multi centre randomized clinical trial of 450 male and 120 female coronary patients, we examined the standard and psychosocial risk factor profiles in relation to SES, as assessed by educational level. All differences in risk factors between low and high SES were in the inverse direction. Of standard risk factors, only smoking was socially graded and more common in low SES. Of psychosocial factors and emotions, exhaustion showed the strongest and most consistent inverse social gradient, but also anger, anxiety and depression were socially graded. The findings suggest that in German patients, as in other national groups, social gradients in CHD risk are considerable. They can be ascribed to both psychosocial and to standard risk factors. In the present two years follow-up, the prospective significance of psychological and social risk factors was analyzed showing that emotional factors played an important role, in that low and high SES patients differed in the expected direction. However, the differences were not statistically significant and therefore firm conclusions from follow up were not possible. Trial registration: ISRCTN 76240576; NCT00705965

Psychoneuroendocrinology, Jan 4, 2018

Natriuretic peptides (NP) are involved in the regulation of blood pressure and blood volume, and ... more Natriuretic peptides (NP) are involved in the regulation of blood pressure and blood volume, and are elevated in patients with coronary artery disease (CAD). They are used as markers for illness severity, but their role in mental health is not well understood. Recently, A-type NP (ANP) has been associated with reduced anxiety in studies on cardiac patients; however, this study is the first to assess this effect for B-type NP (BNP) and for further dimensions of well-being and mental health. Depression, anxiety, and distress are more common in CAD patients than in the general population and are most likely not only influenced by psychological adaptation but also by neurobiological processes. We used baseline N-terminal proBNP (NT-proBNP) samples and psychometric assessments of 529 at least mildly depressed (Hospital Anxiety and Depression Scale, depression score ≥ 8) CAD patients from the multicenter Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPI...

Psychosomatic medicine, 2018

Although diagnosed arterial hypertension and antihypertensive medication usually have an adverse ... more Although diagnosed arterial hypertension and antihypertensive medication usually have an adverse impact on quality of life, recent studies suggest that actual blood pressure may be positively related to better well-being. However, data in older patients with cardiovascular risk factors are lacking, for whom such an association may be of particular relevance. In 1300 adults aged 50 to 85 years with cardiovascular risk factors (51.5% men, mean age = 65.7 ± 8.2 years) participating in an observational study, we performed standardized measurements of blood pressure and assessed quality of life and depressive symptoms at baseline and 1-year follow-up using the Short Form-36 (SF-36) and the Hospital Anxiety and Depression Scale (HADS). Bivariate analysis demonstrated that systolic blood pressure was associated with higher SF-36 mental component summary scores (r = 0.100, p < .001) and reduced HADS depression (r = -0.082, p = .003). Multivariate regression models adjusting for age, sex,...

Geburtshilfe und Frauenheilkunde, 2008

Psychoneuroendocrinology, Jan 13, 2015

It has been postulated that patients with heart failure have a high risk of ventricular arrhythmi... more It has been postulated that patients with heart failure have a high risk of ventricular arrhythmias and sudden cardiac death resulting from anxiety-induced autonomic arousal. In the prospective and multicenter DIAST-CHF (Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure) study, we therefore, tested the hypothesis that adrenomedullin (ADM), a well-established predictor for cardiovascular outcome, is associated with self-rated anxiety symptoms in patients at risk of suffering from or actually with overt heart failure. Study participants with risk factors for diastolic dysfunction were requested to complete the Hospital Anxiety and Depression Scale (HADS), and plasma mid-regional pro-adrenomedullin (MR-proADM) concentrations were measured. In bivariate analysis, we found significantly lower plasma MR-proADM levels in patients with elevated HADS-anxiety scores above the clinically relevant cut-off level of ≥11 (n=118, 536pmol/l, interquartile ...

Geburtshilfe und Frauenheilkunde, 2011

European journal of preventive cardiology, 2015

Previous studies in post-myocardial infarction patients with heart failure have documented that h... more Previous studies in post-myocardial infarction patients with heart failure have documented that high anxiety levels are associated with increased mortality. In this prospective study, we determined the impact of anxiety on long-term event risk in stable coronary heart disease (CHD) patients treated with percutaneous coronary interventions (PCIs). A total of 470 patients referred for PCI completed the Hospital Anxiety and Depression Scale (HADS) before undergoing stent implantation. Over a five-year follow-up period, data on survival, occurrence of major adverse cardiovascular events (MACEs) and repeat revascularization were obtained from n = 462 participants (98.3%). All-cause mortality rates differed significantly across the four quartiles of the HADS anxiety subscale, the lowest number of deaths (1.9%) being seen in patients with the highest HADS-A quartile (scores ≥ 10) as compared to those in the three lower quartiles (11.8%, odds ratio = 0.14, 95%-confidence interval (95% CI): ...

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Giornale italiano di cardiologia (2006), 2008

... Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, Dallongeville J, De Backer ... more ... Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, Dallongeville J, De Backer G, Ebrahim S, Gjelsvik B, Herrmann ... P, Zamorano JL, Hellemans I, Altiner A, Bonora E, Durrington PN, Fagard R, Giampaoli S, Hemingway H, Hakansson J, Kjeldsen SE, Larsen ML ...

$Research paper thumbnail of Effects of exercise training on different quality of life dimensions in heart failure with preserved ejection fraction: the Ex-DHF-P trial$

European Journal of Preventive Cardiology, 2014

Despite suffering from poor prognosis, progressive exercise intolerance, and impaired quality of ... more Despite suffering from poor prognosis, progressive exercise intolerance, and impaired quality of life (QoL), effective therapeutic strategies in heart failure with preserved ejection fraction (HFpEF) are sparse. Exercise training (ET) improves physical QoL in HFpEF, but the effects on other aspects of QoL are unknown. The multicentre, prospective, randomized, controlled Exercise training in Diastolic Heart Failure Pilot study included 64 HFpEF patients (65 ± 7 years, 56% female). They were randomized to supervised endurance/resistance training in addition to usual care (ET, n = 44) or usual care alone (UC, n = 20). At baseline and after 3 months, QoL was assessed (36-item Short-form Health Survey (SF-36), Minnesota Living With Heart Failure Questionnaire (MLWHFQ), and Patient Health Questionnaire (PHQ-9). Exercise improved the following SF-36 dimensions: physical functioning (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.001 vs. UC), bodily pain (p = 0.046), general health perception (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.016 vs. UC), general mental health (p = 0.002), vitality (p = 0.003), social functioning (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) physical (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.001 vs. UC), and mental component score (p = 0.030). ET did not improve role limitations due to physical and emotional problems. The MLWHFQ total scale (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) and the MLWHFQ physical limitation scale (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001, p = 0.04 vs. UC) also improved with ET. The MLWHFQ emotional limitation scale did not change with ET. With ET, also the PHQ-9 total score improved significantly (p = 0.004, p = 0.735 vs. In patients with HFpEF, exercise training improved emotional status, physical and social dimensions of QoL as well as symptoms of depression from pre to post test. Physical dimensions of QoL and general health perception also improved significantly with exercise in comparison to usual care.

PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie, 2005

PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie, 2010

To test the possibility of predicting psychotherapy outcome by measures of cardiovascular adaptab... more To test the possibility of predicting psychotherapy outcome by measures of cardiovascular adaptability to stress at the beginning of treatment we used a prospective, within-subject design with experimental induction of short-term stress. Cardiovascular data during induced stress (mental arithmetic, anger recall) and relaxation were assessed in 21 patients with a main diagnosis of depression at the beginning of their 12-week inpatient psychotherapy treatment. Lower change scores in blood pressure during induced stress at the beginning of therapy were significantly related to better treatment outcome, accounting for 41% of variance, even after controlling for several covariates. Furthermore, there was evidence for the impact of negative affect. Using cardiovascular stress testing as an additional area of information seems a feasible method of incorporating biological parameters in psychotherapy evaluation.

Psychosomatic Medicine, 1999