Clara Varon - Academia.edu (original) (raw)

Papers by Clara Varon

Retinal Cases & Brief Reports, 2013

Purpose: To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B a... more Purpose: To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraconazole Methods: Observational case report of one patient with C. lunata endophthalmitis after penetrating ocular injury with vegetable material. Results: One young adult male patient presented with visual loss after penetrating ocular trauma with vegetable material. Biomicroscopy revealed keratitis and secondary endophthalmitis. Vitreous cultures after vitrectomy were positive for C. lunata and Staphylococcus epidermidis. Patient responded well to intravitreal amphotericin B and moxifloxacin. Conclusion: Fungal endophthalmitis should be suspected after trauma with vegetable material. Curvularia lunata may produce endophthalmitis and keratitis. Amphotericin B and itraconazole should be considered suitable agents for its treatment.

DOAJ (DOAJ: Directory of Open Access Journals), 2017

Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin.

Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti, Dec 5, 2022

Aims: To describe the aetiology and microbial susceptibility profile of endophthalmitis cases tre... more Aims: To describe the aetiology and microbial susceptibility profile of endophthalmitis cases treated at an ophthalmological referral centre in Colombia. Material and Methods: A retrospective descriptive study was carried out with all endophthalmitis cases referred to the Fundación Oftalmológica de Santander FOSCAL (Floridablanca, Colombia) from 1 January 2012 to 31 December 2015. Results: 121 eyes of 121 patients were evaluated. 77.7% of them were male and the mean age was 42.9 years. Five of them (4.1%) corresponded to endogenous endophthalmitis, and 116 (95.9%) to exogenous endophthalmitis. Of the latter, 66.9% were associated with trauma (almost one-half of them associated with intraocular foreign body), and 29.5% with intraocular surgery. The most common isolated microorganisms in the exogenous endophthalmitis group corresponded to methicillin-resistant and methicillin-sensitive strains of Staphylococcus epidermidis and Staphylococcus aureus, which were mostly susceptible to imipenem, vancomycin and moxifloxacin and resistant to ceftazidime. Conclusion: Endophthalmitis is a potentially sight-threatening condition, especially in cases of inadequate treatment. Therefore, antimicrobial therapy should be guided by vitreous humour culture to assure that the causative microorganism is susceptible to the selected agent. The results of our study lead us to propose vancomycin, moxifloxacin or imipenem as first-line antimicrobial options.

Archivos de la Sociedad Española de Oftalmología, May 1, 2021

To report the ocular manifestations in patients with leukaemia. This is a retrospective, descript... more To report the ocular manifestations in patients with leukaemia. This is a retrospective, descriptive and observational study in patients with ocular manifestations of leukaemia. A total of 14 eyes were evaluated corresponding to 8 patients (5 women and 3 men) with ocular manifestations of leukaemia. The mean age at diagnosis was 43 years (31-76 years). Six eyes corresponded to patients with acute myeloid leukaemia (AML), four eyes to acute lymphoid leukaemia (ALL), two eyes to chronic myeloid leukaemia (CML), and the remaining two belonged to patients with hairy cell leukaemia (HCL). The primary ocular findings were choroidal invasion in 12 eyes (85.7%), retinal infiltration in 4 eyes (28.6%), and neuro-ophthalmic disorders in 4 eyes (28.6%). The mean visual acuity improved from 0.689 to 0.449 (logMAR) (P=.012) after the systemic and intrathecal chemotherapy. Of the eight patients, four died from systemic complications of the underlying disease. This is the first report of multiple ocular manifestations secondary to leukaemia in a Colombian population. It is important to keep in mind that this disease is included within the masquerade syndromes and that the ophthalmological findings that, while subtle, can also be devastating and be signs of a life-threatening disease.

Archivos De La Sociedad Española De Oftalmología (english Edition), May 1, 2021

Objective: To report the ocular manifestations in patients with leukaemia. Methods: This is a ret... more Objective: To report the ocular manifestations in patients with leukaemia. Methods: This is a retrospective, descriptive and observational study in patients with ocular manifestations of leukaemia. Results: A total of 14 eyes were evaluated corresponding to 8 patients (5 women and 3 men) with ocular manifestations of leukaemia. The mean age at diagnosis was 43 years (31-76 years). Six eyes corresponded to patients with Acute Myeloid Leukaemia (AML), four eyes to Acute Lymphoid Leukaemia (ALL), two eyes to Chronic Myeloid Leukaemia (CML), and the remaining two belonged to patients with Hairy Cell Leukaemia (HCL). The primary ocular findings were choroidal invasion in 12 eyes (85.7%), retinal infiltration in 4 eyes (28.6%), and neuro-ophthalmic disorders in 4 eyes (28.6%). The mean visual acuity improved from 0.689 to 0.449 (logMAR) (P = .012) after the systemic and intrathecal chemotherapy. Of the eight patients, four died from systemic complications of the underlying disease. Conclusions: This is the first report of multiple ocular manifestations secondary to leukaemia in a Colombian population. It is important to keep in mind that this disease is included within the masquerade syndromes and that the ophthalmological findings that, while subtle, can also be devastating and be signs of a life-threatening disease.

Resumen La retina es un tejido fundamental en el organo de la vision. En este articulo hacemos un... more Resumen La retina es un tejido fundamental en el organo de la vision. En este articulo hacemos una revision sobre la anatomia y fisiologia de esta estructura asi como sobre las principales patologias que la pueden afectar, entre ellas: desprendimiento de retina, retinopatia diabetica y la enfermedad macular relacionada con la edad. Aunque actualmente contamos con tecnicas medicas y quirurgicas seguras y efectivas para el manejo de estas patologias, aun representan un reto para la ciencia medica, y en estados avanzados comprometen seriamente la funcion visual, por ello es de gran importancia que el medico general tenga claros los conceptos basicos sobre el diagnostico de estas enfermedades, para realizar una remision adecuada y asi poder evitar al maximo secuelas visuales en el paciente. [Varon CL, Jaramillo S, Tello A. La retina para el medico no oftalmologo. MedUNAB 2010; 13:31-37]. Palabras clave: Retina, Epitelio pigmentario retiniano, Retinopatia diabetica, Desprendimiento de re...

Medicina-buenos Aires, 2005

La Investigacion como Experiencia Pedagogica en Colombia. Durante los pasados 4 anos, realizamos ... more La Investigacion como Experiencia Pedagogica en Colombia. Durante los pasados 4 anos, realizamos un programa de tamziaje entre 1,763 individuos sordos a traves del pais, para detectar Sindrome de Waardenburg (WS), en el cual identificamos 140 individuos afectados pertenecientes a 95 familias. Se confirmo el diagnostico clinico de WS en 95 propositus y en 45 parientes afectados, lo que significa una frecuencia del 5.38% de WS entre la poblacion sorda Colombiana. Examenes audiologicos, oftalmologicos y geneticos fueron practicados para confirmar el diagnostico. Siguiendo la clasificacion del consorcio del WS, modificada por varios autores, basados en el Indice de Waardenburg (WI) que define el tipo de WS, un indice >1.95 fue considerado WS1 (con dystopia canthorum) mientras que un indice por debajo de este valor fue WS2. En nuestra poblacion el 62.1% de los pacientes fueron clasificados como WS2 y el 37.9% como WS1. Presentamos los resultados del estudio de manifestaciones clinicas...

La vitreorretinopatia exudativa familiar es un trastorno genetico, bilateral, asimetrico y progre... more La vitreorretinopatia exudativa familiar es un trastorno genetico, bilateral, asimetrico y progresivo, de herencia variable. Materiales y metodos. Se practico un examen oftalmologico completo a 32 individuos de una familia con diagnostico de vitreorretinopatia exudativa familiar. Previa firma del consentimiento informado, se tomo una muestra para extraccion de ADN y se obtuvo la secuencia del gen FZD4. Resultados. Se encontraron 11 personas afectadas y 21 que no lo estaban. Se confirmo una herencia autosomica dominante y se identifico la mutacion 1501delCT en el gen FZD4. Se descarto la hipotesis de que algunos familiares presentaran manifestaciones parciales de la enfermedad. Discusion. Se hace una descripcion clinica y se reportan los hallazgos de angiografia, tomografia optica de coherencia y ecografia ocular. Se define una herencia autosomica dominante y se identifica la mutacion causal en el gen FZD4. La caracterizacion molecular de la familia permitio practicar una correcta y ...

GMS ophthalmology cases, 2017

Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods... more Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods: Case report. Results: A 54-year-old female presented bilateral anterior uveitis following a 10-day course of oral moxifloxacin. She developed a bilateral anterior uveitis associated with pigment dispersion syndrome and iris transillumination. Conclusions: Drug-induced uveitis is one of the causes of anterior uveitis. Uveitis related to fluoroquinolones is a rare entity, there are few cases reported in the literature, this is the first case reported in Latin America.

GMS ophthalmology cases, 2017

Objective: To report a case of iatrogenic central retinal artery occlusion after embolization and... more Objective: To report a case of iatrogenic central retinal artery occlusion after embolization and surgical resection of carotid body paraganglioma. Methods: Case report Results: One adult female patient presented with persistent unilateral visual loss after embolization with Embosphere(®) and Contour(®) microparticles of carotid body tumor. Fluorescein angiography revealed intraluminal microspheres in the central retinal artery ramifications. OCT revealed intraretinal spherical, hyporeflective particles with posterior shadowing. Conclusions: Central retinal artery occlusion should be assessed as a possible complication after surgical repair of head and neck paragangliomas.

Medunab, Jun 21, 2010

La retina es un tejido fundamental en el órgano de la visión. En este artículo hacemos una revisi... more La retina es un tejido fundamental en el órgano de la visión. En este artículo hacemos una revisión sobre la anatomía y fisiología de esta estructura así como sobre las principales patologías que la pueden afectar, entre ellas: desprendimiento de retina, retinopatía diabética y la ...

Universitas Medica, 2007

Análisis clinicogénetico de una familia colombiana con vitreorretinopatía exudativa familiar o

BMJ case reports, Jan 3, 2015

A 40-year-old man presented to the emergency service of the Department of Ophthalmology, Fundació... more A 40-year-old man presented to the emergency service of the Department of Ophthalmology, Fundación Oftalmológica de Santander, Floridablanca, Colombia, with blurred vision in his right eye. Anamnesis revealed that he also had newly diagnosed stage C HIV. He had recently started highly active antiretroviral therapy (HAART). Examination disclosed intraocular inflammation, along with plain white peripheral non-exudative lesions with sparse haemorrhaging. The differential diagnosis included cytomegalovirus (CMV) retinitis and immune recovery uveitis (IRU). On follow-up, the patient's left eye presented with decreased visual acuity and increased vitreous haze. A vitrectomy with vitreous tap was performed for microbiological studies. PCR for CMV in the vitreous sample was negative. The patient was discharged with the final diagnosis of IRU. In HIV patients with uveitis, the knowledge of characteristic signs and symptoms of particular entities such as opportunistic infections and IRU w...

International Journal of Pediatric Otorhinolaryngology, 2013

The purpose of this study was to establish a new approach to improve detection of deafness due to... more The purpose of this study was to establish a new approach to improve detection of deafness due to rubella. Colombian institutes for the deaf were visited by a medical team to perform in all enrolled individuals an ophthalmological examination with emphasis in fundus eye by a retina specialist. In cases where ocular alterations compatible with CRS were found, a medical interview by a clinical geneticist analyzing pre-and postnatal history and a thorough medical examination was done. A total of 1383 deaf institutionalized individuals were evaluated in 9 Colombian cities in the period of 2005 to 2006, finding a total of 463 positive cases for salt-and-pepper retinopathy (33.5%), in which rubella could be the etiology of deafness. Medellin, Cartagena, Bucaramanga and Barranquilla were the cities with the highest percentage of Congenital rubella, corresponding to 22.8% of analyzed population. The analysis performed on cases in which reliable prenatal history was obtained in a second appointment (n=88) showed association between positive viral symptoms during pregnancy and salt-and-pepper retinopathy in 62.5% of cases, while both (retinopathy and viral symptoms) were absent in 29.5% of cases; showing a correlation in 92% of cases. The frequency of deafness by rubella obtained by this study is significantly high compared with previous Colombian studies and with international reports. It was possible to correlate the antecedent of symptoms during pregnancy with the presence of salt-and-pepper retinopathy in this deaf population when reliable prenatal history was available, therefore eye testing with emphasis in fundus examination is a good indicator of rubella induced deafness. We propose a new approach in the search of deafness causes, based on a thorough ophthalmologic examination in all deaf people.

Retinal Cases & Brief Reports, 2013

To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraco... more To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraconazole Observational case report of one patient with C. lunata endophthalmitis after penetrating ocular injury with vegetable material. One young adult male patient presented with visual loss after penetrating ocular trauma with vegetable material. Biomicroscopy revealed keratitis and secondary endophthalmitis. Vitreous cultures after vitrectomy were positive for C. lunata and Staphylococcus epidermidis. Patient responded well to intravitreal amphotericin B and moxifloxacin. Fungal endophthalmitis should be suspected after trauma with vegetable material. Curvularia lunata may produce endophthalmitis and keratitis. Amphotericin B and itraconazole should be considered suitable agents for its treatment.

Univ. med, 1994

Resumo: La Unidad de Genética clínica del Instituto de Genética Humana de la universidad Javerian... more Resumo: La Unidad de Genética clínica del Instituto de Genética Humana de la universidad Javeriana y la Fundación oftalmológica Nacional, realizaron un estudio piloto, para determinar las diferentes causas de la ceguera y visión subnormal en población ...

American Journal of Medical Genetics Part A, 2008

A screening program to detect Waardenburg syndrome (WS) conducted between 2002 and 2005, among 1,... more A screening program to detect Waardenburg syndrome (WS) conducted between 2002 and 2005, among 1,763 deaf individuals throughout Columbia identified 95 affected individuals belonging to 95 families, giving a frequency of 5.38% of WS among the institutionalized deaf population. We confirmed the clinical diagnosis of WS in the 95 propositi and, through the family evaluation, we also identified 45 non-institutionalized affected relatives. Audiologic, ophthalmologic, and genetic studies were performed to confirm the diagnosis. Following the classification of the WS consortium, based on the Waardenburg Index (WI), to define the type of WS. We classified 62.1% of the propositi as WS2 and 37.9% as WS1. We present here the results of the study of clinical manifestations, analyzing the presence, severity, and symmetry of clinical findings among this affected population. Overall, among the 95 propositi, in addition to sensorineural deafness in all, the most frequent features were broad nasal root (58.9%), a first degree relative affected (37.9%), heterochromia irides (36.8%), skin hypopigmentation (31.6%), white forelock (28.0%), intense blue iris (27.4%), synophrys (12.6%), premature graying (10.5%), ptosis of the eyelids (9.5%), and hypoplasia alae nasi (1.1%). The majority of individuals had normal psychomotor development (87%), while the remaining 13% had developmental delay. Among the latter, 9.4% corresponded to WS2 and 3.6% to WS1. Our data confirm an interesting inter-and intrafamilial variability in the phenotypic manifestations as well as extremely variable expression.

Retinal Cases & Brief Reports, 2013

Purpose: To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B a... more Purpose: To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraconazole Methods: Observational case report of one patient with C. lunata endophthalmitis after penetrating ocular injury with vegetable material. Results: One young adult male patient presented with visual loss after penetrating ocular trauma with vegetable material. Biomicroscopy revealed keratitis and secondary endophthalmitis. Vitreous cultures after vitrectomy were positive for C. lunata and Staphylococcus epidermidis. Patient responded well to intravitreal amphotericin B and moxifloxacin. Conclusion: Fungal endophthalmitis should be suspected after trauma with vegetable material. Curvularia lunata may produce endophthalmitis and keratitis. Amphotericin B and itraconazole should be considered suitable agents for its treatment.

DOAJ (DOAJ: Directory of Open Access Journals), 2017

Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin.

Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti, Dec 5, 2022

Aims: To describe the aetiology and microbial susceptibility profile of endophthalmitis cases tre... more Aims: To describe the aetiology and microbial susceptibility profile of endophthalmitis cases treated at an ophthalmological referral centre in Colombia. Material and Methods: A retrospective descriptive study was carried out with all endophthalmitis cases referred to the Fundación Oftalmológica de Santander FOSCAL (Floridablanca, Colombia) from 1 January 2012 to 31 December 2015. Results: 121 eyes of 121 patients were evaluated. 77.7% of them were male and the mean age was 42.9 years. Five of them (4.1%) corresponded to endogenous endophthalmitis, and 116 (95.9%) to exogenous endophthalmitis. Of the latter, 66.9% were associated with trauma (almost one-half of them associated with intraocular foreign body), and 29.5% with intraocular surgery. The most common isolated microorganisms in the exogenous endophthalmitis group corresponded to methicillin-resistant and methicillin-sensitive strains of Staphylococcus epidermidis and Staphylococcus aureus, which were mostly susceptible to imipenem, vancomycin and moxifloxacin and resistant to ceftazidime. Conclusion: Endophthalmitis is a potentially sight-threatening condition, especially in cases of inadequate treatment. Therefore, antimicrobial therapy should be guided by vitreous humour culture to assure that the causative microorganism is susceptible to the selected agent. The results of our study lead us to propose vancomycin, moxifloxacin or imipenem as first-line antimicrobial options.

Archivos de la Sociedad Española de Oftalmología, May 1, 2021

To report the ocular manifestations in patients with leukaemia. This is a retrospective, descript... more To report the ocular manifestations in patients with leukaemia. This is a retrospective, descriptive and observational study in patients with ocular manifestations of leukaemia. A total of 14 eyes were evaluated corresponding to 8 patients (5 women and 3 men) with ocular manifestations of leukaemia. The mean age at diagnosis was 43 years (31-76 years). Six eyes corresponded to patients with acute myeloid leukaemia (AML), four eyes to acute lymphoid leukaemia (ALL), two eyes to chronic myeloid leukaemia (CML), and the remaining two belonged to patients with hairy cell leukaemia (HCL). The primary ocular findings were choroidal invasion in 12 eyes (85.7%), retinal infiltration in 4 eyes (28.6%), and neuro-ophthalmic disorders in 4 eyes (28.6%). The mean visual acuity improved from 0.689 to 0.449 (logMAR) (P=.012) after the systemic and intrathecal chemotherapy. Of the eight patients, four died from systemic complications of the underlying disease. This is the first report of multiple ocular manifestations secondary to leukaemia in a Colombian population. It is important to keep in mind that this disease is included within the masquerade syndromes and that the ophthalmological findings that, while subtle, can also be devastating and be signs of a life-threatening disease.

Archivos De La Sociedad Española De Oftalmología (english Edition), May 1, 2021

Objective: To report the ocular manifestations in patients with leukaemia. Methods: This is a ret... more Objective: To report the ocular manifestations in patients with leukaemia. Methods: This is a retrospective, descriptive and observational study in patients with ocular manifestations of leukaemia. Results: A total of 14 eyes were evaluated corresponding to 8 patients (5 women and 3 men) with ocular manifestations of leukaemia. The mean age at diagnosis was 43 years (31-76 years). Six eyes corresponded to patients with Acute Myeloid Leukaemia (AML), four eyes to Acute Lymphoid Leukaemia (ALL), two eyes to Chronic Myeloid Leukaemia (CML), and the remaining two belonged to patients with Hairy Cell Leukaemia (HCL). The primary ocular findings were choroidal invasion in 12 eyes (85.7%), retinal infiltration in 4 eyes (28.6%), and neuro-ophthalmic disorders in 4 eyes (28.6%). The mean visual acuity improved from 0.689 to 0.449 (logMAR) (P = .012) after the systemic and intrathecal chemotherapy. Of the eight patients, four died from systemic complications of the underlying disease. Conclusions: This is the first report of multiple ocular manifestations secondary to leukaemia in a Colombian population. It is important to keep in mind that this disease is included within the masquerade syndromes and that the ophthalmological findings that, while subtle, can also be devastating and be signs of a life-threatening disease.

Resumen La retina es un tejido fundamental en el organo de la vision. En este articulo hacemos un... more Resumen La retina es un tejido fundamental en el organo de la vision. En este articulo hacemos una revision sobre la anatomia y fisiologia de esta estructura asi como sobre las principales patologias que la pueden afectar, entre ellas: desprendimiento de retina, retinopatia diabetica y la enfermedad macular relacionada con la edad. Aunque actualmente contamos con tecnicas medicas y quirurgicas seguras y efectivas para el manejo de estas patologias, aun representan un reto para la ciencia medica, y en estados avanzados comprometen seriamente la funcion visual, por ello es de gran importancia que el medico general tenga claros los conceptos basicos sobre el diagnostico de estas enfermedades, para realizar una remision adecuada y asi poder evitar al maximo secuelas visuales en el paciente. [Varon CL, Jaramillo S, Tello A. La retina para el medico no oftalmologo. MedUNAB 2010; 13:31-37]. Palabras clave: Retina, Epitelio pigmentario retiniano, Retinopatia diabetica, Desprendimiento de re...

Medicina-buenos Aires, 2005

La Investigacion como Experiencia Pedagogica en Colombia. Durante los pasados 4 anos, realizamos ... more La Investigacion como Experiencia Pedagogica en Colombia. Durante los pasados 4 anos, realizamos un programa de tamziaje entre 1,763 individuos sordos a traves del pais, para detectar Sindrome de Waardenburg (WS), en el cual identificamos 140 individuos afectados pertenecientes a 95 familias. Se confirmo el diagnostico clinico de WS en 95 propositus y en 45 parientes afectados, lo que significa una frecuencia del 5.38% de WS entre la poblacion sorda Colombiana. Examenes audiologicos, oftalmologicos y geneticos fueron practicados para confirmar el diagnostico. Siguiendo la clasificacion del consorcio del WS, modificada por varios autores, basados en el Indice de Waardenburg (WI) que define el tipo de WS, un indice >1.95 fue considerado WS1 (con dystopia canthorum) mientras que un indice por debajo de este valor fue WS2. En nuestra poblacion el 62.1% de los pacientes fueron clasificados como WS2 y el 37.9% como WS1. Presentamos los resultados del estudio de manifestaciones clinicas...

La vitreorretinopatia exudativa familiar es un trastorno genetico, bilateral, asimetrico y progre... more La vitreorretinopatia exudativa familiar es un trastorno genetico, bilateral, asimetrico y progresivo, de herencia variable. Materiales y metodos. Se practico un examen oftalmologico completo a 32 individuos de una familia con diagnostico de vitreorretinopatia exudativa familiar. Previa firma del consentimiento informado, se tomo una muestra para extraccion de ADN y se obtuvo la secuencia del gen FZD4. Resultados. Se encontraron 11 personas afectadas y 21 que no lo estaban. Se confirmo una herencia autosomica dominante y se identifico la mutacion 1501delCT en el gen FZD4. Se descarto la hipotesis de que algunos familiares presentaran manifestaciones parciales de la enfermedad. Discusion. Se hace una descripcion clinica y se reportan los hallazgos de angiografia, tomografia optica de coherencia y ecografia ocular. Se define una herencia autosomica dominante y se identifica la mutacion causal en el gen FZD4. La caracterizacion molecular de la familia permitio practicar una correcta y ...

GMS ophthalmology cases, 2017

Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods... more Objective: To report a case of bilateral anterior uveitis secondary to oral moxifloxacin. Methods: Case report. Results: A 54-year-old female presented bilateral anterior uveitis following a 10-day course of oral moxifloxacin. She developed a bilateral anterior uveitis associated with pigment dispersion syndrome and iris transillumination. Conclusions: Drug-induced uveitis is one of the causes of anterior uveitis. Uveitis related to fluoroquinolones is a rare entity, there are few cases reported in the literature, this is the first case reported in Latin America.

GMS ophthalmology cases, 2017

Objective: To report a case of iatrogenic central retinal artery occlusion after embolization and... more Objective: To report a case of iatrogenic central retinal artery occlusion after embolization and surgical resection of carotid body paraganglioma. Methods: Case report Results: One adult female patient presented with persistent unilateral visual loss after embolization with Embosphere(®) and Contour(®) microparticles of carotid body tumor. Fluorescein angiography revealed intraluminal microspheres in the central retinal artery ramifications. OCT revealed intraretinal spherical, hyporeflective particles with posterior shadowing. Conclusions: Central retinal artery occlusion should be assessed as a possible complication after surgical repair of head and neck paragangliomas.

Medunab, Jun 21, 2010

La retina es un tejido fundamental en el órgano de la visión. En este artículo hacemos una revisi... more La retina es un tejido fundamental en el órgano de la visión. En este artículo hacemos una revisión sobre la anatomía y fisiología de esta estructura así como sobre las principales patologías que la pueden afectar, entre ellas: desprendimiento de retina, retinopatía diabética y la ...

Universitas Medica, 2007

Análisis clinicogénetico de una familia colombiana con vitreorretinopatía exudativa familiar o

BMJ case reports, Jan 3, 2015

A 40-year-old man presented to the emergency service of the Department of Ophthalmology, Fundació... more A 40-year-old man presented to the emergency service of the Department of Ophthalmology, Fundación Oftalmológica de Santander, Floridablanca, Colombia, with blurred vision in his right eye. Anamnesis revealed that he also had newly diagnosed stage C HIV. He had recently started highly active antiretroviral therapy (HAART). Examination disclosed intraocular inflammation, along with plain white peripheral non-exudative lesions with sparse haemorrhaging. The differential diagnosis included cytomegalovirus (CMV) retinitis and immune recovery uveitis (IRU). On follow-up, the patient's left eye presented with decreased visual acuity and increased vitreous haze. A vitrectomy with vitreous tap was performed for microbiological studies. PCR for CMV in the vitreous sample was negative. The patient was discharged with the final diagnosis of IRU. In HIV patients with uveitis, the knowledge of characteristic signs and symptoms of particular entities such as opportunistic infections and IRU w...

International Journal of Pediatric Otorhinolaryngology, 2013

The purpose of this study was to establish a new approach to improve detection of deafness due to... more The purpose of this study was to establish a new approach to improve detection of deafness due to rubella. Colombian institutes for the deaf were visited by a medical team to perform in all enrolled individuals an ophthalmological examination with emphasis in fundus eye by a retina specialist. In cases where ocular alterations compatible with CRS were found, a medical interview by a clinical geneticist analyzing pre-and postnatal history and a thorough medical examination was done. A total of 1383 deaf institutionalized individuals were evaluated in 9 Colombian cities in the period of 2005 to 2006, finding a total of 463 positive cases for salt-and-pepper retinopathy (33.5%), in which rubella could be the etiology of deafness. Medellin, Cartagena, Bucaramanga and Barranquilla were the cities with the highest percentage of Congenital rubella, corresponding to 22.8% of analyzed population. The analysis performed on cases in which reliable prenatal history was obtained in a second appointment (n=88) showed association between positive viral symptoms during pregnancy and salt-and-pepper retinopathy in 62.5% of cases, while both (retinopathy and viral symptoms) were absent in 29.5% of cases; showing a correlation in 92% of cases. The frequency of deafness by rubella obtained by this study is significantly high compared with previous Colombian studies and with international reports. It was possible to correlate the antecedent of symptoms during pregnancy with the presence of salt-and-pepper retinopathy in this deaf population when reliable prenatal history was available, therefore eye testing with emphasis in fundus examination is a good indicator of rubella induced deafness. We propose a new approach in the search of deafness causes, based on a thorough ophthalmologic examination in all deaf people.

Retinal Cases & Brief Reports, 2013

To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraco... more To report a case of Curvularia lunata endophthalmitis that responded to amphotericin B and itraconazole Observational case report of one patient with C. lunata endophthalmitis after penetrating ocular injury with vegetable material. One young adult male patient presented with visual loss after penetrating ocular trauma with vegetable material. Biomicroscopy revealed keratitis and secondary endophthalmitis. Vitreous cultures after vitrectomy were positive for C. lunata and Staphylococcus epidermidis. Patient responded well to intravitreal amphotericin B and moxifloxacin. Fungal endophthalmitis should be suspected after trauma with vegetable material. Curvularia lunata may produce endophthalmitis and keratitis. Amphotericin B and itraconazole should be considered suitable agents for its treatment.

Univ. med, 1994

Resumo: La Unidad de Genética clínica del Instituto de Genética Humana de la universidad Javerian... more Resumo: La Unidad de Genética clínica del Instituto de Genética Humana de la universidad Javeriana y la Fundación oftalmológica Nacional, realizaron un estudio piloto, para determinar las diferentes causas de la ceguera y visión subnormal en población ...

American Journal of Medical Genetics Part A, 2008

A screening program to detect Waardenburg syndrome (WS) conducted between 2002 and 2005, among 1,... more A screening program to detect Waardenburg syndrome (WS) conducted between 2002 and 2005, among 1,763 deaf individuals throughout Columbia identified 95 affected individuals belonging to 95 families, giving a frequency of 5.38% of WS among the institutionalized deaf population. We confirmed the clinical diagnosis of WS in the 95 propositi and, through the family evaluation, we also identified 45 non-institutionalized affected relatives. Audiologic, ophthalmologic, and genetic studies were performed to confirm the diagnosis. Following the classification of the WS consortium, based on the Waardenburg Index (WI), to define the type of WS. We classified 62.1% of the propositi as WS2 and 37.9% as WS1. We present here the results of the study of clinical manifestations, analyzing the presence, severity, and symmetry of clinical findings among this affected population. Overall, among the 95 propositi, in addition to sensorineural deafness in all, the most frequent features were broad nasal root (58.9%), a first degree relative affected (37.9%), heterochromia irides (36.8%), skin hypopigmentation (31.6%), white forelock (28.0%), intense blue iris (27.4%), synophrys (12.6%), premature graying (10.5%), ptosis of the eyelids (9.5%), and hypoplasia alae nasi (1.1%). The majority of individuals had normal psychomotor development (87%), while the remaining 13% had developmental delay. Among the latter, 9.4% corresponded to WS2 and 3.6% to WS1. Our data confirm an interesting inter-and intrafamilial variability in the phenotypic manifestations as well as extremely variable expression.