Clarissa Santos - Academia.edu (original) (raw)
Papers by Clarissa Santos
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Introduction: Alzheimer's disease (AD) is characterized by neurotoxic immunoinflammation concomit... more Introduction: Alzheimer's disease (AD) is characterized by neurotoxic immunoinflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
RESUMO: O presente trabalho pretende trazer as contribuições de algumas teorias sobre cinema para... more RESUMO: O presente trabalho pretende trazer as contribuições de algumas teorias sobre cinema para o ensino de Sociologia. As interfaces possíveis entre o conhecimento e os métodos sociológicos/antropológicos e o cinema passam pela análise crítica das imagens, os estudos sobre diversidade cultural e a construção de narrativas. Sendo assim, as aproximações com teorias críticas da imagem e da cultura são elementos que fazem convergir, no campo teórico, o cinema e a sociologia. Na dimensão prática, as propostas de como "fazer cinema" e a construção do objeto a ser filmado possuem afinidades eletivas com a própria forma de "fazer sociologia". Neste trabalho, portanto, apresentaremos diálogos que temos explorado entre Cinema (em particular o documentário) e Ciências Sociais a partir do projeto de documentário feito com alunos no Colégio Pedro II, do Rio de Janeiro. PALAVRAS-CHAVE: Ensino de sociologia; cinema e educação; pedagogia decolonial. ABSTRACT: This paper aims ...
Bioorganic & Medicinal Chemistry, 2021
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized, in part, ... more Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized, in part, by the misfolding, oligomerization and fibrillization of amyloid-β (Aβ). Evidence suggests that the mechanisms underpinning Aβ oligomerization and subsequent fibrillization are distinct, and may therefore require equally distinct therapeutic approaches. Prior studies have suggested that amide derivatives of ferulic acid, a natural polyphenol, may combat multiple AD pathologies, though its impact on Aβ aggregation is controversial. We designed and synthesized a systematic library of amide derivatives of ferulic acid and evaluated their anti-oligomeric and anti-fibrillary capacities independently. Azetidine tethered, triphenyl derivatives were the most potent anti-oligomeric agents (compound 2i: IC50 = 1.8 µM ± 0.73 µM); notably these were only modest anti-fibrillary agents (20.57% inhibition of fibrillization), and exemplify the poor correlation between anti-oligomeric/fibrillary activities. These data were subsequently codified in an in silico QSAR model, which yielded a strong predictive model of anti-Aβ oligomeric activity (κ = 0.919 for test set; κ = 0.737 for validation set).
Busca-se nesse artigo analisar os impactos socioambientais decorrentes da expansao da cultura do ... more Busca-se nesse artigo analisar os impactos socioambientais decorrentes da expansao da cultura do dende no Baixo Tocantins/Para. A pesquisa foi realizada nos municipios de Moju e Tailândia que juntos concentram mais de 50% da area total plantada de dende na regiao. Foram entrevistadas familias que mantem contratos com as "empresas do dende" nas localidades Calmaria II e Nova Paz, assim como outros atores implicados nessa relacao contratual. O padrao de exploracao baseado no extrativismo do acai e da pesca e no desmatamento para a retirada da madeira e implantacao de rocas de mandioca, arroz, milho e feijao, coloca-se frente ao modelo de desenvolvimento calcado no agronegocio, impondo um novo arranjo produtivo, mediado pelo Estado, baseado na relacao empresa-comunidade. O Governo estimula a integracao da agricultura familiar ao agronegocio do dende, atraves de politicas como o Pronaf Eco, o Plano Nacional de Producao e uso do Biodiesel, o selo combustivel social e o Programa...
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2018
Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia, 2016
To develop an experimental model for incisional hernias and to compare morphological and function... more To develop an experimental model for incisional hernias and to compare morphological and functional aspects of hernia repairs by suture, polypropylene mesh and collagen mesh. A defect measuring 7cm x 2cm was created in the anterior abdominal of 28 New Zealand male rabbits, divided into four groups (n = 7): (1) control, (2) suture of the anterior sheath of the rectus abdominal muscle, (3) setting of polypropylene mesh, and (4) setting of collagen mesh. On the 90th postoperative day, the animals were examined to verify the presence of incisional hernia. Samples of abdominal wall and scar were collected for histological study. Incisional hernia was identified in 85.7% of the control group, 57.1% of the suture group, 42.9% of the collagen mesh group, and none in the polypropylene mesh group (p = 0.015). Mesh exposure could be identified in 71.4% of the animals in group 3 and in no animal in group 4 (p = 0.021). The polypropylene mesh is effective in the treatment of abdominal wall defec...
Toxicology Reports, 2016
The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was inve... more The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. Rats Wistar received Pb nitrate (50 mg/Kg/day, i.p., 5 days) followed by GA (13.5 mg/Kg, p.o., 3 days) or a chelating agent (EDTA, 55 mg/Kg, i.p.). As result, Pb decreased body weight, hematocrit and blood ␦-aminolevulinic acid dehydratase (ALA-D) activity. In addition, high Pb levels were observed in blood and tissues, together with increased (1) lipid peroxidation in erythrocytes, plasma and tissues, (2) protein oxidation in tissues and (3) plasma aspartate transaminase (AST) levels. These changes were accompanied by decreasing in antioxidant defenses, like superoxide dismutase (SOD) activity in tissues and catalase (CAT) activity and reduced glutathione (GSH) in liver. GA was able to reverse Pb-induced decrease in body weight and ALA-D activity, as well as Pb-induced oxidative damages and most antioxidant alterations, however it did not decrease Pb bioaccumulation herein as EDTA did. Furthermore, EDTA did not show antioxidant protection in Pb-treated animals as GA did. In conclusion, GA decreased Pb-induced oxidative damages not by decreasing Pb bioaccumulation, but by improving antioxidant defenses, thus GA may be promising in the treatment of Pb intoxications.
Brazilian Journal of Microbiology, 2015
Revista do Colégio Brasileiro de Cirurgiões, 2012
OBJETIVO: Comparar as aderências entre dois grupos de ratas Wistar submetidas à colocação intrape... more OBJETIVO: Comparar as aderências entre dois grupos de ratas Wistar submetidas à colocação intraperitoneal da tela de polipropileno e malha leve de polipropileno revestida com ácido graxo ômega-3. MÉTODOS: Foram utilizadas 27 ratas Wistar randomizadas em três grupos. No grupo 0 não houve colocação de prótese, no grupo 1 houve implantação da prótese de polipropileno e no grupo 2, implantação de prótese de polipropileno revestida com ácido graxo ômega-3. Foi avaliadas a presença de aderências, grau, força de ruptura, percentual de área recoberta e retração das telas aferidas. RESULTADOS: O grupo 0 não apresentou aderência. Os grupos 1 e 2 apresentaram aderência na superfície da prótese, omento, fígado e alça intestinal. Foram encontradas aderências grau 1 e 2 em 100% do grupo polipropileno revestida com ácido graxo ômega-3 e em 60% do grupo polipropileno. As demais eram aderências grau 3, e diferiram significativamente entre os grupos (p< 0,001). A força de ruptura da aderência na t...
Food chemistry, Jan 15, 2015
A new method for the decomposition of soybean based edible products (soy extract, textured soy pr... more A new method for the decomposition of soybean based edible products (soy extract, textured soy protein, transgenic soybeans, and whole soy flour) was developed to essential (Co, Cr, Cu, Fe, Mn, Ni, Se, V, and Zn) and non-essential (As, Ba, Cd, Pb, and Sr) trace elements determination by ICP OES and ICP-MS respectively. Effects related to the concentration of HNO3 (2.1-14.5molL(-1)) and the use of hydrogen peroxide on the efficiency of decomposition was evaluated based on the residual carbon content (RCC). It was demonstrated that 2.1molL(-1) HNO3 plus 1.0mL H2O2 was suitable for an efficient digestion, since RCC was lower than 18% and the agreement with certified values and spike recoveries were higher than 90% for all analytes. The concentrations of analytes in the samples (minimum-maximum in mgkg(-1)) were: The concentrations of analytes in the samples (minimum-maximum in mgkg(-1)) were: As (<0.007-0.040), Ba (0.064-10.6), Cd (<0.006-0.028), Co (0.012-102), Cr (0.56-5.88), C...
International Journal of Surgery Case Reports, 2015
Microchemical Journal, 2012
The Journal of parasitology, 2012
The aim of this study was to evaluate the concentrations of copper, iron, and zinc in blood serum... more The aim of this study was to evaluate the concentrations of copper, iron, and zinc in blood serum of dogs experimentally infected with Ranglia vitalii (n=7) compared with uninfected controls (n=5). Serum metal levels were determined in blood samples collected at days 0, 10, 15, and 20 post-infection (PI). Inductively coupled plasma optical emission spectrometry was used to measure the levels of copper, iron, and zinc. Significant differences were observed among groups (P < 0.05) PI. Increased levels of copper and decreased levels of iron and zinc were observed in the infected animals. The infection by R. vitalii may, therefore, alter the serum metal levels, resulting in metabolic disorders in dogs. These metals are directly involved in many enzymatic systems; accordingly, alterations in their blood concentrations may also influence the pathogenesis of disease.
Analytica Chimica Acta, 2012
Desenvolve Revista de Gestão do Unilasalle
A inovação ainda continua sendo um dos desafios das organizações, uma vez que diferentes fatores ... more A inovação ainda continua sendo um dos desafios das organizações, uma vez que diferentes fatores influenciam no desenvolvimento da capacidade inovadora. Considerando o papel da liderança em cenários de inovação, esta pesquisa busca entender como a literatura acadêmica observa a liderança feminina e sua relação com a capacidade inovadora nas organizações. Além disso, também analisa como as pesquisas abordam as diferenças na atuação do líder, considerando os diferentes gêneros. Para esse entendimento, realizou-se uma revisão sistemática de literatura – RSL, considerando artigos publicados a partir do ano 2000. O pressuposto inicial da pesquisa é que alguns fatores influenciarem a menor representatividade da liderança do gênero feminino em cenários de inovação. Como principais resultados, concluiu-se que não há diferenças significativas na prática de liderança, considerando homens e mulheres em cenários de inovação, mas diferenças de oportunidades. Por outro lado, resultados apontam qu...
Ornithology Research, 2021
Perspectiva Sociológica: A Revista de Professores de Sociologia, 2018
Review of Business Management, 2020
Alzheimer's & Dementia: Translational Research & Clinical Interventions
Introduction: Alzheimer's disease (AD) is characterized by neurotoxic immunoinflammation concomit... more Introduction: Alzheimer's disease (AD) is characterized by neurotoxic immunoinflammation concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
RESUMO: O presente trabalho pretende trazer as contribuições de algumas teorias sobre cinema para... more RESUMO: O presente trabalho pretende trazer as contribuições de algumas teorias sobre cinema para o ensino de Sociologia. As interfaces possíveis entre o conhecimento e os métodos sociológicos/antropológicos e o cinema passam pela análise crítica das imagens, os estudos sobre diversidade cultural e a construção de narrativas. Sendo assim, as aproximações com teorias críticas da imagem e da cultura são elementos que fazem convergir, no campo teórico, o cinema e a sociologia. Na dimensão prática, as propostas de como "fazer cinema" e a construção do objeto a ser filmado possuem afinidades eletivas com a própria forma de "fazer sociologia". Neste trabalho, portanto, apresentaremos diálogos que temos explorado entre Cinema (em particular o documentário) e Ciências Sociais a partir do projeto de documentário feito com alunos no Colégio Pedro II, do Rio de Janeiro. PALAVRAS-CHAVE: Ensino de sociologia; cinema e educação; pedagogia decolonial. ABSTRACT: This paper aims ...
Bioorganic & Medicinal Chemistry, 2021
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized, in part, ... more Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized, in part, by the misfolding, oligomerization and fibrillization of amyloid-β (Aβ). Evidence suggests that the mechanisms underpinning Aβ oligomerization and subsequent fibrillization are distinct, and may therefore require equally distinct therapeutic approaches. Prior studies have suggested that amide derivatives of ferulic acid, a natural polyphenol, may combat multiple AD pathologies, though its impact on Aβ aggregation is controversial. We designed and synthesized a systematic library of amide derivatives of ferulic acid and evaluated their anti-oligomeric and anti-fibrillary capacities independently. Azetidine tethered, triphenyl derivatives were the most potent anti-oligomeric agents (compound 2i: IC50 = 1.8 µM ± 0.73 µM); notably these were only modest anti-fibrillary agents (20.57% inhibition of fibrillization), and exemplify the poor correlation between anti-oligomeric/fibrillary activities. These data were subsequently codified in an in silico QSAR model, which yielded a strong predictive model of anti-Aβ oligomeric activity (κ = 0.919 for test set; κ = 0.737 for validation set).
Busca-se nesse artigo analisar os impactos socioambientais decorrentes da expansao da cultura do ... more Busca-se nesse artigo analisar os impactos socioambientais decorrentes da expansao da cultura do dende no Baixo Tocantins/Para. A pesquisa foi realizada nos municipios de Moju e Tailândia que juntos concentram mais de 50% da area total plantada de dende na regiao. Foram entrevistadas familias que mantem contratos com as "empresas do dende" nas localidades Calmaria II e Nova Paz, assim como outros atores implicados nessa relacao contratual. O padrao de exploracao baseado no extrativismo do acai e da pesca e no desmatamento para a retirada da madeira e implantacao de rocas de mandioca, arroz, milho e feijao, coloca-se frente ao modelo de desenvolvimento calcado no agronegocio, impondo um novo arranjo produtivo, mediado pelo Estado, baseado na relacao empresa-comunidade. O Governo estimula a integracao da agricultura familiar ao agronegocio do dende, atraves de politicas como o Pronaf Eco, o Plano Nacional de Producao e uso do Biodiesel, o selo combustivel social e o Programa...
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2018
Acta cirurgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia, 2016
To develop an experimental model for incisional hernias and to compare morphological and function... more To develop an experimental model for incisional hernias and to compare morphological and functional aspects of hernia repairs by suture, polypropylene mesh and collagen mesh. A defect measuring 7cm x 2cm was created in the anterior abdominal of 28 New Zealand male rabbits, divided into four groups (n = 7): (1) control, (2) suture of the anterior sheath of the rectus abdominal muscle, (3) setting of polypropylene mesh, and (4) setting of collagen mesh. On the 90th postoperative day, the animals were examined to verify the presence of incisional hernia. Samples of abdominal wall and scar were collected for histological study. Incisional hernia was identified in 85.7% of the control group, 57.1% of the suture group, 42.9% of the collagen mesh group, and none in the polypropylene mesh group (p = 0.015). Mesh exposure could be identified in 71.4% of the animals in group 3 and in no animal in group 4 (p = 0.021). The polypropylene mesh is effective in the treatment of abdominal wall defec...
Toxicology Reports, 2016
The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was inve... more The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. Rats Wistar received Pb nitrate (50 mg/Kg/day, i.p., 5 days) followed by GA (13.5 mg/Kg, p.o., 3 days) or a chelating agent (EDTA, 55 mg/Kg, i.p.). As result, Pb decreased body weight, hematocrit and blood ␦-aminolevulinic acid dehydratase (ALA-D) activity. In addition, high Pb levels were observed in blood and tissues, together with increased (1) lipid peroxidation in erythrocytes, plasma and tissues, (2) protein oxidation in tissues and (3) plasma aspartate transaminase (AST) levels. These changes were accompanied by decreasing in antioxidant defenses, like superoxide dismutase (SOD) activity in tissues and catalase (CAT) activity and reduced glutathione (GSH) in liver. GA was able to reverse Pb-induced decrease in body weight and ALA-D activity, as well as Pb-induced oxidative damages and most antioxidant alterations, however it did not decrease Pb bioaccumulation herein as EDTA did. Furthermore, EDTA did not show antioxidant protection in Pb-treated animals as GA did. In conclusion, GA decreased Pb-induced oxidative damages not by decreasing Pb bioaccumulation, but by improving antioxidant defenses, thus GA may be promising in the treatment of Pb intoxications.
Brazilian Journal of Microbiology, 2015
Revista do Colégio Brasileiro de Cirurgiões, 2012
OBJETIVO: Comparar as aderências entre dois grupos de ratas Wistar submetidas à colocação intrape... more OBJETIVO: Comparar as aderências entre dois grupos de ratas Wistar submetidas à colocação intraperitoneal da tela de polipropileno e malha leve de polipropileno revestida com ácido graxo ômega-3. MÉTODOS: Foram utilizadas 27 ratas Wistar randomizadas em três grupos. No grupo 0 não houve colocação de prótese, no grupo 1 houve implantação da prótese de polipropileno e no grupo 2, implantação de prótese de polipropileno revestida com ácido graxo ômega-3. Foi avaliadas a presença de aderências, grau, força de ruptura, percentual de área recoberta e retração das telas aferidas. RESULTADOS: O grupo 0 não apresentou aderência. Os grupos 1 e 2 apresentaram aderência na superfície da prótese, omento, fígado e alça intestinal. Foram encontradas aderências grau 1 e 2 em 100% do grupo polipropileno revestida com ácido graxo ômega-3 e em 60% do grupo polipropileno. As demais eram aderências grau 3, e diferiram significativamente entre os grupos (p< 0,001). A força de ruptura da aderência na t...
Food chemistry, Jan 15, 2015
A new method for the decomposition of soybean based edible products (soy extract, textured soy pr... more A new method for the decomposition of soybean based edible products (soy extract, textured soy protein, transgenic soybeans, and whole soy flour) was developed to essential (Co, Cr, Cu, Fe, Mn, Ni, Se, V, and Zn) and non-essential (As, Ba, Cd, Pb, and Sr) trace elements determination by ICP OES and ICP-MS respectively. Effects related to the concentration of HNO3 (2.1-14.5molL(-1)) and the use of hydrogen peroxide on the efficiency of decomposition was evaluated based on the residual carbon content (RCC). It was demonstrated that 2.1molL(-1) HNO3 plus 1.0mL H2O2 was suitable for an efficient digestion, since RCC was lower than 18% and the agreement with certified values and spike recoveries were higher than 90% for all analytes. The concentrations of analytes in the samples (minimum-maximum in mgkg(-1)) were: The concentrations of analytes in the samples (minimum-maximum in mgkg(-1)) were: As (<0.007-0.040), Ba (0.064-10.6), Cd (<0.006-0.028), Co (0.012-102), Cr (0.56-5.88), C...
International Journal of Surgery Case Reports, 2015
Microchemical Journal, 2012
The Journal of parasitology, 2012
The aim of this study was to evaluate the concentrations of copper, iron, and zinc in blood serum... more The aim of this study was to evaluate the concentrations of copper, iron, and zinc in blood serum of dogs experimentally infected with Ranglia vitalii (n=7) compared with uninfected controls (n=5). Serum metal levels were determined in blood samples collected at days 0, 10, 15, and 20 post-infection (PI). Inductively coupled plasma optical emission spectrometry was used to measure the levels of copper, iron, and zinc. Significant differences were observed among groups (P < 0.05) PI. Increased levels of copper and decreased levels of iron and zinc were observed in the infected animals. The infection by R. vitalii may, therefore, alter the serum metal levels, resulting in metabolic disorders in dogs. These metals are directly involved in many enzymatic systems; accordingly, alterations in their blood concentrations may also influence the pathogenesis of disease.
Analytica Chimica Acta, 2012
Desenvolve Revista de Gestão do Unilasalle
A inovação ainda continua sendo um dos desafios das organizações, uma vez que diferentes fatores ... more A inovação ainda continua sendo um dos desafios das organizações, uma vez que diferentes fatores influenciam no desenvolvimento da capacidade inovadora. Considerando o papel da liderança em cenários de inovação, esta pesquisa busca entender como a literatura acadêmica observa a liderança feminina e sua relação com a capacidade inovadora nas organizações. Além disso, também analisa como as pesquisas abordam as diferenças na atuação do líder, considerando os diferentes gêneros. Para esse entendimento, realizou-se uma revisão sistemática de literatura – RSL, considerando artigos publicados a partir do ano 2000. O pressuposto inicial da pesquisa é que alguns fatores influenciarem a menor representatividade da liderança do gênero feminino em cenários de inovação. Como principais resultados, concluiu-se que não há diferenças significativas na prática de liderança, considerando homens e mulheres em cenários de inovação, mas diferenças de oportunidades. Por outro lado, resultados apontam qu...
Ornithology Research, 2021
Perspectiva Sociológica: A Revista de Professores de Sociologia, 2018
Review of Business Management, 2020