Claudia López - Academia.edu (original) (raw)
Papers by Claudia López
Journal of Molecular Biology, 2009
During the morphogenesis of mature human immunodeficiency virus-1 cores, viral capsid proteins as... more During the morphogenesis of mature human immunodeficiency virus-1 cores, viral capsid proteins assemble conical or tubular shells around viral ribonucleoprotein complexes. This assembly step is mimicked in vitro through reactions in which capsid proteins oligomerize to form long tubes, and this process can be modeled as consisting of a slow nucleation period, followed by a rapid phase of tube growth.
ABSTRACT While there is significant potential for social technologies to strengthen local communi... more ABSTRACT While there is significant potential for social technologies to strengthen local communities, creating viable online spaces for them remains difficult. Maintaining a reliable content stream is challenging for local communities with their bounded emphases and limited population of potential contributors. Some systems focus on specific information types (e.g. restaurant, events). Others allow many different information types. This paper reports our findings about the consequences of content diversity from a study of neighborhood-oriented Facebook groups. The findings raise questions about the viability of designs for local online communities that focus narrowly on single topics, goals, and audiences.
In this poster we introduce Conference Navigator 3, an online social system that helps conference... more In this poster we introduce Conference Navigator 3, an online social system that helps conference attendees in selecting the talks most relevant to their interests, and it also supports them in exploring and building their research contacts' network. In particular, we show how some features that we have progressively incorporated in different conferences have significantly increased user participation.
Microscopy and Microanalysis
Current Topics in Microbiology and Immunology, 2005
Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA ... more Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA virus, FMDV follows a quasispecies dynamics, with the many biological implications of such a dynamics. Mutant spectra provide a reservoir of FMDV variants, and minority subpopulations may become dominant in response to environmental demands or as a result of statistical fluctuations in population size. Accumulation of mutations in the FMDV genome occurs upon subjecting viral populations to repeated bottleneck events and upon viral replication in the presence of mutagenic base or nucleoside analogs. During serial bottleneck passages, FMDV survive during extended rounds of replication maintaining low average relative fitness, despite linear accumulation of mutations in the consensus genomic sequence. The critical event is the occurrence of a low frequency of compensatory mutations. In contrast, upon replication in the presence of mutagens, the complexity of mutant spectra increases, apparently no compensatory mutations can express their fitness-enhancing potential, and the virus can cross an error threshold for maintenance of genetic information, resulting in virus extinction. Low relative fitness and low viral load favor FMDV extinction in cell culture. The comparison of the molecular basis of resistance to extinction upon bottleneck passage and extinction by enhanced mutagenesis is providing new insights in the understanding of quasispecies dynamics. Such a comparison is contributing to the development of new antiviral strategies based on the transition of viral replication into error catastrophe.
Journal of Urban Technology, 2014
Pittsburgh. She studies how information is disseminated, sought for, and discovered both online a... more Pittsburgh. She studies how information is disseminated, sought for, and discovered both online and offline in urban settings. Her investigation combines theories and methods from human computer interaction, information behavior, and urban informatics in order to understand the dynamics of local information consumption and its implications for citizens' civic engagement, and the development of local information systems. Her research has been published at top-tier conferences, including CSCW and CHI.
... Jesús Alberto Ruíz-Ruíz, MD*, Eugenia Corredor-Sánchez, MD**, Carlos Julio García-Perlaza, MD... more ... Jesús Alberto Ruíz-Ruíz, MD*, Eugenia Corredor-Sánchez, MD**, Carlos Julio García-Perlaza, MD***, José Ignacio Madero-Cervera, MD****, Claudia Rocío López, B.Sc+, María Fernanda León, B.Sc++, Magally Escobar, B.Sc+++ ... Figura 1. Miembro superior izquierdo. ...
Virology, 2014
The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the en... more The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the envelope (Env) protein is translated from incompletely spliced Env mRNAs. Nuclear export of vRNAs and Env mRNAs is mediated by the Rev accessory protein which binds to the rev-responsive element (RRE) present on these RNAs. Evidence has shown there is a direct or indirect interaction between the Gag protein, and the cytoplasmic tail (CT) of the Env protein. Our current work shows that env gene expression impacts HIV-1 Gag expression and function in two ways. At the protein level, full-length Env expression altered Gag protein expression, while Env CT-deletion proteins did not. At the RNA level, RRE-containing Env mRNA expression reduced Gag expression, processing, and virus particle release from cells. Our results support models in which Gag is influenced by the Env CT, and Env mRNAs compete with vRNAs for nuclear export.
Objetivo: este estudio pretendió analizar la eficacia de las técnicas de reproducción asistida en... more Objetivo: este estudio pretendió analizar la eficacia de las técnicas de reproducción asistida en un grupo de pacientes con una respuesta disminuida a la estimulación ovárica (tres folículos o menos al finalizar la estimulación ovárica) y correlacionarla con la edad.
Proceedings of the SIGCHI Conference on Human Factors in Computing Systems - CHI '13, 2013
We present a theoretical foundation and empirical findings demonstrating the effectiveness of per... more We present a theoretical foundation and empirical findings demonstrating the effectiveness of personality-targeted design. Much like a medical treatment applied to a person based on his specific genetic profile, we argue that theorydriven, personality-targeted UI design can be more effective than design applied to the entire population. The empirical exploration focused on two settings, two populations and two personality traits: Study 1 shows that users' extroversion level moderates the relationship between the UI cue of audience size and users' contribution. Study 2 demonstrates that the effectiveness of social anchors in encouraging online contributions depends on users' level of emotional stability. Taken together, the findings demonstrate the potential and robustness of the interactionist approach to UI design. The findings contribute to the HCI community, and in particular to designers of social systems, by providing guidelines to targeted design that can increase online participation.
2011 IEEE International Conference on Information Reuse & Integration, 2011
While sharing information is the main purpose of online social networks (OSN), privacy is a major... more While sharing information is the main purpose of online social networks (OSN), privacy is a major concern. It has been argued that the lack of privacy protection caused the massive departure of users from MySpace in 2008 [1] -specially, due to mass media coverage on dangers of teenagers' public profiles and the appearance of Facebook, which provided a more private OSN. Besides mass media, we explore the impact of family and friends in instilling privacy concerns on teenagers. We develop an agent-based model to simulate propagation of privacy concerns through connection in a social network, and the effect of individual users' privacy decisions on the level of overall participation in an OSN. We report the results of simulating different privacy propagation factors. Our results are useful to understand and predict hidden patterns of user behavior that lead to changes in the number of active users in an OSN.
2008 First International Workshop on Managing Requirements Knowledge, 2008
Page 1. NDR Ontology: Sharing and Reusing NFR and Design Rationale Knowledge Claudia López Univer... more Page 1. NDR Ontology: Sharing and Reusing NFR and Design Rationale Knowledge Claudia López Universidad Técnica Federico Santa Marıa Depto. de Informática Av. Espana 1680, Valparaıso, Chile clopez @inf.utfsm.cl ...
2008 32nd Annual IEEE Software Engineering Workshop, 2008
Page 1. Querying Software Interdependence Graphs Luiz Marcio Cysneiros School of Information Tech... more Page 1. Querying Software Interdependence Graphs Luiz Marcio Cysneiros School of Information Technologies York University Toronto, Canada cysneiro @yorku.ca Karin K. Breitman Departamento de Informática Pontifıcia ...
Lecture Notes in Computer Science, 2006
Page 1. Evaluating Alternative COTS Assemblies from Imperfect Component Information Hernán Astudi... more Page 1. Evaluating Alternative COTS Assemblies from Imperfect Component Information Hernán Astudillo1, Javier Pereira2, and Claudia López1 1 Universidad Técnica Federico Santa Marıa, Departamento de Informática, Avenida ...
Lecture Notes in Computer Science, 2006
Software architectures are often designed with respect to some architecture patterns, like the pi... more Software architectures are often designed with respect to some architecture patterns, like the pipeline and peer-to-peer. These patterns are the guarantee of some quality attributes, like maintainability or performance. These patterns should be dynamically enforced in the running system to benefit from their associated quality characteristics at runtime. In dynamic hosting platforms where machines can enter the network, offering new resources, or fail, making the components they host unavailable, these patterns can be affected. In addition, in this kind of infrastructures, some resource requirements can also be altered. In this paper we present an approach which aims at dynamically assist deployment process with information about architectural patterns and resource constraints. This ensures that, faced with disconnections or machine failures, the runtime system complies permanently with the original architectural pattern and the initial resource requirements.
producing lymphoedema, aortic dissection and preeclampsy.
n EN ESTE CASO SE PRESENTAN LAS SIGUIENTES SITUACIONES : La empresa cuenta con una buena posición... more n EN ESTE CASO SE PRESENTAN LAS SIGUIENTES SITUACIONES : La empresa cuenta con una buena posición e imagen en el negocio de los muebles. Un mercado altamente competitivo.Automatización de Oficinas S.A. posee un producto con altos estandares de calidad. La empresa han presentando una disminución en los margenes rentabilidad manejados. DESCRIPCION : El caso muestra la situación de la
Journal of Molecular Biology, 2009
During the morphogenesis of mature human immunodeficiency virus-1 cores, viral capsid proteins as... more During the morphogenesis of mature human immunodeficiency virus-1 cores, viral capsid proteins assemble conical or tubular shells around viral ribonucleoprotein complexes. This assembly step is mimicked in vitro through reactions in which capsid proteins oligomerize to form long tubes, and this process can be modeled as consisting of a slow nucleation period, followed by a rapid phase of tube growth.
ABSTRACT While there is significant potential for social technologies to strengthen local communi... more ABSTRACT While there is significant potential for social technologies to strengthen local communities, creating viable online spaces for them remains difficult. Maintaining a reliable content stream is challenging for local communities with their bounded emphases and limited population of potential contributors. Some systems focus on specific information types (e.g. restaurant, events). Others allow many different information types. This paper reports our findings about the consequences of content diversity from a study of neighborhood-oriented Facebook groups. The findings raise questions about the viability of designs for local online communities that focus narrowly on single topics, goals, and audiences.
In this poster we introduce Conference Navigator 3, an online social system that helps conference... more In this poster we introduce Conference Navigator 3, an online social system that helps conference attendees in selecting the talks most relevant to their interests, and it also supports them in exploring and building their research contacts' network. In particular, we show how some features that we have progressively incorporated in different conferences have significantly increased user participation.
Microscopy and Microanalysis
Current Topics in Microbiology and Immunology, 2005
Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA ... more Foot-and-mouth disease virus (FMDV) is genetically and phenotypically variable. As a typical RNA virus, FMDV follows a quasispecies dynamics, with the many biological implications of such a dynamics. Mutant spectra provide a reservoir of FMDV variants, and minority subpopulations may become dominant in response to environmental demands or as a result of statistical fluctuations in population size. Accumulation of mutations in the FMDV genome occurs upon subjecting viral populations to repeated bottleneck events and upon viral replication in the presence of mutagenic base or nucleoside analogs. During serial bottleneck passages, FMDV survive during extended rounds of replication maintaining low average relative fitness, despite linear accumulation of mutations in the consensus genomic sequence. The critical event is the occurrence of a low frequency of compensatory mutations. In contrast, upon replication in the presence of mutagens, the complexity of mutant spectra increases, apparently no compensatory mutations can express their fitness-enhancing potential, and the virus can cross an error threshold for maintenance of genetic information, resulting in virus extinction. Low relative fitness and low viral load favor FMDV extinction in cell culture. The comparison of the molecular basis of resistance to extinction upon bottleneck passage and extinction by enhanced mutagenesis is providing new insights in the understanding of quasispecies dynamics. Such a comparison is contributing to the development of new antiviral strategies based on the transition of viral replication into error catastrophe.
Journal of Urban Technology, 2014
Pittsburgh. She studies how information is disseminated, sought for, and discovered both online a... more Pittsburgh. She studies how information is disseminated, sought for, and discovered both online and offline in urban settings. Her investigation combines theories and methods from human computer interaction, information behavior, and urban informatics in order to understand the dynamics of local information consumption and its implications for citizens' civic engagement, and the development of local information systems. Her research has been published at top-tier conferences, including CSCW and CHI.
... Jesús Alberto Ruíz-Ruíz, MD*, Eugenia Corredor-Sánchez, MD**, Carlos Julio García-Perlaza, MD... more ... Jesús Alberto Ruíz-Ruíz, MD*, Eugenia Corredor-Sánchez, MD**, Carlos Julio García-Perlaza, MD***, José Ignacio Madero-Cervera, MD****, Claudia Rocío López, B.Sc+, María Fernanda León, B.Sc++, Magally Escobar, B.Sc+++ ... Figura 1. Miembro superior izquierdo. ...
Virology, 2014
The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the en... more The HIV-1 Gag proteins are translated from the full-length HIV-1 viral RNA (vRNA), whereas the envelope (Env) protein is translated from incompletely spliced Env mRNAs. Nuclear export of vRNAs and Env mRNAs is mediated by the Rev accessory protein which binds to the rev-responsive element (RRE) present on these RNAs. Evidence has shown there is a direct or indirect interaction between the Gag protein, and the cytoplasmic tail (CT) of the Env protein. Our current work shows that env gene expression impacts HIV-1 Gag expression and function in two ways. At the protein level, full-length Env expression altered Gag protein expression, while Env CT-deletion proteins did not. At the RNA level, RRE-containing Env mRNA expression reduced Gag expression, processing, and virus particle release from cells. Our results support models in which Gag is influenced by the Env CT, and Env mRNAs compete with vRNAs for nuclear export.
Objetivo: este estudio pretendió analizar la eficacia de las técnicas de reproducción asistida en... more Objetivo: este estudio pretendió analizar la eficacia de las técnicas de reproducción asistida en un grupo de pacientes con una respuesta disminuida a la estimulación ovárica (tres folículos o menos al finalizar la estimulación ovárica) y correlacionarla con la edad.
Proceedings of the SIGCHI Conference on Human Factors in Computing Systems - CHI '13, 2013
We present a theoretical foundation and empirical findings demonstrating the effectiveness of per... more We present a theoretical foundation and empirical findings demonstrating the effectiveness of personality-targeted design. Much like a medical treatment applied to a person based on his specific genetic profile, we argue that theorydriven, personality-targeted UI design can be more effective than design applied to the entire population. The empirical exploration focused on two settings, two populations and two personality traits: Study 1 shows that users' extroversion level moderates the relationship between the UI cue of audience size and users' contribution. Study 2 demonstrates that the effectiveness of social anchors in encouraging online contributions depends on users' level of emotional stability. Taken together, the findings demonstrate the potential and robustness of the interactionist approach to UI design. The findings contribute to the HCI community, and in particular to designers of social systems, by providing guidelines to targeted design that can increase online participation.
2011 IEEE International Conference on Information Reuse & Integration, 2011
While sharing information is the main purpose of online social networks (OSN), privacy is a major... more While sharing information is the main purpose of online social networks (OSN), privacy is a major concern. It has been argued that the lack of privacy protection caused the massive departure of users from MySpace in 2008 [1] -specially, due to mass media coverage on dangers of teenagers' public profiles and the appearance of Facebook, which provided a more private OSN. Besides mass media, we explore the impact of family and friends in instilling privacy concerns on teenagers. We develop an agent-based model to simulate propagation of privacy concerns through connection in a social network, and the effect of individual users' privacy decisions on the level of overall participation in an OSN. We report the results of simulating different privacy propagation factors. Our results are useful to understand and predict hidden patterns of user behavior that lead to changes in the number of active users in an OSN.
2008 First International Workshop on Managing Requirements Knowledge, 2008
Page 1. NDR Ontology: Sharing and Reusing NFR and Design Rationale Knowledge Claudia López Univer... more Page 1. NDR Ontology: Sharing and Reusing NFR and Design Rationale Knowledge Claudia López Universidad Técnica Federico Santa Marıa Depto. de Informática Av. Espana 1680, Valparaıso, Chile clopez @inf.utfsm.cl ...
2008 32nd Annual IEEE Software Engineering Workshop, 2008
Page 1. Querying Software Interdependence Graphs Luiz Marcio Cysneiros School of Information Tech... more Page 1. Querying Software Interdependence Graphs Luiz Marcio Cysneiros School of Information Technologies York University Toronto, Canada cysneiro @yorku.ca Karin K. Breitman Departamento de Informática Pontifıcia ...
Lecture Notes in Computer Science, 2006
Page 1. Evaluating Alternative COTS Assemblies from Imperfect Component Information Hernán Astudi... more Page 1. Evaluating Alternative COTS Assemblies from Imperfect Component Information Hernán Astudillo1, Javier Pereira2, and Claudia López1 1 Universidad Técnica Federico Santa Marıa, Departamento de Informática, Avenida ...
Lecture Notes in Computer Science, 2006
Software architectures are often designed with respect to some architecture patterns, like the pi... more Software architectures are often designed with respect to some architecture patterns, like the pipeline and peer-to-peer. These patterns are the guarantee of some quality attributes, like maintainability or performance. These patterns should be dynamically enforced in the running system to benefit from their associated quality characteristics at runtime. In dynamic hosting platforms where machines can enter the network, offering new resources, or fail, making the components they host unavailable, these patterns can be affected. In addition, in this kind of infrastructures, some resource requirements can also be altered. In this paper we present an approach which aims at dynamically assist deployment process with information about architectural patterns and resource constraints. This ensures that, faced with disconnections or machine failures, the runtime system complies permanently with the original architectural pattern and the initial resource requirements.
producing lymphoedema, aortic dissection and preeclampsy.
n EN ESTE CASO SE PRESENTAN LAS SIGUIENTES SITUACIONES : La empresa cuenta con una buena posición... more n EN ESTE CASO SE PRESENTAN LAS SIGUIENTES SITUACIONES : La empresa cuenta con una buena posición e imagen en el negocio de los muebles. Un mercado altamente competitivo.Automatización de Oficinas S.A. posee un producto con altos estandares de calidad. La empresa han presentando una disminución en los margenes rentabilidad manejados. DESCRIPCION : El caso muestra la situación de la