Claudio Taboga - Academia.edu (original) (raw)
Papers by Claudio Taboga
Patient Education and Counseling, 1994
Patient Education and Counseling, 1994
Pathophysiology of Haemostasis and Thrombosis, 1992
Diabetes Care, 1999
R e f e re nc e s 1. Giugliano D, Ceriello A: Oxidative stre s s and diabetic vascular complicati... more R e f e re nc e s 1. Giugliano D, Ceriello A: Oxidative stre s s and diabetic vascular complications. D i abetes Care 19:257-267, 1996 2. U.K. Prospective Diabetes Study Gro u p : Intensive blood-glucose control with s u l p h o n y l u reas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).
European Journal of Clinical Investigation, 1998
... Measurement of TRAP 2,20-Azobis-(2-amidinopropane) dihydrochloride (ABAP), R-phycoerythrin (R... more ... Measurement of TRAP 2,20-Azobis-(2-amidinopropane) dihydrochloride (ABAP), R-phycoerythrin (R-PE), Trolox and all other chemicals were purchased from Sigma Chemical (St Louis, MO, USA). TRAP was evaluated according to Ghiselli et al. ...
The online version of this article, along with updated information and services, is located on the
OBJECTIVE — To investigate the relationship between beliefs of physicians relative to inten-sive ... more OBJECTIVE — To investigate the relationship between beliefs of physicians relative to inten-sive metabolic control in type 2 diabetes and levels of HbA1c obtained in a sample of their patients. RESEARCHDESIGNANDMETHODS — Physicians ’ beliefs were investigated through a questionnaire sent to a sample of self-selected clinicians participating in a nationwide initiative aimed at assessing the relationship between the quality of care delivered to patients with type 2 diabetes and their outcomes. At the same time, physicians were asked to collect clinical data on a random sample of their patients, stratified by age (,65 vs. $65 years). Mean HbA1c levels in the study population were thus evaluated according to target fasting blood glucose (FBG) used by their physicians. RESULTS — Of 456 physicians, 342 (75%) returned the questionnaire. Among the respond-ers, 200 diabetologists and 99 general practitioners (GPs) recruited 3,297 patients; 2,003 of whom were always followed by the same physi...
Riccardo Candido1 Maria Antonietta Pellegrini2 Giuseppe Felace3 Patrizia Li Volsi4 Paola Gelisio5... more Riccardo Candido1 Maria Antonietta Pellegrini2 Giuseppe Felace3 Patrizia Li Volsi4 Paola Gelisio5 Claudio Taboga6 Laura Tonutti2 Carla Tortul7 Roberta Assaloni7 Barbara Brunato7 Carmela Vinci8 1 S.S. Centro Diabetologico Distretto 3, A.A.S. 1 Triestina, Trieste 2 S.O.C. di Endocrinologia e Malattie del Metabolismo, AOU di Udine, Udine 3 Diabetologia e Malattie Metaboliche, Presidio Ospedaliero di Spilimbergo, A.A.S. 5 Friuli Occidentale, Pordenone 4 S.S.D. Diabetologia, AO di Pordenone, A.A.S. 5 Friuli Occidentale, Pordenone 5 U.O Semplice di Diabetologia, ULSS 12 Veneziana, Venezia 6 Ambulatori Diabetologici, A.A.S. 3 Alto Friuli-CollinareMedio Friuli 7 S.O.S. di Diabetologia, A.A.S. 2 Bassa FriulianaIsontina, Monfalcone, Gorizia 8 UOSD Diabetologia, ULSS 10, S. Donà di Piave, Venezia
OBJECTIVE — Recently, much attention has been paid to the possibility that postprandial hyperglyc... more OBJECTIVE — Recently, much attention has been paid to the possibility that postprandial hyperglycemia may be a cardiovascular risk factor in diabetes. Oxidative stress has been involved in the pathogenesis of diabetic complications, and increased plasma levels of nitrotyrosine, a product of peroxynitrite action, have been found in the plasma of diabetic subjects. The aim of the present study was to evaluate whether postprandial hyperglycemia is accompanied by ni-trotyrosine generation and, if so, to explore a possible direct role of hyperglycemia in such a phenomenon. RESEARCH DESIGN AND METHODS — A total of 23 type 2 diabetic patients and 15 matched normal healthy subjects were recruited for this study. Two different tests were per-formed in diabetic patients: a standard meal preceded by regular insulin (0.15 units/kg body wt) or insulin aspart (0.15 units/kg body wt) to achieve different levels of postprandial hyperglyce-mia. The meal test was also performed in healthy control sub...
Diabetologia, 2001
The relation between diabetes and premature vascular disease is well established [1] and oxidativ... more The relation between diabetes and premature vascular disease is well established [1] and oxidative stress has been claimed as one of the most important pathogenetic factors [2]. In diabetes, oxidative stress could increase the production of superoxide (O 2-) and nitric oxide (NO) [2±3], which could lead to the formation of pro-oxidant peroxynitrite (ONOO-) [4]. The ONOO-, formed by the reaction between NO and O 2-, is a powerful oxidant capable of oxidizing low density lipoprotein [5], of causing vascular dysfunction [6] and of nitrating tyrosine residues in proteins [7]. Because the production of ONOOis difficult to determine, the assay of nitrotyrosine in protein has been proposed as an indirect marker of ONOOproduction [7]. The presence of nitrotyrosine in biological fluids such as plasma and urine have been investigated in a limited number of conditions. Raised values of nitrotyrosine have been found in the plasma of patients Diabetologia (2001) 44: 834±838
Diabetes Care, 2001
OBJECTIVE-To investigate the relationship between beliefs of physicians relative to intensive met... more OBJECTIVE-To investigate the relationship between beliefs of physicians relative to intensive metabolic control in type 2 diabetes and levels of HbA 1c obtained in a sample of their patients. RESEARCH DESIGN AND METHODS-Physicians' beliefs were investigated through a questionnaire sent to a sample of self-selected clinicians participating in a nationwide initiative aimed at assessing the relationship between the quality of care delivered to patients with type 2 diabetes and their outcomes. At the same time, physicians were asked to collect clinical data on a random sample of their patients, stratified by age (Ͻ65 vs. Ն65 years). Mean HbA 1c levels in the study population were thus evaluated according to target fasting blood glucose (FBG) used by their physicians.
Nasally administered (IN) insulin has been advocated as a potentially useful alternative to subcu... more Nasally administered (IN) insulin has been advocated as a potentially useful alternative to subcutaneously administered regular insulin because of its more rapid onset and time to peak action and its shorter duration of action. This study further defines the pharmacodynamics of IN insulin by using a euglycemic clamp technique to determine the bioavailability of IN insulin as compared with intravenous (IV) insulin, and to ascertain whether multiple sequentially administered doses of IN insulin alter pharmacodynamics. Eight normal volunteers received 2 control doses of IV insulin (0.05 U/kg), and 3 high doses (0.7 U/kg) and 3 low doses (0.35 U/kg) of IN insulin with an absorption enhancer (tauro-24,25 dihydrofusidate) given sequentially over a 2 day period. A euglycemic clamp was performed with a Biostator (Ames) that infused dextrose to keep the subject's blood glucose at his fasting level. Analysis of dextrose infusion curves for the low and high doses of IN insulin revealed an onset of action of 9.4 +/- 0.4 and 10.5 +/- 0.3 minutes, time to peak action of 20.6 +/- 5.6 and 23.7 +/- 4.4 minutes and duration of action of 82.1 +/- 5.2 and 95 +/- 5.7 minutes respectively. Both the onset of action and time to peak action were slightly longer (P less than .05) for the high as compared with the low dose IN insulin, although this should not represent a clinically significant difference. The total dextrose requirement was 21.9 +/- 2.3 g for the low dose IN insulin and 34.1 +/- 3.3 g for the high dose IN insulin, the latter value being significantly greater (P less than .01) than the former.(ABSTRACT TRUNCATED AT 250 WORDS)
International Journal of Obesity, 2006
Objective: The aim of this study was to use the Eating Attitudes Test-26 (EAT-26) as a screening ... more Objective: The aim of this study was to use the Eating Attitudes Test-26 (EAT-26) as a screening instrument on a specific population with a marked prevalence of binge eating disorder (BED) and eating disorder not otherwise specified (EDNOS). The EAT-26 questionnaire was used in order to identify the high-risk subjects for referral to clinical evaluation. Method: EAT-26 was administered to 845 subjects who, for the first time, came to the Nutritional Medicine Service looking for a diet between January 1999 and December 2002. From this initial sample, subsequently, 250 subjects were randomly selected and administered a semistructured clinical interview for DSM-IV (SCID I, version 2.0). Results: Discriminant analysis provided a cutoff value of EAT-26 ¼ 11. Logistic regression analysis indicated high Dieting (D) or Bulimia (B) subscale scores as a risk factor of EDNOS or bulimia nervosa (BN) cases, respectively; on the other hand, a high Oral Control (O) subscale score represented a protecting factor for BED cases. Conclusion: Our study tried to assess the usefulness of EAT-26 as a screening instrument for obese patients attending a Medical Nutritional Service. Results from this study suggest that a cutoff score of 11, lower than that indicated in the literature, improves the diagnostic accuracy of the EAT-26 in a high-risk setting regarding sensibility level (68.1%) and leading to a reduction of the false negative rate (31.9%).
Metabolism Clinical and Experimental, Dec 1, 1999
Oxidative stress and its contribution to low-density lipoprotein (LDL) oxidation have been implic... more Oxidative stress and its contribution to low-density lipoprotein (LDL) oxidation have been implicated in the pathogenesis of vascular diabetic complications. However, the relationship between hyperglycemia, hyperinsulinemia, hyperlipidemia, and oxidative stress is still debated. If plasma glucose and/or insulin and/or lipid are some of the most important determinants of oxidative stress in diabetes, then their typical postprandial elevations in diabetes would be expected to favor oxidative stress and LDL oxidation. To test this hypothesis, in type 2 diabetic patients, we evaluated the effects of two different standard meals designed to produce different levels of postprandial hyperglycemia on the plasma oxidative status and LDL oxidation. The meals were administered in randomized order to each of 10 type 2 diabetic patients. Blood samples were collected at baseline and 60 and 120 minutes after the meals. In every sample, plasma levels of glucose, insulin, cholesterol, triglycerides, nonesterified fatty acids (NEFAs), malondialdehyde (MDA), and the total radical-trapping antioxidant parameter (TRAP) were measured. LDL susceptibility to oxidation was evaluated at baseline and after 120 minutes. Plasma glucose, insulin, triglycerides, and MDA increased and NEFAs and TRAP significantly decreased after either meal. The variations in plasma glucose, MDA, and TRAP were significantly greater and LDL was more susceptible to oxidation after the meal that produced a significantly higher degree of hyperglycemia. These results suggest that postprandial hyperglycemia may contribute to oxidative stress in diabetic patients, providing a mechanistic link between hyperglycemia and diabetic vascular disease.
Recenti progressi in medicina
Nicotinamide was shown to prevent damage and to stimulate B cell regeneration in experimental dia... more Nicotinamide was shown to prevent damage and to stimulate B cell regeneration in experimental diabetes but in humans results are still controversial. To ascertain if long term nicotinamide treatment can induce and/or prolong remission of the disease, 21 type 1 (insulin-dependent) recently diagnosed subjects entered a controlled study and randomly divided in two groups comparable for age, genetic and immunologic patterns: group 1 (11 subjects) received insulin and nicotinamide (3 g/day for 1 year) and group 2 (10 subjects) insulin alone. Bimonthly insulin requirement and HbA1c, and every 6 months C-peptide response to glucagon were registered for 2 years. No significant difference was observed between the two groups in the monitored parameters, including rates of clinical remission, along this time period. In conclusion nicotinamide, when employed after the clinical onset of the disease, has no additional effect on natural history of newly diagnosed type 1 diabetes mellitus, besides results obtained by insulin alone.
Giornale di clinica medica
Physical exercise is a well known provocative test for early renal abnormalities detection in dia... more Physical exercise is a well known provocative test for early renal abnormalities detection in diabetes mellitus. Aim of our study was to evaluate the effect of daily activity and physical exercise on albumin excretion rate (AER) in 2 groups of albustix negative type I diabetics (IDDM). In group I of 76 patients aged 7-58 years, AER measured in 24 h urine (14.1 +/- 1.7 micrograms/min) and overnight urine (11.1 +/- 1.7 micrograms/min) was similar. A significant correlation was found between AER values obtained from the two urine collection procedures (r = 0.55; p less than 0.001). In group 2 of 37 patients aged 7-48 years and in 25 matched controls, the effect of physical exercise on AER was evaluated comparing overnight urine and post-exercise urine collection. AER increased significantly in IDDM after exercise. In conclusion our results show that 1) AER is not affected by daily activity; 2) physical exercise is a usefull provocative test to detect early renal abnormalities.
Pathologica
The authors describe a case of an adrenal tumor of unusual dimensions with a benign histological ... more The authors describe a case of an adrenal tumor of unusual dimensions with a benign histological appearance. After a short period diffuse metastases developed. The metastases should the features a poorly differentiated carcinoma. The size of the tumor appears to be a useful element of judgement in differential diagnosis between adenoma and carcinoma of the adrenal glands.
Patient Education and Counseling, 1994
Patient Education and Counseling, 1994
Pathophysiology of Haemostasis and Thrombosis, 1992
Diabetes Care, 1999
R e f e re nc e s 1. Giugliano D, Ceriello A: Oxidative stre s s and diabetic vascular complicati... more R e f e re nc e s 1. Giugliano D, Ceriello A: Oxidative stre s s and diabetic vascular complications. D i abetes Care 19:257-267, 1996 2. U.K. Prospective Diabetes Study Gro u p : Intensive blood-glucose control with s u l p h o n y l u reas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).
European Journal of Clinical Investigation, 1998
... Measurement of TRAP 2,20-Azobis-(2-amidinopropane) dihydrochloride (ABAP), R-phycoerythrin (R... more ... Measurement of TRAP 2,20-Azobis-(2-amidinopropane) dihydrochloride (ABAP), R-phycoerythrin (R-PE), Trolox and all other chemicals were purchased from Sigma Chemical (St Louis, MO, USA). TRAP was evaluated according to Ghiselli et al. ...
The online version of this article, along with updated information and services, is located on the
OBJECTIVE — To investigate the relationship between beliefs of physicians relative to inten-sive ... more OBJECTIVE — To investigate the relationship between beliefs of physicians relative to inten-sive metabolic control in type 2 diabetes and levels of HbA1c obtained in a sample of their patients. RESEARCHDESIGNANDMETHODS — Physicians ’ beliefs were investigated through a questionnaire sent to a sample of self-selected clinicians participating in a nationwide initiative aimed at assessing the relationship between the quality of care delivered to patients with type 2 diabetes and their outcomes. At the same time, physicians were asked to collect clinical data on a random sample of their patients, stratified by age (,65 vs. $65 years). Mean HbA1c levels in the study population were thus evaluated according to target fasting blood glucose (FBG) used by their physicians. RESULTS — Of 456 physicians, 342 (75%) returned the questionnaire. Among the respond-ers, 200 diabetologists and 99 general practitioners (GPs) recruited 3,297 patients; 2,003 of whom were always followed by the same physi...
Riccardo Candido1 Maria Antonietta Pellegrini2 Giuseppe Felace3 Patrizia Li Volsi4 Paola Gelisio5... more Riccardo Candido1 Maria Antonietta Pellegrini2 Giuseppe Felace3 Patrizia Li Volsi4 Paola Gelisio5 Claudio Taboga6 Laura Tonutti2 Carla Tortul7 Roberta Assaloni7 Barbara Brunato7 Carmela Vinci8 1 S.S. Centro Diabetologico Distretto 3, A.A.S. 1 Triestina, Trieste 2 S.O.C. di Endocrinologia e Malattie del Metabolismo, AOU di Udine, Udine 3 Diabetologia e Malattie Metaboliche, Presidio Ospedaliero di Spilimbergo, A.A.S. 5 Friuli Occidentale, Pordenone 4 S.S.D. Diabetologia, AO di Pordenone, A.A.S. 5 Friuli Occidentale, Pordenone 5 U.O Semplice di Diabetologia, ULSS 12 Veneziana, Venezia 6 Ambulatori Diabetologici, A.A.S. 3 Alto Friuli-CollinareMedio Friuli 7 S.O.S. di Diabetologia, A.A.S. 2 Bassa FriulianaIsontina, Monfalcone, Gorizia 8 UOSD Diabetologia, ULSS 10, S. Donà di Piave, Venezia
OBJECTIVE — Recently, much attention has been paid to the possibility that postprandial hyperglyc... more OBJECTIVE — Recently, much attention has been paid to the possibility that postprandial hyperglycemia may be a cardiovascular risk factor in diabetes. Oxidative stress has been involved in the pathogenesis of diabetic complications, and increased plasma levels of nitrotyrosine, a product of peroxynitrite action, have been found in the plasma of diabetic subjects. The aim of the present study was to evaluate whether postprandial hyperglycemia is accompanied by ni-trotyrosine generation and, if so, to explore a possible direct role of hyperglycemia in such a phenomenon. RESEARCH DESIGN AND METHODS — A total of 23 type 2 diabetic patients and 15 matched normal healthy subjects were recruited for this study. Two different tests were per-formed in diabetic patients: a standard meal preceded by regular insulin (0.15 units/kg body wt) or insulin aspart (0.15 units/kg body wt) to achieve different levels of postprandial hyperglyce-mia. The meal test was also performed in healthy control sub...
Diabetologia, 2001
The relation between diabetes and premature vascular disease is well established [1] and oxidativ... more The relation between diabetes and premature vascular disease is well established [1] and oxidative stress has been claimed as one of the most important pathogenetic factors [2]. In diabetes, oxidative stress could increase the production of superoxide (O 2-) and nitric oxide (NO) [2±3], which could lead to the formation of pro-oxidant peroxynitrite (ONOO-) [4]. The ONOO-, formed by the reaction between NO and O 2-, is a powerful oxidant capable of oxidizing low density lipoprotein [5], of causing vascular dysfunction [6] and of nitrating tyrosine residues in proteins [7]. Because the production of ONOOis difficult to determine, the assay of nitrotyrosine in protein has been proposed as an indirect marker of ONOOproduction [7]. The presence of nitrotyrosine in biological fluids such as plasma and urine have been investigated in a limited number of conditions. Raised values of nitrotyrosine have been found in the plasma of patients Diabetologia (2001) 44: 834±838
Diabetes Care, 2001
OBJECTIVE-To investigate the relationship between beliefs of physicians relative to intensive met... more OBJECTIVE-To investigate the relationship between beliefs of physicians relative to intensive metabolic control in type 2 diabetes and levels of HbA 1c obtained in a sample of their patients. RESEARCH DESIGN AND METHODS-Physicians' beliefs were investigated through a questionnaire sent to a sample of self-selected clinicians participating in a nationwide initiative aimed at assessing the relationship between the quality of care delivered to patients with type 2 diabetes and their outcomes. At the same time, physicians were asked to collect clinical data on a random sample of their patients, stratified by age (Ͻ65 vs. Ն65 years). Mean HbA 1c levels in the study population were thus evaluated according to target fasting blood glucose (FBG) used by their physicians.
Nasally administered (IN) insulin has been advocated as a potentially useful alternative to subcu... more Nasally administered (IN) insulin has been advocated as a potentially useful alternative to subcutaneously administered regular insulin because of its more rapid onset and time to peak action and its shorter duration of action. This study further defines the pharmacodynamics of IN insulin by using a euglycemic clamp technique to determine the bioavailability of IN insulin as compared with intravenous (IV) insulin, and to ascertain whether multiple sequentially administered doses of IN insulin alter pharmacodynamics. Eight normal volunteers received 2 control doses of IV insulin (0.05 U/kg), and 3 high doses (0.7 U/kg) and 3 low doses (0.35 U/kg) of IN insulin with an absorption enhancer (tauro-24,25 dihydrofusidate) given sequentially over a 2 day period. A euglycemic clamp was performed with a Biostator (Ames) that infused dextrose to keep the subject's blood glucose at his fasting level. Analysis of dextrose infusion curves for the low and high doses of IN insulin revealed an onset of action of 9.4 +/- 0.4 and 10.5 +/- 0.3 minutes, time to peak action of 20.6 +/- 5.6 and 23.7 +/- 4.4 minutes and duration of action of 82.1 +/- 5.2 and 95 +/- 5.7 minutes respectively. Both the onset of action and time to peak action were slightly longer (P less than .05) for the high as compared with the low dose IN insulin, although this should not represent a clinically significant difference. The total dextrose requirement was 21.9 +/- 2.3 g for the low dose IN insulin and 34.1 +/- 3.3 g for the high dose IN insulin, the latter value being significantly greater (P less than .01) than the former.(ABSTRACT TRUNCATED AT 250 WORDS)
International Journal of Obesity, 2006
Objective: The aim of this study was to use the Eating Attitudes Test-26 (EAT-26) as a screening ... more Objective: The aim of this study was to use the Eating Attitudes Test-26 (EAT-26) as a screening instrument on a specific population with a marked prevalence of binge eating disorder (BED) and eating disorder not otherwise specified (EDNOS). The EAT-26 questionnaire was used in order to identify the high-risk subjects for referral to clinical evaluation. Method: EAT-26 was administered to 845 subjects who, for the first time, came to the Nutritional Medicine Service looking for a diet between January 1999 and December 2002. From this initial sample, subsequently, 250 subjects were randomly selected and administered a semistructured clinical interview for DSM-IV (SCID I, version 2.0). Results: Discriminant analysis provided a cutoff value of EAT-26 ¼ 11. Logistic regression analysis indicated high Dieting (D) or Bulimia (B) subscale scores as a risk factor of EDNOS or bulimia nervosa (BN) cases, respectively; on the other hand, a high Oral Control (O) subscale score represented a protecting factor for BED cases. Conclusion: Our study tried to assess the usefulness of EAT-26 as a screening instrument for obese patients attending a Medical Nutritional Service. Results from this study suggest that a cutoff score of 11, lower than that indicated in the literature, improves the diagnostic accuracy of the EAT-26 in a high-risk setting regarding sensibility level (68.1%) and leading to a reduction of the false negative rate (31.9%).
Metabolism Clinical and Experimental, Dec 1, 1999
Oxidative stress and its contribution to low-density lipoprotein (LDL) oxidation have been implic... more Oxidative stress and its contribution to low-density lipoprotein (LDL) oxidation have been implicated in the pathogenesis of vascular diabetic complications. However, the relationship between hyperglycemia, hyperinsulinemia, hyperlipidemia, and oxidative stress is still debated. If plasma glucose and/or insulin and/or lipid are some of the most important determinants of oxidative stress in diabetes, then their typical postprandial elevations in diabetes would be expected to favor oxidative stress and LDL oxidation. To test this hypothesis, in type 2 diabetic patients, we evaluated the effects of two different standard meals designed to produce different levels of postprandial hyperglycemia on the plasma oxidative status and LDL oxidation. The meals were administered in randomized order to each of 10 type 2 diabetic patients. Blood samples were collected at baseline and 60 and 120 minutes after the meals. In every sample, plasma levels of glucose, insulin, cholesterol, triglycerides, nonesterified fatty acids (NEFAs), malondialdehyde (MDA), and the total radical-trapping antioxidant parameter (TRAP) were measured. LDL susceptibility to oxidation was evaluated at baseline and after 120 minutes. Plasma glucose, insulin, triglycerides, and MDA increased and NEFAs and TRAP significantly decreased after either meal. The variations in plasma glucose, MDA, and TRAP were significantly greater and LDL was more susceptible to oxidation after the meal that produced a significantly higher degree of hyperglycemia. These results suggest that postprandial hyperglycemia may contribute to oxidative stress in diabetic patients, providing a mechanistic link between hyperglycemia and diabetic vascular disease.
Recenti progressi in medicina
Nicotinamide was shown to prevent damage and to stimulate B cell regeneration in experimental dia... more Nicotinamide was shown to prevent damage and to stimulate B cell regeneration in experimental diabetes but in humans results are still controversial. To ascertain if long term nicotinamide treatment can induce and/or prolong remission of the disease, 21 type 1 (insulin-dependent) recently diagnosed subjects entered a controlled study and randomly divided in two groups comparable for age, genetic and immunologic patterns: group 1 (11 subjects) received insulin and nicotinamide (3 g/day for 1 year) and group 2 (10 subjects) insulin alone. Bimonthly insulin requirement and HbA1c, and every 6 months C-peptide response to glucagon were registered for 2 years. No significant difference was observed between the two groups in the monitored parameters, including rates of clinical remission, along this time period. In conclusion nicotinamide, when employed after the clinical onset of the disease, has no additional effect on natural history of newly diagnosed type 1 diabetes mellitus, besides results obtained by insulin alone.
Giornale di clinica medica
Physical exercise is a well known provocative test for early renal abnormalities detection in dia... more Physical exercise is a well known provocative test for early renal abnormalities detection in diabetes mellitus. Aim of our study was to evaluate the effect of daily activity and physical exercise on albumin excretion rate (AER) in 2 groups of albustix negative type I diabetics (IDDM). In group I of 76 patients aged 7-58 years, AER measured in 24 h urine (14.1 +/- 1.7 micrograms/min) and overnight urine (11.1 +/- 1.7 micrograms/min) was similar. A significant correlation was found between AER values obtained from the two urine collection procedures (r = 0.55; p less than 0.001). In group 2 of 37 patients aged 7-48 years and in 25 matched controls, the effect of physical exercise on AER was evaluated comparing overnight urine and post-exercise urine collection. AER increased significantly in IDDM after exercise. In conclusion our results show that 1) AER is not affected by daily activity; 2) physical exercise is a usefull provocative test to detect early renal abnormalities.
Pathologica
The authors describe a case of an adrenal tumor of unusual dimensions with a benign histological ... more The authors describe a case of an adrenal tumor of unusual dimensions with a benign histological appearance. After a short period diffuse metastases developed. The metastases should the features a poorly differentiated carcinoma. The size of the tumor appears to be a useful element of judgement in differential diagnosis between adenoma and carcinoma of the adrenal glands.