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Papers by Clayton Moraes

Brazilian Journal of Medical and Biological Research, 2022

RESUMO O uso de medicamentos é frequente em qualquer faixa etária, todavia é aparente que os idos... more RESUMO O uso de medicamentos é frequente em qualquer faixa etária, todavia é aparente que os idosos utilizam um maior número de medicamentos. A assistência farmacêutica bem planejada e conduzida é importante para o adequado atendimento às necessidades de saúde da população, facilitando o acesso aos medicamentos essenciais e promovendo seu uso racional.O objetivo deste estudo é descrever a importância da assistência farmacêutica e o papel do farmacêutico no uso racional de medicamentos no paciente idoso.Trata-se de uma revisão da literatura, realizada em artigos científicos e documentos governamentais publicados entre os anos de 2010 a 2020. Os estudos farmacêuticos, portanto, podem revelar situações que, por vezes, passam despercebidas, especialmente entre os idosos, os quais apresentam diversos fatores que os predispõem a interações medicamentosas com consequentes reações adversas aos medicamentos. Conclui-se, que o farmacêutico tem um papel importante ao idoso porque deve acompanh...

Received on: 12/28/2019. Approved on: 10/01/2020. Available on: 12/21/2020. RESUMO Objetivou inve... more Received on: 12/28/2019. Approved on: 10/01/2020. Available on: 12/21/2020. RESUMO Objetivou investigar associações entre o declínio cognitivo de idosos longevos em contexto ambulatorial e variáveis sociodemográficas, desempenho funcional, doenças crônicas, número de hospitalizações e acesso aos serviços de saúde. Foram entrevistados idosos longevos (80 anos e mais) residentes no Distrito Federal, avaliados em contexto ambulatorial por questionários padronizados e pelo Miniexame do Estado Mental (MEEM). Nas análises bivariadas, o declínio cognitivo esteve associado à faixa etária (85 anos e mais), possuir uma ou mais limitações nas atividades básicas de vida diária (ABVD), residir em arranjos domiciliares bi e trigeracionais e ter maior número de hospitalizações no último ano. No modelo logístico múltiplo, permaneceram associados ao declínio cognitivo em longevos as ABVD e as hospitalizações no último ano. Por tratar-se de uma população com maior demanda assistencial de saúde, torna...

Brazilian Journal of Health Review, Jun 10, 2021

O envelhecimento da população com múltiplas morbidades e medicamentos traz consigo desafios consi... more O envelhecimento da população com múltiplas morbidades e medicamentos traz consigo desafios consideráveis para a saúde e a sociedade em termos de reações adversas a medicamentos e outros problemas relacionados aos medicamentos (PRM). Desse modo, o processo de intervenções do farmacêutico clínico direcionadas às transições de cuidado do idoso na alta hospitalar, têm sido enfatizadas como uma área-chave para melhorar a segurança do paciente. Assim, o presente trabalho teve como objetivo descrever a contribuição do farmacêutico no processo de transição de cuidados do idoso. Dessa forma, foi realizada uma revisão narrativa de literatura, através de uma análise que compreende um tratamento qualitativo, fundamentada em livros, artigos científicos, revistas e sites atuais que englobam o tema proposto. O banco de dados para busca dos artigos eletrônicos foi o portal BVS e o Google acadêmico, priorizando também os dados

Psicologia, Saúde & Doença, 2020

ps.pt 699 other levels of care. This study aimed to verify the effect of expressive therapies (ET... more ps.pt 699 other levels of care. This study aimed to verify the effect of expressive therapies (ET) on the number of medical appointments and on mental status in elderly FH. This is a quasi-experimental study, with a sample of 69 elderly people attended at the PHC of Granja do Torto, Federal District, divided into: intervention group (IG), with elderly FH; and control group (CG), with elderly people not HF. The elderly HF were submitted to ET for 24 weeks, twice / week. In the data analysis, Pearson's chi-square test, multivariate analysis of variance for repeated MANOVA measures and Wilks' Lambda test were used. The IG showed a mean age of 73.97 years (SD=6.67) and the CG 69.78 years (SD=6.78), with a significant difference between the groups (p =0.04).In the post-intervention, the IG showed a significant decrease in depression (p <0.001), anxiety (p =0.05), loneliness (p =0.01) and stress (p =0.006).There was a significant decrease in the number of consultations in the IG (p <0.001) during the year following the intervention. In HF elderly people, the TE intervention provided positive effects, reducing the number of medical appointments and improving the mental state (depression, anxiety, stress and loneliness) of this group, allowing them to experience alternatives to improve their quality of life. The use of ET minimized health problems from the perspective of resolving low-cost care, in a holistic approach to comprehensive care for the elderly in PHC.

Brazilian Journal of Development, 2021

O envelhecimento populacional aumenta a prevalência de doenças crônicas e consequentemente a prát... more O envelhecimento populacional aumenta a prevalência de doenças crônicas e consequentemente a prática da polifarmácia. Nesse contexto, os anti-inflamatórios não esteroidais (AINEs), amplamente utilizados, devem ser evitados por aumentar a incidência de reações adversas e interações medicamentosas no idoso. O objetivo do estudo foi descrever as reações adversas em uso dos anti-inflamatórios não esteroidais; descrever o mecanismo de ação dos AINES e sua relação com as reações adversas; enumerar as interações medicamentosas envolvendo os AINES e outros medicamentos mais utilizados por essa população; e descrever o cuidado farmacêutico e a sua importância na segurança e eficácia do tratamento no paciente idoso. Trata-se de um estudo de revisão narrativa de literatura, utilizado como estratégias de busca as bases de referências SCIELO, LILACS, PUBMED E BVS. O estudo evidenciou que o uso dos AINEs no paciente idoso deve ser cauteloso, devido os riscos de reações adversas e interações medicamentosas, sendo de grande importância o acompanhamento farmacoterapêutico e a utilização do critério de Beers para garantir a segurança e o uso racional de medicamento. Conclui-se que o farmacêutico é o profissional mais habilitado a realizar o acompanhamento farmacoterapêutico de forma a promover o uso racional dos medicamentos, assim orientando o paciente quanto aos riscos do consumo inapropriado dos mesmos.

Com o avançar das décadas, a longevidade do ser humano aumentou devido a série de fatores que lev... more Com o avançar das décadas, a longevidade do ser humano aumentou devido a série de fatores que levaram ao menor adoecimento das pessoas, com consequente aumento de suas perspectivas de vida. Entre estes fatores, temos: incentivo a estilo de vida mais saudável; boa alimentação; combate ao tabagismo e ao etilismo; prática regular de exercícios físicos; avanço da medicina, com prevenção e tratamento de doenças crônico-degenerativas; controle sanitário, com diminuição das doenças infecciosas e parasitárias; e campanhas de vacinação.1 Evidências epidemiológicas, biológicas e moleculares levam à conclusão de que o câncer de pele não melanoma (CPNM) é praticamente uma doença de indivíduos idosos, raramente vista antes dos 40 anos.2 Ele engloba dois tipos de câncer: carcinoma basocelular (CBC) e espinocelular (CEC). Esse tipo de câncer é o de maior prevalência no Brasil, esperando-se, em 2016, o total de 80.850 novos casos em homens e 94.910 em mulheres.3 A falta de estudos brasileiros e int...

Revista Kairós : Gerontologia, Dec 30, 2019

Prevalência do uso de medicamentos potencialmente inapropriados ao idoso no Brasil: uma revisão s... more Prevalência do uso de medicamentos potencialmente inapropriados ao idoso no Brasil: uma revisão sistemática Prevalence use of potentially inappropriate drugs for elderly in Brazil: a sistematic review Prevalencia del uso de medicamentos potencialmente inapropiados para los ancianos en Brasil: una revisión sistemática

Brazilian Journal of Medical and Biological Research, 2020

The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers f... more The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I polymorphism and serum LDL, total cholesterol, and total lipid levels, with important elevations among T homozygotes compared to the other genotypes. There was homogeneity in all other parameters analyzed (including intake pattern), with a tendency for reduced levels of circulating apolipoprotein B among TT individuals. Our results pointed out that genetic variation in APOB affected the lipemic profile of elderly individuals in a context not biased by diet, generating a pattern suggestive of secretory disorder of lipoprotein particles, with possible implication in atherosclerotic risk.

Archives of Gerontology and Geriatrics, 2015

Measurement of inflammatory markers for risk stratification of vascular disorders has been the fo... more Measurement of inflammatory markers for risk stratification of vascular disorders has been the focus of numerous investigations worldwide, and usually reveals augmented levels of circulating cytokines/ chemokines among carriers of classic risk factors for atherosclerosis. Nonetheless, this low-grade inflammatory milieu detected in aged individuals tends to be influenced by body composition. Moreover, cardiovascular risk factors have a complex genetic etiology, and disregarding the genetic heritage may produce spurious results owing to interethnic differences. In this complex scenario, our study was designed to verify the existence and strength of the association between selected mediators of systemic inflammation and classic risk factors of cardiovascular diseases (CVD). Methods: In a sample of post-menopausal older women, correlation analyses explored the association of circulating levels of IL1a, IL1b, IL8, IL10 and IL12 with atherosclerosis-related clinical/metabolic parameters, using age, body mass index (BMI), genetic ancestry estimates as standard correction factors. Further adjustment for use of therapeutic agents was applied when appropriate. Results: Our analyses revealed association of log 10-transformed IL-12 titers with VLDL-c levels (r = .192; p = .002) and with SBP (rÀ.185; p = .003), and of log 10-transformed IL-8 titers with GLY (r = .235; p < .001). Conclusion: Interpretation to the results account to a possible dysregulation of the PPAR signaling pathway to explain the association of IL12 and VLDL-c, and to IL8-driven mechanisms to promote dysglycemia. No previous report sought to investigate the relationship between this set of inflammatory markers and classic risk factors for atherosclerosis correcting for the heterogeneity in genetic admixture and body composition of Brazilian post-menopausal women.

Revista da Associação Médica Brasileira, 2010

objectIve. To describe the prevalence of stress urinary incontinence (SUI) among women older than... more objectIve. To describe the prevalence of stress urinary incontinence (SUI) among women older than 20 years participating in the Family Health Program (FHP) of the municipality of Dourados (MS), Brazil, and to correlate it with the following variables: age, body mass index (BMI), parity, number of pregnancies, hysterectomy, smoking, and diabetes mellitus. Methods. Cross-sectional household survey. We interviewed 336 women older than 20 years who had no exclusion criteria. Two forms were used during the interviews: an evaluation sheet containing demographic data and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) assessing the impact on quality of life (QOL). For the statistical analysis, we used the chisquare test, Student's t test, the corrected coefficient of contingency and a forward stepwise logistic regression model. results. Prevalence of SUI was 21.4%. In terms of risk factors, age (p = 0.113), smoking (p = 0.796), and diabetes mellitus (p = 0.221) showed no statistically significant association; however, BMI (p = 0.007), number of pregnancies (p = 0.018), parity (p = 0.032), and hysterectomy (p = 0.024) showed a weak association. Using logistic regression, only pairing of weight and hysterectomy was able to predict the outcome (SUI). Most women with SUI (63.9%) had very severe impairment in the QOL. conclusIon. The prevalence of SUI was similar to that found in other studies; BMI, parity, number of pregnancies, and hysterectomy were associated with this disease, which seriously impairs the QOL.

Dementia and Geriatric Cognitive Disorders, 2012

Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp... more Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (AD) is the most common form of dementia worldwide, and bears remarkable evidence for a differential prevalence among continental populations. In this scenario, estimating ancestry proportions in recently admixed populations is a strategy that can help increasing knowledge about the genetic structure of this complex trait. Our purpose was to assess mean ancestry estimates for the three main parental contributors to the Brazilian contingent (European, African and Amerindian) using a panel of 12 ancestry informative markers. Outpatients with the late-onset form of AD (n = 120) were compared for ancestry levels with non-cognitively impaired subjects (n = 412) in the Midwest Brazil, controlling for classic clinical, social and anthropometric risk factors. Our findings show a 3-fold greater genetic Amerindian content among control subjects compared to AD patients (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Our results suggest that the allelic architecture of Native Americans can confer protection against the onset of the disease.

Geriatrics, Gerontology and Aging

OBJECTIVE: The purpose was to assess the effect of Tai Chi Chuan (TCC) on functional capacity (FC... more OBJECTIVE: The purpose was to assess the effect of Tai Chi Chuan (TCC) on functional capacity (FC) and quality of life (QoL) in elderly men with low bone mineral density (BMD). METHODS: This quasi-experimental, controlled blinded trial evaluated 41 senior men (≥ 60 years), divided into two groups: control group 1-G1 (TCC; n = 20; 69.2 ± 6.2 years) and control group 2-G2 (control; n = 21; 69.0 ± 5.7 years). The BMD (of lumbar spine and femur neck) was assessed by dual energy x-ray absorptiometry (DEXA). FC was assessed for aerobic endurance, for upper and lower limbs strength and flexibility, for static, dynamic and functional balance testes, and for risk of falls. QoL was assessed by the SF-36 questionnaire (MOS 36-item Short-Form Health Survey). G1 practiced the 24-form Yang style of TCC, for 12 weeks twice a week on low intensity; G2 did not practice oriented physical activity. RESULTS: TCC practitioners had significantly higher scores for aerobic endurance, upper and lower limbs strength, and dynamic balance. In terms of QoL, values were significantly better in total score and aspects such as FC, general health, vitality, and mental health. DISCUSSION: TCC was proven beneficial to FC and QoL scores, which adds evidence for its practice by elderly men with low BMD. CONCLUSION: TCC training is effective in improving FC and QoL in elderly men with low BMD. KEYWORDS: tai chi chuan; aged; osteoporosis; quality of life. RESUMO OBJETIVO: Avaliar efeitos do Tai Chi Chuan (TCC) na capacidade funcional (CF) e na qualidade de vida (QV) de homens idosos com baixa densidade mineral óssea (DMO). MÉTODO: Estudo quasi-experimental, controlado, cego, com 41 idosos (≥ 60 anos) divididos em dois grupos: grupo experimental-G1 (TCC; n = 20; 69,2 ± 6,2 anos) e grupo controle-G2 (controle; n = 21; 69,0 ± 5,7 anos). A DMO (coluna lombar e colo do fêmur) foi avaliada com raios-x de dupla energia (DEXA). Para aferir CF foram utilizados: testes de resistência aeróbia (RA); de força e flexibilidade de membros superiores e inferiores; de equilíbrio em condições estática, dinâmica e funcional; e de alcance funcional, assim como para risco de quedas. A QV foi pesquisada pelo questionário SF-36 (MOS 36 ltem Short-Form Health Survey). O G1 praticou TCC estilo Yang, com 24 movimentos por 12 semanas, 2 vezes por semana, em intensidade leve; o G2 não praticou atividade física orientada. RESULTADOS: Praticantes de TCC apresentaram valores significativamente maiores em resistência aeróbia, em força de membros superiores e inferiores, e para equilíbrio dinâmico. Ao aferir a QV, surgiu significância para escore total, assim como para as dimensões de capacidade funcional, estado geral de saúde, vitalidade e saúde mental. DISCUSSÃO: Constataram-se efeitos benéficos do TCC em CF e QV, o que agrega evidências à sua utilização em homens idosos com baixa DMO. CONCLUSÃO: O TCC é eficaz na melhora da CF e da QV em homens idosos com baixa DMO. PALAVRAS-CHAVE: tai chi chuan; idoso; osteoporose; qualidade de vida.

Estudos Interdisciplinares sobre o Envelhecimento

O objetivo deste trabalho é avaliar a prevalência de fragilidade e pré--fragilidade em idosos lon... more O objetivo deste trabalho é avaliar a prevalência de fragilidade e pré--fragilidade em idosos longevos atendidos em contexto ambulatorial,e analisar a associação entre as variáveis sociodemográficas, assíndromes da fragilidade e a sarcopenia. Optou-se por um estudode delineamento transversal e quantitativo com idosos do ambulatório de Geriatria do Instituto de Cardiologia do Distrito Federal,sendo avaliados pelo: questionário de dados sociodemográficos;questionário de autorrelato, que avalia o risco de sarcopenia peloSARC-F; e a investigação da fragilidade por meio de cinco fenótipospreviamente estabelecidos por Fried et al., (2001). Foi utilizado oteste não paramétrico Qui-quadrado para comparação das variá-veis qualitativas e o teste t para amostras independentes para osdados quantitativos. Participaram do estudo 71 idosos com médiade idade de 84,73± 3,64 anos, 46 (64,8%) mulheres, sendo que,destas, 25 (54,3%) eram frágeis. Em relação aos homens, no totalde 25 (35,2%), cinco (20%)...

Innovation in Aging

Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemi... more Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemic disorders, especially among older adults. The objective of this study was to investigate the association of a single nucleotide polymorphism on the DPP4 gene with the occurrence of type 2 diabetes mellitus in a sample of older community-dwelling patients. Clinical, anthropometric and physiological characteristics as well as biochemical data related to lipidemia, glycemia and hormonal factors and variables related to the lifestyle were analyzed among 338 individuals aged 60 years and older from two general geriatric outpatient clinics in the Federal District, Brazil. Genotypes related to the polymorphism rs3788979 (A/G) of the DPP4 gene of these patients were determined by conventional polymerase chain reaction followed by enzymatic restriction, whereas the serum levels of DPP-4 were assessed by colorimetric immunoassay. Among the results obtained, there was clear variation in the glyce...

Journal of Aging Research

Background and Aim. Frailty is a geriatric condition resulting from physiological changes coverin... more Background and Aim. Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state. The present research aimed to investigate the association of components of Fried’s frailty (as well as of the phenotype as a whole) with total serum levels of a panel of inflammatory mediators. Methods. One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results. Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, s...

American Journal of Alzheimer's Disease & Other Dementiasr

Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for t... more Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for the clinical diagnosis of Alzheimer disease (AD). We hypothesized that whole-blood microRNAs may be useful to identify individuals with established AD. For this purpose, a sample of community-dwelling women (≥55 years old) carrying the ApoE ∊4 allele were clinically evaluated using the American Psychiatric Association/ Diagnostic and Statistical Manual of Mental Disorders, Fourth edition and the Alzheimer Disease Assessment Scale–Cognitive Subscale criteria to diagnose probable AD, and the Clinical Dementia Rating scale to stage the dementia. A set of 25 mature microRNAs was rationally selected for evaluation based on experimental evidence of interaction with genes linked to the late-onset AD neuropathology. Whole-blood concentrations were determined by quantitative real-time polymerase chain reaction. Compared to patients without dementia, a median 3-fold decrease in miR-9 levels was fou...

Current Gerontology and Geriatrics Research

Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating... more Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating levels detected in several cancer types. Here, we compare serum concentrations of metalloproteinase-1 (MMP-1) across individuals clinically diagnosed with prostate cancer (PCa) or benign prostatic hyperplasia (BPH), correcting results for the rs495366 single nucleotide polymorphism (SNP) that predisposes to differential MMP-1 levels. 196 men aged ≥50 years were followed at a university hospital urology outpatient clinic, with clinical, anthropometric, and rectal examinations performed by one urologist. Blood samples obtained prior to any clinical intervention provided baseline MMP-1 and total/free PSA levels as well as metabolic, hormonal, and inflammatory markers. The SNP was genotyped by real-time PCR. Participants with medical and/or laboratory profile compatible with malignancy composed the PCa group when confirmed by the Gleason scale. As expected, A-allele homozygotes showed reduc...

Journal of Aging Research

Although prostate cancer (PCa) is the sixth most common type of neoplasm in the world and the sec... more Although prostate cancer (PCa) is the sixth most common type of neoplasm in the world and the second in prevalence among men (10% of all cases), there is shortage of studies focused on primary prevention of the disorder as well as little understanding on its pathophysiology. Currently, the PCa screening tools are the prostate specific antigen (PSA) dosage conjugated to rectal examination and confirmed by prostate biopsy. Despite the name, the PSA presents reduced specificity, being necessary the identification of new biomarkers that allow an earlier and more precise diagnosis and even better prognosis. Several studies have associated matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) to PCa tumorigenesis and metastasis. Most of the studies so far have been carried out by investigating in situ expression of the metalloproteinases, either by transcriptional measures or by immunohistochemistry with biopsy or postoperative tissue. Investigations in human plasma and ser...

Revista Brasileira de Ciências do Envelhecimento Humano

O objetivo deste estudo foi analisar, com base na literatura, a aceitação e o uso das tecnologias... more O objetivo deste estudo foi analisar, com base na literatura, a aceitação e o uso das tecnologias assistivas pelos idosos. Trata-se de estudo de revisão sistemática em que foi realizada busca por artigos nas bases de dados PubMed/Medline, Lilacs, e Scielo. Os aspectos discutidos na literatura foram: sobre a aceitação, sobre o uso e sobre as variáveis que poderiam interferir nas colocações pré citadas. Considerando estudos nacionais e internacionais, as discussões acerca do tema, de forma geral, foram igualitárias. Fatores como medo, receio, limitações ao acesso das tecnologias e motivação, foram determinantes no resultado do estudo. Notou-se por fim a necessidade de maior informação aos idosos sobre a existência das tecnologias, dos tipos, das categorias e dos benefícios que podem trazer ao idoso, fomentando o interesse no uso, para que a inserção dos idosos seja plena no mundo tecnológico.

Brazilian Journal of Medical and Biological Research, 2022

RESUMO O uso de medicamentos é frequente em qualquer faixa etária, todavia é aparente que os idos... more RESUMO O uso de medicamentos é frequente em qualquer faixa etária, todavia é aparente que os idosos utilizam um maior número de medicamentos. A assistência farmacêutica bem planejada e conduzida é importante para o adequado atendimento às necessidades de saúde da população, facilitando o acesso aos medicamentos essenciais e promovendo seu uso racional.O objetivo deste estudo é descrever a importância da assistência farmacêutica e o papel do farmacêutico no uso racional de medicamentos no paciente idoso.Trata-se de uma revisão da literatura, realizada em artigos científicos e documentos governamentais publicados entre os anos de 2010 a 2020. Os estudos farmacêuticos, portanto, podem revelar situações que, por vezes, passam despercebidas, especialmente entre os idosos, os quais apresentam diversos fatores que os predispõem a interações medicamentosas com consequentes reações adversas aos medicamentos. Conclui-se, que o farmacêutico tem um papel importante ao idoso porque deve acompanh...

Received on: 12/28/2019. Approved on: 10/01/2020. Available on: 12/21/2020. RESUMO Objetivou inve... more Received on: 12/28/2019. Approved on: 10/01/2020. Available on: 12/21/2020. RESUMO Objetivou investigar associações entre o declínio cognitivo de idosos longevos em contexto ambulatorial e variáveis sociodemográficas, desempenho funcional, doenças crônicas, número de hospitalizações e acesso aos serviços de saúde. Foram entrevistados idosos longevos (80 anos e mais) residentes no Distrito Federal, avaliados em contexto ambulatorial por questionários padronizados e pelo Miniexame do Estado Mental (MEEM). Nas análises bivariadas, o declínio cognitivo esteve associado à faixa etária (85 anos e mais), possuir uma ou mais limitações nas atividades básicas de vida diária (ABVD), residir em arranjos domiciliares bi e trigeracionais e ter maior número de hospitalizações no último ano. No modelo logístico múltiplo, permaneceram associados ao declínio cognitivo em longevos as ABVD e as hospitalizações no último ano. Por tratar-se de uma população com maior demanda assistencial de saúde, torna...

Brazilian Journal of Health Review, Jun 10, 2021

O envelhecimento da população com múltiplas morbidades e medicamentos traz consigo desafios consi... more O envelhecimento da população com múltiplas morbidades e medicamentos traz consigo desafios consideráveis para a saúde e a sociedade em termos de reações adversas a medicamentos e outros problemas relacionados aos medicamentos (PRM). Desse modo, o processo de intervenções do farmacêutico clínico direcionadas às transições de cuidado do idoso na alta hospitalar, têm sido enfatizadas como uma área-chave para melhorar a segurança do paciente. Assim, o presente trabalho teve como objetivo descrever a contribuição do farmacêutico no processo de transição de cuidados do idoso. Dessa forma, foi realizada uma revisão narrativa de literatura, através de uma análise que compreende um tratamento qualitativo, fundamentada em livros, artigos científicos, revistas e sites atuais que englobam o tema proposto. O banco de dados para busca dos artigos eletrônicos foi o portal BVS e o Google acadêmico, priorizando também os dados

Psicologia, Saúde & Doença, 2020

ps.pt 699 other levels of care. This study aimed to verify the effect of expressive therapies (ET... more ps.pt 699 other levels of care. This study aimed to verify the effect of expressive therapies (ET) on the number of medical appointments and on mental status in elderly FH. This is a quasi-experimental study, with a sample of 69 elderly people attended at the PHC of Granja do Torto, Federal District, divided into: intervention group (IG), with elderly FH; and control group (CG), with elderly people not HF. The elderly HF were submitted to ET for 24 weeks, twice / week. In the data analysis, Pearson's chi-square test, multivariate analysis of variance for repeated MANOVA measures and Wilks' Lambda test were used. The IG showed a mean age of 73.97 years (SD=6.67) and the CG 69.78 years (SD=6.78), with a significant difference between the groups (p =0.04).In the post-intervention, the IG showed a significant decrease in depression (p <0.001), anxiety (p =0.05), loneliness (p =0.01) and stress (p =0.006).There was a significant decrease in the number of consultations in the IG (p <0.001) during the year following the intervention. In HF elderly people, the TE intervention provided positive effects, reducing the number of medical appointments and improving the mental state (depression, anxiety, stress and loneliness) of this group, allowing them to experience alternatives to improve their quality of life. The use of ET minimized health problems from the perspective of resolving low-cost care, in a holistic approach to comprehensive care for the elderly in PHC.

Brazilian Journal of Development, 2021

O envelhecimento populacional aumenta a prevalência de doenças crônicas e consequentemente a prát... more O envelhecimento populacional aumenta a prevalência de doenças crônicas e consequentemente a prática da polifarmácia. Nesse contexto, os anti-inflamatórios não esteroidais (AINEs), amplamente utilizados, devem ser evitados por aumentar a incidência de reações adversas e interações medicamentosas no idoso. O objetivo do estudo foi descrever as reações adversas em uso dos anti-inflamatórios não esteroidais; descrever o mecanismo de ação dos AINES e sua relação com as reações adversas; enumerar as interações medicamentosas envolvendo os AINES e outros medicamentos mais utilizados por essa população; e descrever o cuidado farmacêutico e a sua importância na segurança e eficácia do tratamento no paciente idoso. Trata-se de um estudo de revisão narrativa de literatura, utilizado como estratégias de busca as bases de referências SCIELO, LILACS, PUBMED E BVS. O estudo evidenciou que o uso dos AINEs no paciente idoso deve ser cauteloso, devido os riscos de reações adversas e interações medicamentosas, sendo de grande importância o acompanhamento farmacoterapêutico e a utilização do critério de Beers para garantir a segurança e o uso racional de medicamento. Conclui-se que o farmacêutico é o profissional mais habilitado a realizar o acompanhamento farmacoterapêutico de forma a promover o uso racional dos medicamentos, assim orientando o paciente quanto aos riscos do consumo inapropriado dos mesmos.

Com o avançar das décadas, a longevidade do ser humano aumentou devido a série de fatores que lev... more Com o avançar das décadas, a longevidade do ser humano aumentou devido a série de fatores que levaram ao menor adoecimento das pessoas, com consequente aumento de suas perspectivas de vida. Entre estes fatores, temos: incentivo a estilo de vida mais saudável; boa alimentação; combate ao tabagismo e ao etilismo; prática regular de exercícios físicos; avanço da medicina, com prevenção e tratamento de doenças crônico-degenerativas; controle sanitário, com diminuição das doenças infecciosas e parasitárias; e campanhas de vacinação.1 Evidências epidemiológicas, biológicas e moleculares levam à conclusão de que o câncer de pele não melanoma (CPNM) é praticamente uma doença de indivíduos idosos, raramente vista antes dos 40 anos.2 Ele engloba dois tipos de câncer: carcinoma basocelular (CBC) e espinocelular (CEC). Esse tipo de câncer é o de maior prevalência no Brasil, esperando-se, em 2016, o total de 80.850 novos casos em homens e 94.910 em mulheres.3 A falta de estudos brasileiros e int...

Revista Kairós : Gerontologia, Dec 30, 2019

Prevalência do uso de medicamentos potencialmente inapropriados ao idoso no Brasil: uma revisão s... more Prevalência do uso de medicamentos potencialmente inapropriados ao idoso no Brasil: uma revisão sistemática Prevalence use of potentially inappropriate drugs for elderly in Brazil: a sistematic review Prevalencia del uso de medicamentos potencialmente inapropiados para los ancianos en Brasil: una revisión sistemática

Brazilian Journal of Medical and Biological Research, 2020

The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers f... more The apolipoprotein B (APOB) gene contains several polymorphic sites described as risk modifiers for cardiovascular events. The objective of this study was to verify the association of the classic APOB Xba I polymorphism (rs693) with atherosclerotic risk factors in a segment of the Brazilian elderly population considering their usual dietary intake. Clinical and biochemical characteristics as well as total caloric and fat intake data were determined from 644 elderly individuals. Polymorphism analysis was performed by conventional polymerase chain reaction followed by enzyme restriction. Statistical analyses compared measures and proportions according to different APOB genotypic combinations. Statistically significant association was found between Xba I polymorphism and serum LDL, total cholesterol, and total lipid levels, with important elevations among T homozygotes compared to the other genotypes. There was homogeneity in all other parameters analyzed (including intake pattern), with a tendency for reduced levels of circulating apolipoprotein B among TT individuals. Our results pointed out that genetic variation in APOB affected the lipemic profile of elderly individuals in a context not biased by diet, generating a pattern suggestive of secretory disorder of lipoprotein particles, with possible implication in atherosclerotic risk.

Archives of Gerontology and Geriatrics, 2015

Measurement of inflammatory markers for risk stratification of vascular disorders has been the fo... more Measurement of inflammatory markers for risk stratification of vascular disorders has been the focus of numerous investigations worldwide, and usually reveals augmented levels of circulating cytokines/ chemokines among carriers of classic risk factors for atherosclerosis. Nonetheless, this low-grade inflammatory milieu detected in aged individuals tends to be influenced by body composition. Moreover, cardiovascular risk factors have a complex genetic etiology, and disregarding the genetic heritage may produce spurious results owing to interethnic differences. In this complex scenario, our study was designed to verify the existence and strength of the association between selected mediators of systemic inflammation and classic risk factors of cardiovascular diseases (CVD). Methods: In a sample of post-menopausal older women, correlation analyses explored the association of circulating levels of IL1a, IL1b, IL8, IL10 and IL12 with atherosclerosis-related clinical/metabolic parameters, using age, body mass index (BMI), genetic ancestry estimates as standard correction factors. Further adjustment for use of therapeutic agents was applied when appropriate. Results: Our analyses revealed association of log 10-transformed IL-12 titers with VLDL-c levels (r = .192; p = .002) and with SBP (rÀ.185; p = .003), and of log 10-transformed IL-8 titers with GLY (r = .235; p < .001). Conclusion: Interpretation to the results account to a possible dysregulation of the PPAR signaling pathway to explain the association of IL12 and VLDL-c, and to IL8-driven mechanisms to promote dysglycemia. No previous report sought to investigate the relationship between this set of inflammatory markers and classic risk factors for atherosclerosis correcting for the heterogeneity in genetic admixture and body composition of Brazilian post-menopausal women.

Revista da Associação Médica Brasileira, 2010

objectIve. To describe the prevalence of stress urinary incontinence (SUI) among women older than... more objectIve. To describe the prevalence of stress urinary incontinence (SUI) among women older than 20 years participating in the Family Health Program (FHP) of the municipality of Dourados (MS), Brazil, and to correlate it with the following variables: age, body mass index (BMI), parity, number of pregnancies, hysterectomy, smoking, and diabetes mellitus. Methods. Cross-sectional household survey. We interviewed 336 women older than 20 years who had no exclusion criteria. Two forms were used during the interviews: an evaluation sheet containing demographic data and the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) assessing the impact on quality of life (QOL). For the statistical analysis, we used the chisquare test, Student's t test, the corrected coefficient of contingency and a forward stepwise logistic regression model. results. Prevalence of SUI was 21.4%. In terms of risk factors, age (p = 0.113), smoking (p = 0.796), and diabetes mellitus (p = 0.221) showed no statistically significant association; however, BMI (p = 0.007), number of pregnancies (p = 0.018), parity (p = 0.032), and hysterectomy (p = 0.024) showed a weak association. Using logistic regression, only pairing of weight and hysterectomy was able to predict the outcome (SUI). Most women with SUI (63.9%) had very severe impairment in the QOL. conclusIon. The prevalence of SUI was similar to that found in other studies; BMI, parity, number of pregnancies, and hysterectomy were associated with this disease, which seriously impairs the QOL.

Dementia and Geriatric Cognitive Disorders, 2012

Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp... more Alzheimer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s disease (AD) is the most common form of dementia worldwide, and bears remarkable evidence for a differential prevalence among continental populations. In this scenario, estimating ancestry proportions in recently admixed populations is a strategy that can help increasing knowledge about the genetic structure of this complex trait. Our purpose was to assess mean ancestry estimates for the three main parental contributors to the Brazilian contingent (European, African and Amerindian) using a panel of 12 ancestry informative markers. Outpatients with the late-onset form of AD (n = 120) were compared for ancestry levels with non-cognitively impaired subjects (n = 412) in the Midwest Brazil, controlling for classic clinical, social and anthropometric risk factors. Our findings show a 3-fold greater genetic Amerindian content among control subjects compared to AD patients (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). Our results suggest that the allelic architecture of Native Americans can confer protection against the onset of the disease.

Geriatrics, Gerontology and Aging

OBJECTIVE: The purpose was to assess the effect of Tai Chi Chuan (TCC) on functional capacity (FC... more OBJECTIVE: The purpose was to assess the effect of Tai Chi Chuan (TCC) on functional capacity (FC) and quality of life (QoL) in elderly men with low bone mineral density (BMD). METHODS: This quasi-experimental, controlled blinded trial evaluated 41 senior men (≥ 60 years), divided into two groups: control group 1-G1 (TCC; n = 20; 69.2 ± 6.2 years) and control group 2-G2 (control; n = 21; 69.0 ± 5.7 years). The BMD (of lumbar spine and femur neck) was assessed by dual energy x-ray absorptiometry (DEXA). FC was assessed for aerobic endurance, for upper and lower limbs strength and flexibility, for static, dynamic and functional balance testes, and for risk of falls. QoL was assessed by the SF-36 questionnaire (MOS 36-item Short-Form Health Survey). G1 practiced the 24-form Yang style of TCC, for 12 weeks twice a week on low intensity; G2 did not practice oriented physical activity. RESULTS: TCC practitioners had significantly higher scores for aerobic endurance, upper and lower limbs strength, and dynamic balance. In terms of QoL, values were significantly better in total score and aspects such as FC, general health, vitality, and mental health. DISCUSSION: TCC was proven beneficial to FC and QoL scores, which adds evidence for its practice by elderly men with low BMD. CONCLUSION: TCC training is effective in improving FC and QoL in elderly men with low BMD. KEYWORDS: tai chi chuan; aged; osteoporosis; quality of life. RESUMO OBJETIVO: Avaliar efeitos do Tai Chi Chuan (TCC) na capacidade funcional (CF) e na qualidade de vida (QV) de homens idosos com baixa densidade mineral óssea (DMO). MÉTODO: Estudo quasi-experimental, controlado, cego, com 41 idosos (≥ 60 anos) divididos em dois grupos: grupo experimental-G1 (TCC; n = 20; 69,2 ± 6,2 anos) e grupo controle-G2 (controle; n = 21; 69,0 ± 5,7 anos). A DMO (coluna lombar e colo do fêmur) foi avaliada com raios-x de dupla energia (DEXA). Para aferir CF foram utilizados: testes de resistência aeróbia (RA); de força e flexibilidade de membros superiores e inferiores; de equilíbrio em condições estática, dinâmica e funcional; e de alcance funcional, assim como para risco de quedas. A QV foi pesquisada pelo questionário SF-36 (MOS 36 ltem Short-Form Health Survey). O G1 praticou TCC estilo Yang, com 24 movimentos por 12 semanas, 2 vezes por semana, em intensidade leve; o G2 não praticou atividade física orientada. RESULTADOS: Praticantes de TCC apresentaram valores significativamente maiores em resistência aeróbia, em força de membros superiores e inferiores, e para equilíbrio dinâmico. Ao aferir a QV, surgiu significância para escore total, assim como para as dimensões de capacidade funcional, estado geral de saúde, vitalidade e saúde mental. DISCUSSÃO: Constataram-se efeitos benéficos do TCC em CF e QV, o que agrega evidências à sua utilização em homens idosos com baixa DMO. CONCLUSÃO: O TCC é eficaz na melhora da CF e da QV em homens idosos com baixa DMO. PALAVRAS-CHAVE: tai chi chuan; idoso; osteoporose; qualidade de vida.

Estudos Interdisciplinares sobre o Envelhecimento

O objetivo deste trabalho é avaliar a prevalência de fragilidade e pré--fragilidade em idosos lon... more O objetivo deste trabalho é avaliar a prevalência de fragilidade e pré--fragilidade em idosos longevos atendidos em contexto ambulatorial,e analisar a associação entre as variáveis sociodemográficas, assíndromes da fragilidade e a sarcopenia. Optou-se por um estudode delineamento transversal e quantitativo com idosos do ambulatório de Geriatria do Instituto de Cardiologia do Distrito Federal,sendo avaliados pelo: questionário de dados sociodemográficos;questionário de autorrelato, que avalia o risco de sarcopenia peloSARC-F; e a investigação da fragilidade por meio de cinco fenótipospreviamente estabelecidos por Fried et al., (2001). Foi utilizado oteste não paramétrico Qui-quadrado para comparação das variá-veis qualitativas e o teste t para amostras independentes para osdados quantitativos. Participaram do estudo 71 idosos com médiade idade de 84,73± 3,64 anos, 46 (64,8%) mulheres, sendo que,destas, 25 (54,3%) eram frágeis. Em relação aos homens, no totalde 25 (35,2%), cinco (20%)...

Innovation in Aging

Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemi... more Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemic disorders, especially among older adults. The objective of this study was to investigate the association of a single nucleotide polymorphism on the DPP4 gene with the occurrence of type 2 diabetes mellitus in a sample of older community-dwelling patients. Clinical, anthropometric and physiological characteristics as well as biochemical data related to lipidemia, glycemia and hormonal factors and variables related to the lifestyle were analyzed among 338 individuals aged 60 years and older from two general geriatric outpatient clinics in the Federal District, Brazil. Genotypes related to the polymorphism rs3788979 (A/G) of the DPP4 gene of these patients were determined by conventional polymerase chain reaction followed by enzymatic restriction, whereas the serum levels of DPP-4 were assessed by colorimetric immunoassay. Among the results obtained, there was clear variation in the glyce...

Journal of Aging Research

Background and Aim. Frailty is a geriatric condition resulting from physiological changes coverin... more Background and Aim. Frailty is a geriatric condition resulting from physiological changes covering the musculoskeletal, immune, and neuroendocrine systems, leading to a greater inflammatory state. The present research aimed to investigate the association of components of Fried’s frailty (as well as of the phenotype as a whole) with total serum levels of a panel of inflammatory mediators. Methods. One hundred and sixty-one very old patients (aged ≥80 years) devoid of cognitive decline were eligible for analyses. Clinical and biochemical data along with physical and cognitive assessments encompassing dual-energy X-ray scans and hand dynamometry were adopted to investigate frailty criteria, while circulating immune mediators (IFNγ, IL-2, IL-4, IL-6, IL-10, and TNFα) were assessed using high-throughput flow cytometry. Results. Preliminarily, IL-6 correlated positively with waist-to-hip ratio and C-reactive protein and negatively with glycemia. In analyses controlled for these factors, s...

American Journal of Alzheimer's Disease & Other Dementiasr

Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for t... more Recent evidence suggests changes in circulating microRNA levels may be promising biomarkers for the clinical diagnosis of Alzheimer disease (AD). We hypothesized that whole-blood microRNAs may be useful to identify individuals with established AD. For this purpose, a sample of community-dwelling women (≥55 years old) carrying the ApoE ∊4 allele were clinically evaluated using the American Psychiatric Association/ Diagnostic and Statistical Manual of Mental Disorders, Fourth edition and the Alzheimer Disease Assessment Scale–Cognitive Subscale criteria to diagnose probable AD, and the Clinical Dementia Rating scale to stage the dementia. A set of 25 mature microRNAs was rationally selected for evaluation based on experimental evidence of interaction with genes linked to the late-onset AD neuropathology. Whole-blood concentrations were determined by quantitative real-time polymerase chain reaction. Compared to patients without dementia, a median 3-fold decrease in miR-9 levels was fou...

Current Gerontology and Geriatrics Research

Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating... more Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating levels detected in several cancer types. Here, we compare serum concentrations of metalloproteinase-1 (MMP-1) across individuals clinically diagnosed with prostate cancer (PCa) or benign prostatic hyperplasia (BPH), correcting results for the rs495366 single nucleotide polymorphism (SNP) that predisposes to differential MMP-1 levels. 196 men aged ≥50 years were followed at a university hospital urology outpatient clinic, with clinical, anthropometric, and rectal examinations performed by one urologist. Blood samples obtained prior to any clinical intervention provided baseline MMP-1 and total/free PSA levels as well as metabolic, hormonal, and inflammatory markers. The SNP was genotyped by real-time PCR. Participants with medical and/or laboratory profile compatible with malignancy composed the PCa group when confirmed by the Gleason scale. As expected, A-allele homozygotes showed reduc...

Journal of Aging Research

Although prostate cancer (PCa) is the sixth most common type of neoplasm in the world and the sec... more Although prostate cancer (PCa) is the sixth most common type of neoplasm in the world and the second in prevalence among men (10% of all cases), there is shortage of studies focused on primary prevention of the disorder as well as little understanding on its pathophysiology. Currently, the PCa screening tools are the prostate specific antigen (PSA) dosage conjugated to rectal examination and confirmed by prostate biopsy. Despite the name, the PSA presents reduced specificity, being necessary the identification of new biomarkers that allow an earlier and more precise diagnosis and even better prognosis. Several studies have associated matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) to PCa tumorigenesis and metastasis. Most of the studies so far have been carried out by investigating in situ expression of the metalloproteinases, either by transcriptional measures or by immunohistochemistry with biopsy or postoperative tissue. Investigations in human plasma and ser...

Revista Brasileira de Ciências do Envelhecimento Humano

O objetivo deste estudo foi analisar, com base na literatura, a aceitação e o uso das tecnologias... more O objetivo deste estudo foi analisar, com base na literatura, a aceitação e o uso das tecnologias assistivas pelos idosos. Trata-se de estudo de revisão sistemática em que foi realizada busca por artigos nas bases de dados PubMed/Medline, Lilacs, e Scielo. Os aspectos discutidos na literatura foram: sobre a aceitação, sobre o uso e sobre as variáveis que poderiam interferir nas colocações pré citadas. Considerando estudos nacionais e internacionais, as discussões acerca do tema, de forma geral, foram igualitárias. Fatores como medo, receio, limitações ao acesso das tecnologias e motivação, foram determinantes no resultado do estudo. Notou-se por fim a necessidade de maior informação aos idosos sobre a existência das tecnologias, dos tipos, das categorias e dos benefícios que podem trazer ao idoso, fomentando o interesse no uso, para que a inserção dos idosos seja plena no mundo tecnológico.