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Papers by Cleber Alexandre

Research, Society and Development, Nov 6, 2020

Maxillary osteonecrosis induced by antiresorptive medication (bisphosphonate) in a patient with m... more Maxillary osteonecrosis induced by antiresorptive medication (bisphosphonate) in a patient with multiple myeloma-Case report Osteonecrose Maxilar Induzida por medicamento anti-reabsortivo (Bisfosfonato) em Paciente Portador de Mieloma Múltiplo-Relato de caso Osteonecrosis maxilar inducida por medicación antirresortiva (bisfosfonatos) en un paciente con mieloma múltiple-Reporte de caso

Audiology - Communication Research

RESUMO Objetivo Identificar a ocorrência de disfunções orofaciais em pacientes infantojuvenis com... more RESUMO Objetivo Identificar a ocorrência de disfunções orofaciais em pacientes infantojuvenis com leucemia aguda, submetidos à quimioterapia de remissão. Métodos Em um período de 16 meses, 40 pacientes com leucemias agudas, entre 3 e 18 anos de idade, foram admitidos em um hemocentro no estado do Amazonas. Destes, 23 foram incluídos neste estudo transversal e submetidos à avaliação das funções orofaciais, por meio do Nordic Orofacial Test-Screening (NOT-S), entre o trigésimo (D30) e o trigésimo terceiro dia (D33) da fase de indução da remissão. A presença de manifestações orais também foi avaliada por meio de exame clínico. Resultados Disfunção orofacial foi observada em, aproximadamente, metade dos casos avaliados (n=11). Destes pacientes, todos tiveram o domínio Secura de Boca (VI) alterado e 81,8% (n=9) apresentaram alteração no domínio Mastigação e Deglutição (IV). Mucosites em lábios, língua, soalho e orofaringe foram as lesões orais mais encontradas após a fase de indução. Hou...

Microscopy Research and Technique, 2021

The current research aims to perform a comparative evaluation of vegetable matter involved lesion... more The current research aims to perform a comparative evaluation of vegetable matter involved lesions with oral parasitic infections found in oral mucosa, presenting histochemical methods to differentiate their microscopic similarities. Eight cases were selected out of a sample of 1.975 reports from a single Oral and Maxillofacial Pathology Service of the author's institution from 2012 to 2019. Specimens were examined by hematoxylin and eosin staining (HE), periodic acid‐Schiff (PAS) staining, Gomori–Grocott staining, Ziehl–Neelsen staining, Giemsa, and mucicarmine staining. Microscopic analysis included fluorescence, polarized light, and confocal microscopy. Microscopically, in HE coloration, hookworm eggs showed as eosinophilic. Inflammatory multinucleated giant cells and lymphocytes, were usually related to the nematode eggs, forming an intense inflammatory infiltrate. Biofluorescent properties of eggs and larvae revealed to be sensitive in the detection of parasitic structures contrasting with the inflamed connective tissue. Vegetable presence was confirmed by polarized light microscopy and it was found to be associated with microbial biofilms. Confocal microscopy has showed to be an excellent method for morphotype differentiation of parasitic eggs. Parasitic infection and vegetable matter displayed similarities in the inflammatory response, but the latter can rot and agglomerate biofilms. The microscopic diagnosis of such infections requires the interpretation of challenging morphological features since the parasites are usually sectioned and mixed with an inflammatory reaction. These histochemical approaches proved to be excellent to distinguish both lesions.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2018

Toxicon : official journal of the International Society on Toxinology, Jan 28, 2016

Scorpion stings are a public health problem in the Brazilian Amazon. However, detailed clinical c... more Scorpion stings are a public health problem in the Brazilian Amazon. However, detailed clinical characterization with the proper animal identification is scarce. Here we report a confirmed case of envenoming by Tityus cf. silvestris in the Brazilian Amazon. The case evolved with generalized muscle spasms and was treated with antivenom and supportive therapy, requiring intensive care unit admission. The patient evolved favourably and was discharged after 9 days of hospitalization.

Research, Society and Development, 2020

Objective: to describe the clinical case of a patient with multiple myeloma, who developed maxill... more Objective: to describe the clinical case of a patient with multiple myeloma, who developed maxillary osteonecrosis induced by anti-resorptive medication (bisphosphonate) submitted to a conservative and surgical therapeutic approach and subsequent prosthetic rehabilitation. Patients and methods: the case report is presented based on a simple review of the literature and clinical experience for the diagnosis, clinical staging of the lesion, carrying out the excision of the necrotic bone, debridement, lesion control and making a obturator prosthesis. Results: Despite the difficulty offered by the pathological condition and continuous use of medication, the treatment employed was successful, restoring health and providing a better quality of life to the patient, which allowed the obturation prosthesis to be made in the 8-month postoperative period. Conclusion: The result obtained emphasizes the importance of knowledge of the staging of the lesion for the application of the treatment pro...