Clive Kelty - Academia.edu (original) (raw)

Papers by Clive Kelty

World journal of gastrointestinal pathophysiology, Jan 15, 2014

The optimal management for low-grade dysplasia (LGD) in Barrett's esophagus is unclear. In th... more The optimal management for low-grade dysplasia (LGD) in Barrett's esophagus is unclear. In this article the importance of LGD is discussed, including the significant risk of progression to esophageal adenocarcinoma. Endoscopic surveillance is a management option but is plagued by sampling error and issues of suboptimal endoscopy. Furthermore endoscopic surveillance has not been demonstrated to be cost-effective or to reduce cancer mortality. The emergence of endoluminal therapy over the past decade has resulted in a paradigm shift in the management of LGD. Ablative therapy, including radiofrequency ablation, has demonstrated promising results in the management of LGD with regards to safety, cost-effectiveness, durability and reduction in cancer risk. It is, however, vital that a shared-decision making process occurs between the physician and the patient as to the preferred management of LGD. As such the management of LGD should be "individualised."

Surgical Endoscopy, Nov 1, 2000

Insertion of the first trocar during the "closed" technique of creating a pneum... more Insertion of the first trocar during the "closed" technique of creating a pneumoperitoneum remains one of the most hazardous maneuvres in laparoscopic surgery, with complications such as major vascular and bowel injuries. The ease with which trocars are inserted through the abdominal wall may have some bearing on these complications. A range of both disposable and reusable trocars, which were identical in point cross section and size, were compared in an abdominal wall model reconstructed with animal hide, using a hand-held pressure transducer. Multiple insertions were performed, and the results were expressed in pounds per square inch (PSI). The disposable trocar tested required the least effort to insert (mean pressure, 2.76 PSI), followed by the new reusable (mean pressure, 3.42 PSI), with the used reusable trocar requiring the greatest force for insertion (mean pressure, 4.80 PSI). The effect of previous use on ease of insertion demonstrates an obvious disadvantage of reusable instruments. The excessive force required to insert some trocars may place the patient at greater risk of trocar injury.

European Journal of Cardio Thoracic Surgery, 1998

Anz Journal of Surgery, 2008

... INTRALUMINAL DUODENAL DIVERTICULUM: A CASE. Bernard Cheung MB BS,; Clive Kelty PhD, FRCS(Ed),... more ... INTRALUMINAL DUODENAL DIVERTICULUM: A CASE. Bernard Cheung MB BS,; Clive Kelty PhD, FRCS(Ed),; Matthew JFX Rickard MB BS, FRACS,; John Hollinshead MD, FRACS. Article first published online: 28 OCT 2007. DOI: 10.1111/j.1445-2197.2007.04337.x. Issue. ...

Photochemistry and Photobiology, Nov 1, 2001

Archives of Orthopaedic and Trauma Surgery

Pectoralis major rupture is a well-recognised but uncommon injury that rarely leads to complicati... more Pectoralis major rupture is a well-recognised but uncommon injury that rarely leads to complications. We present an unusual case where the resultant haematoma following a partial rupture became infected and caused problems with diagnosis. We are only aware of one previous report of this.

Surgical Endoscopy

ABSTRACT

Postgraduate medical journal, 1999

A sixty-one year old man was referred with a history of progressive dysphagia, vomiting and weigh... more A sixty-one year old man was referred with a history of progressive dysphagia, vomiting and weight loss with some back pain. Upper gastrointestinal endoscopy and biopsies revealed a gastro-oesophageal junction adenocarcinoma. Despite the absence of metastatic disease on computed tomography, positron emission tomography demonstrated multiple vertebral and sternal deposits. He was reviewed in an ENT clinic with a sudden onset of hearing loss accompanied by dizziness, but no focal neurology. Magnetic resonance imaging identified bilateral 2cm lesions at the internal auditory meatus, consistent with a diagnosis of bilateral acoustic neuromas. The patient subsequently died of carcinomatosis and, because of the potential familial significance of bilateral acoustic neuromas, a limited post-mortem examination was carried out. Unexpectedly, this revealed bilateral adenocarcinoma metastases infiltrating the internal auditory meatus affecting the acoustic nerves. The authors believe this a very rare presentation of metastatic gastric disease.

Trauma, 2012

ABSTRACT Injuries to the duodenum pose a diagnostic and therapeutic challenge to the surgeon. Due... more ABSTRACT Injuries to the duodenum pose a diagnostic and therapeutic challenge to the surgeon. Due to the intra- and extra-peritoneal location of the duodenum, the presentation can be overt or occult, and delay in diagnosis is associated with an increased mortality rate. A range of interventions have been described and this article reviews the relevant literature, highlights the salient points and suggests a treatment algorithm.

Surgical Endoscopy, 2000

Insertion of the first trocar during the "closed" technique of creating a pneum... more Insertion of the first trocar during the "closed" technique of creating a pneumoperitoneum remains one of the most hazardous maneuvres in laparoscopic surgery, with complications such as major vascular and bowel injuries. The ease with which trocars are inserted through the abdominal wall may have some bearing on these complications. A range of both disposable and reusable trocars, which were identical in point cross section and size, were compared in an abdominal wall model reconstructed with animal hide, using a hand-held pressure transducer. Multiple insertions were performed, and the results were expressed in pounds per square inch (PSI). The disposable trocar tested required the least effort to insert (mean pressure, 2.76 PSI), followed by the new reusable (mean pressure, 3.42 PSI), with the used reusable trocar requiring the greatest force for insertion (mean pressure, 4.80 PSI). The effect of previous use on ease of insertion demonstrates an obvious disadvantage of reusable instruments. The excessive force required to insert some trocars may place the patient at greater risk of trocar injury.

Scandinavian Journal of Gastroenterology, 2007

Barrett's oesophagus is the main identifiable risk factor... more Barrett's oesophagus is the main identifiable risk factor for oesophageal adenocarcinoma. It has been suggested that only patients with intestinal metaplasia are at risk of cancer, but the British Society of Gastroenterology (BSG) guidelines suggest that glandular mucosa is all that is needed. The aim of this study was to quantify the risk of adenocarcinoma in columnar-lined lower oesophagus, with or without specialized intestinal metaplasia. All patients who had endoscopic biopsies of the lower oesophagus between 1980 and 1994 in a single-centre teaching hospital were included in the study. All histological specimens were re-examined and reported according to whether they contained columnar epithelial-lined lower oesophagus, glandular mucosa, with or without intestinal metaplasia. The primary outcome measure was the development of adenocarcinoma. In total, 712 patients were identified. Of these, 379 (55.1%) were found to have specialized intestinal metaplasia (SIM), and the remaining 309 (44.9%, p = NS) were reported as having glandular mucosa (GM). The median follow-up for patients was 12 years (range 8-20 years). Twenty-eight patients went on to develop adenocarcinoma (4.1%) during the follow-up period - 17 in the SIM group (4.5%) and 11 in the GM group (3.6%, p =NS). The oesophageal malignancy rate was 0.34% per year (SIM 0.37%, GM 0.30%; p =NS). Patients who have glandular mucosa on biopsy without intestinal metaplasia have a similar cancer risk to those with specialized intestinal metaplasia.

Photodiagnosis and Photodynamic Therapy, 2006

Photochemistry and Photobiology, 2007

Photochemical & Photobiological Sciences, 2002

Photodynamic therapy (PDT) is a treatment for cancer and pre-malignant conditions, which involves... more Photodynamic therapy (PDT) is a treatment for cancer and pre-malignant conditions, which involves the administration of a photosensitising agent followed by exposure of the tissue to light. 5-Aminolaevulinic acid (ALA) is a naturally occurring compound in the haem biosynthetic pathway, which is metabolised to a photosensitive product, protoporphyrin IX (PpIX). The major advantage of ALA when compared to synthetic photosensitisers is the rapid metabolism, which significantly reduces the period of cutaneous photosensitivity. This review focuses on the development of ALA as a photosensitiser in photodynamic therapy and photodiagnosis, and the wide range of clinical applications in which ALA is now being used as a therapeutic modality.

Journal of Thoracic Oncology, 2010

The role of the number of metastatic nodes in esophageal cancer surgery is of interest. We assess... more The role of the number of metastatic nodes in esophageal cancer surgery is of interest. We assess predictors of survival after oesophagectomy for esophageal and gastroesophageal junction malignancy. Prospective data of consecutive patients undergoing oesophagectomy and systematic lymphadenectomy between 1991 and 2007. Of 224 patients, 148 patients (66%) had adenocarcinoma, 70 (31%) squamous cell carcinoma, and 6 (2.6%) were other tumor types. Five-year survival was 43% with hospital mortality of 3.5%. Locoregional recurrence occurred in 14%. The total number of affected nodes significantly reduced survival (four or more metastatic nodes). Further analysis of the ratio of nodes affected to the total number resected showed a significant decrease in survival as the percentage of positive nodes increased (p < 0.001). Patients undergoing surgery for esophageal cancer should be staged according to a minimum total number of metastatic lymph nodes and ratios because this more accurately predicts survival than current staging systems.

JSLS, Journal of the Society of Laparoendoscopic Surgeons, 2011

World journal of gastrointestinal pathophysiology, Jan 15, 2014

The optimal management for low-grade dysplasia (LGD) in Barrett's esophagus is unclear. In th... more The optimal management for low-grade dysplasia (LGD) in Barrett's esophagus is unclear. In this article the importance of LGD is discussed, including the significant risk of progression to esophageal adenocarcinoma. Endoscopic surveillance is a management option but is plagued by sampling error and issues of suboptimal endoscopy. Furthermore endoscopic surveillance has not been demonstrated to be cost-effective or to reduce cancer mortality. The emergence of endoluminal therapy over the past decade has resulted in a paradigm shift in the management of LGD. Ablative therapy, including radiofrequency ablation, has demonstrated promising results in the management of LGD with regards to safety, cost-effectiveness, durability and reduction in cancer risk. It is, however, vital that a shared-decision making process occurs between the physician and the patient as to the preferred management of LGD. As such the management of LGD should be "individualised."

Surgical Endoscopy, Nov 1, 2000

Insertion of the first trocar during the "closed" technique of creating a pneum... more Insertion of the first trocar during the "closed" technique of creating a pneumoperitoneum remains one of the most hazardous maneuvres in laparoscopic surgery, with complications such as major vascular and bowel injuries. The ease with which trocars are inserted through the abdominal wall may have some bearing on these complications. A range of both disposable and reusable trocars, which were identical in point cross section and size, were compared in an abdominal wall model reconstructed with animal hide, using a hand-held pressure transducer. Multiple insertions were performed, and the results were expressed in pounds per square inch (PSI). The disposable trocar tested required the least effort to insert (mean pressure, 2.76 PSI), followed by the new reusable (mean pressure, 3.42 PSI), with the used reusable trocar requiring the greatest force for insertion (mean pressure, 4.80 PSI). The effect of previous use on ease of insertion demonstrates an obvious disadvantage of reusable instruments. The excessive force required to insert some trocars may place the patient at greater risk of trocar injury.

European Journal of Cardio Thoracic Surgery, 1998

Anz Journal of Surgery, 2008

... INTRALUMINAL DUODENAL DIVERTICULUM: A CASE. Bernard Cheung MB BS,; Clive Kelty PhD, FRCS(Ed),... more ... INTRALUMINAL DUODENAL DIVERTICULUM: A CASE. Bernard Cheung MB BS,; Clive Kelty PhD, FRCS(Ed),; Matthew JFX Rickard MB BS, FRACS,; John Hollinshead MD, FRACS. Article first published online: 28 OCT 2007. DOI: 10.1111/j.1445-2197.2007.04337.x. Issue. ...

Photochemistry and Photobiology, Nov 1, 2001

Archives of Orthopaedic and Trauma Surgery

Pectoralis major rupture is a well-recognised but uncommon injury that rarely leads to complicati... more Pectoralis major rupture is a well-recognised but uncommon injury that rarely leads to complications. We present an unusual case where the resultant haematoma following a partial rupture became infected and caused problems with diagnosis. We are only aware of one previous report of this.

Surgical Endoscopy

ABSTRACT

Postgraduate medical journal, 1999

A sixty-one year old man was referred with a history of progressive dysphagia, vomiting and weigh... more A sixty-one year old man was referred with a history of progressive dysphagia, vomiting and weight loss with some back pain. Upper gastrointestinal endoscopy and biopsies revealed a gastro-oesophageal junction adenocarcinoma. Despite the absence of metastatic disease on computed tomography, positron emission tomography demonstrated multiple vertebral and sternal deposits. He was reviewed in an ENT clinic with a sudden onset of hearing loss accompanied by dizziness, but no focal neurology. Magnetic resonance imaging identified bilateral 2cm lesions at the internal auditory meatus, consistent with a diagnosis of bilateral acoustic neuromas. The patient subsequently died of carcinomatosis and, because of the potential familial significance of bilateral acoustic neuromas, a limited post-mortem examination was carried out. Unexpectedly, this revealed bilateral adenocarcinoma metastases infiltrating the internal auditory meatus affecting the acoustic nerves. The authors believe this a very rare presentation of metastatic gastric disease.

Trauma, 2012

ABSTRACT Injuries to the duodenum pose a diagnostic and therapeutic challenge to the surgeon. Due... more ABSTRACT Injuries to the duodenum pose a diagnostic and therapeutic challenge to the surgeon. Due to the intra- and extra-peritoneal location of the duodenum, the presentation can be overt or occult, and delay in diagnosis is associated with an increased mortality rate. A range of interventions have been described and this article reviews the relevant literature, highlights the salient points and suggests a treatment algorithm.

Surgical Endoscopy, 2000

Insertion of the first trocar during the "closed" technique of creating a pneum... more Insertion of the first trocar during the "closed" technique of creating a pneumoperitoneum remains one of the most hazardous maneuvres in laparoscopic surgery, with complications such as major vascular and bowel injuries. The ease with which trocars are inserted through the abdominal wall may have some bearing on these complications. A range of both disposable and reusable trocars, which were identical in point cross section and size, were compared in an abdominal wall model reconstructed with animal hide, using a hand-held pressure transducer. Multiple insertions were performed, and the results were expressed in pounds per square inch (PSI). The disposable trocar tested required the least effort to insert (mean pressure, 2.76 PSI), followed by the new reusable (mean pressure, 3.42 PSI), with the used reusable trocar requiring the greatest force for insertion (mean pressure, 4.80 PSI). The effect of previous use on ease of insertion demonstrates an obvious disadvantage of reusable instruments. The excessive force required to insert some trocars may place the patient at greater risk of trocar injury.

Scandinavian Journal of Gastroenterology, 2007

Barrett's oesophagus is the main identifiable risk factor... more Barrett's oesophagus is the main identifiable risk factor for oesophageal adenocarcinoma. It has been suggested that only patients with intestinal metaplasia are at risk of cancer, but the British Society of Gastroenterology (BSG) guidelines suggest that glandular mucosa is all that is needed. The aim of this study was to quantify the risk of adenocarcinoma in columnar-lined lower oesophagus, with or without specialized intestinal metaplasia. All patients who had endoscopic biopsies of the lower oesophagus between 1980 and 1994 in a single-centre teaching hospital were included in the study. All histological specimens were re-examined and reported according to whether they contained columnar epithelial-lined lower oesophagus, glandular mucosa, with or without intestinal metaplasia. The primary outcome measure was the development of adenocarcinoma. In total, 712 patients were identified. Of these, 379 (55.1%) were found to have specialized intestinal metaplasia (SIM), and the remaining 309 (44.9%, p = NS) were reported as having glandular mucosa (GM). The median follow-up for patients was 12 years (range 8-20 years). Twenty-eight patients went on to develop adenocarcinoma (4.1%) during the follow-up period - 17 in the SIM group (4.5%) and 11 in the GM group (3.6%, p =NS). The oesophageal malignancy rate was 0.34% per year (SIM 0.37%, GM 0.30%; p =NS). Patients who have glandular mucosa on biopsy without intestinal metaplasia have a similar cancer risk to those with specialized intestinal metaplasia.

Photodiagnosis and Photodynamic Therapy, 2006

Photochemistry and Photobiology, 2007

Photochemical & Photobiological Sciences, 2002

Photodynamic therapy (PDT) is a treatment for cancer and pre-malignant conditions, which involves... more Photodynamic therapy (PDT) is a treatment for cancer and pre-malignant conditions, which involves the administration of a photosensitising agent followed by exposure of the tissue to light. 5-Aminolaevulinic acid (ALA) is a naturally occurring compound in the haem biosynthetic pathway, which is metabolised to a photosensitive product, protoporphyrin IX (PpIX). The major advantage of ALA when compared to synthetic photosensitisers is the rapid metabolism, which significantly reduces the period of cutaneous photosensitivity. This review focuses on the development of ALA as a photosensitiser in photodynamic therapy and photodiagnosis, and the wide range of clinical applications in which ALA is now being used as a therapeutic modality.

Journal of Thoracic Oncology, 2010

The role of the number of metastatic nodes in esophageal cancer surgery is of interest. We assess... more The role of the number of metastatic nodes in esophageal cancer surgery is of interest. We assess predictors of survival after oesophagectomy for esophageal and gastroesophageal junction malignancy. Prospective data of consecutive patients undergoing oesophagectomy and systematic lymphadenectomy between 1991 and 2007. Of 224 patients, 148 patients (66%) had adenocarcinoma, 70 (31%) squamous cell carcinoma, and 6 (2.6%) were other tumor types. Five-year survival was 43% with hospital mortality of 3.5%. Locoregional recurrence occurred in 14%. The total number of affected nodes significantly reduced survival (four or more metastatic nodes). Further analysis of the ratio of nodes affected to the total number resected showed a significant decrease in survival as the percentage of positive nodes increased (p < 0.001). Patients undergoing surgery for esophageal cancer should be staged according to a minimum total number of metastatic lymph nodes and ratios because this more accurately predicts survival than current staging systems.

JSLS, Journal of the Society of Laparoendoscopic Surgeons, 2011