Mauricio Cohen - Academia.edu (original) (raw)

Papers by Mauricio Cohen

Research paper thumbnail of Hospital Admissions for Chest Pain Associated with Cocaine use in the United States

The American journal of medicine, Jun 4, 2017

The outcomes related to chest pain associated with cocaine use and its burden on healthcare syste... more The outcomes related to chest pain associated with cocaine use and its burden on healthcare system are not well studied. Data were collected from the Nationwide Inpatient Sample (2001 - 2012). Subjects were identified by using the ICD-9-CM codes. Primary outcome was a composite of mortality, myocardial infarction, stroke and cardiac arrest. We identified 363,143 admissions for cocaine induced chest pain. Mean age was 44.9 (+ 21.1) years with male predominance. Left heart catheterizations were performed in 6.7%, whereas the frequency of acute MI and percutaneous coronary interventions were 0.69% and 0.22% respectively. The in-hospital mortality was 0.09% and the primary outcome occurred in 1.19% of patients. Statistically significant predictors of primary outcome included female sex (OR=1.16, CI 1.00-1.35, p=0.046), age > 50 years (OR=1.24, CI 1.07-1.43, p=0.004), history of heart failure (OR=1.63, CI 1.37-1.93, p<0.001), supraventricular tachycardia (OR=2.94, CI 1.34-6.42, p=0...

Research paper thumbnail of TCT-118 Sex Differences in Coronary Angiography, Percutaneous Coronary Intervention, and Outcomes During Hospitalization After Out of Hospital Cardiac Arrest with Ventricular Fibrillation or Pulseless Ventricular Tachycardia

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-697 Comparison of Outcomes of Transcatheter Aortic Valve Replacement plus Percutaneous Coronary Intervention versus Transcatheter Aortic Valve Replacement Alone in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-151 Ventricular Septal Rupture Complicating ST-Elevation Myocardical Infarctions: A Nationwide Analysis

Journal of the American College of Cardiology, 2016

Ventricular septal rupture (VSR) is a sporadic but lethal complication after an acute myocardial ... more Ventricular septal rupture (VSR) is a sporadic but lethal complication after an acute myocardial infarction (MI). With the advent of reperfusion strategies, VSRs have become all the more infrequent, yet the outcomes continue to negatively impact the clinical prognosis of these patients while

Research paper thumbnail of TCT-380 Outcomes of Patients with Acute Myocardial Infarction in Moderate to Severe Chronic Kidney Disease in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitalized After Out-of-Hospital Cardiac Arrest

Journal of the American College of Cardiology, 2016

TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitali... more TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitalized After Out-of-Hospital Cardiac Arrest Nileshkumar Patel, Nish Patel, Gabriel Hernandez, Shilpkumar Arora, Apurva Badheka, Abhishek Deshmukh, Eduardo DeMarchena, Mauricio Cohen, Carlos Alfonso, Deepak Bhatt, Navin Kapur University of Miami, MIAMI, Florida, United States; University of Miami Miller School of Medicine, Miami, Florida, United States; Novosibirsk State Research Institute of Circulation Pathology; Mount Sinai st luke’s roosevelt, New York, New York, United States; Yale university, New haven, Connecticut, United States; UAMS erwqeqweqw, little rock, Arkansas, United States; University of Miami, Miami, Florida, United States; University of Miami Hospital, Miami, Florida, United States; University of Miami Miller School of Medicine, Miami, Florida, United States; Brigham and Women’s Hospital, Boston, Massachusetts, United States; Tufts Medical Center, Boston, Massachusetts, United States

Research paper thumbnail of TCT-845 Regional Differences in the Incidence and Outcomes of Hospitalization after Out-of-Hospital Cardiac Arrest in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-680 Impact of Annual Hospital Percutaneous Coronary Intervention Volume on Transcatheter Aortic-Valve Replacement Outcomes

Journal of the American College of Cardiology, 2016

Research paper thumbnail of Trends and Outcomes of Coronary Angiography and Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest Associated With Ventricular Fibrillation or Pulseless Ventricular Tachycardia

Research paper thumbnail of Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention

The American Journal of Cardiology, 2016

Research paper thumbnail of Iconography : QRS Duration on Electrocardiography and Cardiovascular Mortality (from the National Health and Nutrition Examination Survey—III)

Data Revues 00029149 Unassign S0002914913010576, May 30, 2013

Research paper thumbnail of Abstract 18793: Impact of Chronic Kidney Disease on Outcomes in Patients Undergoing Balloon Aortic Valvuloplasty: Results from the BRAVO Study

Circulation, Nov 20, 2012

Background Balloon aortic valvuloplasty (BAV) is a palliative treatment for severe aortic stenosi... more Background Balloon aortic valvuloplasty (BAV) is a palliative treatment for severe aortic stenosis that is increasingly performed as a bridge to transcatheter aortic valve replacement. While chronic kidney disease (CKD) is a frequent comorbidity in elderly patients with aortic stenosis undergoing BAV, its impact on in-hospital outcomes has not yet been determined. Methods We conducted a retrospective analysis of 421 consecutive patients who underwent non-emergent BAV at two high-volume centers. We analyzed baseline and procedural characteristics as well as in-hospital outcomes according to the presence or absence of CKD, defined as a glomerular filtration rate of 2 . All adverse events were adjudicated by a blinded, independent clinical events committee. Results Of the 421 patients who underwent BAV, 251 (59.2%) had CKD. Patients with CKD had significantly higher rates of mortality (8.0% vs. 2.4%, p=0.02) and major bleeding (14.3% vs. 7.6%, p=0.04) as well as net adverse clinical events (18.7% vs. 11.2%, p=0.04) compared to patients without CKD. A secondary analysis stratifying the groups by type of antithrombotic used revealed an almost 3-fold decrease in major bleeding events in CKD patients treated with bivalirudin compared to those receiving heparin (5.8% vs. 14.9%, p=0.01). After multivariate analysis controlling for multiple confounders, CKD remained associated with an increased risk for bleeding (OR 1.99; 95%CI [0.83, 4.78]; p=0.12) and death (OR 2.12; 95%CI [0.61, 7.33]; p=0.24), without statistical significance. Conclusions CKD is associated with an increased risk of in-hospital mortality and bleeding complications post-BAV. Further research is warranted to determine whether adverse outcomes in CKD patients can be reduced through selective use of novel devices or alternative pharmacological approaches.

Research paper thumbnail of Management Strategies and Outcomes of ST-Segment Elevation Myocardial Infarction Patients Transferred After Receiving Fibrinolytic Therapy in the United States

Clinical cardiology, 2016

Fibrinolytic therapy is still used in patients with ST-segment elevation myocardial infarction (S... more Fibrinolytic therapy is still used in patients with ST-segment elevation myocardial infarction (STEMI) when the primary percutaneous coronary intervention cannot be provided in a timely fashion. Management strategies and outcomes in transferred fibrinolytic-treated STEMI patients have not been well assessed in real-world settings. Using the Nationwide Inpatient Sample from 2008 to 2012, we identified 18 814 patients with STEMI who received fibrinolytic therapy and were transferred to a different facility within 24 hours. The primary outcome was in-hospital mortality. Secondary outcomes included gastrointestinal bleeding, bleeding requiring transfusion, intracranial hemorrhage (ICH), length of stay, and cost. The patients were divided into 3 groups: those who received medical therapy alone (n = 853; 4.5%), those who underwent coronary artery angiography without revascularization (n = 2573; 13.7%), and those who underwent coronary artery angiography with revascularization (n = 15 388;...

Research paper thumbnail of Percutaneous Coronary Interventions and Hemodynamic Support in the USA: A 5 Year Experience

Journal of interventional cardiology, 2015

To compare the utilization and outcomes in patients who had percutaneous coronary interventions (... more To compare the utilization and outcomes in patients who had percutaneous coronary interventions (PCIs) performed with intra-aortic balloon pump (IABP) versus percutaneous ventricular assist devices (PVADs) such as Impella and TandemHeart and identify a sub-group of patient population who may derive the most benefit from the use of PVADs over IABP. Despite the lack of clear benefit, the use of PVADs has increased substantially in the last decade when compared to IABP. We performed a cross sectional study including using the Nationwide Inpatient Sample. Procedures performed with hemodynamic support were identified through appropriate ICD-9-CM codes. We identified 18,094 PCIs performed with hemodynamic support. IABP was the most commonly utilized hemodynamic support device (93%, n = 16, 803) whereas 6% (n = 1069) were performed with PVADs and 1% (n = 222) utilized both IABP and PVAD. Patients in the PVAD group were older in age and had greater burden of co-morbidities whereas IABP grou...

Research paper thumbnail of Contemporary Trends of Pharmacoinvasive Strategy in Patients with ST-Segment Elevation Myocardial Infarction in Different Region of United States: Insights from Nationwide Inpatient Sample

Journal of the American College of Cardiology, 2015

Research paper thumbnail of Aspiration thrombectomy in patients undergoing primary angioplasty: Totality of data to 2013

Catheterization and Cardiovascular Interventions, 2014

Research paper thumbnail of Effect of bivalirudin on aortic valve intervention outcomes study: a two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2014

We sought to assess if bivalirudin use during balloon aortic valvuloplasty (BAV) would affect cli... more We sought to assess if bivalirudin use during balloon aortic valvuloplasty (BAV) would affect clinical outcomes compared with heparin. We compared the outcomes of consecutive patients who underwent elective or urgent BAV with intraprocedural use of bivalirudin or heparin at two high-volume centres. All in-hospital events post BAV were adjudicated by an independent, blinded clinical events committee. Of 427 patients, 223 patients (52.2%) received bivalirudin and 204 (47.8%) received heparin. Compared with patients who received heparin, patients who received bivalirudin had significantly less major bleeding (4.9% vs. 13.2%, p=0.003). Net adverse clinical events (NACE, major bleeding or major adverse cardiovascular events [MACE]) were also reduced (11.2% vs. 20.1%, p=0.01). There was no significant difference in the rates of MACE (mortality, myocardial infarction or stroke, 6.7% vs. 11.3%, p=0.1), or vascular complications (major, 2.7% vs. 2.0%; minor, 4.5% vs. 4.9%; p=0.83). After mul...

Research paper thumbnail of Propéptido natriurético tipo B N-terminal: un predictor de mal pronóstico en síndromes coronarios sin elevación del segmento ST

Revista argentina de …, 2005

Research paper thumbnail of TCT-100 Effect of Intra cardiac echocardiography and yearly operator volume on Length of Stay and Cost of Care for Percutaneous Closure of Atrial Septal Defects and Patent Foramen Ovale: A Perspective of Last Decade

Journal of the American College of Cardiology, 2013

Research paper thumbnail of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in a Low to Intermediate Risk Population

Journal of the American College of Cardiology, 2014

Research paper thumbnail of Hospital Admissions for Chest Pain Associated with Cocaine use in the United States

The American journal of medicine, Jun 4, 2017

The outcomes related to chest pain associated with cocaine use and its burden on healthcare syste... more The outcomes related to chest pain associated with cocaine use and its burden on healthcare system are not well studied. Data were collected from the Nationwide Inpatient Sample (2001 - 2012). Subjects were identified by using the ICD-9-CM codes. Primary outcome was a composite of mortality, myocardial infarction, stroke and cardiac arrest. We identified 363,143 admissions for cocaine induced chest pain. Mean age was 44.9 (+ 21.1) years with male predominance. Left heart catheterizations were performed in 6.7%, whereas the frequency of acute MI and percutaneous coronary interventions were 0.69% and 0.22% respectively. The in-hospital mortality was 0.09% and the primary outcome occurred in 1.19% of patients. Statistically significant predictors of primary outcome included female sex (OR=1.16, CI 1.00-1.35, p=0.046), age > 50 years (OR=1.24, CI 1.07-1.43, p=0.004), history of heart failure (OR=1.63, CI 1.37-1.93, p<0.001), supraventricular tachycardia (OR=2.94, CI 1.34-6.42, p=0...

Research paper thumbnail of TCT-118 Sex Differences in Coronary Angiography, Percutaneous Coronary Intervention, and Outcomes During Hospitalization After Out of Hospital Cardiac Arrest with Ventricular Fibrillation or Pulseless Ventricular Tachycardia

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-697 Comparison of Outcomes of Transcatheter Aortic Valve Replacement plus Percutaneous Coronary Intervention versus Transcatheter Aortic Valve Replacement Alone in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-151 Ventricular Septal Rupture Complicating ST-Elevation Myocardical Infarctions: A Nationwide Analysis

Journal of the American College of Cardiology, 2016

Ventricular septal rupture (VSR) is a sporadic but lethal complication after an acute myocardial ... more Ventricular septal rupture (VSR) is a sporadic but lethal complication after an acute myocardial infarction (MI). With the advent of reperfusion strategies, VSRs have become all the more infrequent, yet the outcomes continue to negatively impact the clinical prognosis of these patients while

Research paper thumbnail of TCT-380 Outcomes of Patients with Acute Myocardial Infarction in Moderate to Severe Chronic Kidney Disease in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitalized After Out-of-Hospital Cardiac Arrest

Journal of the American College of Cardiology, 2016

TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitali... more TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitalized After Out-of-Hospital Cardiac Arrest Nileshkumar Patel, Nish Patel, Gabriel Hernandez, Shilpkumar Arora, Apurva Badheka, Abhishek Deshmukh, Eduardo DeMarchena, Mauricio Cohen, Carlos Alfonso, Deepak Bhatt, Navin Kapur University of Miami, MIAMI, Florida, United States; University of Miami Miller School of Medicine, Miami, Florida, United States; Novosibirsk State Research Institute of Circulation Pathology; Mount Sinai st luke’s roosevelt, New York, New York, United States; Yale university, New haven, Connecticut, United States; UAMS erwqeqweqw, little rock, Arkansas, United States; University of Miami, Miami, Florida, United States; University of Miami Hospital, Miami, Florida, United States; University of Miami Miller School of Medicine, Miami, Florida, United States; Brigham and Women’s Hospital, Boston, Massachusetts, United States; Tufts Medical Center, Boston, Massachusetts, United States

Research paper thumbnail of TCT-845 Regional Differences in the Incidence and Outcomes of Hospitalization after Out-of-Hospital Cardiac Arrest in the United States

Journal of the American College of Cardiology, 2016

Research paper thumbnail of TCT-680 Impact of Annual Hospital Percutaneous Coronary Intervention Volume on Transcatheter Aortic-Valve Replacement Outcomes

Journal of the American College of Cardiology, 2016

Research paper thumbnail of Trends and Outcomes of Coronary Angiography and Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest Associated With Ventricular Fibrillation or Pulseless Ventricular Tachycardia

Research paper thumbnail of Temporal Trends, Predictors, and Outcomes of In-Hospital Gastrointestinal Bleeding Associated With Percutaneous Coronary Intervention

The American Journal of Cardiology, 2016

Research paper thumbnail of Iconography : QRS Duration on Electrocardiography and Cardiovascular Mortality (from the National Health and Nutrition Examination Survey—III)

Data Revues 00029149 Unassign S0002914913010576, May 30, 2013

Research paper thumbnail of Abstract 18793: Impact of Chronic Kidney Disease on Outcomes in Patients Undergoing Balloon Aortic Valvuloplasty: Results from the BRAVO Study

Circulation, Nov 20, 2012

Background Balloon aortic valvuloplasty (BAV) is a palliative treatment for severe aortic stenosi... more Background Balloon aortic valvuloplasty (BAV) is a palliative treatment for severe aortic stenosis that is increasingly performed as a bridge to transcatheter aortic valve replacement. While chronic kidney disease (CKD) is a frequent comorbidity in elderly patients with aortic stenosis undergoing BAV, its impact on in-hospital outcomes has not yet been determined. Methods We conducted a retrospective analysis of 421 consecutive patients who underwent non-emergent BAV at two high-volume centers. We analyzed baseline and procedural characteristics as well as in-hospital outcomes according to the presence or absence of CKD, defined as a glomerular filtration rate of 2 . All adverse events were adjudicated by a blinded, independent clinical events committee. Results Of the 421 patients who underwent BAV, 251 (59.2%) had CKD. Patients with CKD had significantly higher rates of mortality (8.0% vs. 2.4%, p=0.02) and major bleeding (14.3% vs. 7.6%, p=0.04) as well as net adverse clinical events (18.7% vs. 11.2%, p=0.04) compared to patients without CKD. A secondary analysis stratifying the groups by type of antithrombotic used revealed an almost 3-fold decrease in major bleeding events in CKD patients treated with bivalirudin compared to those receiving heparin (5.8% vs. 14.9%, p=0.01). After multivariate analysis controlling for multiple confounders, CKD remained associated with an increased risk for bleeding (OR 1.99; 95%CI [0.83, 4.78]; p=0.12) and death (OR 2.12; 95%CI [0.61, 7.33]; p=0.24), without statistical significance. Conclusions CKD is associated with an increased risk of in-hospital mortality and bleeding complications post-BAV. Further research is warranted to determine whether adverse outcomes in CKD patients can be reduced through selective use of novel devices or alternative pharmacological approaches.

Research paper thumbnail of Management Strategies and Outcomes of ST-Segment Elevation Myocardial Infarction Patients Transferred After Receiving Fibrinolytic Therapy in the United States

Clinical cardiology, 2016

Fibrinolytic therapy is still used in patients with ST-segment elevation myocardial infarction (S... more Fibrinolytic therapy is still used in patients with ST-segment elevation myocardial infarction (STEMI) when the primary percutaneous coronary intervention cannot be provided in a timely fashion. Management strategies and outcomes in transferred fibrinolytic-treated STEMI patients have not been well assessed in real-world settings. Using the Nationwide Inpatient Sample from 2008 to 2012, we identified 18 814 patients with STEMI who received fibrinolytic therapy and were transferred to a different facility within 24 hours. The primary outcome was in-hospital mortality. Secondary outcomes included gastrointestinal bleeding, bleeding requiring transfusion, intracranial hemorrhage (ICH), length of stay, and cost. The patients were divided into 3 groups: those who received medical therapy alone (n = 853; 4.5%), those who underwent coronary artery angiography without revascularization (n = 2573; 13.7%), and those who underwent coronary artery angiography with revascularization (n = 15 388;...

Research paper thumbnail of Percutaneous Coronary Interventions and Hemodynamic Support in the USA: A 5 Year Experience

Journal of interventional cardiology, 2015

To compare the utilization and outcomes in patients who had percutaneous coronary interventions (... more To compare the utilization and outcomes in patients who had percutaneous coronary interventions (PCIs) performed with intra-aortic balloon pump (IABP) versus percutaneous ventricular assist devices (PVADs) such as Impella and TandemHeart and identify a sub-group of patient population who may derive the most benefit from the use of PVADs over IABP. Despite the lack of clear benefit, the use of PVADs has increased substantially in the last decade when compared to IABP. We performed a cross sectional study including using the Nationwide Inpatient Sample. Procedures performed with hemodynamic support were identified through appropriate ICD-9-CM codes. We identified 18,094 PCIs performed with hemodynamic support. IABP was the most commonly utilized hemodynamic support device (93%, n = 16, 803) whereas 6% (n = 1069) were performed with PVADs and 1% (n = 222) utilized both IABP and PVAD. Patients in the PVAD group were older in age and had greater burden of co-morbidities whereas IABP grou...

Research paper thumbnail of Contemporary Trends of Pharmacoinvasive Strategy in Patients with ST-Segment Elevation Myocardial Infarction in Different Region of United States: Insights from Nationwide Inpatient Sample

Journal of the American College of Cardiology, 2015

Research paper thumbnail of Aspiration thrombectomy in patients undergoing primary angioplasty: Totality of data to 2013

Catheterization and Cardiovascular Interventions, 2014

Research paper thumbnail of Effect of bivalirudin on aortic valve intervention outcomes study: a two-centre registry study comparing bivalirudin and unfractionated heparin in balloon aortic valvuloplasty

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2014

We sought to assess if bivalirudin use during balloon aortic valvuloplasty (BAV) would affect cli... more We sought to assess if bivalirudin use during balloon aortic valvuloplasty (BAV) would affect clinical outcomes compared with heparin. We compared the outcomes of consecutive patients who underwent elective or urgent BAV with intraprocedural use of bivalirudin or heparin at two high-volume centres. All in-hospital events post BAV were adjudicated by an independent, blinded clinical events committee. Of 427 patients, 223 patients (52.2%) received bivalirudin and 204 (47.8%) received heparin. Compared with patients who received heparin, patients who received bivalirudin had significantly less major bleeding (4.9% vs. 13.2%, p=0.003). Net adverse clinical events (NACE, major bleeding or major adverse cardiovascular events [MACE]) were also reduced (11.2% vs. 20.1%, p=0.01). There was no significant difference in the rates of MACE (mortality, myocardial infarction or stroke, 6.7% vs. 11.3%, p=0.1), or vascular complications (major, 2.7% vs. 2.0%; minor, 4.5% vs. 4.9%; p=0.83). After mul...

Research paper thumbnail of Propéptido natriurético tipo B N-terminal: un predictor de mal pronóstico en síndromes coronarios sin elevación del segmento ST

Revista argentina de …, 2005

Research paper thumbnail of TCT-100 Effect of Intra cardiac echocardiography and yearly operator volume on Length of Stay and Cost of Care for Percutaneous Closure of Atrial Septal Defects and Patent Foramen Ovale: A Perspective of Last Decade

Journal of the American College of Cardiology, 2013

Research paper thumbnail of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in a Low to Intermediate Risk Population

Journal of the American College of Cardiology, 2014