Sara Colella - Academia.edu (original) (raw)

Papers by Sara Colella

Research paper thumbnail of EBUS-Guided Cryobiopsy of Mediastinal Lymphonodes

Journal of Bronchology & Interventional Pulmonology

Research paper thumbnail of Regional anesthesia in the era of COVID-19

Regional Anesthesia and Pain Medicine, Jan 17, 2023

Research paper thumbnail of Bronchoscopy in suspected severe acute respiratory syndrome-Coronavirus 2 pneumonia with atypical and indeterminate computed tomography presentation: indispensable or dispensable?

Minerva Respiratory Medicine

Research paper thumbnail of Thoracic Surgeons (ESTS)

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

Research paper thumbnail of COVID-19-related pericarditis with pericardial clotting as a hallmark: Two cases and a review

Journal of Cardiovascular Echography, 2021

The prevalence of pericardial effusion and its clinical significance is not well understood in CO... more The prevalence of pericardial effusion and its clinical significance is not well understood in COVID-19 patients. We report two cases of COVID-19-related pericardial effusion complicated by intrapericardial clot formation. The final outcome was favorable, but intrapericardial clot remained mostly unchanged at 6-month follow-up. The treatment approach and the long-term consequences are still unclear. We propose a review of this particular cardiovascular complication in COVID-19 patients.

Research paper thumbnail of Technique and Equipment in Transbronchial Cryobiopsy

Transbronchial cryobiopsy in diffuse parenchymal lung disease, 2019

Sedation/anaesthesia, airway management, patient ventilation, different types of bronchial blocke... more Sedation/anaesthesia, airway management, patient ventilation, different types of bronchial blockers, the role of fluoroscopic guidance, different cryogenic gases and cryoprobes are all components that need to be discussed in order to standardize the procedure. Eventually biotic strategies (where a TBLC should be carried out and how many samples should be taken, the freezing time) and how to manage the TBLC samples will be discussed.

Research paper thumbnail of Pulmonary involvement in haematological disorders and bone marrow transplant recipients

Research paper thumbnail of Radial endobronchial ultrasound-assisted transbronchial needle aspiration for pulmonary peripheral lesions in the segmental bronchi adjacent to the central airway

Background Tissue samples from lesions located in the 3rd to 5th segmental bronchi are challengin... more Background Tissue samples from lesions located in the 3rd to 5th segmental bronchi are challenging to obtain. In this retrospective study, we aimed to evaluate the diagnostic rate of pulmonary peripheral lesions located in the 3rd to 5th segmental bronchi, near the inner field of lung on the computed tomography (CT) image and outside the bronchus, using radial endobronchial ultrasound (REBUS) followed by transbronchial needle aspiration (TBNA). Methods This retrospective study enrolled patients whose preoperative CT examinations showed a lesion located in the segmental bronchi (3rd to 5th), yet adjacent to the inner field of lung on the CT image. REBUS followed by TBNA was used to acquire tissue samples from these lesions. A bronchoscope was used to reach the bronchi surrounding the lesion, and an ultrasound probe was used to determine the lesion's location. Then, the ultrasound probe was withdrawn, and puncture was performed at the location that was determined by ultrasound. Th...

Research paper thumbnail of Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

The European respiratory journal, 2015

Research paper thumbnail of How to learn and to perform endoscopic ultrasound and endobronchial ultrasound for lung cancer staging: A structured guide and review

Endoscopic ultrasound

The learning of transesophageal ultrasound guided fine needle aspiration (FNA) (endoscopic ultras... more The learning of transesophageal ultrasound guided fine needle aspiration (FNA) (endoscopic ultrasound-FNA), and endobronchial ultrasound guided transbronchial needle aspiration (endosonography) should be based on the following steps: Acquiring theoretical knowledge, training on simulators, and supervised performance on patients. Each step should be completed by passing a validated exam before proceeding to the next step. This approach will assure basic competency on all levels, and testing also facilitates learning and improves retention. Competence in endosonography can be based on a systematic an easy principle consisting of 2 times six anatomical landmarks.

Research paper thumbnail of Profuse coarse pulmonary nodules in a patient with lymphangioleiomyomatosis: thirty-three years of follow-up

European Clinical Respiratory Journal, 2014

Research paper thumbnail of Assessment of Competence in Simulated Flexible Bronchoscopy Using Motion Analysis

Respiration, 2015

The total deviation from the straight scope correlated negatively with the performance on the sim... more The total deviation from the straight scope correlated negatively with the performance on the simulator (virtual-reality simulator score; p < 0.001). Conclusion: The motion analysis system could discriminate between different levels of experience. Automatic feedback on correct movements during self-directed training on simulators might help new bronchoscopists learn how to handle the bronchoscope like an expert.

Research paper thumbnail of Diagnostic Accuracy and Safety of Semirigid Thoracoscopy in Exudative Pleural Effusions

Research paper thumbnail of Indagine under 40 e attività scientifica: i risultati della survey AIPO

Rassegna di Patologia dell'Apparato Respiratorio, Apr 15, 2019

La professione medica si basa, oltre che sulla pratica clinica quotidiana, sull’attivita di studi... more La professione medica si basa, oltre che sulla pratica clinica quotidiana, sull’attivita di studio e di ricerca: tale attivitaconsiste principalmente nella partecipazione a progetti di ricerca, nella stesura di articoli scientifici, nella partecipazione acorsi e congressi, sia come relatori che come discenti, e nell’avere un ruolo attivo all’interno di societa scientifiche. Tuttoquesto rientra nell’attivita scientifica, fondamentale nella nostra vita lavorativa poiche costituisce un momento importantedi crescita culturale, crescita di cui beneficiamo noi e la nostra pratica clinica quotidiana. (...)

Research paper thumbnail of Diagnosis and staging of lung cancer with the use of one single echoendoscope in both the trachea and the esophagus: A practical guide

Research paper thumbnail of Comparison between closed pleural biopsy and medical thoracoscopy for the diagnosis of undiagnosed exudative pleural effusions: a systematic review and meta-analysis

Translational Lung Cancer Research

Background: Exudative pleural effusion (EPE) is a common diagnostic challenge. The utility of med... more Background: Exudative pleural effusion (EPE) is a common diagnostic challenge. The utility of medical thoracoscopy (MT) and closed pleural biopsy (CPB) to aid in the diagnosis of EPE has been reported in many published studies. Herein, we perform a systematic review and meta-analysis to compare the diagnostic yield and safety of CPB and MT in EPE. Methods: Four databases were searched for studies reporting the diagnostic yield of CPB and MT for EPE. The quality of the included studies was evaluated according to the quality assessment of diagnostic accuracy studies (QUADAS) tool. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and complication risks were compared between the two groups. Results: Ten studies dealing with CPB and twenty-three studies dealing with MT for the diagnosis of EPE were included in this meta-analysis.

Research paper thumbnail of Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidisciplinary Respiratory Medicine

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of... more Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes. Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma. Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Results: Three patients were detected. TBLC described pathological abnormalities in peribronchiolar and alveolar spaces already well identified with SLB (surgical lung biopsy); the pathological information provided could be useful to better understand the pathobiology of the disease. Finally, we had no complications, confirming a satisfactory safety profile of TBLC. Conclusion: We suggest the potential role of TBLC in asthmatic patients: its safety and its acceptable diagnostic accuracy lead to consider this procedure instead of SLB when histological changes in lung parenchyma are needed for the differential diagnosis. Furthermore, TLBC could be useful for research in the pathobiology of asthma and severe asthma.

Research paper thumbnail of Diagnostic yield and safety of EUS-FNA biopsy in sub-aortic and para-aortic lymph node stations with the trans-aortic approach: a case series and literature review

European Clinical Respiratory Journal

Background: Sub-aortic (station 5) and para-aortic (station 6) lymph nodes are not easily accessi... more Background: Sub-aortic (station 5) and para-aortic (station 6) lymph nodes are not easily accessible due to the interposition of the aorta and the left pulmonary artery. Taking a biopsy from those stations could be of value when there are no other mediastinal lymph node stations or when biopsy in other sites failed to reach a diagnosis. Surgery is the gold standard technique in the evaluation of those stations; endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been proposed as a minimally invasive technique through the trans-aortic approach, with an acceptable diagnostic yield and safety profile. Objective: To evaluate diagnostic accuracy and safety of the trans-aortic EUS-FNA in lymph node stations 5 and 6. Methods: We reviewed all patients who underwent trans-aortic EUS-FNA from 2010 to 2017, for mediastinal lymph node enlargement or positron emission tomography/computed tomography (PET/CT) positivity (integrated 2-deoxy-2-fluoro-D-glucose). Demographic characteristics, lesion site and size, needle, final diagnosis, and complications were collected. Results: A total of 11 patients were included, 5 males, mean age 59 years. Samples were inadequate in two cases, a diagnosis of lung cancer was reached in four patients (two adenocarcinoma and two squamous cell carcinoma) and five cases were negative for malignancy (one confirmed by surgery, two were found to be cancer at percutaneous lung biopsy and transbronchial biopsy, one patient received a diagnosis of Langerhans cell histiocytosis by transbronchial lung cryobiopsy, and one patient was lost at follow-up). The sensitivity for malignancy was 57%, and the overall diagnostic accuracy was 45%. No complications occurred. Conclusions: Trans-aortic EUS-FNA could be proposed as a valuable and safe approach for taking biopsy from mediastinal lymph node stations 5 and 6.

Research paper thumbnail of Cryobiopsy: Physics

Transbronchial cryobiopsy in diffuse parenchymal lung disease

Research paper thumbnail of Report Standardization in Transbronchial Lung Cryobiopsy

Archives of Pathology & Laboratory Medicine

Research paper thumbnail of EBUS-Guided Cryobiopsy of Mediastinal Lymphonodes

Journal of Bronchology & Interventional Pulmonology

Research paper thumbnail of Regional anesthesia in the era of COVID-19

Regional Anesthesia and Pain Medicine, Jan 17, 2023

Research paper thumbnail of Bronchoscopy in suspected severe acute respiratory syndrome-Coronavirus 2 pneumonia with atypical and indeterminate computed tomography presentation: indispensable or dispensable?

Minerva Respiratory Medicine

Research paper thumbnail of Thoracic Surgeons (ESTS)

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

Research paper thumbnail of COVID-19-related pericarditis with pericardial clotting as a hallmark: Two cases and a review

Journal of Cardiovascular Echography, 2021

The prevalence of pericardial effusion and its clinical significance is not well understood in CO... more The prevalence of pericardial effusion and its clinical significance is not well understood in COVID-19 patients. We report two cases of COVID-19-related pericardial effusion complicated by intrapericardial clot formation. The final outcome was favorable, but intrapericardial clot remained mostly unchanged at 6-month follow-up. The treatment approach and the long-term consequences are still unclear. We propose a review of this particular cardiovascular complication in COVID-19 patients.

Research paper thumbnail of Technique and Equipment in Transbronchial Cryobiopsy

Transbronchial cryobiopsy in diffuse parenchymal lung disease, 2019

Sedation/anaesthesia, airway management, patient ventilation, different types of bronchial blocke... more Sedation/anaesthesia, airway management, patient ventilation, different types of bronchial blockers, the role of fluoroscopic guidance, different cryogenic gases and cryoprobes are all components that need to be discussed in order to standardize the procedure. Eventually biotic strategies (where a TBLC should be carried out and how many samples should be taken, the freezing time) and how to manage the TBLC samples will be discussed.

Research paper thumbnail of Pulmonary involvement in haematological disorders and bone marrow transplant recipients

Research paper thumbnail of Radial endobronchial ultrasound-assisted transbronchial needle aspiration for pulmonary peripheral lesions in the segmental bronchi adjacent to the central airway

Background Tissue samples from lesions located in the 3rd to 5th segmental bronchi are challengin... more Background Tissue samples from lesions located in the 3rd to 5th segmental bronchi are challenging to obtain. In this retrospective study, we aimed to evaluate the diagnostic rate of pulmonary peripheral lesions located in the 3rd to 5th segmental bronchi, near the inner field of lung on the computed tomography (CT) image and outside the bronchus, using radial endobronchial ultrasound (REBUS) followed by transbronchial needle aspiration (TBNA). Methods This retrospective study enrolled patients whose preoperative CT examinations showed a lesion located in the segmental bronchi (3rd to 5th), yet adjacent to the inner field of lung on the CT image. REBUS followed by TBNA was used to acquire tissue samples from these lesions. A bronchoscope was used to reach the bronchi surrounding the lesion, and an ultrasound probe was used to determine the lesion's location. Then, the ultrasound probe was withdrawn, and puncture was performed at the location that was determined by ultrasound. Th...

Research paper thumbnail of Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer

The European respiratory journal, 2015

Research paper thumbnail of How to learn and to perform endoscopic ultrasound and endobronchial ultrasound for lung cancer staging: A structured guide and review

Endoscopic ultrasound

The learning of transesophageal ultrasound guided fine needle aspiration (FNA) (endoscopic ultras... more The learning of transesophageal ultrasound guided fine needle aspiration (FNA) (endoscopic ultrasound-FNA), and endobronchial ultrasound guided transbronchial needle aspiration (endosonography) should be based on the following steps: Acquiring theoretical knowledge, training on simulators, and supervised performance on patients. Each step should be completed by passing a validated exam before proceeding to the next step. This approach will assure basic competency on all levels, and testing also facilitates learning and improves retention. Competence in endosonography can be based on a systematic an easy principle consisting of 2 times six anatomical landmarks.

Research paper thumbnail of Profuse coarse pulmonary nodules in a patient with lymphangioleiomyomatosis: thirty-three years of follow-up

European Clinical Respiratory Journal, 2014

Research paper thumbnail of Assessment of Competence in Simulated Flexible Bronchoscopy Using Motion Analysis

Respiration, 2015

The total deviation from the straight scope correlated negatively with the performance on the sim... more The total deviation from the straight scope correlated negatively with the performance on the simulator (virtual-reality simulator score; p < 0.001). Conclusion: The motion analysis system could discriminate between different levels of experience. Automatic feedback on correct movements during self-directed training on simulators might help new bronchoscopists learn how to handle the bronchoscope like an expert.

Research paper thumbnail of Diagnostic Accuracy and Safety of Semirigid Thoracoscopy in Exudative Pleural Effusions

Research paper thumbnail of Indagine under 40 e attività scientifica: i risultati della survey AIPO

Rassegna di Patologia dell'Apparato Respiratorio, Apr 15, 2019

La professione medica si basa, oltre che sulla pratica clinica quotidiana, sull’attivita di studi... more La professione medica si basa, oltre che sulla pratica clinica quotidiana, sull’attivita di studio e di ricerca: tale attivitaconsiste principalmente nella partecipazione a progetti di ricerca, nella stesura di articoli scientifici, nella partecipazione acorsi e congressi, sia come relatori che come discenti, e nell’avere un ruolo attivo all’interno di societa scientifiche. Tuttoquesto rientra nell’attivita scientifica, fondamentale nella nostra vita lavorativa poiche costituisce un momento importantedi crescita culturale, crescita di cui beneficiamo noi e la nostra pratica clinica quotidiana. (...)

Research paper thumbnail of Diagnosis and staging of lung cancer with the use of one single echoendoscope in both the trachea and the esophagus: A practical guide

Research paper thumbnail of Comparison between closed pleural biopsy and medical thoracoscopy for the diagnosis of undiagnosed exudative pleural effusions: a systematic review and meta-analysis

Translational Lung Cancer Research

Background: Exudative pleural effusion (EPE) is a common diagnostic challenge. The utility of med... more Background: Exudative pleural effusion (EPE) is a common diagnostic challenge. The utility of medical thoracoscopy (MT) and closed pleural biopsy (CPB) to aid in the diagnosis of EPE has been reported in many published studies. Herein, we perform a systematic review and meta-analysis to compare the diagnostic yield and safety of CPB and MT in EPE. Methods: Four databases were searched for studies reporting the diagnostic yield of CPB and MT for EPE. The quality of the included studies was evaluated according to the quality assessment of diagnostic accuracy studies (QUADAS) tool. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and complication risks were compared between the two groups. Results: Ten studies dealing with CPB and twenty-three studies dealing with MT for the diagnosis of EPE were included in this meta-analysis.

Research paper thumbnail of Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidisciplinary Respiratory Medicine

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of... more Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes. Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma. Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Results: Three patients were detected. TBLC described pathological abnormalities in peribronchiolar and alveolar spaces already well identified with SLB (surgical lung biopsy); the pathological information provided could be useful to better understand the pathobiology of the disease. Finally, we had no complications, confirming a satisfactory safety profile of TBLC. Conclusion: We suggest the potential role of TBLC in asthmatic patients: its safety and its acceptable diagnostic accuracy lead to consider this procedure instead of SLB when histological changes in lung parenchyma are needed for the differential diagnosis. Furthermore, TLBC could be useful for research in the pathobiology of asthma and severe asthma.

Research paper thumbnail of Diagnostic yield and safety of EUS-FNA biopsy in sub-aortic and para-aortic lymph node stations with the trans-aortic approach: a case series and literature review

European Clinical Respiratory Journal

Background: Sub-aortic (station 5) and para-aortic (station 6) lymph nodes are not easily accessi... more Background: Sub-aortic (station 5) and para-aortic (station 6) lymph nodes are not easily accessible due to the interposition of the aorta and the left pulmonary artery. Taking a biopsy from those stations could be of value when there are no other mediastinal lymph node stations or when biopsy in other sites failed to reach a diagnosis. Surgery is the gold standard technique in the evaluation of those stations; endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been proposed as a minimally invasive technique through the trans-aortic approach, with an acceptable diagnostic yield and safety profile. Objective: To evaluate diagnostic accuracy and safety of the trans-aortic EUS-FNA in lymph node stations 5 and 6. Methods: We reviewed all patients who underwent trans-aortic EUS-FNA from 2010 to 2017, for mediastinal lymph node enlargement or positron emission tomography/computed tomography (PET/CT) positivity (integrated 2-deoxy-2-fluoro-D-glucose). Demographic characteristics, lesion site and size, needle, final diagnosis, and complications were collected. Results: A total of 11 patients were included, 5 males, mean age 59 years. Samples were inadequate in two cases, a diagnosis of lung cancer was reached in four patients (two adenocarcinoma and two squamous cell carcinoma) and five cases were negative for malignancy (one confirmed by surgery, two were found to be cancer at percutaneous lung biopsy and transbronchial biopsy, one patient received a diagnosis of Langerhans cell histiocytosis by transbronchial lung cryobiopsy, and one patient was lost at follow-up). The sensitivity for malignancy was 57%, and the overall diagnostic accuracy was 45%. No complications occurred. Conclusions: Trans-aortic EUS-FNA could be proposed as a valuable and safe approach for taking biopsy from mediastinal lymph node stations 5 and 6.

Research paper thumbnail of Cryobiopsy: Physics

Transbronchial cryobiopsy in diffuse parenchymal lung disease

Research paper thumbnail of Report Standardization in Transbronchial Lung Cryobiopsy

Archives of Pathology & Laboratory Medicine