Colin Muirhead - Profile on Academia.edu (original) (raw)
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Papers by Colin Muirhead
Health Physics, 2013
AbstractVAnalyses of lung cancer risk were carried out using restrictions to nested case-control ... more AbstractVAnalyses of lung cancer risk were carried out using restrictions to nested case-control data on uranium miners in the Czech Republic, France, and Germany. With the data restricted to cumulative exposures below 300 working-level-months (WLM) and adjustment for smoking status, the excess relative risk (ERR) per WLM was 0.0174 (95% CI: 0.009Y0.035), compared to the estimate of 0.008 (95% CI: 0.004Y0.014) using the unrestricted data. Analysis of both the restricted and unrestricted data showed that time since exposure windows had a major effect; the ERR/WLM was six times higher for more recent exposures (5Y24 y) than for more distant exposures (25 y or more). Based on a linear model fitted to data on exposures G300 WLM, the ERR WLM j1 of lung cancer at 30 y after exposure was estimated to be 0.021 (95% CI: 0.011Y0.040), and the risks decreased by 47% per decade increase in time since exposure. The results from analyzing the joint effects of radon and smoking were consistent with a sub-multiplicative interaction; the ERR WLM j1 was greater for non-smokers compared with current or ex-smokers, although there was no statistically significant variation in the ERR WLM j1 by smoking status. The patterns of risk with radon exposure from the combined European nested case-control miner analysis were generally consistent with those based on the BEIR VI Exposure-Age-Concentration model. Based on conversions from WLM to time weighted averaged radon concentration (expressed per 100 Bq m j3 ), the results from this analysis of miner data were in agreement with those from the joint analysis of the European residential radon studies. Health Phys. 104(3):282Y292; 2013
Health Physics, 2013
AbstractVAnalyses of lung cancer risk were carried out using restrictions to nested case-control ... more AbstractVAnalyses of lung cancer risk were carried out using restrictions to nested case-control data on uranium miners in the Czech Republic, France, and Germany. With the data restricted to cumulative exposures below 300 working-level-months (WLM) and adjustment for smoking status, the excess relative risk (ERR) per WLM was 0.0174 (95% CI: 0.009Y0.035), compared to the estimate of 0.008 (95% CI: 0.004Y0.014) using the unrestricted data. Analysis of both the restricted and unrestricted data showed that time since exposure windows had a major effect; the ERR/WLM was six times higher for more recent exposures (5Y24 y) than for more distant exposures (25 y or more). Based on a linear model fitted to data on exposures G300 WLM, the ERR WLM j1 of lung cancer at 30 y after exposure was estimated to be 0.021 (95% CI: 0.011Y0.040), and the risks decreased by 47% per decade increase in time since exposure. The results from analyzing the joint effects of radon and smoking were consistent with a sub-multiplicative interaction; the ERR WLM j1 was greater for non-smokers compared with current or ex-smokers, although there was no statistically significant variation in the ERR WLM j1 by smoking status. The patterns of risk with radon exposure from the combined European nested case-control miner analysis were generally consistent with those based on the BEIR VI Exposure-Age-Concentration model. Based on conversions from WLM to time weighted averaged radon concentration (expressed per 100 Bq m j3 ), the results from this analysis of miner data were in agreement with those from the joint analysis of the European residential radon studies. Health Phys. 104(3):282Y292; 2013