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Posttraumatic Stress Disorder (PTSD) is associated with mild-to-moderate deficits in neurocogniti... more Posttraumatic Stress Disorder (PTSD) is associated with mild-to-moderate deficits in neurocognitive functioning. Single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) gene, namely, the Met allele, may also be associated with mild deficits in neurocognitive functioning. However, findings are inconsistent and may be sensitive to environmental epigenetic moderators such as psychopathology. The current study analyzed data from European-American U.S. military veterans (n = 1,244) who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Multivariate analyses of covariances were conducted to evaluate the unique and interactive effects of the Met allele and probable PTSD on objective and subjective neurocognitive functioning. Significant (p ≤ .001) interactions between Met allele carrier status and probable PTSD were observed in objective (ηp2 = .028) and subjective neurocognitive functioning (ηp2 = .029). In individuals without...
Psychoneuroendocrinology, Aug 1, 2022
Conclusions: Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on... more Conclusions: Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on long-term cardiac outcomes were found in ACS.
International Journal of Geriatric Psychiatry, Feb 1, 2023
Neurobiology of Learning and Memory
International Journal of Geriatric Psychiatry
The Clinical psychologist, 2020
Assessment
Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) are commonly comorbi... more Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) are commonly comorbid and share prominent features (e.g., intrusions, safety behaviors, and avoidance). Excellent self-report and clinician-administered assessments exist for OCD and PTSD individually, but few assess both disorders, and even fewer provide instruction on differential diagnosis or detection of comorbid OCD and PTSD. To address this gap in the literature, the current paper aims to (1) highlight diagnostic and functional similarities and differences between OCD and PTSD to inform differential diagnosis, (2) outline assessment recommendations for individuals with suspected comorbid OCD and PTSD, OCD with a significant trauma history or posttraumatic symptoms, or PTSD with significant obsessive-compulsive symptoms, and (3) explore future directions to evaluate and improve methods for assessing co-occurring OCD and PTSD.
Posttraumatic Stress Disorder (PTSD) is associated with mild-to-moderate deficits in neurocogniti... more Posttraumatic Stress Disorder (PTSD) is associated with mild-to-moderate deficits in neurocognitive functioning. Single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF) gene, namely, the Met allele, may also be associated with mild deficits in neurocognitive functioning. However, findings are inconsistent and may be sensitive to environmental epigenetic moderators such as psychopathology. The current study analyzed data from European-American U.S. military veterans (n = 1,244) who participated in the 2011 National Health and Resilience in Veterans Study (NHRVS). Multivariate analyses of covariances were conducted to evaluate the unique and interactive effects of the Met allele and probable PTSD on objective and subjective neurocognitive functioning. Significant (p ≤ .001) interactions between Met allele carrier status and probable PTSD were observed in objective (ηp2 = .028) and subjective neurocognitive functioning (ηp2 = .029). In individuals without...
Psychoneuroendocrinology, Aug 1, 2022
Conclusions: Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on... more Conclusions: Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on long-term cardiac outcomes were found in ACS.
International Journal of Geriatric Psychiatry, Feb 1, 2023
Neurobiology of Learning and Memory
International Journal of Geriatric Psychiatry
The Clinical psychologist, 2020
Assessment
Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) are commonly comorbi... more Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) are commonly comorbid and share prominent features (e.g., intrusions, safety behaviors, and avoidance). Excellent self-report and clinician-administered assessments exist for OCD and PTSD individually, but few assess both disorders, and even fewer provide instruction on differential diagnosis or detection of comorbid OCD and PTSD. To address this gap in the literature, the current paper aims to (1) highlight diagnostic and functional similarities and differences between OCD and PTSD to inform differential diagnosis, (2) outline assessment recommendations for individuals with suspected comorbid OCD and PTSD, OCD with a significant trauma history or posttraumatic symptoms, or PTSD with significant obsessive-compulsive symptoms, and (3) explore future directions to evaluate and improve methods for assessing co-occurring OCD and PTSD.