Connor Pyles - Academia.edu (original) (raw)

Papers by Connor Pyles

Research paper thumbnail of Monitoring at-home prosthesis control improvements through real-time data logging

Journal of Neural Engineering

Objective. Validating the ability for advanced prostheses to improve function beyond the laborato... more Objective. Validating the ability for advanced prostheses to improve function beyond the laboratory remains a critical step in enabling long-term benefits for prosthetic limb users. Approach. A nine week take-home case study was completed with a single participant with upper limb amputation and osseointegration to better understand how an advanced prosthesis is used during daily activities. The participant was already an expert prosthesis user and used the Modular Prosthetic Limb (MPL) at home during the study. The MPL was controlled using wireless electromyography (EMG) pattern recognition-based movement decoding. Clinical assessments were performed before and after the take-home portion of the study. Data was recorded using an onboard data log in order to measure daily prosthesis usage, sensor data, and EMG data. Main results. The participant’s continuous prosthesis usage steadily increased (p= 0.04, max = 5.5 h) over time and over 30% of the total time was spent actively controll...

Research paper thumbnail of Novel Measurement of Intradiscal Pressure in Underbody Blast Simulation

Volume 3: Biomedical and Biotechnology Engineering, 2016

Underbody Blast (UBB) events subject vehicle occupants to large accelerations that often result i... more Underbody Blast (UBB) events subject vehicle occupants to large accelerations that often result in severe lumbar spine injury. Little knowledge exists on the intervertebral disc response during high-rate vertical accelerative loading. To address this gap, the current study investigates intradiscal pressures under UBB loading utilizing biomechanical testing from: 1) isolated Post Mortem Human Surrogate (PMHS) lumbar spine motion segments (LMS) in a custom-designed drop tower fixture; and 2) whole body (WHBO) PMHS in a custom-designed Vertically Accelerated Load Transfer System. During testing, intradiscal pressures were comparable between the LMS and WHBO tests, with non-fracture cases producing higher average peak pressures than fractured tests. Additionally, WHBO testing demonstrated that upper body posture can influence lumbar pressure responses. The current study evaluates lumbar intradiscal pressure transduction as it relates to vertebral fracture in both component and whole bod...

Research paper thumbnail of Experimental Characterization of the Anatomical Structures of the Lumbar Spine Under Dynamic Sagittal Bending

Biomedical sciences instrumentation, 2015

Underbody blast (UBB) events transmit high-rate vertical loads through the seated occupant’s lumb... more Underbody blast (UBB) events transmit high-rate vertical loads through the seated occupant’s lumbar spine and have a high probability of inducing severe injury. While previous studies have characterized the lumbar spine under quasi-static loading, additional work should focus on the complex kinetic and kinematic response under high loading rates. To discern the biomechanical influence of the lumbar spine’s anatomical structures during dynamic loading, the axial force, flexion-extension moments and range of motion for lumbar motion segments (n=18) were measured during different states of progressive dissection. Pre-compression was applied using a static mass while dynamic bending was applied using an offset drop mass. Dynamic loading resulted in peak axial loads of 4,224±133 N, while maximum peak extension and flexion moments were 19.6±12.5 and -44.8±8.6 Nm in the pre-dissected state, respectively. Upon dissection, transection of the interspinous ligament, ligamentum flavum and facet...

Research paper thumbnail of Material Parameter Determination of an L4-L5 Motion Segment Finite Element Model Under High Loading Rates

Biomedical sciences instrumentation, Jan 10, 2015

he objective of the present study was to derive injury probability curves applicable to the Hybri... more he objective of the present study was to derive injury probability curves applicable to the Hybrid III dummy (also termed the Anthropomorphic Test Device, ATD) lower leg under axial impacts for military applications. A matched-pair approach was used. Axial impacts were delivered to below knee foot-ankle complex preparations of the lower leg of the ATD using pendulum and custom vertical accelerator devices. Military boot was used in some tests. Post mortem human surrogate (PMHS) preparations were used as matched-pair tests for injury outcomes. The alignment was such that the foot-ankle complex was orthogonal to the leg (below knee tibia-fibula complex), termed as the normal 90-90 posture. Injury outcomes from the biological surrogate focused on calcaneus and or distal tibia fractures with or without the involvement of articular surfaces. Peak lower tibia load cell forces were obtained from matched-pair dummy tests. Injury and force data were paired, censoring was assigned based on in...

Research paper thumbnail of Longitudinal Tibia Stress Fracture Risk During High-Volume Training: A Multiscale Modeling Pipeline Incorporating Bone Remodeling

Journal of Biomechanical Engineering

Tibia stress fractures are prevalent during high-intensity training, yet a mechanistic model link... more Tibia stress fractures are prevalent during high-intensity training, yet a mechanistic model linking longitudinal training intensity, bone health, and long-term injury risk has yet to be demonstrated. The objective of this study was to develop and validate a multiscale model of gross and tissue level loading on the tibia including bone remodeling on a timescale of week. Peak tensile tibial strain (3517 μstrain) during 4 m/s running was below injury thresholds, and the peak anteromedial tibial strain (1248 μstrain) was 0.17 standard deviations away from the mean of reported literature values. An initial study isolated the effects of cortical density and stiffness on tibial strain during a simulated eight week training period. Tibial strains and cortical microcracking correlated with initial cortical modulus, with all simulations presenting peak anteromedial tensile strains (1047–1600 μstrain) near day 11. Average cortical densities decreased by 7–8% of their nominal value by day 11, ...

Research paper thumbnail of E-textile based modular sEMG suit for large area level of effort analysis

Scientific Reports

We present a novel design for an e-textile based surface electromyography (sEMG) suit that incorp... more We present a novel design for an e-textile based surface electromyography (sEMG) suit that incorporates stretchable conductive textiles as electrodes and interconnects within an athletic compression garment. The fabrication and assembly approach is a facile combination of laser cutting and heat-press lamination that provides for rapid prototyping of designs in a typical research environment without need for any specialized textile or garment manufacturing equipment. The materials used are robust to wear, resilient to the high strains encountered in clothing, and can be machine laundered. The suit produces sEMG signal quality comparable to conventional adhesive electrodes, but with improved comfort, longevity, and reusability. The embedded electronics provide signal conditioning, amplification, digitization, and processing power to convert the raw EMG signals to a level-of-effort estimation for flexion and extension of the elbow and knee joints. The approach we detail herein is also ...

Research paper thumbnail of Applications of Pose Estimation in Human Health and Performance across the Lifespan

Sensors

The emergence of pose estimation algorithms represents a potential paradigm shift in the study an... more The emergence of pose estimation algorithms represents a potential paradigm shift in the study and assessment of human movement. Human pose estimation algorithms leverage advances in computer vision to track human movement automatically from simple videos recorded using common household devices with relatively low-cost cameras (e.g., smartphones, tablets, laptop computers). In our view, these technologies offer clear and exciting potential to make measurement of human movement substantially more accessible; for example, a clinician could perform a quantitative motor assessment directly in a patient’s home, a researcher without access to expensive motion capture equipment could analyze movement kinematics using a smartphone video, and a coach could evaluate player performance with video recordings directly from the field. In this review, we combine expertise and perspectives from physical therapy, speech-language pathology, movement science, and engineering to provide insight into ap...

Research paper thumbnail of Augmented Reality–Based Rehabilitation of Gait Impairments: Case Report

JMIR mHealth and uHealth

Background Gait and balance impairments are common in neurological diseases, including stroke, an... more Background Gait and balance impairments are common in neurological diseases, including stroke, and negatively affect patients’ quality of life. Improving balance and gait are among the main goals of rehabilitation. Rehabilitation is mainly performed in clinics, which lack context specificity; therefore, training in the patient’s home environment is preferable. In the last decade, developed rehabilitation technologies such as virtual reality and augmented reality (AR) have enabled gait and balance training outside clinics. Here, we propose a new method for gait rehabilitation in persons who have had a stroke in which mobile AR technology and a sensor-based motion capture system are combined to provide fine-grained feedback on gait performance in real time. Objective The aims of this study were (1) to investigate manipulation of the gait pattern of persons who have had a stroke based on virtual augmentation during overground walking compared to walking without AR performance feedback ...

Research paper thumbnail of Warrior Injury Assessment Manikin (WIAMan) Lumbar Spine Model Validation: Development, Testing, and Analysis of Physical and Computational Models of the WIAMan Lumbar Spine Materials Demonstrator

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188),

Research paper thumbnail of Expression of DDR1 and DDR2 in Peripheral Blood

Research paper thumbnail of Monitoring at-home prosthesis control improvements through real-time data logging

Journal of Neural Engineering

Objective. Validating the ability for advanced prostheses to improve function beyond the laborato... more Objective. Validating the ability for advanced prostheses to improve function beyond the laboratory remains a critical step in enabling long-term benefits for prosthetic limb users. Approach. A nine week take-home case study was completed with a single participant with upper limb amputation and osseointegration to better understand how an advanced prosthesis is used during daily activities. The participant was already an expert prosthesis user and used the Modular Prosthetic Limb (MPL) at home during the study. The MPL was controlled using wireless electromyography (EMG) pattern recognition-based movement decoding. Clinical assessments were performed before and after the take-home portion of the study. Data was recorded using an onboard data log in order to measure daily prosthesis usage, sensor data, and EMG data. Main results. The participant’s continuous prosthesis usage steadily increased (p= 0.04, max = 5.5 h) over time and over 30% of the total time was spent actively controll...

Research paper thumbnail of Novel Measurement of Intradiscal Pressure in Underbody Blast Simulation

Volume 3: Biomedical and Biotechnology Engineering, 2016

Underbody Blast (UBB) events subject vehicle occupants to large accelerations that often result i... more Underbody Blast (UBB) events subject vehicle occupants to large accelerations that often result in severe lumbar spine injury. Little knowledge exists on the intervertebral disc response during high-rate vertical accelerative loading. To address this gap, the current study investigates intradiscal pressures under UBB loading utilizing biomechanical testing from: 1) isolated Post Mortem Human Surrogate (PMHS) lumbar spine motion segments (LMS) in a custom-designed drop tower fixture; and 2) whole body (WHBO) PMHS in a custom-designed Vertically Accelerated Load Transfer System. During testing, intradiscal pressures were comparable between the LMS and WHBO tests, with non-fracture cases producing higher average peak pressures than fractured tests. Additionally, WHBO testing demonstrated that upper body posture can influence lumbar pressure responses. The current study evaluates lumbar intradiscal pressure transduction as it relates to vertebral fracture in both component and whole bod...

Research paper thumbnail of Experimental Characterization of the Anatomical Structures of the Lumbar Spine Under Dynamic Sagittal Bending

Biomedical sciences instrumentation, 2015

Underbody blast (UBB) events transmit high-rate vertical loads through the seated occupant’s lumb... more Underbody blast (UBB) events transmit high-rate vertical loads through the seated occupant’s lumbar spine and have a high probability of inducing severe injury. While previous studies have characterized the lumbar spine under quasi-static loading, additional work should focus on the complex kinetic and kinematic response under high loading rates. To discern the biomechanical influence of the lumbar spine’s anatomical structures during dynamic loading, the axial force, flexion-extension moments and range of motion for lumbar motion segments (n=18) were measured during different states of progressive dissection. Pre-compression was applied using a static mass while dynamic bending was applied using an offset drop mass. Dynamic loading resulted in peak axial loads of 4,224±133 N, while maximum peak extension and flexion moments were 19.6±12.5 and -44.8±8.6 Nm in the pre-dissected state, respectively. Upon dissection, transection of the interspinous ligament, ligamentum flavum and facet...

Research paper thumbnail of Material Parameter Determination of an L4-L5 Motion Segment Finite Element Model Under High Loading Rates

Biomedical sciences instrumentation, Jan 10, 2015

he objective of the present study was to derive injury probability curves applicable to the Hybri... more he objective of the present study was to derive injury probability curves applicable to the Hybrid III dummy (also termed the Anthropomorphic Test Device, ATD) lower leg under axial impacts for military applications. A matched-pair approach was used. Axial impacts were delivered to below knee foot-ankle complex preparations of the lower leg of the ATD using pendulum and custom vertical accelerator devices. Military boot was used in some tests. Post mortem human surrogate (PMHS) preparations were used as matched-pair tests for injury outcomes. The alignment was such that the foot-ankle complex was orthogonal to the leg (below knee tibia-fibula complex), termed as the normal 90-90 posture. Injury outcomes from the biological surrogate focused on calcaneus and or distal tibia fractures with or without the involvement of articular surfaces. Peak lower tibia load cell forces were obtained from matched-pair dummy tests. Injury and force data were paired, censoring was assigned based on in...

Research paper thumbnail of Longitudinal Tibia Stress Fracture Risk During High-Volume Training: A Multiscale Modeling Pipeline Incorporating Bone Remodeling

Journal of Biomechanical Engineering

Tibia stress fractures are prevalent during high-intensity training, yet a mechanistic model link... more Tibia stress fractures are prevalent during high-intensity training, yet a mechanistic model linking longitudinal training intensity, bone health, and long-term injury risk has yet to be demonstrated. The objective of this study was to develop and validate a multiscale model of gross and tissue level loading on the tibia including bone remodeling on a timescale of week. Peak tensile tibial strain (3517 μstrain) during 4 m/s running was below injury thresholds, and the peak anteromedial tibial strain (1248 μstrain) was 0.17 standard deviations away from the mean of reported literature values. An initial study isolated the effects of cortical density and stiffness on tibial strain during a simulated eight week training period. Tibial strains and cortical microcracking correlated with initial cortical modulus, with all simulations presenting peak anteromedial tensile strains (1047–1600 μstrain) near day 11. Average cortical densities decreased by 7–8% of their nominal value by day 11, ...

Research paper thumbnail of E-textile based modular sEMG suit for large area level of effort analysis

Scientific Reports

We present a novel design for an e-textile based surface electromyography (sEMG) suit that incorp... more We present a novel design for an e-textile based surface electromyography (sEMG) suit that incorporates stretchable conductive textiles as electrodes and interconnects within an athletic compression garment. The fabrication and assembly approach is a facile combination of laser cutting and heat-press lamination that provides for rapid prototyping of designs in a typical research environment without need for any specialized textile or garment manufacturing equipment. The materials used are robust to wear, resilient to the high strains encountered in clothing, and can be machine laundered. The suit produces sEMG signal quality comparable to conventional adhesive electrodes, but with improved comfort, longevity, and reusability. The embedded electronics provide signal conditioning, amplification, digitization, and processing power to convert the raw EMG signals to a level-of-effort estimation for flexion and extension of the elbow and knee joints. The approach we detail herein is also ...

Research paper thumbnail of Applications of Pose Estimation in Human Health and Performance across the Lifespan

Sensors

The emergence of pose estimation algorithms represents a potential paradigm shift in the study an... more The emergence of pose estimation algorithms represents a potential paradigm shift in the study and assessment of human movement. Human pose estimation algorithms leverage advances in computer vision to track human movement automatically from simple videos recorded using common household devices with relatively low-cost cameras (e.g., smartphones, tablets, laptop computers). In our view, these technologies offer clear and exciting potential to make measurement of human movement substantially more accessible; for example, a clinician could perform a quantitative motor assessment directly in a patient’s home, a researcher without access to expensive motion capture equipment could analyze movement kinematics using a smartphone video, and a coach could evaluate player performance with video recordings directly from the field. In this review, we combine expertise and perspectives from physical therapy, speech-language pathology, movement science, and engineering to provide insight into ap...

Research paper thumbnail of Augmented Reality–Based Rehabilitation of Gait Impairments: Case Report

JMIR mHealth and uHealth

Background Gait and balance impairments are common in neurological diseases, including stroke, an... more Background Gait and balance impairments are common in neurological diseases, including stroke, and negatively affect patients’ quality of life. Improving balance and gait are among the main goals of rehabilitation. Rehabilitation is mainly performed in clinics, which lack context specificity; therefore, training in the patient’s home environment is preferable. In the last decade, developed rehabilitation technologies such as virtual reality and augmented reality (AR) have enabled gait and balance training outside clinics. Here, we propose a new method for gait rehabilitation in persons who have had a stroke in which mobile AR technology and a sensor-based motion capture system are combined to provide fine-grained feedback on gait performance in real time. Objective The aims of this study were (1) to investigate manipulation of the gait pattern of persons who have had a stroke based on virtual augmentation during overground walking compared to walking without AR performance feedback ...

Research paper thumbnail of Warrior Injury Assessment Manikin (WIAMan) Lumbar Spine Model Validation: Development, Testing, and Analysis of Physical and Computational Models of the WIAMan Lumbar Spine Materials Demonstrator

Public reporting burden for this collection of information is estimated to average 1 hour per res... more Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188),

Research paper thumbnail of Expression of DDR1 and DDR2 in Peripheral Blood