Consuelo Morgado-valle - Academia.edu (original) (raw)

Papers by Consuelo Morgado-valle

$Research paper thumbnail of Fractal and multifractal characterization of in vitro respiratory recordings of the pre-Bötzinger complex$

Advances in Experimental Medicine and Biology

Sleep Disorders

Neuroglobin (Ngb) is a protein member of the globin family, expressed mainly in the central and p... more Neuroglobin (Ngb) is a protein member of the globin family, expressed mainly in the central and peripheral nervous system. It is involved in the transport of oxygen in response to hypoxic/ischemic and oxidative stress-related insults. We recently showed that sleep deprivation reduces the number of Ngb-positive cells in brain areas related to sleep. However, it is poorly understood whether Ngb expression correlates with sleep occurrence. Here, we aimed to study if sleep recovery produced by 24 h of sleep deprivation restores the number of Ngb-positive cells in the pedunculopontine tegmentum (PPTg) and laterodorsal tegmentum (LDTg), brain areas related to sleep-wake regulation. Male Wistar rats were sleep-deprived for 24 h using the gentle handling method. After sleep deprivation, rats were allowed a sleep recovery for three or six hours. After sleep recovery, rats were euthanized, and their brains processed for Ngb immunohistochemistry. We found that a 3 h sleep recovery is enough to...

Journal of Molecular Neuroscience

Advances in experimental medicine and biology, 2017

The mechanisms responsible for the onset of respiratory activity during fetal life are unknown. T... more The mechanisms responsible for the onset of respiratory activity during fetal life are unknown. The onset of respiratory rhythm may be a consequence of the genetic program of each of the constituents of the respiratory network, so they start to interact and generate respiratory cycles when reaching a certain degree of maturation. Alternatively, generation of cycles might require the contribution of recently formed sensory inputs that will trigger oscillatory activity in the nascent respiratory neural network. If this hypothesis is true, then sensory input to the respiratory generator must be already formed and become functional before the onset of fetal respiration. In this review, we evaluate the timing of the onset of the respiratory rhythm in comparison to the appearance of receptors, neurotransmitter machinery, and afferent projections provided by two central chemoreceptive nuclei, the raphe and locus coeruleus nuclei.

PeerJ, 2016

Background Epidemiological evidence indicates epilepsy is more common in patients with autism spe... more Background Epidemiological evidence indicates epilepsy is more common in patients with autism spectrum disorders (ASD) (20–25%) than in the general population. The aim of this project was to analyze seizure susceptibility in developing rats prenatally exposed to valproic acid (VPA) as autism model. Methods Pregnant females were injected with VPA during the twelfth embryonic day. Seizures were induced in fourteen-days-old rat pups using two models of convulsions: pentylenetetrazole (PTZ) and lithium-pilocarpine (Li-Pilo). Results Two subgroups with different PTZ-induced seizure susceptibility in rats exposed to VPA were found: a high susceptibility (VPA+) (28/42, seizure severity 5) and a low susceptibility (VPA−) (14/42, seizure severity 2). The VPA+ subgroup exhibited an increased duration of the generalized tonic-clonic seizure (GTCS; 45 ± 2.7 min), a higher number of rats showed several GTCS (14/28) and developed status epilepticus (SE) after PTZ injection (19/27) compared with c...

Neurobiology of Aging, 1995

Dopamine agonists or grafts compensate impaired motor functions in aged rats. However, there is n... more Dopamine agonists or grafts compensate impaired motor functions in aged rats. However, there is no evidence showing whether grafting in adulthood retard aging manifestations. Motor performance of 13-month-old rats was tested on 2 meter-long wooden beams which had a 15 degree inclination and whose thickness varied from 3, 6, 12, 18, to 24 mm. Rats at 14 months were randomly assigned to 3 groups: sham graft (Group 1); intrastriatal graft of chromaffin cells cultured with NGF (Group 2); intrastriatal graft of chromaffin cells (Group 3). Motor performance was tested at monthly intervals up until rats were 26 months old. Two more groups were included: 26-month-old naive rats (Group 4); and 3- to 5-month-old naive rats (Group 5) both evaluated only once. At 26 months, the basal activity of ventral mesencephalic dopaminergic neurons was recorded. Results showed in Group 2 delay of motor detriments seen in aged rats, maintenance of basal firing rates of nigral cells compared to those of younger rats, and greater survival of substantia nigra cells. It is suggested that NGF cultured chromaffin cells produce a delay of motor detriments in aged rats, as a result of inducing survival and firing rates of nigral cells comparable to those seen in young rats.

Neurobiology of aging, Dec 31, 1995

Autism is a disorder characterized by three basic deficits: verbal, communicative and affective; ... more Autism is a disorder characterized by three basic deficits: verbal, communicative and affective; it is accompanied by obsessive behaviors and persists throughout life. In the past it was considered a rare disorder but now its incidence has increased considerably; this has led to speculation and the need of information for both, parents and physicians. Aspects such as diagnosis and psychological treatment have been elucidated, but others such as etiology and genetic and neurological alterations remain ambiguous and are a matter of intensive research. The aim of this review is to explore the main myths around autistic children such as: "they are gifted kids", "they are mentally retarded", "it is because of a vaccine," "it will be relieved when they grow up", "prescription drugs are a good cure," "it is inherited", "the autistic cannot fend for themselves", among others, and based on the actual information reject or confirm such myths.

Recibido: 03 de febrero de 2015 Aceptado: 11 de marzo 2015 Puedes encontrar este artículo en: Res... more Recibido: 03 de febrero de 2015 Aceptado: 11 de marzo 2015 Puedes encontrar este artículo en: Resumen Entre las funciones fisiológicas clásicamente atribuidas al cerebelo se encuentra el control del movimiento, la postura y el equilibrio. Los estudios clínicos como los realizados en modelos animales, indican que el cerebelo también participa en la coordinación de movimientos finos, la respuesta ocular, la memoria motora, e incluso la conducta sexual. El cerebelo también ha mostrado ser importante en la etiología de enfermedades del sistema nervioso central, tales como las ataxias cerebelosas y el autismo. Sin embargo, la relación entre la epilepsia y el cerebelo ha sido menos explorada. Por lo tanto, esta revisión recopila y discute los estudios que indican cómo las crisis epilépticas afectan al cerebelo, así como el posible papel modulador de éste en la epilepsia. Abstract Movement control, posture and equilibrium are some physiological functions classically attributed to cerebellu...

Archives of medical research, 1997

Levels of DARP in the cerebrospinal fluid (CSF) of patients having a wide variety of neurological... more Levels of DARP in the cerebrospinal fluid (CSF) of patients having a wide variety of neurological disorders were determined. Neurological disorders were categorized as degenerative, demyelinating, epilepsy, trauma, hydrocephalia, inflammatory, A-V malformation, CNS neoplasia, parasitic and stroke. DARP levels were determined by an enzyme-linked immunoabsorbent assay (ELISA) using monoclonal anti-DARP antibodies. A synthetic peptide corresponding to the first 36 aa of the N-terminal of DARP was used as standard. A total of 7 non-neurological patients and 73 patients with neurological disorders were tested. The relative concentrations of DARP decreased in patients with Parkinson's diseases vs. patients with non-neurological diseases and increased in other neuropathologies such as demyelinating, hydrocephalia and A-V malformations. Data obtained suggest that changes in the percentage and concentration of DARP may correlate with certain neurological disorders, showing particularly l...

Smith, 1999; Smith et al., 1991; Thoby-Brisson and Ramirez, 2001). Synaptically isolated preBö tC... more Smith, 1999; Smith et al., 1991; Thoby-Brisson and Ramirez, 2001). Synaptically isolated preBö tC pacemaker Systems Neurobiology Laboratory Department of Neurobiology neurons generate repeating cycles of transient bursts of impulses separated by longer-lasting quiescent inter-University of California-Los Angeles Box 95-1763 vals, which are due to voltage-dependent membrane properties (Butera et al., 1999a; Thoby-Brisson and Ra-Los Angeles, California 90095 mirez, 2001). The frequency and duration of these cellular bursts are similar to the frequency and duration of the respiratory-related motor output generated by the Summary intact network in vitro (Johnson et al., 1994). Predictions following from mathematical models of rhythmically ac-We tested the hypothesis that pacemaker neurons generate breathing rhythm in mammals. We monitored tive networks of voltage-dependent pacemaker neurons (Butera et al., 1999a, 1999b), when evaluated experimen-respiratory-related motor nerve rhythm in neonatal rodent slice preparations. Blockade of the persistent tally (Del Negro et al., 2001), also produce results consistent with the pacemaker hypothesis. Consequently, sodium current (I NaP ), which was postulated to underlie voltage-dependent bursting in respiratory pacemaker voltage-dependent pacemaker neurons are favored candidates for the critical respiratory rhythm-generating neurons, with riluzole (Յ200 M) did not alter the frequency of respiratory-related motor output. Yet, in ev-cells contained in the preBö tC (Ballanyi et al., 1999; Koshiya and Smith, 1999; Rekling and Feldman, 1998; ery pacemaker neuron recorded (50/50), bursting was abolished at much lower concentrations of riluzole Richter and Spyer, 2001).