Corrado Marini - Academia.edu (original) (raw)

Papers by Corrado Marini

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Cirugía Española (English Edition)

Official Journal of the Italian Society of Psychopathology, Mar 1, 2015

Objective To report a case of neuroleptic nalignant syndrome (NMS) in a young woman who survived ... more Objective To report a case of neuroleptic nalignant syndrome (NMS) in a young woman who survived the acute stage that gradually resolved after 3 months. Afterward she developed a chronic motor disability that was resistant to pharmacological treatment. Case summary Mrs C.A. is 30-year-old Caucasian woman with mental disability and bipolar disorder type I. In October 2013, she presented with very severe behavioural abnormalities and was treated with intensification of therapy with quetiapine 300 mg TID, haloperidol 4 mg TID, paliperidone 6 mg OD, and fluphenazine decanoate 25 mg i.m. once every 21 days, clonazepam 1 mg OD and lorazepam 2.5 mg OD. In December 2013 extrapyramidal effects developed and hospital admission was necessary. Neuroleptic therapy was immediately stopped. After a few days, fever appeared with consciousness disorders and high levels of creatine kinase. Laboratory tests and imaging studies with negative results were performed. A diagnosis of NMS was made and she received supportive and specific therapy with dantrolene, diazepam, baclofen, rotigotine and L-Dopa. After 3 months, Mrs. C.A. survived NMS but she showed chronic rigidity and mutism. She was transferred to an intensive neurorehabilitation centre. Discussion The peculiarity of this case is pre-existing central nervous system (CNS) abnormality and atypical symptoms of NMS at presentation. Her mental disability, the use of polypharmacy and longacting drug likely contributed to the long duration of NMS and its sequelae. Conclusion In a patient with extrapyramidal symptoms associated with fever and pre-existing CNS abnormalities and mental disability, particular attention must be given to the use of polypharmacy.

Journal of the American College of Surgeons, 2021

Journal of the American College of Surgeons, 2021

Current Problems in Surgery, 2021

European Journal of Trauma and Emergency Surgery, 2020

Introduction Current treatment guidelines for patients with severe TBI (sTBI) are aimed at preven... more Introduction Current treatment guidelines for patients with severe TBI (sTBI) are aimed at preventing secondary brain injury targeting specific endpoints of intracranial physiology to avoid the development of metabolic crisis. We sought to identify factors contributing to development of metabolic crisis in the setting of a Multi-modality Monitoring and Goal-Directed Therapy (MM&GDTP) approach to patients with severe TBI. Methods Prospective monitoring of sTBI patients was performed, with retrospective data analysis. MM&GDTP was targeted to intracranial pressure (ICP) ≤ 20 mmHg, cerebral perfusion pressure (CPP) ≥ 60 mmHg, brain tissue oxygen pressure (PbtO 2) ≥ 20 mmHg, and cerebral oxygen extraction measured by bi-frontal Near infrared Spectroscopy (NIRS) > 55%. Brain flow abnormality was defined by one of the following combinations: CPP < 60 mmHg with NIRS < 55% (Type 1), CPP < 60 mmHg with PbtO 2 < 20 mmHg (Type 2), or PbtO 2 < 20 mmHg with NIRS < 55% (Type 3). Cerebral micro-dialysate was analyzed hourly for glucose, lactate, pyruvate, glutamate, glycerol, and lactate/pyruvate ratio (LPR). Statistical analysis was performed with student t-test, chi-square and Pearson's tests as applicable. Results A total of 109,474 consecutive minutes of recorded multimodality monitoring was available for analysis. There was a significant difference in the number of minutes of brain flow abnormalities between survivors and non-survivors: 0.8% (875) versus 7.49% (8,199), respectively (p < 0.05). The duration of Type 1-3 flow abnormality per patient was higher in non-survivors (5.7 ± 2.5 h) compared to survivors (0.7 ± 0.6 h) as well as the duration of metabolic crisis, namely, 5.2 ± 2.2 versus 0.6 ± 1.0 h per patient. The occurrence of severe metabolic crisis was associated with a Type 2 flow abnormality (CPP < 60 mmHg and PbtO 2 < 20 mmHg), r = 0.97, p < 0.001, but not with Type 1 and 3. Conclusions Metabolic crisis can occur despite a MM&GDTP approach aimed at optimizing cerebral blood flow. Severe metabolic crisis is associated to failure to maintain CPP and PbtO 2 above 60 and 20 mmHg, respectively. The occurrence of severe metabolic crisis portends a poor prognosis in patients with sTBI.

European Journal of Trauma and Emergency Surgery, 2017

Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA + PRP, MRSA + Vancomyc... more Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA + PRP, MRSA + Vancomycin, and MRSA + Vancomycin + PRP groups. We inoculated 0.1 mL (3 × 10 8 CFU/mL) of MRSA in contaminated groups. After 8 days, all rats were killed, wounds were excised and subjected to histopathologic examination, and MRSA counts were determined. Results MRSA counts in MRSA, MRSA + PRP, MRSA + Vancomycin and MRSA + Vancomycin + PRP groups were 5.1 × 10 6 (SD ± 0.4) CFU/mL, 4.3 × 10 6 (SD ± 0.7) CFU/mL, 2.3 × 10 6 (SD ± 0.3) CFU/mL, 1.1 × 10 6 (SD ± 0.4) CFU/mL, respectively. The inflammation scores

Implant dentistry, 2018

The main objective of this study, involving 11 patients, is to share our experience on an integra... more The main objective of this study, involving 11 patients, is to share our experience on an integrated treatment modality, namely, the use of cellular therapy simultaneously with surgical reconstruction. Published works show that the implantation of monocytes in ischemic tissue enhances healing by providing neo-angiogenesis, a key mechanism in tissue regenerative processes. Our approach included the utilization of autologous monocytes and endothelial precursor cells in the bone graft itself to improve the success rate of the integration of the bone graft and its long-term viability/survival by promoting angiogenesis. We compared the standard regenerative procedures, namely sinus lift grafting performed with xenogeneic particle bone graft and posterior mandible grafting performed with on-lay or in-lay autologous cortical/medullary bone-block graft harvested from the iliac crest, with and without the use of cellular implementation. We evaluated results by both radiological and histologi...

Vascular Surgery, 1990

... Anastomosis: Etiology, Growth Rate, and Prevention Su Wang, MS Samir Basu, MD Sharon Thomsen,... more ... Anastomosis: Etiology, Growth Rate, and Prevention Su Wang, MS Samir Basu, MD Sharon Thomsen, MD Corrado Marini, MD Lenny Tachmes, MD Israel J. Jacobowitz, MD and Joseph N. Cunningham, Jr., MD BROOKLYN, NEW YORK and HOUSTON, TEXAS ...

Cirugía Española (English Edition), 2017

Abstract Pancreatic injury is an uncommon event often difficult to diagnose at an early stage. Af... more Abstract Pancreatic injury is an uncommon event often difficult to diagnose at an early stage. After abdominal trauma, the surgeon must always be aware of the possibility of pancreatic trauma due to the complications associated with missed pancreatic injuries. Due to its retroperitoneal position, associated organs and vascular injuries are almost always present, which along with frequent extra abdominal injuries explain the high morbidity and mortality. The aim of this study is to present a concise description of the incidence of these injuries, lesional mechanisms, recommended diagnostic methods, therapeutic indications including nonoperative management, endoscopy and surgery, and an analysis of pancreas-specific complications and mortality rates in these patients based on a 60-year review of the literature, encompassing 6364 patients. Due to pancreatic retroperitoneal position, associated organs and vascular injuries are almost always present, which along with frequent extraaabdominal injuries explain the high morbidity and mortality of these patients.

European Journal of Trauma and Emergency Surgery, 2017

Materials and methods Articles in the English language between January 2006 and July 2016 on trau... more Materials and methods Articles in the English language between January 2006 and July 2016 on trauma during pregnancy were identified using the following key words: trauma and pregnancy, blunt trauma, penetrating wound, injury during pregnancy, motor vehicle accident/crash, falls, assault, interpersonal violence, fetal monitoring, perimortem cesarean section, obstetrical patient, pregnant trauma patient, and mortality and pregnancy. Results Of the 200 articles identified, 51 were included in this study for a total of 95,949 patients. Blunt trauma is the most common mechanism of trauma among pregnant women accounting for 69% of the total number of traumas, whereas penetrating trauma accounts for only 1.5% of episodes of trauma during pregnancy. In 37 articles reviewed herein, MVC is not only the most common but also the most life-threatening of mechanisms on injury. Mortality occurred in 100 of 728 (13.7%) mothers

Injury, 2017

Traumatic esophageal injuries occur less than 10% of the time in the setting of blunt or penetrat... more Traumatic esophageal injuries occur less than 10% of the time in the setting of blunt or penetrating trauma. The purpose of this literature review is to provide an update on the most recent changes involving the diagnosis and treatment of esophageal injuries. A literature search was conducted using PubMed, to identify articles written in English language with the terms "noniatrogenic", "esophageal", "trauma", "diagnosis", "management", and "prognosis". Case reports and articles involving nontraumatic esophageal perforations were excluded. Fifty pertinent articles in English language from 1947 to 2015 were selected for review. Based on the review of all articles, we designed a diagnostic and therapeutic algorithm to facilitate the diagnosis and management of the traumatic esophageal injury.

Current Problems in Surgery, 2017

Journal of Trauma and Acute Care Surgery, 2017

[

Cirugía Española (English Edition)

Official Journal of the Italian Society of Psychopathology, Mar 1, 2015

Objective To report a case of neuroleptic nalignant syndrome (NMS) in a young woman who survived ... more Objective To report a case of neuroleptic nalignant syndrome (NMS) in a young woman who survived the acute stage that gradually resolved after 3 months. Afterward she developed a chronic motor disability that was resistant to pharmacological treatment. Case summary Mrs C.A. is 30-year-old Caucasian woman with mental disability and bipolar disorder type I. In October 2013, she presented with very severe behavioural abnormalities and was treated with intensification of therapy with quetiapine 300 mg TID, haloperidol 4 mg TID, paliperidone 6 mg OD, and fluphenazine decanoate 25 mg i.m. once every 21 days, clonazepam 1 mg OD and lorazepam 2.5 mg OD. In December 2013 extrapyramidal effects developed and hospital admission was necessary. Neuroleptic therapy was immediately stopped. After a few days, fever appeared with consciousness disorders and high levels of creatine kinase. Laboratory tests and imaging studies with negative results were performed. A diagnosis of NMS was made and she received supportive and specific therapy with dantrolene, diazepam, baclofen, rotigotine and L-Dopa. After 3 months, Mrs. C.A. survived NMS but she showed chronic rigidity and mutism. She was transferred to an intensive neurorehabilitation centre. Discussion The peculiarity of this case is pre-existing central nervous system (CNS) abnormality and atypical symptoms of NMS at presentation. Her mental disability, the use of polypharmacy and longacting drug likely contributed to the long duration of NMS and its sequelae. Conclusion In a patient with extrapyramidal symptoms associated with fever and pre-existing CNS abnormalities and mental disability, particular attention must be given to the use of polypharmacy.

Journal of the American College of Surgeons, 2021

Journal of the American College of Surgeons, 2021

Current Problems in Surgery, 2021

European Journal of Trauma and Emergency Surgery, 2020

Introduction Current treatment guidelines for patients with severe TBI (sTBI) are aimed at preven... more Introduction Current treatment guidelines for patients with severe TBI (sTBI) are aimed at preventing secondary brain injury targeting specific endpoints of intracranial physiology to avoid the development of metabolic crisis. We sought to identify factors contributing to development of metabolic crisis in the setting of a Multi-modality Monitoring and Goal-Directed Therapy (MM&GDTP) approach to patients with severe TBI. Methods Prospective monitoring of sTBI patients was performed, with retrospective data analysis. MM&GDTP was targeted to intracranial pressure (ICP) ≤ 20 mmHg, cerebral perfusion pressure (CPP) ≥ 60 mmHg, brain tissue oxygen pressure (PbtO 2) ≥ 20 mmHg, and cerebral oxygen extraction measured by bi-frontal Near infrared Spectroscopy (NIRS) > 55%. Brain flow abnormality was defined by one of the following combinations: CPP < 60 mmHg with NIRS < 55% (Type 1), CPP < 60 mmHg with PbtO 2 < 20 mmHg (Type 2), or PbtO 2 < 20 mmHg with NIRS < 55% (Type 3). Cerebral micro-dialysate was analyzed hourly for glucose, lactate, pyruvate, glutamate, glycerol, and lactate/pyruvate ratio (LPR). Statistical analysis was performed with student t-test, chi-square and Pearson's tests as applicable. Results A total of 109,474 consecutive minutes of recorded multimodality monitoring was available for analysis. There was a significant difference in the number of minutes of brain flow abnormalities between survivors and non-survivors: 0.8% (875) versus 7.49% (8,199), respectively (p < 0.05). The duration of Type 1-3 flow abnormality per patient was higher in non-survivors (5.7 ± 2.5 h) compared to survivors (0.7 ± 0.6 h) as well as the duration of metabolic crisis, namely, 5.2 ± 2.2 versus 0.6 ± 1.0 h per patient. The occurrence of severe metabolic crisis was associated with a Type 2 flow abnormality (CPP < 60 mmHg and PbtO 2 < 20 mmHg), r = 0.97, p < 0.001, but not with Type 1 and 3. Conclusions Metabolic crisis can occur despite a MM&GDTP approach aimed at optimizing cerebral blood flow. Severe metabolic crisis is associated to failure to maintain CPP and PbtO 2 above 60 and 20 mmHg, respectively. The occurrence of severe metabolic crisis portends a poor prognosis in patients with sTBI.

European Journal of Trauma and Emergency Surgery, 2017

Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA + PRP, MRSA + Vancomyc... more Study groups comprised of Sham (no treatment), PRP alone, MRSA alone, MRSA + PRP, MRSA + Vancomycin, and MRSA + Vancomycin + PRP groups. We inoculated 0.1 mL (3 × 10 8 CFU/mL) of MRSA in contaminated groups. After 8 days, all rats were killed, wounds were excised and subjected to histopathologic examination, and MRSA counts were determined. Results MRSA counts in MRSA, MRSA + PRP, MRSA + Vancomycin and MRSA + Vancomycin + PRP groups were 5.1 × 10 6 (SD ± 0.4) CFU/mL, 4.3 × 10 6 (SD ± 0.7) CFU/mL, 2.3 × 10 6 (SD ± 0.3) CFU/mL, 1.1 × 10 6 (SD ± 0.4) CFU/mL, respectively. The inflammation scores

Implant dentistry, 2018

The main objective of this study, involving 11 patients, is to share our experience on an integra... more The main objective of this study, involving 11 patients, is to share our experience on an integrated treatment modality, namely, the use of cellular therapy simultaneously with surgical reconstruction. Published works show that the implantation of monocytes in ischemic tissue enhances healing by providing neo-angiogenesis, a key mechanism in tissue regenerative processes. Our approach included the utilization of autologous monocytes and endothelial precursor cells in the bone graft itself to improve the success rate of the integration of the bone graft and its long-term viability/survival by promoting angiogenesis. We compared the standard regenerative procedures, namely sinus lift grafting performed with xenogeneic particle bone graft and posterior mandible grafting performed with on-lay or in-lay autologous cortical/medullary bone-block graft harvested from the iliac crest, with and without the use of cellular implementation. We evaluated results by both radiological and histologi...

Vascular Surgery, 1990

... Anastomosis: Etiology, Growth Rate, and Prevention Su Wang, MS Samir Basu, MD Sharon Thomsen,... more ... Anastomosis: Etiology, Growth Rate, and Prevention Su Wang, MS Samir Basu, MD Sharon Thomsen, MD Corrado Marini, MD Lenny Tachmes, MD Israel J. Jacobowitz, MD and Joseph N. Cunningham, Jr., MD BROOKLYN, NEW YORK and HOUSTON, TEXAS ...

Cirugía Española (English Edition), 2017

Abstract Pancreatic injury is an uncommon event often difficult to diagnose at an early stage. Af... more Abstract Pancreatic injury is an uncommon event often difficult to diagnose at an early stage. After abdominal trauma, the surgeon must always be aware of the possibility of pancreatic trauma due to the complications associated with missed pancreatic injuries. Due to its retroperitoneal position, associated organs and vascular injuries are almost always present, which along with frequent extra abdominal injuries explain the high morbidity and mortality. The aim of this study is to present a concise description of the incidence of these injuries, lesional mechanisms, recommended diagnostic methods, therapeutic indications including nonoperative management, endoscopy and surgery, and an analysis of pancreas-specific complications and mortality rates in these patients based on a 60-year review of the literature, encompassing 6364 patients. Due to pancreatic retroperitoneal position, associated organs and vascular injuries are almost always present, which along with frequent extraaabdominal injuries explain the high morbidity and mortality of these patients.

European Journal of Trauma and Emergency Surgery, 2017

Materials and methods Articles in the English language between January 2006 and July 2016 on trau... more Materials and methods Articles in the English language between January 2006 and July 2016 on trauma during pregnancy were identified using the following key words: trauma and pregnancy, blunt trauma, penetrating wound, injury during pregnancy, motor vehicle accident/crash, falls, assault, interpersonal violence, fetal monitoring, perimortem cesarean section, obstetrical patient, pregnant trauma patient, and mortality and pregnancy. Results Of the 200 articles identified, 51 were included in this study for a total of 95,949 patients. Blunt trauma is the most common mechanism of trauma among pregnant women accounting for 69% of the total number of traumas, whereas penetrating trauma accounts for only 1.5% of episodes of trauma during pregnancy. In 37 articles reviewed herein, MVC is not only the most common but also the most life-threatening of mechanisms on injury. Mortality occurred in 100 of 728 (13.7%) mothers

Injury, 2017

Traumatic esophageal injuries occur less than 10% of the time in the setting of blunt or penetrat... more Traumatic esophageal injuries occur less than 10% of the time in the setting of blunt or penetrating trauma. The purpose of this literature review is to provide an update on the most recent changes involving the diagnosis and treatment of esophageal injuries. A literature search was conducted using PubMed, to identify articles written in English language with the terms "noniatrogenic", "esophageal", "trauma", "diagnosis", "management", and "prognosis". Case reports and articles involving nontraumatic esophageal perforations were excluded. Fifty pertinent articles in English language from 1947 to 2015 were selected for review. Based on the review of all articles, we designed a diagnostic and therapeutic algorithm to facilitate the diagnosis and management of the traumatic esophageal injury.

Current Problems in Surgery, 2017

Journal of Trauma and Acute Care Surgery, 2017