Cristiana Simionescu - Academia.edu (original) (raw)
Papers by Cristiana Simionescu
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of th... more The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of the global Antiphospholipid Antibody Syndrome (APS), focusing the pregnancy morbidity. OAAS is generating morphopathological changes in almost all components of the gestational biologic transitory system (GBTS): placenta, umbilical cord or uterine wall. The most important, serious and lengthened anomalies are occuring in placenta. Our research has been developed on a group of 68 patients diagnosed with OAAS, initially using the Sapporo criteria and later using the "Sydney" ones. There have been morphopathologically examined: placenta, umbilical cord and myometrium. Histological examination revealed on one hand macroscopic modifications: fibrinoid deposits, white or red placental infarctions, intervillous thrombosis, marginal or basal decidual hematoma, calcareous deposits, umbilical cord thrombosis, and on the other hand microscopic findings: placental infarction, fibrinoid necro...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2011
Warthin tumor is the second most common benign tumors of the parotid gland, after pleomorphic ade... more Warthin tumor is the second most common benign tumors of the parotid gland, after pleomorphic adenoma. Our study was performed on 21 cases with Warthin tumor diagnosed between 2005-2010, which were analyzed clinically, histologically and immunohistochemically, using anti-CD20 and anti-CD45RO antibodies. The analysis of age distribution within the investigated cases indicated that Warthin tumor incidence is increasing in the seventh decade of life, most patients being male (M/F 5/2). Histopathological, the analysis report of stroma÷parenchyma in 14 cases revealed a balanced distribution of the two components, in four cases, the epithelial component was predominant and in three cases, the stromal component was predominant. Immunohistochemical study for the two specific lymphocyte proliferation markers indicated positivity for both epithelial component and stroma. Cell layout of CD45RO and CD20cy at the level of lymphoid stroma had a similar pattern with normal or reactive lymph nodes.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2012
UNLABELLED The research focused on a systematic review of 959 cases operated for uterine fibromyo... more UNLABELLED The research focused on a systematic review of 959 cases operated for uterine fibromyoma (24.8%) from 3859 gynecological surgeries performed over a period of 10 years (2000-2010). MATERIALS AND METHODS The important parameters were those related to the general clinical and laboratory data, and especially those focused on the macro- and microscopic histopathological diagnostic methods. Thus, we inserted some details on the methods used for the histopathological examination of surgically removed samples. RESULTS The age of patients operated for uterine fibromyoma was between 20 and 60 years, with the highest incidence in the 40-50 years group (594 cases--62.4%). The most frequent anatomo-clinical forms observed were uterine fibromyoma with menometrorrhagia (78.9%), large uterine fibromyoma associated with compression and metrorrhagia (81.1%), uterine fibromyoma with aseptic necrobiosis (33.6%). The other forms showed a reduced frequency. Uterine fibromyoma associated with i...
REALITIES AND PERSPECTIVES IN EARLY DIAGNOSIS OF LUNG CANCER IN GORJ COUNTY Scientific coordinato... more REALITIES AND PERSPECTIVES IN EARLY DIAGNOSIS OF LUNG CANCER IN GORJ COUNTY Scientific coordinator: Professor CRISTIANA SIMIONESCU, PhD PhD Student: VLAD ELENA
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
Recent studies revealed that CD105 is intensively expressed in tumor vasculature, and may be an i... more Recent studies revealed that CD105 is intensively expressed in tumor vasculature, and may be an important prognostic indicator for the outcome in a number of malignancies. The aim of our study was to evaluate the CD105 expression and microvessel density in oral squamous cell carcinoma (OSCC). Nineteen surgical specimens with OSCC were immunohistochemical analyzed with CD105 (Endoglin). We determined the microvessel density (MVD) by "hot spot method". Endoglin was intensively expressed in vessels from the inner and invading front of all investigated OSCC. The highest value of MVD, about 30.89 +/- 22.4, were record in peritumoral area of OSCC, since intratumoral MVD average was about 10.18 +/- 4.7. We did not observe any significant association of MVD with age, sex, primary tumor's location, clinical stage or differentiation grade. In conclusion, CD105 expression is up-regulated in OSCC, and has a significant role in the development of such malignancies.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2010
Although a series of premalignant or potentially malignant lesions are described in the tongue, t... more Although a series of premalignant or potentially malignant lesions are described in the tongue, there are many other lesions whose potential of degeneration can be determined by a prolonged action of irritant or carcinogenic factors. Even if they are practically considered to be harmless, benign formations of mesenchymal origin with lingual location represent in the same time a neoplastic lesion under the influence of local and general factors, for a variable period of time. When these structures are located in major risk areas from the oral cavity and in particular, those directly related to the tongue, special attention should be paid to their development. In this study (conducted on a total of 16 cases of benign mesenchymal malignancies), we planned a histopathological evaluation of surgical excision samples obtained from interventions on lingual neoplasias, and harvested from areas with the highest risk for lingual cancer development (pelvilingual groove, the base of the tongue ...
The early gastric cancer is an endoscopic notion in which gastric cancer is strictly placed to mu... more The early gastric cancer is an endoscopic notion in which gastric cancer is strictly placed to mucosis and submucosis without extensive manifestations. It is the form with favorable prognosis and better survival at 5 and 10 years. Our study tries to systematize the debut forms of early gastric cancer and their association with the lesions with malignisation risk. We also try to evaluate the incidence of endoscopic and histopathologic forms of early gastric cancer found in an internal medicine division. Our study included 435 patients with gastric cancer endoscopic and histologic diagnosed. Statistically, 64.36% were men and 35.64% were women, the mean age 48 +/- 7 years. The endoscopic forms of early gastric cancer were type I: protruded in 19 cases, type II: superficially in eight cases, type III: excavated in six cases. Early gastric cancer is diagnosed with difficulty, it represents in 7.58% of the gastric cancer, being most frequently asymptomatic. The endoscopic forms frequentl...
We present a retrospective hystopathological study which comprised a number of 23 endometrial car... more We present a retrospective hystopathological study which comprised a number of 23 endometrial carcinomas, hospitalised and operated in the Gynecology Clinics of the Emergency Hospital of Craiova. We have analysed the following aspects of the previous mentioned cases: the average age at diagnosis, the tumoral grading, the miometrial penetration degree and the existence of the local or loco-regional invasion. The correlation of the differentiation level with that of the tumoral progression allowed us to observe the fact that while the well differentiated invasive endometroide adenocarcinomas were limited at the level of the uterine body, the moderated and the poorly differentiated ones associated, in some cases, beside cervical invasion and metastasis in structures situated at some distance, a deep myometrial invasion.
Basal cell carcinomas (BCC) make up about 90% of malignant tumors of the eyelids. Although they a... more Basal cell carcinomas (BCC) make up about 90% of malignant tumors of the eyelids. Although they are generally slow-growing tumors, in the periocular region can cause significant morbidity due to orbital invasion. In the present study we followed the associations between the various types of BCC with the depth of invasion, respectively the Breslow stage (BS) and with the pT category. The study included a number of 92 cases of eyelid BCC from the Plastic Surgery and Ophthalmology Departments of the Craiova County Emergency Clinical Hospital which were processed and diagnosed in the Pathological Laboratory of the same hospital. Histopathological analysis of the 92 BCCs indicated that in 72 cases the tumors were composed of a single growth pattern, and in 20 cases they were composite, associating two or more growth patterns. The cases with a single growth pattern corresponded in 53 cases of nodular BCC, in 9 cases of infiltrative BCC, in 2 cases of superficial BCC and in 8 cases of micr...
UNLABELLED The CA19-9 antigen is a tumoral marker that can be found in high concentration within ... more UNLABELLED The CA19-9 antigen is a tumoral marker that can be found in high concentration within a maligned digestive pathology. OBJECTIVE Study of CA19-9 antigen from the immunological point of view, at the patients with pancreatic cancer, and his relation with the histopathological aspects. MATERIAL AND METHOD The determinations have been done at the time of the diagnosis and after the treatment of the patients with pancreatic cancer (25). METHOD indirect ELISA. RESULTS The values of the CA19-9 marker have been increased at the time of the diagnosis either in pancreatic cancer of the head and mid. At the moment of the diagnosis the CA19-9 marker has higher values (150-400 U/ml) in cancer of the pancreatic body than in cancer of the head of the pancreas (40-200 U/ml). Correlating the size of the tumor with the value of the CA19-9 marker in the case of pancreatic cancer we have been shown the highest serum values (300-400 U/ml) at patients whose tumor was 3 cm bigger. Four weeks pos...
The study includes 16 cases of Warthin’s tumor in a period of 4 years (2004-2008). The tumors wer... more The study includes 16 cases of Warthin’s tumor in a period of 4 years (2004-2008). The tumors were diagnosed at patients of VII decade, most of them smoker. The studies of Warthin’s tumor macroscopic morphological parameters allow us to establish the localization exclusive at parotid glands like solitary tumor and the tumoral volume oscillate mostly between 2-4 cm in diameter. Histopathologically we notice the prevalence of typical tumor forms, with balanced raport epithelium / stroma. In this study we have found in 10 cases typical forms, in 4 cases the prevalence of epithelium component and in 2 cases the prevalence of stroma component.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2010
In this paper, we studied 15 cases of early rheumatoid arthritis presenting with inflammatory les... more In this paper, we studied 15 cases of early rheumatoid arthritis presenting with inflammatory lesions in different degrees of evolution. We want to highlight B- and T-lymphocytes in synovial tissue collected from patients diagnosed with early rheumatoid arthritis, to establish the pattern of their distribution, possibly in relation to local neovascularisation to determine the role played by these types of cells. The pathological samples were represented by synovial membrane biopsy fragments, which were examined by histopathological and immunohistochemical methods. We noticed a perivascular distribution of lymphocyte infiltrate, up to formation of lymphoid follicles with germinal centers. There is a close interdependence between B- and T-lymphocytes in these lesions, and their presence in the synovial membrane in relation to newly formed blood vessels facilitates their action and their chemical mediators. Studying the interdependence of different types of lymphocytes and their connec...
Ultrasound in Obstetrics & Gynecology
Basal cell carcinoma (BCC) is a malignant tumor with slow extension and local malignancy, with an... more Basal cell carcinoma (BCC) is a malignant tumor with slow extension and local malignancy, with an exceptionally rare metastatic potential. BCC incidence is continuously increasing and there are geographical variations, the highest values being reported in Australia. The following are involved in BCC pathogenesis: actinic radiation, ionizing radiation, genetic factor, chemical carcinogens, immunosuppression, smoking etc. Actinic radiation is the main etiologic factor. There are multiple mechanisms of photocar-cinogenesis, without being fully elucidated yet. Changing the attitudes towards the sun (tanning fashion), increased life expectancy and the presence of immunosuppression (organ transplant, HIV / AIDS) are factors that will further contribue to the increased incidence of BCC. Rezumat Carcinomul bazocelular (CBC) este o tumoră cu extensie lentă şi malignitate locală, având potențial excepțional de rar de metastazare. Incidența CBC este în continuă creștere și există variații geog...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2006
This paper analyzes 18 endometrial carcinomas with different degrees of differentiation, the obje... more This paper analyzes 18 endometrial carcinomas with different degrees of differentiation, the objective being to estimate involvement of p53 oncoprotein in the mechanism of endometrial carcinogenesis and the possible correlations with the tumoral proliferative activity evaluated by PCNA. The p53 immunoexpression was positive in 44.4% of the studied endometrial carcinomas, divided in three groups, the intensity of the immunostaining for p53 being increased for the low differentiated and undifferentiated endometrial carcinomas, whereas the differentiated endometrial carcinomas were moderate or low p53 positive. All the investigated tumors were PCNA positive, the PCNA index being of 40% in well-differentiated carcinomas, while in low differentiated and undifferentiated endometrial carcinomas the medium values of PCNA were of 60%, respectively 85%. Correlating the p53 and PCNA findings, we noted that PCNA was expressed especially in the cases with increased proliferative activity, withou...
Chirurgia (Bucharest, Romania : 1990)
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of th... more The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of the global Antiphospholipid Antibody Syndrome (APS), focusing the pregnancy morbidity. OAAS is generating morphopathological changes in almost all components of the gestational biologic transitory system (GBTS): placenta, umbilical cord or uterine wall. The most important, serious and lengthened anomalies are occuring in placenta. Our research has been developed on a group of 68 patients diagnosed with OAAS, initially using the Sapporo criteria and later using the "Sydney" ones. There have been morphopathologically examined: placenta, umbilical cord and myometrium. Histological examination revealed on one hand macroscopic modifications: fibrinoid deposits, white or red placental infarctions, intervillous thrombosis, marginal or basal decidual hematoma, calcareous deposits, umbilical cord thrombosis, and on the other hand microscopic findings: placental infarction, fibrinoid necro...
APMIS, 1989
... analysis of lung tumors: Description of a convenient technique for use with fine needle biops... more ... analysis of lung tumors: Description of a convenient technique for use with fine needle biopsy HANS NORDGREN1, STEN NILSSON\ ANN ... of non-Hodgkin type, which was im-possible to subclassify according to the Kiel classi-fication (21) and the Luke-Collins nomenclature (22 ...
More than 90% of malignant neoplasms of the oral cavity are squamous carcinomas of oral mucosa an... more More than 90% of malignant neoplasms of the oral cavity are squamous carcinomas of oral mucosa and most are conventional type. This study included 60 cases of oral squamous carcinoma processed by usual histological technique and stained with Hematoxylin-Eosin and Alcian Blue-Safranin (Alcian Blue powder from Sigma Aldrich, code A5268-25G) and diagnosed in the Department of Pathology, University of Medicine and Pharmacy of Craiova. Double immunohistochemical (CD105-tryptase, VEGF-, VEGFR1-, VEGFR2-tryptase) or combined histochemical and immunohistochemical reactions (VEGF÷ VEGFR1÷ VEGFR2÷Alcian Blue-Safranin) followed the particular morphological aspects of the mast cells, their relation with the blood vessels and the overlap signal of tryptase and Alcian Blue-Safranin÷VEGF and its R1 and R2 receptors in mast cells. Immunostaining for VEGF and its R1 and R2 receptors was present both in tumor cells and mast cells. Double immunohistochemical-histochemical reactions allowed us angiogen...
Romanian Journal of Morphology and Embryology Revue Roumaine De Morphologie Et Embryologie, 2012
The study included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data p... more The study included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data processing was followed by histopathological and immunohistochemical analysis, following the expression of p53, Bcl-2 and Ki67 in the tumor epithelial compartments. Lesions predominated in the age range 20-40 years, to male gender, being located mainly in the mandible (88.2%). Typical follicular ameloblastoma was present in 70.6% of analyzed tumors. P53 and Bcl-2 immunoexpression was identified especially in the peripheral cells, the number of marked cells being over 50%, while the percentage of positive cells from the stellate reticulum was below 10%. The Ki67 positivity index was below 10% in both compartments. Squamous and granular cells reveal no stain for the investigated markers. Peripheral columnar cells are active compartment of ameloblastomas being involved in the processes of proliferation-apoptosis.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of th... more The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of the global Antiphospholipid Antibody Syndrome (APS), focusing the pregnancy morbidity. OAAS is generating morphopathological changes in almost all components of the gestational biologic transitory system (GBTS): placenta, umbilical cord or uterine wall. The most important, serious and lengthened anomalies are occuring in placenta. Our research has been developed on a group of 68 patients diagnosed with OAAS, initially using the Sapporo criteria and later using the "Sydney" ones. There have been morphopathologically examined: placenta, umbilical cord and myometrium. Histological examination revealed on one hand macroscopic modifications: fibrinoid deposits, white or red placental infarctions, intervillous thrombosis, marginal or basal decidual hematoma, calcareous deposits, umbilical cord thrombosis, and on the other hand microscopic findings: placental infarction, fibrinoid necro...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2011
Warthin tumor is the second most common benign tumors of the parotid gland, after pleomorphic ade... more Warthin tumor is the second most common benign tumors of the parotid gland, after pleomorphic adenoma. Our study was performed on 21 cases with Warthin tumor diagnosed between 2005-2010, which were analyzed clinically, histologically and immunohistochemically, using anti-CD20 and anti-CD45RO antibodies. The analysis of age distribution within the investigated cases indicated that Warthin tumor incidence is increasing in the seventh decade of life, most patients being male (M/F 5/2). Histopathological, the analysis report of stroma÷parenchyma in 14 cases revealed a balanced distribution of the two components, in four cases, the epithelial component was predominant and in three cases, the stromal component was predominant. Immunohistochemical study for the two specific lymphocyte proliferation markers indicated positivity for both epithelial component and stroma. Cell layout of CD45RO and CD20cy at the level of lymphoid stroma had a similar pattern with normal or reactive lymph nodes.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2012
UNLABELLED The research focused on a systematic review of 959 cases operated for uterine fibromyo... more UNLABELLED The research focused on a systematic review of 959 cases operated for uterine fibromyoma (24.8%) from 3859 gynecological surgeries performed over a period of 10 years (2000-2010). MATERIALS AND METHODS The important parameters were those related to the general clinical and laboratory data, and especially those focused on the macro- and microscopic histopathological diagnostic methods. Thus, we inserted some details on the methods used for the histopathological examination of surgically removed samples. RESULTS The age of patients operated for uterine fibromyoma was between 20 and 60 years, with the highest incidence in the 40-50 years group (594 cases--62.4%). The most frequent anatomo-clinical forms observed were uterine fibromyoma with menometrorrhagia (78.9%), large uterine fibromyoma associated with compression and metrorrhagia (81.1%), uterine fibromyoma with aseptic necrobiosis (33.6%). The other forms showed a reduced frequency. Uterine fibromyoma associated with i...
REALITIES AND PERSPECTIVES IN EARLY DIAGNOSIS OF LUNG CANCER IN GORJ COUNTY Scientific coordinato... more REALITIES AND PERSPECTIVES IN EARLY DIAGNOSIS OF LUNG CANCER IN GORJ COUNTY Scientific coordinator: Professor CRISTIANA SIMIONESCU, PhD PhD Student: VLAD ELENA
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
Recent studies revealed that CD105 is intensively expressed in tumor vasculature, and may be an i... more Recent studies revealed that CD105 is intensively expressed in tumor vasculature, and may be an important prognostic indicator for the outcome in a number of malignancies. The aim of our study was to evaluate the CD105 expression and microvessel density in oral squamous cell carcinoma (OSCC). Nineteen surgical specimens with OSCC were immunohistochemical analyzed with CD105 (Endoglin). We determined the microvessel density (MVD) by "hot spot method". Endoglin was intensively expressed in vessels from the inner and invading front of all investigated OSCC. The highest value of MVD, about 30.89 +/- 22.4, were record in peritumoral area of OSCC, since intratumoral MVD average was about 10.18 +/- 4.7. We did not observe any significant association of MVD with age, sex, primary tumor's location, clinical stage or differentiation grade. In conclusion, CD105 expression is up-regulated in OSCC, and has a significant role in the development of such malignancies.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2010
Although a series of premalignant or potentially malignant lesions are described in the tongue, t... more Although a series of premalignant or potentially malignant lesions are described in the tongue, there are many other lesions whose potential of degeneration can be determined by a prolonged action of irritant or carcinogenic factors. Even if they are practically considered to be harmless, benign formations of mesenchymal origin with lingual location represent in the same time a neoplastic lesion under the influence of local and general factors, for a variable period of time. When these structures are located in major risk areas from the oral cavity and in particular, those directly related to the tongue, special attention should be paid to their development. In this study (conducted on a total of 16 cases of benign mesenchymal malignancies), we planned a histopathological evaluation of surgical excision samples obtained from interventions on lingual neoplasias, and harvested from areas with the highest risk for lingual cancer development (pelvilingual groove, the base of the tongue ...
The early gastric cancer is an endoscopic notion in which gastric cancer is strictly placed to mu... more The early gastric cancer is an endoscopic notion in which gastric cancer is strictly placed to mucosis and submucosis without extensive manifestations. It is the form with favorable prognosis and better survival at 5 and 10 years. Our study tries to systematize the debut forms of early gastric cancer and their association with the lesions with malignisation risk. We also try to evaluate the incidence of endoscopic and histopathologic forms of early gastric cancer found in an internal medicine division. Our study included 435 patients with gastric cancer endoscopic and histologic diagnosed. Statistically, 64.36% were men and 35.64% were women, the mean age 48 +/- 7 years. The endoscopic forms of early gastric cancer were type I: protruded in 19 cases, type II: superficially in eight cases, type III: excavated in six cases. Early gastric cancer is diagnosed with difficulty, it represents in 7.58% of the gastric cancer, being most frequently asymptomatic. The endoscopic forms frequentl...
We present a retrospective hystopathological study which comprised a number of 23 endometrial car... more We present a retrospective hystopathological study which comprised a number of 23 endometrial carcinomas, hospitalised and operated in the Gynecology Clinics of the Emergency Hospital of Craiova. We have analysed the following aspects of the previous mentioned cases: the average age at diagnosis, the tumoral grading, the miometrial penetration degree and the existence of the local or loco-regional invasion. The correlation of the differentiation level with that of the tumoral progression allowed us to observe the fact that while the well differentiated invasive endometroide adenocarcinomas were limited at the level of the uterine body, the moderated and the poorly differentiated ones associated, in some cases, beside cervical invasion and metastasis in structures situated at some distance, a deep myometrial invasion.
Basal cell carcinomas (BCC) make up about 90% of malignant tumors of the eyelids. Although they a... more Basal cell carcinomas (BCC) make up about 90% of malignant tumors of the eyelids. Although they are generally slow-growing tumors, in the periocular region can cause significant morbidity due to orbital invasion. In the present study we followed the associations between the various types of BCC with the depth of invasion, respectively the Breslow stage (BS) and with the pT category. The study included a number of 92 cases of eyelid BCC from the Plastic Surgery and Ophthalmology Departments of the Craiova County Emergency Clinical Hospital which were processed and diagnosed in the Pathological Laboratory of the same hospital. Histopathological analysis of the 92 BCCs indicated that in 72 cases the tumors were composed of a single growth pattern, and in 20 cases they were composite, associating two or more growth patterns. The cases with a single growth pattern corresponded in 53 cases of nodular BCC, in 9 cases of infiltrative BCC, in 2 cases of superficial BCC and in 8 cases of micr...
UNLABELLED The CA19-9 antigen is a tumoral marker that can be found in high concentration within ... more UNLABELLED The CA19-9 antigen is a tumoral marker that can be found in high concentration within a maligned digestive pathology. OBJECTIVE Study of CA19-9 antigen from the immunological point of view, at the patients with pancreatic cancer, and his relation with the histopathological aspects. MATERIAL AND METHOD The determinations have been done at the time of the diagnosis and after the treatment of the patients with pancreatic cancer (25). METHOD indirect ELISA. RESULTS The values of the CA19-9 marker have been increased at the time of the diagnosis either in pancreatic cancer of the head and mid. At the moment of the diagnosis the CA19-9 marker has higher values (150-400 U/ml) in cancer of the pancreatic body than in cancer of the head of the pancreas (40-200 U/ml). Correlating the size of the tumor with the value of the CA19-9 marker in the case of pancreatic cancer we have been shown the highest serum values (300-400 U/ml) at patients whose tumor was 3 cm bigger. Four weeks pos...
The study includes 16 cases of Warthin’s tumor in a period of 4 years (2004-2008). The tumors wer... more The study includes 16 cases of Warthin’s tumor in a period of 4 years (2004-2008). The tumors were diagnosed at patients of VII decade, most of them smoker. The studies of Warthin’s tumor macroscopic morphological parameters allow us to establish the localization exclusive at parotid glands like solitary tumor and the tumoral volume oscillate mostly between 2-4 cm in diameter. Histopathologically we notice the prevalence of typical tumor forms, with balanced raport epithelium / stroma. In this study we have found in 10 cases typical forms, in 4 cases the prevalence of epithelium component and in 2 cases the prevalence of stroma component.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2010
In this paper, we studied 15 cases of early rheumatoid arthritis presenting with inflammatory les... more In this paper, we studied 15 cases of early rheumatoid arthritis presenting with inflammatory lesions in different degrees of evolution. We want to highlight B- and T-lymphocytes in synovial tissue collected from patients diagnosed with early rheumatoid arthritis, to establish the pattern of their distribution, possibly in relation to local neovascularisation to determine the role played by these types of cells. The pathological samples were represented by synovial membrane biopsy fragments, which were examined by histopathological and immunohistochemical methods. We noticed a perivascular distribution of lymphocyte infiltrate, up to formation of lymphoid follicles with germinal centers. There is a close interdependence between B- and T-lymphocytes in these lesions, and their presence in the synovial membrane in relation to newly formed blood vessels facilitates their action and their chemical mediators. Studying the interdependence of different types of lymphocytes and their connec...
Ultrasound in Obstetrics & Gynecology
Basal cell carcinoma (BCC) is a malignant tumor with slow extension and local malignancy, with an... more Basal cell carcinoma (BCC) is a malignant tumor with slow extension and local malignancy, with an exceptionally rare metastatic potential. BCC incidence is continuously increasing and there are geographical variations, the highest values being reported in Australia. The following are involved in BCC pathogenesis: actinic radiation, ionizing radiation, genetic factor, chemical carcinogens, immunosuppression, smoking etc. Actinic radiation is the main etiologic factor. There are multiple mechanisms of photocar-cinogenesis, without being fully elucidated yet. Changing the attitudes towards the sun (tanning fashion), increased life expectancy and the presence of immunosuppression (organ transplant, HIV / AIDS) are factors that will further contribue to the increased incidence of BCC. Rezumat Carcinomul bazocelular (CBC) este o tumoră cu extensie lentă şi malignitate locală, având potențial excepțional de rar de metastazare. Incidența CBC este în continuă creștere și există variații geog...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2006
This paper analyzes 18 endometrial carcinomas with different degrees of differentiation, the obje... more This paper analyzes 18 endometrial carcinomas with different degrees of differentiation, the objective being to estimate involvement of p53 oncoprotein in the mechanism of endometrial carcinogenesis and the possible correlations with the tumoral proliferative activity evaluated by PCNA. The p53 immunoexpression was positive in 44.4% of the studied endometrial carcinomas, divided in three groups, the intensity of the immunostaining for p53 being increased for the low differentiated and undifferentiated endometrial carcinomas, whereas the differentiated endometrial carcinomas were moderate or low p53 positive. All the investigated tumors were PCNA positive, the PCNA index being of 40% in well-differentiated carcinomas, while in low differentiated and undifferentiated endometrial carcinomas the medium values of PCNA were of 60%, respectively 85%. Correlating the p53 and PCNA findings, we noted that PCNA was expressed especially in the cases with increased proliferative activity, withou...
Chirurgia (Bucharest, Romania : 1990)
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2008
The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of th... more The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of the global Antiphospholipid Antibody Syndrome (APS), focusing the pregnancy morbidity. OAAS is generating morphopathological changes in almost all components of the gestational biologic transitory system (GBTS): placenta, umbilical cord or uterine wall. The most important, serious and lengthened anomalies are occuring in placenta. Our research has been developed on a group of 68 patients diagnosed with OAAS, initially using the Sapporo criteria and later using the "Sydney" ones. There have been morphopathologically examined: placenta, umbilical cord and myometrium. Histological examination revealed on one hand macroscopic modifications: fibrinoid deposits, white or red placental infarctions, intervillous thrombosis, marginal or basal decidual hematoma, calcareous deposits, umbilical cord thrombosis, and on the other hand microscopic findings: placental infarction, fibrinoid necro...
APMIS, 1989
... analysis of lung tumors: Description of a convenient technique for use with fine needle biops... more ... analysis of lung tumors: Description of a convenient technique for use with fine needle biopsy HANS NORDGREN1, STEN NILSSON\ ANN ... of non-Hodgkin type, which was im-possible to subclassify according to the Kiel classi-fication (21) and the Luke-Collins nomenclature (22 ...
More than 90% of malignant neoplasms of the oral cavity are squamous carcinomas of oral mucosa an... more More than 90% of malignant neoplasms of the oral cavity are squamous carcinomas of oral mucosa and most are conventional type. This study included 60 cases of oral squamous carcinoma processed by usual histological technique and stained with Hematoxylin-Eosin and Alcian Blue-Safranin (Alcian Blue powder from Sigma Aldrich, code A5268-25G) and diagnosed in the Department of Pathology, University of Medicine and Pharmacy of Craiova. Double immunohistochemical (CD105-tryptase, VEGF-, VEGFR1-, VEGFR2-tryptase) or combined histochemical and immunohistochemical reactions (VEGF÷ VEGFR1÷ VEGFR2÷Alcian Blue-Safranin) followed the particular morphological aspects of the mast cells, their relation with the blood vessels and the overlap signal of tryptase and Alcian Blue-Safranin÷VEGF and its R1 and R2 receptors in mast cells. Immunostaining for VEGF and its R1 and R2 receptors was present both in tumor cells and mast cells. Double immunohistochemical-histochemical reactions allowed us angiogen...
Romanian Journal of Morphology and Embryology Revue Roumaine De Morphologie Et Embryologie, 2012
The study included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data p... more The study included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data processing was followed by histopathological and immunohistochemical analysis, following the expression of p53, Bcl-2 and Ki67 in the tumor epithelial compartments. Lesions predominated in the age range 20-40 years, to male gender, being located mainly in the mandible (88.2%). Typical follicular ameloblastoma was present in 70.6% of analyzed tumors. P53 and Bcl-2 immunoexpression was identified especially in the peripheral cells, the number of marked cells being over 50%, while the percentage of positive cells from the stellate reticulum was below 10%. The Ki67 positivity index was below 10% in both compartments. Squamous and granular cells reveal no stain for the investigated markers. Peripheral columnar cells are active compartment of ameloblastomas being involved in the processes of proliferation-apoptosis.