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Papers by Cristina López Sánchez

Research paper thumbnail of Ventriculoperitoneal Shunt Infection

Research paper thumbnail of Purple ulcerated nodules in a middle‐aged man

International Journal of Dermatology, 2020

Research paper thumbnail of Liver biopsy-related infection in liver transplant recipients: A current matter of concern?

Liver Transplantation, 2014

Data from published studies regarding risk factors for liver biopsy (LB)-related infectious compl... more Data from published studies regarding risk factors for liver biopsy (LB)-related infectious complications in liver transplant recipients are inconsistent. We carried out a retrospective cohort study analyzing consecutive LBs for orthotopic liver transplant patients at a tertiary hospital (2001-2011): there were 667 LB procedures (575 percutaneous procedures and 92 transjugular procedures) in 286 liver transplant recipients. There were 20 complications in 19 patients (overall incidence 5 3.0%): 10 were infectious complications (8 cases of bacteremia and 2 cases of peritonitis). The causal microorganisms were mainly Pseudomonas aeruginosa (4 patients) and Enterobacteriaceae (4 patients). All complications occurred with biopsies performed in patients hospitalized for more than 48 hours (381 biopsies for 201 patients); hence, only this group was included in the risk factor analysis. The variables associated with the development of infectious complications after LB were the presence of impaired biliary drainage at the time of biopsy (40% versus 15.1%, P 5 0.03) and low albumin levels (2.4 versus 3.1 g/dL, P 5 0.01). In conclusion, according to our experience, infectious complications secondary to LB in liver transplant recipients are related to hospitalization at the time of biopsy, particularly in the presence of impaired biliary drainage and low albumin levels.

Research paper thumbnail of Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC)

Revista Española de Quimioterapia, 2020

Profilaxis antifúngica con micafungina en pacientes que reciben un trasplante alogénico de progen... more Profilaxis antifúngica con micafungina en pacientes que reciben un trasplante alogénico de progenitores hematopoyéticos (alo-TPH) en España (GETH-MIC) RESUMEN Introducción. Las infecciones fúngicas siguen representando un problema en el trasplante alogénico de progenitores hematopoyéticos (alo-TPH) por lo que es habitual el uso de profilaxis antifúngica en estos pacientes. El tratamiento antifúngico debe presentar al menos actividad frente a Candida y Aspergillus spp, un buen perfil de seguridad y baja probabilidad de infecciones, siendo micafungina una de las opciones que podría cumplir todos estos requisitos. El objetivo del estudio fue describir la experiencia con micafungina como profilaxis primaria en pacientes sometidos a alo-TPH en una cohorte de hospitales españoles, y evaluar su eficacia y seguridad en esta población. Material y métodos. Estudio retrospectivo multicéntrico observacional consecutivo de todos los pacientes adultos ingresados para alo-TPH en los centros del Grupo Español de Trasplante Hematopoyético (GETH) desde enero de 2010 a diciembre de 2013 y que recibieron micafungina como profilaxis primaria durante el periodo de neutropenia. Resultados. Se identificaron 240 pacientes de 13 hospitales y 159 fueron incluidos para el análisis. La mayoría (95.6%) de ellos recibieron dosis de 50mg/día de micafungina. Durante el seguimiento, 7 (4.4%) pacientes desarrollaron infecciones de brecha, 1 probada y 6 probables; en un paciente se suspendió el tratamiento por interacciones medicamentosas graves. La profilaxis con micafungina se consideró efectiva en el 94,9% de los pacientes (151 de 159). Conclusiones. En base a nuestros resultados, consideramos que Micafungina es una buena alternativa como profilaxis antifúngica en pacientes sometidos a alo-TPH, por su eficacia, el bajo riesgo de interacciones y de efectos adversos. Palabras clave: trasplante de células madre, micafungina, profilaxis.

Research paper thumbnail of Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract

Research paper thumbnail of Levamisole-Induced Vasculopathy

Research paper thumbnail of Papules and vesicles on the ears of a young boy

International Journal of Dermatology, 2020

Clinicopathologic challenge Papules and vesicles on ears of a young boy Rozas-Muñoz et al.

Research paper thumbnail of A facility and community-based assessment of scabies in rural Malawi

ABSTRACTBackgroundScabies is a neglected tropical disease of the skin, causing severe itching, st... more ABSTRACTBackgroundScabies is a neglected tropical disease of the skin, causing severe itching, stigmatizing skin lesions and systemic complications. Since 2015, the DerMalawi project provides an integrated skin diseases clinics and Tele-dermatology care in Malawi. Clinic-based data suggested a progressive increase in scabies cases observed. To better identify and treat individuals with scabies in the region, we shifted from a clinic-based model to a community-based outreach programme.MethodsFrom May 2015, DerMalawi project provide integrated skin diseases and Tele-dermatological care in the Nkhotakota and Salima health districts in Malawi. Demographic and clinical data of all patients personally attended are recorded. Due to a progressive increase in the number of cases of scabies the project shifted to a community-based outreach programme.For the community outreach activities, we conducted three visits between 2018 to 2019 and undertook screening in schools and villages of Alinafe ...

Research paper thumbnail of Guselkumab in the treatment of moderate-to-severe plaque psoriasis

Immunotherapy, 2020

Recent advances in our understanding of the immunopathogenesis of psoriasis have resulted in nove... more Recent advances in our understanding of the immunopathogenesis of psoriasis have resulted in novel therapeutic agents. IL-23, mainly produced by dendritic cells, maintains the differentiation of naive T cells to Th17 cells, the keystone effector cells in psoriasis. The clinical effectiveness of therapeutic agents targeting this cytokine has been demonstrated in moderate-to-severe plaque psoriasis. Guselkumab (Tremfya®, Janssen Biotech, Inc., PA, USA) is the first human antibody against the p40 subunit of the IL-23 receptor approved by the US FDA and the EMA for this indication in adult patients (2017). It has also been approved for treatment of psoriatic arthritis in Japan (April 2018). This article reviews the published data relating to the efficacy and safety of guselkumab for treatment of moderate-to-severe plaque psoriasis.

Research paper thumbnail of Good response to pulsed dye laser in patients with capillary malformation‐arteriovenous malformation syndrome (CM‐AVM)

Pediatric Dermatology, 2020

Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant diso... more Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant disorder caused by heterozygous mutations in RASA1 and EPHB4. Capillary stains in CM-AVM are compatible with Schöbinger's phase I AVMs. Vascular laser has been classically contraindicated for the treatment of AVMs, as there is a fear of accelerating their progression. In this study, we have treated capillary stains in five CM-AVM patients with pulsed dye laser, with improvement and without worsening or recurrence of the lesions after 1 year of clinical and ultrasound follow-up.

Research paper thumbnail of Hair repigmentation as a clue for scalp melanoma

Australasian Journal of Dermatology, 2019

Research paper thumbnail of Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair

International Journal of Dermatology, 2019

Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair Dea... more Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair Dear Editor, Dermoscopy is a simple and noninvasive bedside technique that significantly improves the diagnostic accuracy of many cutaneous tumoral and inflammatory diseases. Through the recognition of specific dermoscopic signs, the clinician can predict the presence of several skin structures as well as foreign materials thus helping clinical diagnosis and management. recognition of Acid Violet in patients with actinic keratosis neglecta is important to advise the patient to remove the product properly as it may cause sensitization and development of allergic contact dermatitis.

Research paper thumbnail of Plaques en Prairie Fauchée as single manifestation of secondary syphilis

Sexually Transmitted Diseases, 2019

Research paper thumbnail of Basal cell carcinoma of the palm: An unusual presentation of a common tumour

Australasian Journal of Dermatology, 2019

Research paper thumbnail of Retiform Purpura After Percutaneous Angioplasty

The American Journal of Dermatopathology, 2019

Research paper thumbnail of Teicoplanin – An old new treatment for enterococcal prosthetic joint infections

Journal of Infection, 2016

Research paper thumbnail of Epidemiology and Long-Term Survival in HIV-Infected Patients With Pneumocystis jirovecii Pneumonia in the HAART Era

Medicine, 2015

As highly active antiretroviral treatment (HAART) is widely available, the incidence of Pneumocys... more As highly active antiretroviral treatment (HAART) is widely available, the incidence of Pneumocystis jirovecii pneumonia (PJP) has decreased significantly but still represents a significant cause of morbidity and mortality in developed countries. We analyzed all the cases with PJP in human immunodeficiency virus (HIV)-infected patients from 2000 to 2013 in a university hospital in Barcelona, Spain, and conducted a systematic literature review to evaluate data regarding incidence, mortality, and long-term survival after PJP in developed settings. One hundred thirty-six episodes of PJP were analyzed. During the study period, the incidence decreased significantly (from 13.4 cases/1000 patients-year to 3.3 cases/1000 patients-year, P < 0.001). Oppositely, median age of the patients increased from 34 years in 2000 to 45 in 2013 (P ¼ 0.024). PJP preceded HIV diagnosis in nearly 50% of the cases. Fifteen (11%) patients died during the PJP episode. The main risk factor for in-hospital mortality in our cohort was age >50 years (odds ratio 4.96, 95% confidence interval [CI] 1.45-15.14). Patients who survived were followed-up during a mean time of 44 months. Overall 5-year survival of patients after hospital discharge was 73%. Survival likelihood was 54% higher (88% [95% CI 81-96]) among HAART-adherent patients. Mean age and the proportion of patients with unknown HIV infection at the time of PJP diagnosis have increased in developed countries in the HAART era. Although the incidence has decreased, in-hospital mortality remains stable in this setting. Long-term survival is very high among HAART-adherent patients.

Research paper thumbnail of Ventriculoperitoneal Shunt Infection

Research paper thumbnail of Purple ulcerated nodules in a middle‐aged man

International Journal of Dermatology, 2020

Research paper thumbnail of Liver biopsy-related infection in liver transplant recipients: A current matter of concern?

Liver Transplantation, 2014

Data from published studies regarding risk factors for liver biopsy (LB)-related infectious compl... more Data from published studies regarding risk factors for liver biopsy (LB)-related infectious complications in liver transplant recipients are inconsistent. We carried out a retrospective cohort study analyzing consecutive LBs for orthotopic liver transplant patients at a tertiary hospital (2001-2011): there were 667 LB procedures (575 percutaneous procedures and 92 transjugular procedures) in 286 liver transplant recipients. There were 20 complications in 19 patients (overall incidence 5 3.0%): 10 were infectious complications (8 cases of bacteremia and 2 cases of peritonitis). The causal microorganisms were mainly Pseudomonas aeruginosa (4 patients) and Enterobacteriaceae (4 patients). All complications occurred with biopsies performed in patients hospitalized for more than 48 hours (381 biopsies for 201 patients); hence, only this group was included in the risk factor analysis. The variables associated with the development of infectious complications after LB were the presence of impaired biliary drainage at the time of biopsy (40% versus 15.1%, P 5 0.03) and low albumin levels (2.4 versus 3.1 g/dL, P 5 0.01). In conclusion, according to our experience, infectious complications secondary to LB in liver transplant recipients are related to hospitalization at the time of biopsy, particularly in the presence of impaired biliary drainage and low albumin levels.

Research paper thumbnail of Use of micafungin as antifungal prophylaxis in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Spain (GETH-MIC)

Revista Española de Quimioterapia, 2020

Profilaxis antifúngica con micafungina en pacientes que reciben un trasplante alogénico de progen... more Profilaxis antifúngica con micafungina en pacientes que reciben un trasplante alogénico de progenitores hematopoyéticos (alo-TPH) en España (GETH-MIC) RESUMEN Introducción. Las infecciones fúngicas siguen representando un problema en el trasplante alogénico de progenitores hematopoyéticos (alo-TPH) por lo que es habitual el uso de profilaxis antifúngica en estos pacientes. El tratamiento antifúngico debe presentar al menos actividad frente a Candida y Aspergillus spp, un buen perfil de seguridad y baja probabilidad de infecciones, siendo micafungina una de las opciones que podría cumplir todos estos requisitos. El objetivo del estudio fue describir la experiencia con micafungina como profilaxis primaria en pacientes sometidos a alo-TPH en una cohorte de hospitales españoles, y evaluar su eficacia y seguridad en esta población. Material y métodos. Estudio retrospectivo multicéntrico observacional consecutivo de todos los pacientes adultos ingresados para alo-TPH en los centros del Grupo Español de Trasplante Hematopoyético (GETH) desde enero de 2010 a diciembre de 2013 y que recibieron micafungina como profilaxis primaria durante el periodo de neutropenia. Resultados. Se identificaron 240 pacientes de 13 hospitales y 159 fueron incluidos para el análisis. La mayoría (95.6%) de ellos recibieron dosis de 50mg/día de micafungina. Durante el seguimiento, 7 (4.4%) pacientes desarrollaron infecciones de brecha, 1 probada y 6 probables; en un paciente se suspendió el tratamiento por interacciones medicamentosas graves. La profilaxis con micafungina se consideró efectiva en el 94,9% de los pacientes (151 de 159). Conclusiones. En base a nuestros resultados, consideramos que Micafungina es una buena alternativa como profilaxis antifúngica en pacientes sometidos a alo-TPH, por su eficacia, el bajo riesgo de interacciones y de efectos adversos. Palabras clave: trasplante de células madre, micafungina, profilaxis.

Research paper thumbnail of Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract

Research paper thumbnail of Levamisole-Induced Vasculopathy

Research paper thumbnail of Papules and vesicles on the ears of a young boy

International Journal of Dermatology, 2020

Clinicopathologic challenge Papules and vesicles on ears of a young boy Rozas-Muñoz et al.

Research paper thumbnail of A facility and community-based assessment of scabies in rural Malawi

ABSTRACTBackgroundScabies is a neglected tropical disease of the skin, causing severe itching, st... more ABSTRACTBackgroundScabies is a neglected tropical disease of the skin, causing severe itching, stigmatizing skin lesions and systemic complications. Since 2015, the DerMalawi project provides an integrated skin diseases clinics and Tele-dermatology care in Malawi. Clinic-based data suggested a progressive increase in scabies cases observed. To better identify and treat individuals with scabies in the region, we shifted from a clinic-based model to a community-based outreach programme.MethodsFrom May 2015, DerMalawi project provide integrated skin diseases and Tele-dermatological care in the Nkhotakota and Salima health districts in Malawi. Demographic and clinical data of all patients personally attended are recorded. Due to a progressive increase in the number of cases of scabies the project shifted to a community-based outreach programme.For the community outreach activities, we conducted three visits between 2018 to 2019 and undertook screening in schools and villages of Alinafe ...

Research paper thumbnail of Guselkumab in the treatment of moderate-to-severe plaque psoriasis

Immunotherapy, 2020

Recent advances in our understanding of the immunopathogenesis of psoriasis have resulted in nove... more Recent advances in our understanding of the immunopathogenesis of psoriasis have resulted in novel therapeutic agents. IL-23, mainly produced by dendritic cells, maintains the differentiation of naive T cells to Th17 cells, the keystone effector cells in psoriasis. The clinical effectiveness of therapeutic agents targeting this cytokine has been demonstrated in moderate-to-severe plaque psoriasis. Guselkumab (Tremfya®, Janssen Biotech, Inc., PA, USA) is the first human antibody against the p40 subunit of the IL-23 receptor approved by the US FDA and the EMA for this indication in adult patients (2017). It has also been approved for treatment of psoriatic arthritis in Japan (April 2018). This article reviews the published data relating to the efficacy and safety of guselkumab for treatment of moderate-to-severe plaque psoriasis.

Research paper thumbnail of Good response to pulsed dye laser in patients with capillary malformation‐arteriovenous malformation syndrome (CM‐AVM)

Pediatric Dermatology, 2020

Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant diso... more Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant disorder caused by heterozygous mutations in RASA1 and EPHB4. Capillary stains in CM-AVM are compatible with Schöbinger's phase I AVMs. Vascular laser has been classically contraindicated for the treatment of AVMs, as there is a fear of accelerating their progression. In this study, we have treated capillary stains in five CM-AVM patients with pulsed dye laser, with improvement and without worsening or recurrence of the lesions after 1 year of clinical and ultrasound follow-up.

Research paper thumbnail of Hair repigmentation as a clue for scalp melanoma

Australasian Journal of Dermatology, 2019

Research paper thumbnail of Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair

International Journal of Dermatology, 2019

Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair Dea... more Iceberg sign in actinic keratosis neglecta caused by toning shampoo for blonde and white hair Dear Editor, Dermoscopy is a simple and noninvasive bedside technique that significantly improves the diagnostic accuracy of many cutaneous tumoral and inflammatory diseases. Through the recognition of specific dermoscopic signs, the clinician can predict the presence of several skin structures as well as foreign materials thus helping clinical diagnosis and management. recognition of Acid Violet in patients with actinic keratosis neglecta is important to advise the patient to remove the product properly as it may cause sensitization and development of allergic contact dermatitis.

Research paper thumbnail of Plaques en Prairie Fauchée as single manifestation of secondary syphilis

Sexually Transmitted Diseases, 2019

Research paper thumbnail of Basal cell carcinoma of the palm: An unusual presentation of a common tumour

Australasian Journal of Dermatology, 2019

Research paper thumbnail of Retiform Purpura After Percutaneous Angioplasty

The American Journal of Dermatopathology, 2019

Research paper thumbnail of Teicoplanin – An old new treatment for enterococcal prosthetic joint infections

Journal of Infection, 2016

Research paper thumbnail of Epidemiology and Long-Term Survival in HIV-Infected Patients With Pneumocystis jirovecii Pneumonia in the HAART Era

Medicine, 2015

As highly active antiretroviral treatment (HAART) is widely available, the incidence of Pneumocys... more As highly active antiretroviral treatment (HAART) is widely available, the incidence of Pneumocystis jirovecii pneumonia (PJP) has decreased significantly but still represents a significant cause of morbidity and mortality in developed countries. We analyzed all the cases with PJP in human immunodeficiency virus (HIV)-infected patients from 2000 to 2013 in a university hospital in Barcelona, Spain, and conducted a systematic literature review to evaluate data regarding incidence, mortality, and long-term survival after PJP in developed settings. One hundred thirty-six episodes of PJP were analyzed. During the study period, the incidence decreased significantly (from 13.4 cases/1000 patients-year to 3.3 cases/1000 patients-year, P < 0.001). Oppositely, median age of the patients increased from 34 years in 2000 to 45 in 2013 (P ¼ 0.024). PJP preceded HIV diagnosis in nearly 50% of the cases. Fifteen (11%) patients died during the PJP episode. The main risk factor for in-hospital mortality in our cohort was age >50 years (odds ratio 4.96, 95% confidence interval [CI] 1.45-15.14). Patients who survived were followed-up during a mean time of 44 months. Overall 5-year survival of patients after hospital discharge was 73%. Survival likelihood was 54% higher (88% [95% CI 81-96]) among HAART-adherent patients. Mean age and the proportion of patients with unknown HIV infection at the time of PJP diagnosis have increased in developed countries in the HAART era. Although the incidence has decreased, in-hospital mortality remains stable in this setting. Long-term survival is very high among HAART-adherent patients.