Cristina Maria Souza - Academia.edu (original) (raw)

Papers by Cristina Maria Souza

Research paper thumbnail of Antitumoral activity and toxicity of PEG-coated and PEG-folate-coated pH-sensitive liposomes containing 159Gd-DTPA-BMA in Ehrlich tumor bearing mice

European Journal of Pharmaceutical Sciences, 2000

In the present study, PEG-coated pH-sensitive and PEG-folate-coated pH-sensitive liposomes contai... more In the present study, PEG-coated pH-sensitive and PEG-folate-coated pH-sensitive liposomes containing the 159Gd-DTPA-BMA were prepared and radiolabeled through neutron activation technique, aiming to study the in vivo antitumoral activity and toxicity on mice bearing a previously-developed solid Ehrlich tumor. The treatment efficacy was verified through tumoral volume increase and histomorphometry studies. The toxicity of formulations was investigated through animal weight variations, as well as hematological and biochemical tests. The results showed that after 31 days of treatment, animals treated with radioactive formulations had a lower increase in tumor volume and a significantly higher percentage of necrosis compared with controls revealed by histomorphometry studies. Furthermore, mice treated with radioactive formulations exhibited lower weight gain without significant hematological or biochemical changes, except for toxicity to hepatocytes which requires more detailed studies. From the results obtained to date, we believe that the radioactive formulations can be considered potential therapeutic agents for cancer.

Research paper thumbnail of Heavy metal distribution in two cetacean species from Rio de Janeiro State, south-eastern Brazil

Journal of The Marine Biological Association of The United Kingdom, 2008

Mercury (Hg), cadmium (Cd) and zinc (Zn) concentration were analysed in muscular and liver tissue... more Mercury (Hg), cadmium (Cd) and zinc (Zn) concentration were analysed in muscular and liver tissues of two cetacean species, franciscana Pontoporia blainvillei and boto-cinza Sotalia guianensis, in order to compare their contamination levels in northern Rio de Janeiro State, south-eastern Brazil. The cutlassfish, Trichiurus lepturus, which is the preferential prey of the boto-cinza, have also been analysed. Liver tissue always presented higher concentrations when compared with muscle samples for all the studied metals. The boto-cinza showed higher concentrations for all metals in both tissues than in the franciscana, and the only exception was Cd. This result is probably related to the difference in size prey preference of each cetacean. Mercury was the only element that presented significant positive correlations with body length and age in both cetacean species. The cutlassfish showed rising Hg concentrations with weight and total length, suggesting a possible mercury pathway for marine mammals' contamination.

Research paper thumbnail of ESTADO E POLÍTICAS SOCIAIS

Este texto tem como objetivo contribuir para a compreensão do processo de constituição e desenvol... more Este texto tem como objetivo contribuir para a compreensão do processo de constituição e desenvolvimento das Políticas Sociais na sociedade capitalista contemporânea, particularizando, o caso brasileiro e as políticas de natureza socio-assistencial, que, impulsionadas pela Constituição de 1988 vem alcançando centralidade na agenda social do país. Está organizado em duas partes: Em uma primeira parte desenvolve uma reflexão histórico conceitual, sobre a relação Estado / Políticas Sociais, destacando a emergência do Estado de Bem Estar Social, apresentando os princípios que o estruturaram e sua crise nos anos recentes, nos marcos da reestruturação do processo de acumulação do capital globalizado. Nesta parte são apresentadas também as principais características históricas da Política Social no país. Em sua segunda parte o texto apresenta a Política de Assistência Social em seu movimento de constituição como política pública, destacando a PNAS e o SUAS.

Research paper thumbnail of Antitumoral activity and toxicity of PEG-coated and PEG-folate-coated pH-sensitive liposomes containing 159Gd-DTPA-BMA in Ehrlich tumor bearing mice

European Journal of Pharmaceutical Sciences, 2000

In the present study, PEG-coated pH-sensitive and PEG-folate-coated pH-sensitive liposomes contai... more In the present study, PEG-coated pH-sensitive and PEG-folate-coated pH-sensitive liposomes containing the 159Gd-DTPA-BMA were prepared and radiolabeled through neutron activation technique, aiming to study the in vivo antitumoral activity and toxicity on mice bearing a previously-developed solid Ehrlich tumor. The treatment efficacy was verified through tumoral volume increase and histomorphometry studies. The toxicity of formulations was investigated through animal weight variations, as well as hematological and biochemical tests. The results showed that after 31 days of treatment, animals treated with radioactive formulations had a lower increase in tumor volume and a significantly higher percentage of necrosis compared with controls revealed by histomorphometry studies. Furthermore, mice treated with radioactive formulations exhibited lower weight gain without significant hematological or biochemical changes, except for toxicity to hepatocytes which requires more detailed studies. From the results obtained to date, we believe that the radioactive formulations can be considered potential therapeutic agents for cancer.

Research paper thumbnail of Heavy metal distribution in two cetacean species from Rio de Janeiro State, south-eastern Brazil

Journal of The Marine Biological Association of The United Kingdom, 2008

Mercury (Hg), cadmium (Cd) and zinc (Zn) concentration were analysed in muscular and liver tissue... more Mercury (Hg), cadmium (Cd) and zinc (Zn) concentration were analysed in muscular and liver tissues of two cetacean species, franciscana Pontoporia blainvillei and boto-cinza Sotalia guianensis, in order to compare their contamination levels in northern Rio de Janeiro State, south-eastern Brazil. The cutlassfish, Trichiurus lepturus, which is the preferential prey of the boto-cinza, have also been analysed. Liver tissue always presented higher concentrations when compared with muscle samples for all the studied metals. The boto-cinza showed higher concentrations for all metals in both tissues than in the franciscana, and the only exception was Cd. This result is probably related to the difference in size prey preference of each cetacean. Mercury was the only element that presented significant positive correlations with body length and age in both cetacean species. The cutlassfish showed rising Hg concentrations with weight and total length, suggesting a possible mercury pathway for marine mammals' contamination.

Research paper thumbnail of ESTADO E POLÍTICAS SOCIAIS

Este texto tem como objetivo contribuir para a compreensão do processo de constituição e desenvol... more Este texto tem como objetivo contribuir para a compreensão do processo de constituição e desenvolvimento das Políticas Sociais na sociedade capitalista contemporânea, particularizando, o caso brasileiro e as políticas de natureza socio-assistencial, que, impulsionadas pela Constituição de 1988 vem alcançando centralidade na agenda social do país. Está organizado em duas partes: Em uma primeira parte desenvolve uma reflexão histórico conceitual, sobre a relação Estado / Políticas Sociais, destacando a emergência do Estado de Bem Estar Social, apresentando os princípios que o estruturaram e sua crise nos anos recentes, nos marcos da reestruturação do processo de acumulação do capital globalizado. Nesta parte são apresentadas também as principais características históricas da Política Social no país. Em sua segunda parte o texto apresenta a Política de Assistência Social em seu movimento de constituição como política pública, destacando a PNAS e o SUAS.