Cruz Velazquez - Academia.edu (original) (raw)
Papers by Cruz Velazquez
Blood, Nov 15, 2013
In patients who are or develop resistance to IM and without access to therapeutic alternatives as... more In patients who are or develop resistance to IM and without access to therapeutic alternatives as second generation tyrosine kinase (TKI) inhibitors or hematopoietic stem cell transplantation, the use of alkylating drugs or investigational agents is indicated. NF Kappa B pathway is constitutively activated in CML patients therefore the combination of IM with a NF Kappa β inhibitor (as thalidomide) contributes a new very interesting field of research. Thalidomide has antiproliferative activity in Hemato-oncologic diseases, therefore we decided to use in patients with CML Ph + resistant to IM with excellent results. Herein we report 14 cases of CML Ph (+): 6 males, 8 females with a median age of 38 years (19-62) treated with Imatinib (median maximum tolerated dose of 600 mg [200-800 mg/day]) plus Thalidomide 100 mg PO/day. At diagnosis (79%) were classified as high risk according with EUTOS scale. Follow up was done every month (Mo) with CBC, Hepatic and Renal Function Test and FISH test for BCR/ABL every 3 months. Median time of diagnosis 20 months (5-49); Imatinib treatment median time 20 months (3-60). The main reason to add thalidomide was lost of Cytogenetic Response (CgR) in 7, and suboptimal response in 7. Median Follow-up since Thalidomide addition 16 months (6-54 months) Table 1. Results Within the median time of follow-up all patients achieved Complete Hematologic Response. There was 9/14 (64%) Cytogenetic Responses (CgR): 7 Major CgR (4 Complete, 3 Majors), and 2 minor CgR. Five (5/14) patients (36%) do not achieve any type of response. The median time of thalidomide treatment was 12 months and median time to response 8 months (Table 2). The responses still on during follow-up and there is no lost of responses. In all cases no studies were carried out ABL mutations because lack of financial resources. Toxicity has been minimal, mainly grade 1 peripheral neurotoxicity, constipation and none had severe adverse event. Immunomodulatory drugs (thalidomide and its analogues) have several effects and do modify signals induced by receptor-ligand and include generation of Inflammatory Cytokines, anti angiogenic responses of cellular and immune adherence and antiproliferative direct effect perhaps by inhibition of transcriptional factor NF-κβ (Nuclear Factor KB) signaling, which promotes the survival of malignant cells and recognizes their activity in leukemias and myelodysplastic syndromes, therefore it is suggested as a potential therapeutic objective, immunomodulators block the activation of NF-κβ and may be a therapeutic option in CML. Our patients achieved the CyR cases of primary resistance and secondary Imatinib Resistance. As previously we reported (ASH 2012), this is the second communication of the use of Thalidomide with Imatinib with promising results, which may represent a therapeutic alternative in CML with antiproliferative enhancer and/or synergistic effect in patients with resistance to IM without opportunity of access to other treatments. Disclosures: No relevant conflicts of interest to declare.
El auge mercantil transatlántico que tuvo el puerto de Veracruz durante el siglo XVIII provocó qu... more El auge mercantil transatlántico que tuvo el puerto de Veracruz durante el siglo XVIII provocó que la población creciera considerablemente, ya que, atraídos por este incremento comercial, vinieron a radicar a la plaza nuevos mercaderes, artesanos, estibadores, y Itubo un mayor número de soldados permanentes en la ciudad, además de los tripulantes de los diferentes barros que arribaban al embarcadero. Este crecimiento de habitantes hizo que aumentaran las necesidades de la ciudad, tales como el suministro de agua potable el desalojo de desperdicios y la eliminación (en la ciudad) de los lugares que se consideraba pudieran provocar alguna enfermedad contagiosa Ante estas nuevas carencias, el Cabildo veracruzano llevó a calió, en ol último tercio del siglo XVIII. una política de mejoramientos para la ciudadanía Dentro de estos proyectos estuvo el de empedrar las calles de la plaza, considerando que de esta forma no se formarían lagunas de agua sucia dentro de la ciudad, las cuales, según su criterio, provocaban enfermedades entre la población y daban una mala imagen al puerto de Veracruz. La primera noticia que tenemos sobre esta obra es la que nos proporciona el historiador Miguel l/crdo de Tejada en su libro Apuntes históricos de \'crucruz. en el que menciona que el empedrado de la plaza porteña empezó en 1786, gobernando Félix de Térras Kn 1767 se continuaba la obra; lo que puede comprobarse, pues el ayuntamiento porteño envió una carta el l.'í de noviembre de ese año al virrey Carlos Francisco de Croix, marques de Croix, en contestación a una misiva que habla recibido el 20 de marzo; en ella, el ayuntamiento indicaba que esta institución se daba por enterada de que el rey Carlos III 'Investigador del Archivo y Biblioteca Historien do Vorurruz
Blood, Nov 15, 2013
In patients who are or develop resistance to IM and without access to therapeutic alternatives as... more In patients who are or develop resistance to IM and without access to therapeutic alternatives as second generation tyrosine kinase (TKI) inhibitors or hematopoietic stem cell transplantation, the use of alkylating drugs or investigational agents is indicated. NF Kappa B pathway is constitutively activated in CML patients therefore the combination of IM with a NF Kappa β inhibitor (as thalidomide) contributes a new very interesting field of research. Thalidomide has antiproliferative activity in Hemato-oncologic diseases, therefore we decided to use in patients with CML Ph + resistant to IM with excellent results. Herein we report 14 cases of CML Ph (+): 6 males, 8 females with a median age of 38 years (19-62) treated with Imatinib (median maximum tolerated dose of 600 mg [200-800 mg/day]) plus Thalidomide 100 mg PO/day. At diagnosis (79%) were classified as high risk according with EUTOS scale. Follow up was done every month (Mo) with CBC, Hepatic and Renal Function Test and FISH test for BCR/ABL every 3 months. Median time of diagnosis 20 months (5-49); Imatinib treatment median time 20 months (3-60). The main reason to add thalidomide was lost of Cytogenetic Response (CgR) in 7, and suboptimal response in 7. Median Follow-up since Thalidomide addition 16 months (6-54 months) Table 1. Results Within the median time of follow-up all patients achieved Complete Hematologic Response. There was 9/14 (64%) Cytogenetic Responses (CgR): 7 Major CgR (4 Complete, 3 Majors), and 2 minor CgR. Five (5/14) patients (36%) do not achieve any type of response. The median time of thalidomide treatment was 12 months and median time to response 8 months (Table 2). The responses still on during follow-up and there is no lost of responses. In all cases no studies were carried out ABL mutations because lack of financial resources. Toxicity has been minimal, mainly grade 1 peripheral neurotoxicity, constipation and none had severe adverse event. Immunomodulatory drugs (thalidomide and its analogues) have several effects and do modify signals induced by receptor-ligand and include generation of Inflammatory Cytokines, anti angiogenic responses of cellular and immune adherence and antiproliferative direct effect perhaps by inhibition of transcriptional factor NF-κβ (Nuclear Factor KB) signaling, which promotes the survival of malignant cells and recognizes their activity in leukemias and myelodysplastic syndromes, therefore it is suggested as a potential therapeutic objective, immunomodulators block the activation of NF-κβ and may be a therapeutic option in CML. Our patients achieved the CyR cases of primary resistance and secondary Imatinib Resistance. As previously we reported (ASH 2012), this is the second communication of the use of Thalidomide with Imatinib with promising results, which may represent a therapeutic alternative in CML with antiproliferative enhancer and/or synergistic effect in patients with resistance to IM without opportunity of access to other treatments. Disclosures: No relevant conflicts of interest to declare.
El auge mercantil transatlántico que tuvo el puerto de Veracruz durante el siglo XVIII provocó qu... more El auge mercantil transatlántico que tuvo el puerto de Veracruz durante el siglo XVIII provocó que la población creciera considerablemente, ya que, atraídos por este incremento comercial, vinieron a radicar a la plaza nuevos mercaderes, artesanos, estibadores, y Itubo un mayor número de soldados permanentes en la ciudad, además de los tripulantes de los diferentes barros que arribaban al embarcadero. Este crecimiento de habitantes hizo que aumentaran las necesidades de la ciudad, tales como el suministro de agua potable el desalojo de desperdicios y la eliminación (en la ciudad) de los lugares que se consideraba pudieran provocar alguna enfermedad contagiosa Ante estas nuevas carencias, el Cabildo veracruzano llevó a calió, en ol último tercio del siglo XVIII. una política de mejoramientos para la ciudadanía Dentro de estos proyectos estuvo el de empedrar las calles de la plaza, considerando que de esta forma no se formarían lagunas de agua sucia dentro de la ciudad, las cuales, según su criterio, provocaban enfermedades entre la población y daban una mala imagen al puerto de Veracruz. La primera noticia que tenemos sobre esta obra es la que nos proporciona el historiador Miguel l/crdo de Tejada en su libro Apuntes históricos de \'crucruz. en el que menciona que el empedrado de la plaza porteña empezó en 1786, gobernando Félix de Térras Kn 1767 se continuaba la obra; lo que puede comprobarse, pues el ayuntamiento porteño envió una carta el l.'í de noviembre de ese año al virrey Carlos Francisco de Croix, marques de Croix, en contestación a una misiva que habla recibido el 20 de marzo; en ella, el ayuntamiento indicaba que esta institución se daba por enterada de que el rey Carlos III 'Investigador del Archivo y Biblioteca Historien do Vorurruz