DS 15 - Academia.edu (original) (raw)

Papers by DS 15

Molecular and Cellular Biology, 2002

The mouse genome contains two Sim genes, Sim1 and Sim2. They are presumed to be important for cen... more The mouse genome contains two Sim genes, Sim1 and Sim2. They are presumed to be important for central nervous system (CNS) development because they are homologous to the Drosophila single-minded (sim) gene, mutations in which cause a complete loss of CNS midline cells. In the mammalian CNS, Sim2 and Sim1 are coexpressed in the paraventricular nucleus (PVN). While Sim1 is essential for the development of the PVN (J. L. Michaud, T. Rosenquist, N. R. May, and C.-M. Fan, Genes Dev. 12:3264-3275, 1998), we report here that Sim2 mutant has a normal PVN. Analyses of the Sim1 and Sim2 compound mutants did not reveal obvious genetic interaction between them in PVN histogenesis. However, Sim2 mutant mice die within 3 days of birth due to lung atelectasis and breathing failure. We attribute the diminished efficacy of lung inflation to the compromised structural components surrounding the pleural cavity, which include rib protrusions, abnormal intercostal muscle attachments, diaphragm hypoplasia, and pleural mesothelium tearing. Although each of these structures is minimally affected, we propose that their combined effects lead to the mechanical failure of lung inflation and death. Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity.

A set of physical layer specifications is provided for a single-band system. The system fulfills ... more A set of physical layer specifications is provided for a single-band system. The system fulfills the FCC regulations on UWB devices and the physical layer requirements from IEEE 802.15.3a. It gives reliable communication, i.e., a 90th-percentile PER equal to 8% for 1024 payload bytes, at 110 Mbps with a transmitter-receiver separation of up to 10 meters on the IEEE 802.15.3a channel model CM4. 205 Mbps at 6.7 meters on CM4 and 513 Mbps at 3.8 meters on CM2 are also achieved. The system uses the spectrum 3.1-4.9 GHz, a chip-spaced rake combiner with 60 fingers, a sliding window channel estimator, and a sampling rate of 1540 Msamples/s.

IEEE Transactions on Knowledge and Data Engineering, 1997

Spatial join is one of the fundamental operations in a Spatial Data Base Management System. Recen... more Spatial join is one of the fundamental operations in a Spatial Data Base Management System. Recently, the family of R-tree-based data structures has been adopted to support the execution of spatial joins. This paper introduces an analytical model that efficiently estimates the cost (in terms of disk accesses) of a spatial join query between two spatial datasets. The proposed model is based on an analytical formula that estimates the cost of the range query using Rtrees. In addition, comparison results are presented which show the accuracy of the analytical estimations when compared to actual tests on both synthetic and real datasets. It turns out that the relative error rarely exceeds 15% for all combinations.

Journal of Dairy Science, 2007

Emphasis by dairy producers on various yield and fitness traits when culling cows was documented ... more Emphasis by dairy producers on various yield and fitness traits when culling cows was documented for US Holstein calvings since 1982. Least squares differences between cows retained for additional parities and those culled were estimated for milk, fat, and protein yields; somatic cell score (SCS); days open (DO); dystocia score (DS), final score (FS), and 14 type traits. Compared with cows culled during first lactation, superiority for first-parity milk yield was 569 to 1,175 kg for cows with 2 lactations, 642 to 1,283 kg for cows with ≥2 lactations, 710 to 1,350 kg for cows with 3 lactations, and 663 to 1,331 kg for cows with ≥4 lactations. Cows retained for ≥2 lactations had first-parity SCS that were 0.34 to 0.62 lower (more favorable) than those of cows culled during first lactation; first-parity SCS for cows retained for 3 or ≥4 lactations were even more favorable than those of cows with 1 or 2 lactations. The negative genetic relationship between yield and fertility contributed to increased DO as selection for higher milk yield persisted across time despite considerable preference for early conception when culling cows. In 1982, cows retained in the herd for 2, 3, and ≥4 lactations conceived earlier during first lactation (19, 17, and 23 fewer DO, respectively) than those culled during first lactation; those differences had increased to 34, 41, and 52 fewer DO by 2000. Although DS has a negative relationship with survival, first-parity DS were only slightly lower (by 0.10 to 0.14) for survivors than for cows culled during first lactation. Cows retained for ≥2 lactations had greater first-parity FS by 1.4 to 1.9 points than those culled during first lactation. On a standardized basis, the most intense selection during first lactation was for milk and protein yields with less for fat (74 to 86% of that for milk), DO (18 to 74%), FS (22 to 38%), SCS (19 to 37%), and DS (7 to 15%). Producers continued to emphasize the same traits when culling during second and third lactations. Trait priority by producers during 1008 culling could aid in setting trait emphasis when selecting bulls for progeny test and could also be useful in developing software for index-based culling guides.

Sexually Transmitted Infections, 1989

Acquisition by the syphilis spirochaete, Treponema pallidum, of radioiodinated total human plasma... more Acquisition by the syphilis spirochaete, Treponema pallidum, of radioiodinated total human plasma lipoprotein and lipoprotein subfractions was examined. Time dependent and saturation binding kinetics were observed for total lipoproteins and subfractions, including high density lipoproteins, low density lipoproteins (LDL), and very low density lipoproteins. All subfractions competed equally well in binding iodinated total lipoproteins and individual subfractions, but apoproteins common to all subfractions were ineffective in inhibiting lipoprotein acquisition. The interaction of LDL with T pallidum was studied further and, interestingly, the presence of 17% sulphated dextran sulphate (DS) in the reaction mixture containing treponemes and LDL resulted in up to 172 times more LDL being bound by live treponemes. Biological variability was observed in the extent of increased LDL bound in the presence of 17% sulphated DS by preparations of Tpallidum isolated from different infected rabbits. Saturation kinetics of iodinated LDL acquisition was obtained in the presence of 17% sulphated DS but not 1% sulphated DS. Other proteoglycan molecules, such as chondroitin sulphate, hyaluronic acid and heparin, and fibronectin, the extracellular matrix protein targeted by treponemes in parasitism of host cells and tissues neither diminished nor enhanced LDL binding by live treponemes. Only 5% and 10% of associated radioactivity was released from treponemal surfaces after Tpallidum was incubated with iodinated LDL and 17% sulphated-DS for 15 and 30 minutes, respectively. These data show binding and possible internalisation of host lipoproteins by T pallidum, which may be mediated by sulphated proteoglycan. Sulphated proteoglycans accumulate during Tpallidum infections of host cells.

Journal of Bioactive and Compatible Polymers, 2011

Bundle membranes were made by electrospinning poly(L-lactide) (PLLA) and PLLA/poly(ethylene glyco... more Bundle membranes were made by electrospinning poly(L-lactide) (PLLA) and PLLA/poly(ethylene glycol) (PEG) using the ionic properties of diclofenac sodium (DS), lidocaine hydrochloride (LHC), benzalkonium chloride (BC), and combinations thereof. The self-bundling of the fibers was initiated by using a designed grounded multi-needle electrode. Computer simulations on the electrostatic field distribution depended on the multi-needle position with respect to a grounded

Introducción: El síndrome metabólico (SM) se caracteriza por la intolerancia a la glucosa, dislip... more Introducción: El síndrome metabólico (SM) se caracteriza por la intolerancia a la glucosa, dislipemia, obesidad e hipertensión arterial. Su importancia radica en que las personas que lo padecen tienen un mayor riesgo de eventos coronarios a 10 años vista. En determinadas poblaciones presenta una alta prevalencia, que lega hasta casi el 20%.

Dementia and Geriatric Cognitive Disorders, 1994

Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomog... more Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer's disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal-parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT- (n = 10), DS DAT+ (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD.

Molecular and Cellular Biology, 2002

The mouse genome contains two Sim genes, Sim1 and Sim2. They are presumed to be important for cen... more The mouse genome contains two Sim genes, Sim1 and Sim2. They are presumed to be important for central nervous system (CNS) development because they are homologous to the Drosophila single-minded (sim) gene, mutations in which cause a complete loss of CNS midline cells. In the mammalian CNS, Sim2 and Sim1 are coexpressed in the paraventricular nucleus (PVN). While Sim1 is essential for the development of the PVN (J. L. Michaud, T. Rosenquist, N. R. May, and C.-M. Fan, Genes Dev. 12:3264-3275, 1998), we report here that Sim2 mutant has a normal PVN. Analyses of the Sim1 and Sim2 compound mutants did not reveal obvious genetic interaction between them in PVN histogenesis. However, Sim2 mutant mice die within 3 days of birth due to lung atelectasis and breathing failure. We attribute the diminished efficacy of lung inflation to the compromised structural components surrounding the pleural cavity, which include rib protrusions, abnormal intercostal muscle attachments, diaphragm hypoplasia, and pleural mesothelium tearing. Although each of these structures is minimally affected, we propose that their combined effects lead to the mechanical failure of lung inflation and death. Sim2 mutants also develop congenital scoliosis, reflected by the unequal sizes of the left and right vertebrae and ribs. The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity.

A set of physical layer specifications is provided for a single-band system. The system fulfills ... more A set of physical layer specifications is provided for a single-band system. The system fulfills the FCC regulations on UWB devices and the physical layer requirements from IEEE 802.15.3a. It gives reliable communication, i.e., a 90th-percentile PER equal to 8% for 1024 payload bytes, at 110 Mbps with a transmitter-receiver separation of up to 10 meters on the IEEE 802.15.3a channel model CM4. 205 Mbps at 6.7 meters on CM4 and 513 Mbps at 3.8 meters on CM2 are also achieved. The system uses the spectrum 3.1-4.9 GHz, a chip-spaced rake combiner with 60 fingers, a sliding window channel estimator, and a sampling rate of 1540 Msamples/s.

IEEE Transactions on Knowledge and Data Engineering, 1997

Spatial join is one of the fundamental operations in a Spatial Data Base Management System. Recen... more Spatial join is one of the fundamental operations in a Spatial Data Base Management System. Recently, the family of R-tree-based data structures has been adopted to support the execution of spatial joins. This paper introduces an analytical model that efficiently estimates the cost (in terms of disk accesses) of a spatial join query between two spatial datasets. The proposed model is based on an analytical formula that estimates the cost of the range query using Rtrees. In addition, comparison results are presented which show the accuracy of the analytical estimations when compared to actual tests on both synthetic and real datasets. It turns out that the relative error rarely exceeds 15% for all combinations.

Journal of Dairy Science, 2007

Emphasis by dairy producers on various yield and fitness traits when culling cows was documented ... more Emphasis by dairy producers on various yield and fitness traits when culling cows was documented for US Holstein calvings since 1982. Least squares differences between cows retained for additional parities and those culled were estimated for milk, fat, and protein yields; somatic cell score (SCS); days open (DO); dystocia score (DS), final score (FS), and 14 type traits. Compared with cows culled during first lactation, superiority for first-parity milk yield was 569 to 1,175 kg for cows with 2 lactations, 642 to 1,283 kg for cows with ≥2 lactations, 710 to 1,350 kg for cows with 3 lactations, and 663 to 1,331 kg for cows with ≥4 lactations. Cows retained for ≥2 lactations had first-parity SCS that were 0.34 to 0.62 lower (more favorable) than those of cows culled during first lactation; first-parity SCS for cows retained for 3 or ≥4 lactations were even more favorable than those of cows with 1 or 2 lactations. The negative genetic relationship between yield and fertility contributed to increased DO as selection for higher milk yield persisted across time despite considerable preference for early conception when culling cows. In 1982, cows retained in the herd for 2, 3, and ≥4 lactations conceived earlier during first lactation (19, 17, and 23 fewer DO, respectively) than those culled during first lactation; those differences had increased to 34, 41, and 52 fewer DO by 2000. Although DS has a negative relationship with survival, first-parity DS were only slightly lower (by 0.10 to 0.14) for survivors than for cows culled during first lactation. Cows retained for ≥2 lactations had greater first-parity FS by 1.4 to 1.9 points than those culled during first lactation. On a standardized basis, the most intense selection during first lactation was for milk and protein yields with less for fat (74 to 86% of that for milk), DO (18 to 74%), FS (22 to 38%), SCS (19 to 37%), and DS (7 to 15%). Producers continued to emphasize the same traits when culling during second and third lactations. Trait priority by producers during 1008 culling could aid in setting trait emphasis when selecting bulls for progeny test and could also be useful in developing software for index-based culling guides.

Sexually Transmitted Infections, 1989

Acquisition by the syphilis spirochaete, Treponema pallidum, of radioiodinated total human plasma... more Acquisition by the syphilis spirochaete, Treponema pallidum, of radioiodinated total human plasma lipoprotein and lipoprotein subfractions was examined. Time dependent and saturation binding kinetics were observed for total lipoproteins and subfractions, including high density lipoproteins, low density lipoproteins (LDL), and very low density lipoproteins. All subfractions competed equally well in binding iodinated total lipoproteins and individual subfractions, but apoproteins common to all subfractions were ineffective in inhibiting lipoprotein acquisition. The interaction of LDL with T pallidum was studied further and, interestingly, the presence of 17% sulphated dextran sulphate (DS) in the reaction mixture containing treponemes and LDL resulted in up to 172 times more LDL being bound by live treponemes. Biological variability was observed in the extent of increased LDL bound in the presence of 17% sulphated DS by preparations of Tpallidum isolated from different infected rabbits. Saturation kinetics of iodinated LDL acquisition was obtained in the presence of 17% sulphated DS but not 1% sulphated DS. Other proteoglycan molecules, such as chondroitin sulphate, hyaluronic acid and heparin, and fibronectin, the extracellular matrix protein targeted by treponemes in parasitism of host cells and tissues neither diminished nor enhanced LDL binding by live treponemes. Only 5% and 10% of associated radioactivity was released from treponemal surfaces after Tpallidum was incubated with iodinated LDL and 17% sulphated-DS for 15 and 30 minutes, respectively. These data show binding and possible internalisation of host lipoproteins by T pallidum, which may be mediated by sulphated proteoglycan. Sulphated proteoglycans accumulate during Tpallidum infections of host cells.

Journal of Bioactive and Compatible Polymers, 2011

Bundle membranes were made by electrospinning poly(L-lactide) (PLLA) and PLLA/poly(ethylene glyco... more Bundle membranes were made by electrospinning poly(L-lactide) (PLLA) and PLLA/poly(ethylene glycol) (PEG) using the ionic properties of diclofenac sodium (DS), lidocaine hydrochloride (LHC), benzalkonium chloride (BC), and combinations thereof. The self-bundling of the fibers was initiated by using a designed grounded multi-needle electrode. Computer simulations on the electrostatic field distribution depended on the multi-needle position with respect to a grounded

Introducción: El síndrome metabólico (SM) se caracteriza por la intolerancia a la glucosa, dislip... more Introducción: El síndrome metabólico (SM) se caracteriza por la intolerancia a la glucosa, dislipemia, obesidad e hipertensión arterial. Su importancia radica en que las personas que lo padecen tienen un mayor riesgo de eventos coronarios a 10 años vista. En determinadas poblaciones presenta una alta prevalencia, que lega hasta casi el 20%.

Dementia and Geriatric Cognitive Disorders, 1994

Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomog... more Correlational analysis of cerebral metabolic (rCMRglc) data obtained with positron emission tomography (PET) assesses group differences and has demonstrated reduced frontal-parietal rCMRglc interdependencies in Alzheimer's disease (AD). A multivariate analysis of rCMRglc data assesses individual differences. We recently identified discriminant functions, reflecting frontal-parietal rCMRglc interdependencies, that separated AD from control subjects. To test if the functions would identify an AD rCMRglc pattern in older Down syndrome (DS) adults with (DS DAT+) or without (DS DAT-) dementia, we applied the functions to longitudinal rCMRglc data in: young DS (n = 15), DS DAT- (n = 10), DS DAT+ (n = 4), and young controls (n = 15). All DS DAT+ and some of the later DS DAT- scans were classified as AD. The results provide additional validation of the functions and suggest their utility for the early detection of AD.