Fabrice DAVID - Academia.edu (original) (raw)

Uploads

Videos by Fabrice DAVID

Presentation about the replication of Direct Conversion of LENR energy ( Lattice Energy) into el... more Presentation about the replication of Direct Conversion of LENR energy ( Lattice Energy) into electricity, made during the RNBE 2020 meeting at Paris, 21th november 2020.

8 views

Papers by Fabrice DAVID

Research paper thumbnail of Detection and typing of human papillomavirus DNA from cervical biopsies by the slot-blot hybridization method

Molecular and Cellular Probes, Feb 1, 1990

Cervical biopsies collected from 105 consecutive patients participating in a prospective follow-u... more Cervical biopsies collected from 105 consecutive patients participating in a prospective follow-up study for cervical human papillomavirus (HPV) infections were tested for the presence of HPV 6, 11, 16 and 18 DNA by the slot-blot hybridization method. Detectable HPV types 6 and 11 could be distinguished in high stringency hybridization assay. The overall HPV-DNA detection rate was 35.2% in our group of patients. The slot-blot technique is more rapid than Southern-blotting procedure and well suited for analysis of multiple specimens.

Research paper thumbnail of Alzheimer's mutation

Research paper thumbnail of Notre expérience de la détection de l'ADN du virus de l'hépatite B par hybridation moléculaire

Immuno-analyse & biologie spécialisée, Nov 1, 1989

Resume Nous avons utilise une technique d'hybridation moleculaire par slot-blot pour la detec... more Resume Nous avons utilise une technique d'hybridation moleculaire par slot-blot pour la detection de l'ADN du virus de l'hepatite B (HBV) dans le serum. Le procede utilise comprend une methode rapide de preparation du serum, le depot par aspiration des echantillons sur membrane de nitrocellulose, l'emploi d'une sonde virale d'ADN entiere marquee au 32P, et l'enregistrement densitometrique des bandes autoradiographiees. Les resultats obtenus sont compares a ceux des marqueurs Ag HBe et Ac anti-HBe.

Research paper thumbnail of Molecular deletion patterns in Duchenne muscular dystrophy patients

PubMed, 1989

We have studied 30 French patients with X-linked muscular dystrophy of the Duchenne (DMD) and Bec... more We have studied 30 French patients with X-linked muscular dystrophy of the Duchenne (DMD) and Becker (BMD) types for intragenic deletions, using the cDNA probes of the DMD/BMD gene. Sixteen patients (53%) had molecular deletions in one or several of the 65 Hind III fragments containing exons detected with the DNA probes; in four deletion cases junction, fragments of altered size were seen. Fourteen (87%) of the deletions were detected using only two (1-2a and 8) and fifteen with 8+(2b-3) of the cDNA subclones. In our limited sample, BMD was caused by deletions in the 5' end of the gene, and in two instances of DMD, deletions of similar types resulted in diseases of similar severity. Of two patients with mental retardation, both had deletions comprised exons contained in probe 8, but other patients without mental retardation are also deleted with probe 8. We conclude that cDNA hybridization studies provide a powerful diagnostic tool in DMD and BMD families.

Research paper thumbnail of Brief Communication: Y-Chromosome-Specific Haplotypes of Jews Detected by Probes 49f and 49a

Research paper thumbnail of Détection des mutations de la mucoviscidose dans les familles de la région parisienne

Journal de Pédiatrie et de Puériculture, Apr 1, 1994

Nous avons procede a la detection de la mutation principale (ΔF508) de la mucoviscidose et de sep... more Nous avons procede a la detection de la mutation principale (ΔF508) de la mucoviscidose et de sept autres mutations relativement frequentes en Europe pour 78 familles domiciliees dans la region parisienne. Les resultats obtenus sont discutes en fonction de l'origine ethnique/regionale des familles, de la structure familiale et du nombre d'individus testes dans chaque famille. Les motivations de la demande d'analyse sont aussi examinees. Dans 24 familles cependant (un certain nombre d'entre elles concernant des formes adultes, ou mal definies), aucun des deux alleles au gene mute n'a pu etre identifie.

Research paper thumbnail of Une méthode d'amplification génique isotherme

Comptes Rendus Biologies, Nov 1, 1998

Research paper thumbnail of Méthode de détection directe simplifiée par PCR sur tache de sang séché de la mutation principale responsable de la mucoviscidose

Immuno-analyse & biologie spécialisée, Sep 1, 1991

Resume Nous decrivons une methode de detection de la deletion, nommee ΔF508, par une reaction de ... more Resume Nous decrivons une methode de detection de la deletion, nommee ΔF508, par une reaction de polymerisation en chaine (PCR) faisant intervenir deux combinaisons d'amoroes oligonucleotiques, qui peuvent permettre la distinction des alleles mutants et normaux. Cette amplification specifique d'alleles constitue une methode rapide, non radioactive et tres fiable de detection genique directe sur les taches de sang seche.

Research paper thumbnail of Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population

Human Genetics, 1989

In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs)... more In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.

Research paper thumbnail of Nucleotide sequence of p49a, a genomic Y-specific probe with potential utilization in sex determination

Molecular and Cellular Probes, Oct 1, 1991

The nucleotide sequence of probe 49a, a genomic polymorphic probe located on the long arm of the ... more The nucleotide sequence of probe 49a, a genomic polymorphic probe located on the long arm of the Y chromosome, is described. It is an untranslated sequence of about 750 bp with a high A + T content. This sort of selectively neutral sequence can be used with the polymerase chain reaction in sex determination.

Research paper thumbnail of Association of apolipoprotein E allele ε4 with late-onset sporadic Alzheimer's disease

American journal of medical genetics, Sep 15, 1994

Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic ... more Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.

Research paper thumbnail of Apolipoprotein E-∈A allele and Alzheimer's disease

Research paper thumbnail of Brief Communication: Y-Chromosome-Specific Haplotypes of Jews Detected by Probes 49f and 49a

A sample of Ashkenazic and Sephardic Jews has been studied with respect to haplotypes at the 49f-... more A sample of Ashkenazic and Sephardic Jews has been studied with respect to haplotypes at the 49f-49a Y-specific DNA probes. Only seven haplotypes were found in Jews, three of them (VII, VIII, and XI) being the most widespread. Haplotype distribution in the European non-Jewish population is different

Research paper thumbnail of DIRECT CONVERSION : REPLICATIONS F. David 14th IWAHLM, 29 august-1 september 2021 Assisi, Italy

Research paper thumbnail of Poster Iccf 23 Direct Conversion: Replications

Research paper thumbnail of ABOUT DISCRETE BREATHERS AND LENR Fabrice DAVID 14 th International Workshop on Anomalies in Hydrogen Loaded Metals Asti, Italy , 5-9 june 2017

Research paper thumbnail of Alternatives to Calorimetry, Présentation F. David & J. Giles ICCF21 Fort Collins, Co, june 2018

Research paper thumbnail of Son Of The Thunder : ABOUT BALL LIGHTNING (Présentation F. David at ANV4 Meeting Assise2020 LENR & EARTH)

Research paper thumbnail of Erratum primers PANAC

Presentation about the replication of Direct Conversion of LENR energy ( Lattice Energy) into el... more Presentation about the replication of Direct Conversion of LENR energy ( Lattice Energy) into electricity, made during the RNBE 2020 meeting at Paris, 21th november 2020.

8 views

Research paper thumbnail of Detection and typing of human papillomavirus DNA from cervical biopsies by the slot-blot hybridization method

Molecular and Cellular Probes, Feb 1, 1990

Cervical biopsies collected from 105 consecutive patients participating in a prospective follow-u... more Cervical biopsies collected from 105 consecutive patients participating in a prospective follow-up study for cervical human papillomavirus (HPV) infections were tested for the presence of HPV 6, 11, 16 and 18 DNA by the slot-blot hybridization method. Detectable HPV types 6 and 11 could be distinguished in high stringency hybridization assay. The overall HPV-DNA detection rate was 35.2% in our group of patients. The slot-blot technique is more rapid than Southern-blotting procedure and well suited for analysis of multiple specimens.

Research paper thumbnail of Alzheimer's mutation

Research paper thumbnail of Notre expérience de la détection de l'ADN du virus de l'hépatite B par hybridation moléculaire

Immuno-analyse & biologie spécialisée, Nov 1, 1989

Resume Nous avons utilise une technique d'hybridation moleculaire par slot-blot pour la detec... more Resume Nous avons utilise une technique d'hybridation moleculaire par slot-blot pour la detection de l'ADN du virus de l'hepatite B (HBV) dans le serum. Le procede utilise comprend une methode rapide de preparation du serum, le depot par aspiration des echantillons sur membrane de nitrocellulose, l'emploi d'une sonde virale d'ADN entiere marquee au 32P, et l'enregistrement densitometrique des bandes autoradiographiees. Les resultats obtenus sont compares a ceux des marqueurs Ag HBe et Ac anti-HBe.

Research paper thumbnail of Molecular deletion patterns in Duchenne muscular dystrophy patients

PubMed, 1989

We have studied 30 French patients with X-linked muscular dystrophy of the Duchenne (DMD) and Bec... more We have studied 30 French patients with X-linked muscular dystrophy of the Duchenne (DMD) and Becker (BMD) types for intragenic deletions, using the cDNA probes of the DMD/BMD gene. Sixteen patients (53%) had molecular deletions in one or several of the 65 Hind III fragments containing exons detected with the DNA probes; in four deletion cases junction, fragments of altered size were seen. Fourteen (87%) of the deletions were detected using only two (1-2a and 8) and fifteen with 8+(2b-3) of the cDNA subclones. In our limited sample, BMD was caused by deletions in the 5' end of the gene, and in two instances of DMD, deletions of similar types resulted in diseases of similar severity. Of two patients with mental retardation, both had deletions comprised exons contained in probe 8, but other patients without mental retardation are also deleted with probe 8. We conclude that cDNA hybridization studies provide a powerful diagnostic tool in DMD and BMD families.

Research paper thumbnail of Brief Communication: Y-Chromosome-Specific Haplotypes of Jews Detected by Probes 49f and 49a

Research paper thumbnail of Détection des mutations de la mucoviscidose dans les familles de la région parisienne

Journal de Pédiatrie et de Puériculture, Apr 1, 1994

Nous avons procede a la detection de la mutation principale (ΔF508) de la mucoviscidose et de sep... more Nous avons procede a la detection de la mutation principale (ΔF508) de la mucoviscidose et de sept autres mutations relativement frequentes en Europe pour 78 familles domiciliees dans la region parisienne. Les resultats obtenus sont discutes en fonction de l'origine ethnique/regionale des familles, de la structure familiale et du nombre d'individus testes dans chaque famille. Les motivations de la demande d'analyse sont aussi examinees. Dans 24 familles cependant (un certain nombre d'entre elles concernant des formes adultes, ou mal definies), aucun des deux alleles au gene mute n'a pu etre identifie.

Research paper thumbnail of Une méthode d'amplification génique isotherme

Comptes Rendus Biologies, Nov 1, 1998

Research paper thumbnail of Méthode de détection directe simplifiée par PCR sur tache de sang séché de la mutation principale responsable de la mucoviscidose

Immuno-analyse & biologie spécialisée, Sep 1, 1991

Resume Nous decrivons une methode de detection de la deletion, nommee ΔF508, par une reaction de ... more Resume Nous decrivons une methode de detection de la deletion, nommee ΔF508, par une reaction de polymerisation en chaine (PCR) faisant intervenir deux combinaisons d'amoroes oligonucleotiques, qui peuvent permettre la distinction des alleles mutants et normaux. Cette amplification specifique d'alleles constitue une methode rapide, non radioactive et tres fiable de detection genique directe sur les taches de sang seche.

Research paper thumbnail of Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population

Human Genetics, 1989

In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs)... more In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.

Research paper thumbnail of Nucleotide sequence of p49a, a genomic Y-specific probe with potential utilization in sex determination

Molecular and Cellular Probes, Oct 1, 1991

The nucleotide sequence of probe 49a, a genomic polymorphic probe located on the long arm of the ... more The nucleotide sequence of probe 49a, a genomic polymorphic probe located on the long arm of the Y chromosome, is described. It is an untranslated sequence of about 750 bp with a high A + T content. This sort of selectively neutral sequence can be used with the polymerase chain reaction in sex determination.

Research paper thumbnail of Association of apolipoprotein E allele ε4 with late-onset sporadic Alzheimer's disease

American journal of medical genetics, Sep 15, 1994

Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic ... more Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.

Research paper thumbnail of Apolipoprotein E-∈A allele and Alzheimer's disease

Research paper thumbnail of Brief Communication: Y-Chromosome-Specific Haplotypes of Jews Detected by Probes 49f and 49a

A sample of Ashkenazic and Sephardic Jews has been studied with respect to haplotypes at the 49f-... more A sample of Ashkenazic and Sephardic Jews has been studied with respect to haplotypes at the 49f-49a Y-specific DNA probes. Only seven haplotypes were found in Jews, three of them (VII, VIII, and XI) being the most widespread. Haplotype distribution in the European non-Jewish population is different

Research paper thumbnail of DIRECT CONVERSION : REPLICATIONS F. David 14th IWAHLM, 29 august-1 september 2021 Assisi, Italy

Research paper thumbnail of Poster Iccf 23 Direct Conversion: Replications

Research paper thumbnail of ABOUT DISCRETE BREATHERS AND LENR Fabrice DAVID 14 th International Workshop on Anomalies in Hydrogen Loaded Metals Asti, Italy , 5-9 june 2017

Research paper thumbnail of Alternatives to Calorimetry, Présentation F. David & J. Giles ICCF21 Fort Collins, Co, june 2018

Research paper thumbnail of Son Of The Thunder : ABOUT BALL LIGHTNING (Présentation F. David at ANV4 Meeting Assise2020 LENR & EARTH)

Research paper thumbnail of Erratum primers PANAC

Research paper thumbnail of EXPERIMENTAL RESULTS AND PROJECTS IN THE FIELD OF COLD NUCLEAR TRANSMUTATIONS & NEW ENERGY 19 th Russian Conférence on Cold Nuclear Transmutation and Ball Lightning October 2012 KRINITSA (Russia) FABRICE DAVID & JOHN GILES

Research paper thumbnail of J. Brandenburg F. David Kepler ICCF 24 presentation Direct Conversion PDF

Direct Conversion of LENR in Solid-State-Fusion Diodes : Preliminary Results, 2022

The technology of “Fusion Diodes” makes it possible to transform the energy produced by the Low ... more The technology of “Fusion Diodes” makes it possible to transform the energy produced by the Low Energy Nuclear Reactions directly into electricity. Light, reliable, able to operate for long periods of time, LENR -powered Solid State Generators are the ideal sources of electrical energy for space applications. The absence of moving parts makes Solids States Generators with Fusion Diodes particularly reliable. The author also report the results of their replication experiments of Gas Fusion Diodes or “Lattice Energy Converters”.

The fusion diodes could be used to power the on-board electronics, but also ion thrusters. They can be used in deep space where solar panels are unusable.

The new physical phenomena discovered during the study of the properties of hydrogen isotopes in alloys will also make it possible to build new space propulsion devices with high specific impulse.

Latest results are presented.

Research paper thumbnail of Direct Conversion of LNENR into Solid-State Fusion Diodes

Solid-State Fusion Summit, july 25-28, Mountain View CA, 2022

The technology of “Fusion Diodes” makes it possible to transform the energy produced by the Low E... more The technology of “Fusion Diodes” makes it possible to transform the energy produced by the Low Energy Nuclear Reactions directly into electricity. Light, reliable, able to operate for long periods of time, LENR -powered Solid State Generators are the ideal sources of electrical energy for space applications. The absence of moving parts makes Solids States Generators with Fusion Diodes particularly reliable. The author also report the results of their replication experiments of Gas Fusion Diodes or “Lattice Energy Converters”. The fusion diodes could be used to power the on-board electronics, but also ion thrusters. They can be used in deep space where solar panels are unusable. The new physical phenomena discovered during the study of the properties of hydrogen isotopes in alloys will also make it possible to build new space propulsion devices with high specific impulse. Latest results are presented.