DAVID LEE BEZERRA AMARAL - Academia.edu (original) (raw)

Papers by DAVID LEE BEZERRA AMARAL

Research paper thumbnail of Magnetic Resonance Imaging of the Post-Mortem Autistic Brain

Journal of Autism and Developmental Disorders, 2001

Magnetic resonance imaging (MRI) is a valuable, noninvasive tool for understanding structural abn... more Magnetic resonance imaging (MRI) is a valuable, noninvasive tool for understanding structural abnormalities in the brain. The M.I.N.D. Institute at UC Davis has developed a protocol utilizing MRI to investigate anatomical differences in the post-mortem brain by applying a proton density weighted imaging sequence for optimal differences in image intensity (contrast) between gray and white matter. Images of the brain

Research paper thumbnail of Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders

Proceedings of the National Academy of Sciences, 2011

Autism is a heterogeneous disorder with multiple behavioral and biological phenotypes. Accelerate... more Autism is a heterogeneous disorder with multiple behavioral and biological phenotypes. Accelerated brain growth during early childhood is a well-established biological feature of autism. Onset pattern, i.e., early onset or regressive, is an intensely studied behavioral phenotype of autism. There is currently little known, however, about whether, or how, onset status maps onto the abnormal brain growth. We examined the relationship between total brain volume and onset status in a large sample of 2- to 4-y-old boys and girls with autism spectrum disorder (ASD) [ n = 53, no regression (nREG); n = 61, regression (REG)] and a comparison group of age-matched typically developing controls ( n = 66). We also examined retrospective head circumference measurements from birth through 18 mo of age. We found that abnormal brain enlargement was most commonly found in boys with regressive autism. Brain size in boys without regression did not differ from controls. Retrospective head circumference m...

Research paper thumbnail of Against Le Packing: A Consensus Statement

Journal of the American Academy of Child & Adolescent Psychiatry, 2011

Research paper thumbnail of Description of brain injury in the amnesic patient N.A. Based on magnetic resonance imaging

Experimental Neurology, 1989

Research paper thumbnail of Progress and Implications for Mental Health

ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biolo... more ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biological systems implement social processes and behavior. Social neuroscience capitalizes on biological concepts and methods to inform and refine theories of social behavior, and it uses social and behavioral constructs and data to inform and refine theories of neural organization and function. We focus here on the progress and potential of social neuroscience in the area of mental health. Research in social neuroscience has grown ...

Research paper thumbnail of Progress and Implications for Mental Health

ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biolo... more ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biological systems implement social processes and behavior. Social neuroscience capitalizes on biological concepts and methods to inform and refine theories of social behavior, and it uses social and behavioral constructs and data to inform and refine theories of neural organization and function. We focus here on the progress and potential of social neuroscience in the area of mental health. Research in social neuroscience has grown ...

Research paper thumbnail of Magnetic Resonance Imaging of the Post-Mortem Autistic Brain

Journal of Autism and Developmental Disorders, 2001

Magnetic resonance imaging (MRI) is a valuable, noninvasive tool for understanding structural abn... more Magnetic resonance imaging (MRI) is a valuable, noninvasive tool for understanding structural abnormalities in the brain. The M.I.N.D. Institute at UC Davis has developed a protocol utilizing MRI to investigate anatomical differences in the post-mortem brain by applying a proton density weighted imaging sequence for optimal differences in image intensity (contrast) between gray and white matter. Images of the brain

Research paper thumbnail of Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders

Proceedings of the National Academy of Sciences, 2011

Autism is a heterogeneous disorder with multiple behavioral and biological phenotypes. Accelerate... more Autism is a heterogeneous disorder with multiple behavioral and biological phenotypes. Accelerated brain growth during early childhood is a well-established biological feature of autism. Onset pattern, i.e., early onset or regressive, is an intensely studied behavioral phenotype of autism. There is currently little known, however, about whether, or how, onset status maps onto the abnormal brain growth. We examined the relationship between total brain volume and onset status in a large sample of 2- to 4-y-old boys and girls with autism spectrum disorder (ASD) [ n = 53, no regression (nREG); n = 61, regression (REG)] and a comparison group of age-matched typically developing controls ( n = 66). We also examined retrospective head circumference measurements from birth through 18 mo of age. We found that abnormal brain enlargement was most commonly found in boys with regressive autism. Brain size in boys without regression did not differ from controls. Retrospective head circumference m...

Research paper thumbnail of Against Le Packing: A Consensus Statement

Journal of the American Academy of Child & Adolescent Psychiatry, 2011

Research paper thumbnail of Description of brain injury in the amnesic patient N.A. Based on magnetic resonance imaging

Experimental Neurology, 1989

Research paper thumbnail of Progress and Implications for Mental Health

ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biolo... more ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biological systems implement social processes and behavior. Social neuroscience capitalizes on biological concepts and methods to inform and refine theories of social behavior, and it uses social and behavioral constructs and data to inform and refine theories of neural organization and function. We focus here on the progress and potential of social neuroscience in the area of mental health. Research in social neuroscience has grown ...

Research paper thumbnail of Progress and Implications for Mental Health

ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biolo... more ABSTRACT—Social neuroscience is a new, interdisciplinary field devoted to understanding how biological systems implement social processes and behavior. Social neuroscience capitalizes on biological concepts and methods to inform and refine theories of social behavior, and it uses social and behavioral constructs and data to inform and refine theories of neural organization and function. We focus here on the progress and potential of social neuroscience in the area of mental health. Research in social neuroscience has grown ...