Daniel Boixeda - Academia.edu (original) (raw)

Papers by Daniel Boixeda

Antimicrobial Agents and Chemotherapy, 1999

Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were stu... more Mutations conferring resistance to erythromycin or clarithromycin in Helicobacter pylori were studied. Mutation A2142G was consistently associated with clarithromycin MIC of >256 μg/ml, whereas mutants carrying A2143G had MICs ranging from ≤0.016 to >256 μg/ml, suggesting that additional factors account for the observed multiple levels of resistance to clarithromycin.

American Journal of Clinical Pathology, 1986

The existence of tumors producing prostaglandins is well documented in the literature. At present... more The existence of tumors producing prostaglandins is well documented in the literature. At present, no case report of a prostaglandin-producing hepatocellular carcinoma has been published, to our knowledge. The authors report a patient with hepatocellular carcinoma associated with diarrhea mediated by prostaglandins, surviving 30 months after receiving treatment with indomethacin and Adriamycin. The authors will discuss the possible role played by indomethacin in the exceptional clinical course of the patient.

Gastroenterología y Hepatología, 2001

Hepato-gastroenterology

To establish rapid urease test utility for initial diagnosis of Helicobacter pylori infection in ... more To establish rapid urease test utility for initial diagnosis of Helicobacter pylori infection in gastric ulcer patients and to determine the best site for sampling for gastric biopsies. Seventy consecutive gastric ulcer patients were prospectively studied. All these patients underwent three biopsies from both antrum and body (two for hematoxylin-eosin staining and one for rapid urease test -Jatrox H. p. Test-). Likewise, IgG ELISA serology and 13C-urea breath test were carried out. Gold standard for H. pylori infection was defined as two or more tests (i.e., histology, serology, breath test) with positive results. Rapid urease test yielded 96.8% sensitivity (95% CI = 89-99%) and 100% (66-100%) specificity when using biopsy specimens from the body, with identical results when biopsy specimens from both antrum and body were considered together. However, when only biopsy specimens from the antrum were used, sensitivity dropped to 72.6% (60-82%) and specificity was 100% (66-100%). As fa...

Gastroenterología y Hepatología, 2009

ABSTRACT

Medicina Clínica, 2000

espanolFundamento. Valorar la influencia de la erradicacion de Helicobacter pylori sobre la incid... more espanolFundamento. Valorar la influencia de la erradicacion de Helicobacter pylori sobre la incidencia de recurrencias ulcerosas durante un periodo de seguimiento de 12 meses en enfermos con ulcera gastrica. Pacientes y metodo. Se estudiaron prospectivamente a 73 enfermos con ulcera gastrica. Durante la endoscopia se tomaron, tanto de antro como de cuerpo, dos biopsias para estudio histologico (hematoxilina-eosina) y una para test rapido de la ureasa. Tambien se realizaron serologia y prueba del aliento con urea-13C. Cincuenta y seis pacientes infectados por H. pylori fueron seguidos tras administrar una terapia erradicadora con omeprazol, claritromicina y amoxicilina. Inmediatamente despues de completar el tratamiento erradicador, se llevo a cabo una endoscopia de control de la cicatrizacion. Al mes de finalizar la terapia se realizo una segunda endoscopia con estudio histologico y un test del aliento (se definio la erradicacion como la ausencia de H. pylori por ambas tecnicas). Finalmente, para estudiar las recurrencias ulcerosas se efectuo de nuevo una endoscopia a los 6 y 12 meses. Resultados. La edad media de los pacientes estudiados fue de 54 ± 13 anos, y el 69% eran va-rones. La tasa acumulada de recurrencias ulcerosas a los 12 meses en los grupos con exito y fracaso erradicador fue, respectivamente, del 2,3% (IC del 95%, 0-12%) y del 70% (IC del 95%, 34-93%) (?2: 23,9; p Conclusiones. La erradicacion de H. pylori se asocia con una drastica reduccion de la recidiva de la ulcera gastrica, con una tasa de recurrencia acumulada durante 12 meses de solo el 2,3%. Esto indica que podria lograrse la curacion definitiva de esta enfermedad mediante la erradicacion del microorganismo. EnglishBackground: To study the influence of Helicobacter pylori eradication on the incidence of ulcer recurrence during 12 months of follow-up in gastric ulcer patients. Patients and methods: Seventy-three patients with gastric ulcer were prospectively studied. At endoscopy two biopsies from both antrum and body for haematoxylin-eosin staining and one for rapid urease test were obtained. Likewise, serology and 13C-urea breath test were carried out. Fifty-six H. pylori infected patients were monitored after giving an eradication therapy with omeprazole, clarithromycin and amoxicillin. A first control endoscopy was performed immediately after completing treatment to confirm ulcer healing. A second control endoscopy (with histologic study) and a breath test were performed one month after completing therapy (eradication was defined as the absence of H. pylori by both methods). Finally, an endoscopy was repeated at 6 and 12 months to study ulcer recurrences. Results: Mean age was 54 ± 13 years (69% males). Cumulative ulcer recurrence rate for 12 months, respectively for patients with eradication success and failure, was 2.3% (95% CI, 012%) and 70% (34-93%) (?2: 23.9; p Conclusions: H. pylori eradication is associated with a dramatic reduction on the recurrence of gastric ulcer, with a cumulative recurrence rate during 12 months of only 2.3%, which suggests that definitive cure of gastric ulcer disease is possible by means of microorganism eradication.

Gastroenterología y Hepatología, 2008

Gastroenterología y Hepatología, 2013

El consenso se ajustó a las recomendaciones éticas establecidas 7. Recomendaciones Cada recomenda... more El consenso se ajustó a las recomendaciones éticas establecidas 7. Recomendaciones Cada recomendación se acompaña del resultado de la votación (porcentaje de acuerdo), el grado de recomendación (GR; fuerte o débil), la calidad de la evidencia (CE; alta, moderada, baja o muy baja) y de la discusión de la evidencia correspondiente. Sección A: Indicaciones de tratamiento de la infección por Helicobacter pylori En la tabla 1 se incluyen las recomendaciones aprobadas por el consenso español sobre las indicaciones de tratamiento de la infección por H. pylori. En la tabla 2 se resumen las indicaciones aceptadas. Recomendación A1 En los pacientes con úlcera péptica e infección por H. pylori se recomienda administrar tratamiento erradicador.

Scandinavian Journal of Gastroenterology, 2008

Objective. Diagnosis of Wilson's disease (WD) is reliant on liver biopsy (LB) and measurement of ... more Objective. Diagnosis of Wilson's disease (WD) is reliant on liver biopsy (LB) and measurement of hepatic copper. The aim of this study was to determine the usefulness of penicillamine-stimulated urinary copper excretion (PS-UCE), a noninvasive diagnostic test, for the diagnosis of WD in adults. Material and methods. In this prospective study of patients with suspected WD, total serum copper, ceruloplasmin, basal 24-h UCE and PS-UCE levels were measured. LB with copper determination was performed in those patients with persistent hypertransaminasemia and low ceruloplasmin or basal UCE 40 mg/24 h. Diagnosis was established if the ceruloplasmin level was found to be B20 mg/dl and hepatic copper 250 mg/g. Results. A total of 115 patients were studied; LB was performed in 43, and WD was diagnosed in 6 (13.9%). Significant differences between WD and non-WD patients were found for basal UCE (WD: median 134.3 mg/24 h versus non-WD: median 19.0 mg/24 h (pB0.05)) and PS-UCE (WD: median 1284.0 mg/24 h versus non-WD: median 776.0 mg/24 h; p B0.01). In the ROC (receiver-operated curve) analysis, PS-UCE was the best discriminant between WD and non-WD (area under the curve (AUC) 00.911, best cutoff point 1057 mg/24 h, 100% sensitivity, 82.3% specificity). Conclusions. PS-UCE is probably a useful non-invasive test in the diagnosis of WD, improving the selection of patients for diagnostic liver biopsy. Patients with PS-UCE under 1057 mg/24 h only rarely will suffer from WD and are unlikely to benefit from LB.

Journal of Hepatology, 1999

Gastrointestinal Endoscopy, 2004