DEBENDRA MAJHI 222062404006 - Academia.edu (original) (raw)
Uploads
Papers by DEBENDRA MAJHI 222062404006
Asian Journal of Chemistry
Pyrrolyl-pyridine heterocyclic compounds have received considerable attention because of its uniq... more Pyrrolyl-pyridine heterocyclic compounds have received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the synthesis of novel C–N, C–C bond formations like 5-substituted-1-benzyl-1Hpyrrolo[ 2,3-b]pyridines (3), 2-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenol (5) and screened for their anticancer activity. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, mass spectral techniques and elemental analysis. The outcomes of these compounds 2,6-difluorobenzylpyrrolidin- 1H-pyrrolo[2,3-b]pyridine, 2,6-difluorobenzyl-N,N-dimethyl-1H-pyrrolo[2,3-b]-pyridin-5-amine had a signicant anticancer activity against human cervical cancer cell line (Hela) with IC50 4.8, 9.7 μg/mL and whereas pyrrolo[2,3-b]pyridin-5-phenol, pyrrolo[2,3-b]pyridin-5-vinylphenol are active against human breast cancer cell line (MCF-7) with IC50 8.1, 3.2 μg/mL, respectively.
Current Drug Discovery Technologies
Aims/Background: In the present study, a new series of 1,2,4-triazole linked to pyrazole derivati... more Aims/Background: In the present study, a new series of 1,2,4-triazole linked to pyrazole derivatives (8a-j) of 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized and assessed for their antibacterial and anticancer activity. Objective: Encouraged by these results, these analogues 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones 8 have been synthesized and their inhibitory potential activity against different bacterial microorganisms and cancer cell lines was discussed. Methods: All the synthesized final scaffolds were characterized by 1H NMR, 13C NMR, IR, mass and elemental analysis. All the synthesized 1,2,4–triazole linked to pyrazole compounds were evaluated for their antimicrobial sensitivity by using the agar dilution technique. The anticancer activity of these compounds has been assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt...
Asian Journal of Chemistry
Pyrrolyl-pyridine heterocyclic compounds have received considerable attention because of its uniq... more Pyrrolyl-pyridine heterocyclic compounds have received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the synthesis of novel C–N, C–C bond formations like 5-substituted-1-benzyl-1Hpyrrolo[ 2,3-b]pyridines (3), 2-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenol (5) and screened for their anticancer activity. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, mass spectral techniques and elemental analysis. The outcomes of these compounds 2,6-difluorobenzylpyrrolidin- 1H-pyrrolo[2,3-b]pyridine, 2,6-difluorobenzyl-N,N-dimethyl-1H-pyrrolo[2,3-b]-pyridin-5-amine had a signicant anticancer activity against human cervical cancer cell line (Hela) with IC50 4.8, 9.7 μg/mL and whereas pyrrolo[2,3-b]pyridin-5-phenol, pyrrolo[2,3-b]pyridin-5-vinylphenol are active against human breast cancer cell line (MCF-7) with IC50 8.1, 3.2 μg/mL, respectively.
Current Drug Discovery Technologies
Aims/Background: In the present study, a new series of 1,2,4-triazole linked to pyrazole derivati... more Aims/Background: In the present study, a new series of 1,2,4-triazole linked to pyrazole derivatives (8a-j) of 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized and assessed for their antibacterial and anticancer activity. Objective: Encouraged by these results, these analogues 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones 8 have been synthesized and their inhibitory potential activity against different bacterial microorganisms and cancer cell lines was discussed. Methods: All the synthesized final scaffolds were characterized by 1H NMR, 13C NMR, IR, mass and elemental analysis. All the synthesized 1,2,4–triazole linked to pyrazole compounds were evaluated for their antimicrobial sensitivity by using the agar dilution technique. The anticancer activity of these compounds has been assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt...