DEEPTI KATIYAR - Academia.edu (original) (raw)

Papers by DEEPTI KATIYAR

Toxin reviews, Apr 2, 2024

Combinatorial chemistry & high throughput screening, Jan 25, 2024

Materials Today: Proceedings, Sep 30, 2023

Current Drug Therapy, Aug 17, 2023

Combinatorial chemistry & high throughput screening, Jan 25, 2024

Materials Today: Proceedings, May 1, 2023

Routledge eBooks, May 18, 2023

International Journal of Pharmaceutical Sciences and Research, 2010

The Natural Products Journal

: Hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and a... more : Hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, occurring in high concentrations in citrus fruits. Citrus fruits and juices are widely consumed worldwide and are readily available dietary sources for their intake. Its use has been associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, anti-inflammatory and anti-carcinogenic properties. Due to its biological activities, hesperidin is often used in the food, cosmetic and pharmaceutical industries. Supplements containing hesperidin, alone or in combination with other citrus bioflavonoids, are commercially available. The utilization of hesperidin can be used for the production of novel nutraceuticals or for the improvement of older ones. This piece of review aims to discuss the various diversified aspects of the naturally occurring bioflavonoid hesperidin.

The journal of phytopharmacology, Apr 25, 2015

A steam distilled volatile oil from the fresh leaves of Citrus sinensis Linn. analysed by capilla... more A steam distilled volatile oil from the fresh leaves of Citrus sinensis Linn. analysed by capillary-GC and GC-MS yielded eight components, of which seven were monoterpenic (99.6%) and one ester (0.4%). Cis-sabinene hydrate (35.1%) was the predominant monoterpene, followed by l-limonene (30.1%), citral (27.9%), lavendulol (2.5%), perillaldehyde (2.0%), α-pinene (1.4%) and perillyl alcohol (0.6%). The ester obtained was tert.-butyl benzoate (0.4%). Whereas volatile oil from its fresh fruit peels yielded five components of which three were monoterpenes (76.5%) and remaining two were non-terpenic compounds. α-pinene (60.80%) was the predominant monoterpene, followed by verbenone (15.40%) and α-thujene (0.30%).The non-terpenic compounds obtained was N-pentylcyclopentane (11.80%) and cyclopentenyl ethyne (11.70%). The maximum antibacterial activity was shown with 1%v/v of volatile oil collected from Greater Noida, U.P on Staphylococcus aureus (16.4 mm) followed by Escherichia coli (14.2 mm), and maximum anti-fungal activity was shown on Candida albicans (13.1 mm) followed by Aspergillus niger (12.5 mm).

Current Drug Therapy

: For a very long time, clay has been widely utilized in cosmetics, and it is still one of the mo... more : For a very long time, clay has been widely utilized in cosmetics, and it is still one of the most widely used components today. There is clay for every skincare issue and problem, including dryness, irritation, sunburn, and oiliness. Finding the appropriate clay for the skin's type, texture, and needs is the primary consideration. The current effort attempts to compile knowledge on the many dermatological types of clay that are naturally present, their composition, and various views regarding the care, skin nourishment, and benefits needed to suit the various needs of various skin types. The present work aims to gather the information available on the different types of dermatological clays present naturally, their composition, and different perspectives regarding the care and skin nourishment, and their benefits required to suit different needs of different skin types.

Current Molecular Medicine

Background: Fungal infections have become a worldwide problem due to their involvement in numerou... more Background: Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The problem of resistance in fungi against drug therapies is widespread, becoming a severe health-related problem. Objective: The study's objective was to identify molecular targets that may open new paths for fungal treatment. Methods: Several research and review articles were studied to gather information regarding the novel mechanism of antifungal drugs. However, identifying novel targets is challenging due to the similarities between host and fungal cells. Although, the plasma membrane and cell wall of fungus offer various drug targets that may target to fight against microbial infections. Unfortunately, biofilm formation and over-expression of protein are a few mechanisms through which fungi develop re...

Materials Today: Proceedings

Current Drug Therapy

: Secondary metabolites of natural origin exhibit numerous pharmacological activities, like anti-... more : Secondary metabolites of natural origin exhibit numerous pharmacological activities, like anti-inflammatory and anti-oxidant effects. Lipid peroxidation has been observed to be prevented by terminating free radical chains and chelating redox active metal ions. These properties of the secondary products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed with plenty of unexplored phytometabolites, which contain the probability to carry huge antineoplastic potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and series of developmental methods. They are very powerful apoptosis inducers that can regulate the exclusion of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule that can be found in both natural and manufactured products. Marine species, which are also examples of naturally derived drug sources, such as algae, sponges, tunicates, and bryozoans, have emerged as important components of choice for the separation of novel anticancer drugs obtained from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic targets, which are being explored to unprecedented heights, and they have proven to be sources of various medicinal agents, such as antibiotics, etc. Numerous secondary metabolites have been isolated from marine fungi that were active biologically, structurally unique, and also therapeutically beneficial. So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive to lichens. This mini-review discusses different aspects related to the natural derivatives obtained from various sources, which play a pivotal role as anti-neoplastic agents.

World Journal of Pharmaceutical and life sciences, Apr 8, 2005

Journal of Complementary Medicine Research

The liver is an important organ that aids in the anabolism and elimination of xenobiotics from th... more The liver is an important organ that aids in the anabolism and elimination of xenobiotics from the body. Liver malfunction is a serious public health problem which affects not only doctors and nurses, but also the pharmaceutical industry and a governing authority of drugs. Excessive alcohol use, toxic chemicals (particular antibiotics, chemotherapeutic drugs, carbon tetrachloride (CCL4), thioacetamide (TAA), and microorganisms all induce liver cell harm. In this scenario, the current synthetic medications to treat liver problems promote more liver damage. As a result, herbal drugs have grown in popularity and are widely used. For a long time, plants have been utilized to treat hepatic illness. There are a variety of herbal preparations on the market. The goal of this review is to compile information on promising phytochemicals from medicinal plants that have been investigated in hepatotoxicity models utilising cutting-edge scientific methods.

Toxin reviews, Apr 2, 2024

Combinatorial chemistry & high throughput screening, Jan 25, 2024

Materials Today: Proceedings, Sep 30, 2023

Current Drug Therapy, Aug 17, 2023

Combinatorial chemistry & high throughput screening, Jan 25, 2024

Materials Today: Proceedings, May 1, 2023

Routledge eBooks, May 18, 2023

International Journal of Pharmaceutical Sciences and Research, 2010

The Natural Products Journal

: Hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and a... more : Hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, occurring in high concentrations in citrus fruits. Citrus fruits and juices are widely consumed worldwide and are readily available dietary sources for their intake. Its use has been associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, anti-inflammatory and anti-carcinogenic properties. Due to its biological activities, hesperidin is often used in the food, cosmetic and pharmaceutical industries. Supplements containing hesperidin, alone or in combination with other citrus bioflavonoids, are commercially available. The utilization of hesperidin can be used for the production of novel nutraceuticals or for the improvement of older ones. This piece of review aims to discuss the various diversified aspects of the naturally occurring bioflavonoid hesperidin.

The journal of phytopharmacology, Apr 25, 2015

A steam distilled volatile oil from the fresh leaves of Citrus sinensis Linn. analysed by capilla... more A steam distilled volatile oil from the fresh leaves of Citrus sinensis Linn. analysed by capillary-GC and GC-MS yielded eight components, of which seven were monoterpenic (99.6%) and one ester (0.4%). Cis-sabinene hydrate (35.1%) was the predominant monoterpene, followed by l-limonene (30.1%), citral (27.9%), lavendulol (2.5%), perillaldehyde (2.0%), α-pinene (1.4%) and perillyl alcohol (0.6%). The ester obtained was tert.-butyl benzoate (0.4%). Whereas volatile oil from its fresh fruit peels yielded five components of which three were monoterpenes (76.5%) and remaining two were non-terpenic compounds. α-pinene (60.80%) was the predominant monoterpene, followed by verbenone (15.40%) and α-thujene (0.30%).The non-terpenic compounds obtained was N-pentylcyclopentane (11.80%) and cyclopentenyl ethyne (11.70%). The maximum antibacterial activity was shown with 1%v/v of volatile oil collected from Greater Noida, U.P on Staphylococcus aureus (16.4 mm) followed by Escherichia coli (14.2 mm), and maximum anti-fungal activity was shown on Candida albicans (13.1 mm) followed by Aspergillus niger (12.5 mm).

Current Drug Therapy

: For a very long time, clay has been widely utilized in cosmetics, and it is still one of the mo... more : For a very long time, clay has been widely utilized in cosmetics, and it is still one of the most widely used components today. There is clay for every skincare issue and problem, including dryness, irritation, sunburn, and oiliness. Finding the appropriate clay for the skin's type, texture, and needs is the primary consideration. The current effort attempts to compile knowledge on the many dermatological types of clay that are naturally present, their composition, and various views regarding the care, skin nourishment, and benefits needed to suit the various needs of various skin types. The present work aims to gather the information available on the different types of dermatological clays present naturally, their composition, and different perspectives regarding the care and skin nourishment, and their benefits required to suit different needs of different skin types.

Current Molecular Medicine

Background: Fungal infections have become a worldwide problem due to their involvement in numerou... more Background: Fungal infections have become a worldwide problem due to their involvement in numerous diseases. The risk factors for fungal infections are multiple surgeries, transplant therapies, frequent administration of antibiotics, cancer treatments, and prosthetic devices. The problem of resistance in fungi against drug therapies is widespread, becoming a severe health-related problem. Objective: The study's objective was to identify molecular targets that may open new paths for fungal treatment. Methods: Several research and review articles were studied to gather information regarding the novel mechanism of antifungal drugs. However, identifying novel targets is challenging due to the similarities between host and fungal cells. Although, the plasma membrane and cell wall of fungus offer various drug targets that may target to fight against microbial infections. Unfortunately, biofilm formation and over-expression of protein are a few mechanisms through which fungi develop re...

Materials Today: Proceedings

Current Drug Therapy

: Secondary metabolites of natural origin exhibit numerous pharmacological activities, like anti-... more : Secondary metabolites of natural origin exhibit numerous pharmacological activities, like anti-inflammatory and anti-oxidant effects. Lipid peroxidation has been observed to be prevented by terminating free radical chains and chelating redox active metal ions. These properties of the secondary products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed with plenty of unexplored phytometabolites, which contain the probability to carry huge antineoplastic potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and series of developmental methods. They are very powerful apoptosis inducers that can regulate the exclusion of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule that can be found in both natural and manufactured products. Marine species, which are also examples of naturally derived drug sources, such as algae, sponges, tunicates, and bryozoans, have emerged as important components of choice for the separation of novel anticancer drugs obtained from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic targets, which are being explored to unprecedented heights, and they have proven to be sources of various medicinal agents, such as antibiotics, etc. Numerous secondary metabolites have been isolated from marine fungi that were active biologically, structurally unique, and also therapeutically beneficial. So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive to lichens. This mini-review discusses different aspects related to the natural derivatives obtained from various sources, which play a pivotal role as anti-neoplastic agents.

World Journal of Pharmaceutical and life sciences, Apr 8, 2005

Journal of Complementary Medicine Research

The liver is an important organ that aids in the anabolism and elimination of xenobiotics from th... more The liver is an important organ that aids in the anabolism and elimination of xenobiotics from the body. Liver malfunction is a serious public health problem which affects not only doctors and nurses, but also the pharmaceutical industry and a governing authority of drugs. Excessive alcohol use, toxic chemicals (particular antibiotics, chemotherapeutic drugs, carbon tetrachloride (CCL4), thioacetamide (TAA), and microorganisms all induce liver cell harm. In this scenario, the current synthetic medications to treat liver problems promote more liver damage. As a result, herbal drugs have grown in popularity and are widely used. For a long time, plants have been utilized to treat hepatic illness. There are a variety of herbal preparations on the market. The goal of this review is to compile information on promising phytochemicals from medicinal plants that have been investigated in hepatotoxicity models utilising cutting-edge scientific methods.