D. Gocke - Academia.edu (original) (raw)

Papers by D. Gocke

Research paper thumbnail of Correlation of Australia Antigen With Posttransfusion Hepatitis

JAMA: The Journal of the American Medical Association, 1970

ABSTRACT Transfusion of blood containing Australia antigen was associated with development of hep... more ABSTRACT Transfusion of blood containing Australia antigen was associated with development of hepatitis or an antibody response in 74% (31 of 42) recipients. However, hepatitis also occurs in recipients of antigen-negative donor blood. Further study is required to determine precisely how much hepatitis could be prevented by screening donor blood for Australia antigen. At present, it appears that about 25% of transfusion hepatitis could be prevented in this way, and we are optimistic that this figure can be revised upward.

Research paper thumbnail of Alternating and intermittent regimens of zidovudine (3′-azido-3′-deoxythymidine) and dideoxycytidine (2′,3′-dideoxycytidine) in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

The American Journal of Medicine, 1990

The deoxynucleoside analogues 2',3'-dideoxycytidine (ddC) and 3'-azido-3'-deoxythymidine (zidovud... more The deoxynucleoside analogues 2',3'-dideoxycytidine (ddC) and 3'-azido-3'-deoxythymidine (zidovudine, AZT) are active as single agents in conferring immunologic and virologic benefits in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Both drugs, however, produce dose-limiting toxicities. AZT is associated with unacceptable levels of bone marrow suppression, and ddC can cause painful peripheral neuropathy. The differeiit toxicity profiles of these two drugs provide the rationale for testing them in alternating dosing combinations in an attempt to retain the aritiretroviral activity of each against human immunodeficiency virus, while reducirig the toxicities of both. A preliminary trial showed thtit 200 mg AZT given orally every four hours for seven-day periods, alternating with ddC at 0.03 mg/kg body weight orally every four hours for seven-day periods is a promising treatment regimen. An expanded multicenter study is evaluating ddC at 0.01 m$kg and 0.03 mg/kg alternating with AZT at 200 mg in weekly or monthly periods. Weekly intermittent doses of AZT at 200 mg and ddC at 0.03 mg/kg are also being tested. The rationale and methods of the trial are discussed.

Research paper thumbnail of Vasculitis in association with Australia Antigen

Journal of Experimental Medicine

Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are descri... more Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are described. Evidence was found in these patients for the presence of circulating immune complexes composed of Australia antigen and immunoglobulin. In addition, in two patients immunofluorescent studies localized Australia antigen, IgM, and complement in the blood vessel walls.

Research paper thumbnail of Spontaneous remission of retinitis in a case of infection with human immunodeficiency virus type 1 (HIV-1)

Annals of internal medicine

Research paper thumbnail of Increased anti-HBAg titers after administration of human protein solutions

The New England journal of medicine, Jan 13, 1972

Two years ago, one of us (AGR) observed three patients admitted to our hospital who had anti-HBAg... more Two years ago, one of us (AGR) observed three patients admitted to our hospital who had anti-HBAg (HBAb) present in their serums at high titer Each had received plasma protein solution or human serum albumin to correct low plasma albumin levels during the prior three ...

Research paper thumbnail of Legionnaires' disease: a two-year experience

The Journal of the Medical Society of New Jersey, 1980

Research paper thumbnail of Vasculitis in association with Australia antigen

The Journal of experimental medicine, 1971

Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are descri... more Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are described. Evidence was found in these patients for the presence of circulating immune complexes composed of Australia antigen and immunoglobulin. In addition, in two patients immunofluorescent studies localized Australia antigen, IgM, and complement in the blood vessel walls.

Research paper thumbnail of Physiological and pathological variations of plasma angiotensin II in man. Correlation with renin activity and sodium balance

Circulation research, 1969

Research paper thumbnail of The epidemiology of hepatitis B infection in housestaff

Infection, 1978

Ninety-nine medical and surgical house officers were prospectively evaluated during internship an... more Ninety-nine medical and surgical house officers were prospectively evaluated during internship and residency for the development of hepatitis B virus (HBV) infection. The overall incidence of hepatitis B was 10.2% per year. Eighty-six percent of episodes were subclinical. The greatest risk factor appeared to be frequent hand-to-mouth activity such as smoking or licking requisition labels. The presence of a hemodialysis or transplantation unit may be an additional institutional risk factor. HBV infection was not associated with a history of needle-sticks or contact with known antigen-positive patients. Educational efforts to minimize HBV infection should concentrate on handwashing techniques and discouragement of hand-to-mouth activity in patient care areas.

Research paper thumbnail of Chronic hepatic injury following experimental viral hepatitis in the dog

Research paper thumbnail of Chronic constrictive pericarditis. A case report and review of the literature

Archives of Internal Medicine, 1989

Research paper thumbnail of Radiologic distinction of pyogenic pulmonary infection from Pneumocystis carinii pneumonia in AIDS patients

Radiology, 1990

Thirty-four episodes of pyogenic pulmonary infection in 30 patients infected with human immunodef... more Thirty-four episodes of pyogenic pulmonary infection in 30 patients infected with human immunodeficiency virus (HIV) and 30 episodes of Pneumocystis carinii pneumonia (PCP) in 30 AIDS patients were reviewed to determine if the radiologic features were more helpful than clinical and laboratory findings in the differential diagnosis. The radiologic features of pyogenic pulmonary infection included lobar consolidation, nodules, infiltrates with pleural effusions, round infiltrates, and pleural effusions alone. These features are uncommon in PCP. The chest radiograph may be highly suggestive of a pyogenic process, especially when it shows local consolidation or nodules. Since bacterial pneumonias have a more favorable outcome, it is concluded that the radiologic features should be the primary guide to prompt diagnosis and treatment.

Research paper thumbnail of Correlation of Australia Antigen With Posttransfusion Hepatitis

JAMA: The Journal of the American Medical Association, 1970

ABSTRACT Transfusion of blood containing Australia antigen was associated with development of hep... more ABSTRACT Transfusion of blood containing Australia antigen was associated with development of hepatitis or an antibody response in 74% (31 of 42) recipients. However, hepatitis also occurs in recipients of antigen-negative donor blood. Further study is required to determine precisely how much hepatitis could be prevented by screening donor blood for Australia antigen. At present, it appears that about 25% of transfusion hepatitis could be prevented in this way, and we are optimistic that this figure can be revised upward.

Research paper thumbnail of Alternating and intermittent regimens of zidovudine (3′-azido-3′-deoxythymidine) and dideoxycytidine (2′,3′-dideoxycytidine) in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

The American Journal of Medicine, 1990

The deoxynucleoside analogues 2',3'-dideoxycytidine (ddC) and 3'-azido-3'-deoxythymidine (zidovud... more The deoxynucleoside analogues 2',3'-dideoxycytidine (ddC) and 3'-azido-3'-deoxythymidine (zidovudine, AZT) are active as single agents in conferring immunologic and virologic benefits in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Both drugs, however, produce dose-limiting toxicities. AZT is associated with unacceptable levels of bone marrow suppression, and ddC can cause painful peripheral neuropathy. The differeiit toxicity profiles of these two drugs provide the rationale for testing them in alternating dosing combinations in an attempt to retain the aritiretroviral activity of each against human immunodeficiency virus, while reducirig the toxicities of both. A preliminary trial showed thtit 200 mg AZT given orally every four hours for seven-day periods, alternating with ddC at 0.03 mg/kg body weight orally every four hours for seven-day periods is a promising treatment regimen. An expanded multicenter study is evaluating ddC at 0.01 m$kg and 0.03 mg/kg alternating with AZT at 200 mg in weekly or monthly periods. Weekly intermittent doses of AZT at 200 mg and ddC at 0.03 mg/kg are also being tested. The rationale and methods of the trial are discussed.

Research paper thumbnail of Vasculitis in association with Australia Antigen

Journal of Experimental Medicine

Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are descri... more Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are described. Evidence was found in these patients for the presence of circulating immune complexes composed of Australia antigen and immunoglobulin. In addition, in two patients immunofluorescent studies localized Australia antigen, IgM, and complement in the blood vessel walls.

Research paper thumbnail of Spontaneous remission of retinitis in a case of infection with human immunodeficiency virus type 1 (HIV-1)

Annals of internal medicine

Research paper thumbnail of Increased anti-HBAg titers after administration of human protein solutions

The New England journal of medicine, Jan 13, 1972

Two years ago, one of us (AGR) observed three patients admitted to our hospital who had anti-HBAg... more Two years ago, one of us (AGR) observed three patients admitted to our hospital who had anti-HBAg (HBAb) present in their serums at high titer Each had received plasma protein solution or human serum albumin to correct low plasma albumin levels during the prior three ...

Research paper thumbnail of Legionnaires' disease: a two-year experience

The Journal of the Medical Society of New Jersey, 1980

Research paper thumbnail of Vasculitis in association with Australia antigen

The Journal of experimental medicine, 1971

Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are descri... more Six patients with biopsy-proven polyarteritis nodosa and chronic Australia antigenemia are described. Evidence was found in these patients for the presence of circulating immune complexes composed of Australia antigen and immunoglobulin. In addition, in two patients immunofluorescent studies localized Australia antigen, IgM, and complement in the blood vessel walls.

Research paper thumbnail of Physiological and pathological variations of plasma angiotensin II in man. Correlation with renin activity and sodium balance

Circulation research, 1969

Research paper thumbnail of The epidemiology of hepatitis B infection in housestaff

Infection, 1978

Ninety-nine medical and surgical house officers were prospectively evaluated during internship an... more Ninety-nine medical and surgical house officers were prospectively evaluated during internship and residency for the development of hepatitis B virus (HBV) infection. The overall incidence of hepatitis B was 10.2% per year. Eighty-six percent of episodes were subclinical. The greatest risk factor appeared to be frequent hand-to-mouth activity such as smoking or licking requisition labels. The presence of a hemodialysis or transplantation unit may be an additional institutional risk factor. HBV infection was not associated with a history of needle-sticks or contact with known antigen-positive patients. Educational efforts to minimize HBV infection should concentrate on handwashing techniques and discouragement of hand-to-mouth activity in patient care areas.

Research paper thumbnail of Chronic hepatic injury following experimental viral hepatitis in the dog

Research paper thumbnail of Chronic constrictive pericarditis. A case report and review of the literature

Archives of Internal Medicine, 1989

Research paper thumbnail of Radiologic distinction of pyogenic pulmonary infection from Pneumocystis carinii pneumonia in AIDS patients

Radiology, 1990

Thirty-four episodes of pyogenic pulmonary infection in 30 patients infected with human immunodef... more Thirty-four episodes of pyogenic pulmonary infection in 30 patients infected with human immunodeficiency virus (HIV) and 30 episodes of Pneumocystis carinii pneumonia (PCP) in 30 AIDS patients were reviewed to determine if the radiologic features were more helpful than clinical and laboratory findings in the differential diagnosis. The radiologic features of pyogenic pulmonary infection included lobar consolidation, nodules, infiltrates with pleural effusions, round infiltrates, and pleural effusions alone. These features are uncommon in PCP. The chest radiograph may be highly suggestive of a pyogenic process, especially when it shows local consolidation or nodules. Since bacterial pneumonias have a more favorable outcome, it is concluded that the radiologic features should be the primary guide to prompt diagnosis and treatment.