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Additional file1: Figure S1. The effects of exercise on serum levels of CPK and LDH in control gr... more Additional file1: Figure S1. The effects of exercise on serum levels of CPK and LDH in control groups, * if the differences were significantly different from the control group.
Sohag Medical Journal, 2020
Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder in elderly peopl... more Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder in elderly people. The condition is associated with damage to the dopaminergic neurons in the substantia nigra pars compacta, a great decrement of dopamine neurotransmitter in the striatum, and a deficiency of tyrosine hydroxylase; the rate-determining enzyme during dopamine formation. In rats, rotenone has been administered to induce a syndrome that mimics the behavioral and pathophysiological finding of Parkinson's disease. Aim of the work: To evaluate the behavioral aspects of PD in rotenone-treated Wistar rats. Materials and Methods: Rotenone at 2 mg/kg was injected subcutaneously to male adult Wistar rats in the rotenone-treated group once a day for 4 weeks for induction of PD. Open Field test, object recognition test, Rota-rod test, footprint test and forced swim test were performed at the end of induction. Tyrosine hydroxylase levels in the brain were measured. Results: Our data showed deteriorated behavioral aspects after rotenone treatment, with a decrease in exploration and locomotion, impaired motor coordination, asymmetrical impaired gait, increased depressive-like behaviors, reduction in shortterm memory and reduction in tyrosine hydroxylase levels. Conclusion: in this study, rotenone subcutaneously at a dose of 2 mg/kg daily for 4 weeks, in adult male Wistar rats, caused the appearance of the motor and the nonmotor features of PD with a marked drop-off tyrosine hydroxylase levels in the striatum.
Sohag Medical Journal
Sleep is a universal phenomenon that is observed not only in humans but also in birds, fishes, an... more Sleep is a universal phenomenon that is observed not only in humans but also in birds, fishes, and flies even in simpler organisms such as worms also we spend about 8 hours each day in sleep which represents nearly one-third of our life. All these observations indicate the physiological importance of sleep. study of sleep mechanisms requires the first study of the mechanisms, neurocircuits, and neurotransmitters involved in the promotion of wakefulness. Observation of Von Economo in 1930 of patients affected by "encephalitis lethargica", an epidemic that causes widespread and prolonged sleepiness most of the day, opened the door for the study of the brain regions responsible for wakefulness. Researchers recognized now many brain regions that are responsible for wakefulness and other brain regions responsible for the induction of different types of sleep. This review will try to discuss the most recent mechanisms and neural circuits involved in the promotion of wakefulness.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by ... more Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism.This study aimed to evaluate the role of treadmill exercise in male Wister rats as a single treatment and as an aid-therapy with L-dopa for rotenone-induced PD. To study the role of NRF2-ARE pathway as a mechanism involved in exercise associated improvement in rotenone rat model of PD.Method: Animals were divided into 5 groups, (Control, rotenone, rotenone\exercise, rotenone\L-dopa, and rotenone\exercise\L-dopa (combination) groups). After the PD induction, rats in the rotenone\exercise and combination groups were daily treadmill exercised for 4 weeks.Results: Treadmill exercise significantly improved ...
Additional file1: Figure S1. The effects of exercise on serum levels of CPK and LDH in control gr... more Additional file1: Figure S1. The effects of exercise on serum levels of CPK and LDH in control groups, * if the differences were significantly different from the control group.
Sohag Medical Journal, 2020
Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder in elderly peopl... more Introduction: Parkinson's disease (PD) is a prevalent neurodegenerative disorder in elderly people. The condition is associated with damage to the dopaminergic neurons in the substantia nigra pars compacta, a great decrement of dopamine neurotransmitter in the striatum, and a deficiency of tyrosine hydroxylase; the rate-determining enzyme during dopamine formation. In rats, rotenone has been administered to induce a syndrome that mimics the behavioral and pathophysiological finding of Parkinson's disease. Aim of the work: To evaluate the behavioral aspects of PD in rotenone-treated Wistar rats. Materials and Methods: Rotenone at 2 mg/kg was injected subcutaneously to male adult Wistar rats in the rotenone-treated group once a day for 4 weeks for induction of PD. Open Field test, object recognition test, Rota-rod test, footprint test and forced swim test were performed at the end of induction. Tyrosine hydroxylase levels in the brain were measured. Results: Our data showed deteriorated behavioral aspects after rotenone treatment, with a decrease in exploration and locomotion, impaired motor coordination, asymmetrical impaired gait, increased depressive-like behaviors, reduction in shortterm memory and reduction in tyrosine hydroxylase levels. Conclusion: in this study, rotenone subcutaneously at a dose of 2 mg/kg daily for 4 weeks, in adult male Wistar rats, caused the appearance of the motor and the nonmotor features of PD with a marked drop-off tyrosine hydroxylase levels in the striatum.
Sohag Medical Journal
Sleep is a universal phenomenon that is observed not only in humans but also in birds, fishes, an... more Sleep is a universal phenomenon that is observed not only in humans but also in birds, fishes, and flies even in simpler organisms such as worms also we spend about 8 hours each day in sleep which represents nearly one-third of our life. All these observations indicate the physiological importance of sleep. study of sleep mechanisms requires the first study of the mechanisms, neurocircuits, and neurotransmitters involved in the promotion of wakefulness. Observation of Von Economo in 1930 of patients affected by "encephalitis lethargica", an epidemic that causes widespread and prolonged sleepiness most of the day, opened the door for the study of the brain regions responsible for wakefulness. Researchers recognized now many brain regions that are responsible for wakefulness and other brain regions responsible for the induction of different types of sleep. This review will try to discuss the most recent mechanisms and neural circuits involved in the promotion of wakefulness.
Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by ... more Background: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive loss of nigrostriatal dopaminergic neurons leading to dopamine depletion and problems of movement, emotions and cognition. While the pathogenesis of PD is not clear, damage of dopaminergic neurons by oxygen-derived free radicals is considered an important contributing mechanism.This study aimed to evaluate the role of treadmill exercise in male Wister rats as a single treatment and as an aid-therapy with L-dopa for rotenone-induced PD. To study the role of NRF2-ARE pathway as a mechanism involved in exercise associated improvement in rotenone rat model of PD.Method: Animals were divided into 5 groups, (Control, rotenone, rotenone\exercise, rotenone\L-dopa, and rotenone\exercise\L-dopa (combination) groups). After the PD induction, rats in the rotenone\exercise and combination groups were daily treadmill exercised for 4 weeks.Results: Treadmill exercise significantly improved ...