D. Paskalev - Academia.edu (original) (raw)
Papers by D. Paskalev
Treatment with Apheresis
Scripta scientifica medica, 1991
Vitamin D: beyond the calcemic effect
European Urology Supplements, 2013
Scripta Scientifica Medica, 1991
Scripta Scientifica Medica, 2002
We are what we are because ofthe kind of the kidneys we have. Homer Smith ABSTRACT owadays the nu... more We are what we are because ofthe kind of the kidneys we have. Homer Smith ABSTRACT owadays the number of the patients with chronic renal failure and the syndrome of end-stage renal disease permanently increases. New dietary regimens are necessary to improve the status of the patients with severe kidney diseases. Nutrition plays an essential role in the contemporary approach to the management of the pa tients with renal failure. Low-protein diet delays the progression of the renal failure. The meta-analysis of the effect of dietary protein restriction on the course of diabetic and non-diabetic renal diseases outlines the im portance of the adequate correction of the uremic syndrome and the absence of side effects of this nutritional regimen. The development of appropriate diet therapy to be administered at the predialytic stage of the dis ease could prevent or at least delay the progression of chronic renal failure and, in this way, it represents a challenge for the nephrologists and hope for the patients.
Scripta Scientifica Medica, 2011
Treatment of Wegener's granulomatosis using plasmapheresis
Vutreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.
[Treatment of Wegener's granulomatosis using plasmapheresis]
Vutreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.
Use of Intensive Methods for Treatment of Renal Diseases
Ivan Vazov's death: some medical facts
[Acute kidney failure as a "mask" of a dissecting aortic aneurysm]
Vutreshni bolesti, 1991
Two cases--of a 52-year-old man and a 59-year-old woman--are presented. The onset of the disease ... more Two cases--of a 52-year-old man and a 59-year-old woman--are presented. The onset of the disease was acute with diarrheal syndrome and the patients were hospitalized in the Infectious Disease Clinic. The diagnosis of acute infectious enterocolitis was rejected. In the first days after the hospitalization the patients became oligoanuric and increased levels of urea and creatinine were established. A diagnosis of acute renal failure after acute enterocolitis was made and the patients were transferred to the Nephrologic Clinic. In spite of the rapid restoration of the diuresis after i.v. infusions, the patients died suddenly. The postmortem examination revealed an aortic dissecting aneurysm.
Staphylococci species - classical pathogens and commensals in the human ecosystem
Robert Koch „ловецът на микроби“ 175 години от рождението на учения
International Bulletin of Otorhinolaryngology, 2018
Extrapulmonary tuberculosis with intestinal and peritoneal localization (case report)
Catheter-associated urinary tract infections in patients undergoing operative and intensive care treatment
Experimental cell …, 2007
Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca 2+ homeost... more Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca 2+ homeostasis were investigated in cybrid cells incorporating two pathogenic mitochondrial DNA point mutations, 3243A N G and 3302A N G in tRNA Leu(UUR) , as well as Rho 0 cells and compared to their parental 143B osteosarcoma cell line. All cells suffering from a severe respiratory chain deficiency were able to proliferate as fast as controls. The major defect in oxidative phosphorylation was efficiently compensated by a rise in anaerobic glycolysis, so that the total ATP production rate was preserved. This enhancement of glycolysis was enabled by a considerable decrease of cellular total adenine nucleotide pools and a concomitant shift in the AMP + ADP/ATP ratios, while the energy charge potential was still in the normal range. Further important consequences were an increased production of superoxide which, however, was neither escorted by major changes in the antioxidative
Correlation Between the In Vitro Antioxidant Activity and Polyphenol Content of Aqueous Extracts From Bulgarian Herbs
Phytotherapy …, 2006
The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied i... more The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied in relation to their polyphenol content in comparison with mate, black tea, honeybush and rooibos foreign species. Antioxidant activity was measured by the ABTS (2,2′-azinobis(3-...
Nephrology (Saint-Petersburg)
INTRODUCTION: Twenty years ago, the metabolism of vitamin K was connected with its role in hemost... more INTRODUCTION: Twenty years ago, the metabolism of vitamin K was connected with its role in hemostasis. Since that time has been shown that vitamin K exerts multiple functions mediated by the Gla-proteins, having as a cofactor vitamin K. Numerous publications affirm that these Gla-proteins are related to physiological processes beyond coagulations such as bone metabolism, vascular health and energy homeostasis. THE AIM: The aim of this research is to provide new data for vitamin K role in a myriad of physiological processes beyond blood clotting. Additionally, it aims to assess the potential new applications of vitamin K as a supplement for prevention bone and vascular disease. MATERIALS AND METHODS: Using the online databases Scopus, PubMed and Google Scholar a search with the keywords: «vitamin K2», «bone metabolism», «cardiovascular diseases», «osteocalcin» and «MGP» was conducted. Information regarding the effects of vitamin K on bone and vascular health was referred to in this work. RESULTS: Vitamin K and vitamin K-dependent-proteins play pivotal roles in the physiology of bone mineralization and in preventing ectopic calcification. Osteocalcin, a Gla protein located in bone and dentin, is important for bone mineralization. Following the posttranslational carboxylation of Glu-residues with a cofactor vitamin K2 (menaquinone), rather than vitamin K1 (phylloquinone), osteocalcin shows increased affinity for calcium. osteocalcin is believed to be involved in osteoblast regulation and hydroxyapatite crystal growth. Matrix GLa-protein (MGP), sharing some sequences with osteocalcin, is a local inhibitor of arterial calcification. Vitamin K deficiency impairs the function of osteocalcin and MGP and, therefore, presumably contributes to bone demineralization and vascular calcification, the so-called calcium paradox. CONCLUSIONS: Vitamin K deficiencies, traditionally regarded as a cause for internal hemorrhages and blood clotting disorders, apparently can be linked to cardiovascular calcification and abnormal bone modelling. Appropriate treatment of vitamin K deficiency may improve bone and arterial health.
Nephrology (Saint-Petersburg)
Tamm–Horsfall Protein (uromodulin) is named after Igor Tamm and Franc Horsfall Jr who described i... more Tamm–Horsfall Protein (uromodulin) is named after Igor Tamm and Franc Horsfall Jr who described it for the first time in 1952. It is a glycoprotein, secreted by the cells in the thick ascending limb of the loop of Henle. This protein will perform a number of important pathophysiological functions, including protection against uroinfections, especially caused by E. Сoli, and protection against formation of calcium concernments in the kidney. Igor Tamm (1922-1995) is an outstanding cytologist, virologist and biochemist. He is one of the pioneers in the study of viral replication. He was born in Estonia and died in the USA. In 1964 he was elected for a professorship in Rockefeller Institute for Medical Research, where has been working continuously. Since 1959, he became a head of the virology lab established by his mentor and co-author Franc Horsfall. In the course of studies on the natural inhibitor of viral replication, Tamm and Horsfall isolated and characterized biochemically a new...
[Treatment of Wegener's granulomatosis using plasmapheresis]
Vŭtreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.
Treatment with Apheresis
Scripta scientifica medica, 1991
Vitamin D: beyond the calcemic effect
European Urology Supplements, 2013
Scripta Scientifica Medica, 1991
Scripta Scientifica Medica, 2002
We are what we are because ofthe kind of the kidneys we have. Homer Smith ABSTRACT owadays the nu... more We are what we are because ofthe kind of the kidneys we have. Homer Smith ABSTRACT owadays the number of the patients with chronic renal failure and the syndrome of end-stage renal disease permanently increases. New dietary regimens are necessary to improve the status of the patients with severe kidney diseases. Nutrition plays an essential role in the contemporary approach to the management of the pa tients with renal failure. Low-protein diet delays the progression of the renal failure. The meta-analysis of the effect of dietary protein restriction on the course of diabetic and non-diabetic renal diseases outlines the im portance of the adequate correction of the uremic syndrome and the absence of side effects of this nutritional regimen. The development of appropriate diet therapy to be administered at the predialytic stage of the dis ease could prevent or at least delay the progression of chronic renal failure and, in this way, it represents a challenge for the nephrologists and hope for the patients.
Scripta Scientifica Medica, 2011
Treatment of Wegener's granulomatosis using plasmapheresis
Vutreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.
[Treatment of Wegener's granulomatosis using plasmapheresis]
Vutreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.
Use of Intensive Methods for Treatment of Renal Diseases
Ivan Vazov's death: some medical facts
[Acute kidney failure as a "mask" of a dissecting aortic aneurysm]
Vutreshni bolesti, 1991
Two cases--of a 52-year-old man and a 59-year-old woman--are presented. The onset of the disease ... more Two cases--of a 52-year-old man and a 59-year-old woman--are presented. The onset of the disease was acute with diarrheal syndrome and the patients were hospitalized in the Infectious Disease Clinic. The diagnosis of acute infectious enterocolitis was rejected. In the first days after the hospitalization the patients became oligoanuric and increased levels of urea and creatinine were established. A diagnosis of acute renal failure after acute enterocolitis was made and the patients were transferred to the Nephrologic Clinic. In spite of the rapid restoration of the diuresis after i.v. infusions, the patients died suddenly. The postmortem examination revealed an aortic dissecting aneurysm.
Staphylococci species - classical pathogens and commensals in the human ecosystem
Robert Koch „ловецът на микроби“ 175 години от рождението на учения
International Bulletin of Otorhinolaryngology, 2018
Extrapulmonary tuberculosis with intestinal and peritoneal localization (case report)
Catheter-associated urinary tract infections in patients undergoing operative and intensive care treatment
Experimental cell …, 2007
Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca 2+ homeost... more Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca 2+ homeostasis were investigated in cybrid cells incorporating two pathogenic mitochondrial DNA point mutations, 3243A N G and 3302A N G in tRNA Leu(UUR) , as well as Rho 0 cells and compared to their parental 143B osteosarcoma cell line. All cells suffering from a severe respiratory chain deficiency were able to proliferate as fast as controls. The major defect in oxidative phosphorylation was efficiently compensated by a rise in anaerobic glycolysis, so that the total ATP production rate was preserved. This enhancement of glycolysis was enabled by a considerable decrease of cellular total adenine nucleotide pools and a concomitant shift in the AMP + ADP/ATP ratios, while the energy charge potential was still in the normal range. Further important consequences were an increased production of superoxide which, however, was neither escorted by major changes in the antioxidative
Correlation Between the In Vitro Antioxidant Activity and Polyphenol Content of Aqueous Extracts From Bulgarian Herbs
Phytotherapy …, 2006
The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied i... more The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied in relation to their polyphenol content in comparison with mate, black tea, honeybush and rooibos foreign species. Antioxidant activity was measured by the ABTS (2,2′-azinobis(3-...
Nephrology (Saint-Petersburg)
INTRODUCTION: Twenty years ago, the metabolism of vitamin K was connected with its role in hemost... more INTRODUCTION: Twenty years ago, the metabolism of vitamin K was connected with its role in hemostasis. Since that time has been shown that vitamin K exerts multiple functions mediated by the Gla-proteins, having as a cofactor vitamin K. Numerous publications affirm that these Gla-proteins are related to physiological processes beyond coagulations such as bone metabolism, vascular health and energy homeostasis. THE AIM: The aim of this research is to provide new data for vitamin K role in a myriad of physiological processes beyond blood clotting. Additionally, it aims to assess the potential new applications of vitamin K as a supplement for prevention bone and vascular disease. MATERIALS AND METHODS: Using the online databases Scopus, PubMed and Google Scholar a search with the keywords: «vitamin K2», «bone metabolism», «cardiovascular diseases», «osteocalcin» and «MGP» was conducted. Information regarding the effects of vitamin K on bone and vascular health was referred to in this work. RESULTS: Vitamin K and vitamin K-dependent-proteins play pivotal roles in the physiology of bone mineralization and in preventing ectopic calcification. Osteocalcin, a Gla protein located in bone and dentin, is important for bone mineralization. Following the posttranslational carboxylation of Glu-residues with a cofactor vitamin K2 (menaquinone), rather than vitamin K1 (phylloquinone), osteocalcin shows increased affinity for calcium. osteocalcin is believed to be involved in osteoblast regulation and hydroxyapatite crystal growth. Matrix GLa-protein (MGP), sharing some sequences with osteocalcin, is a local inhibitor of arterial calcification. Vitamin K deficiency impairs the function of osteocalcin and MGP and, therefore, presumably contributes to bone demineralization and vascular calcification, the so-called calcium paradox. CONCLUSIONS: Vitamin K deficiencies, traditionally regarded as a cause for internal hemorrhages and blood clotting disorders, apparently can be linked to cardiovascular calcification and abnormal bone modelling. Appropriate treatment of vitamin K deficiency may improve bone and arterial health.
Nephrology (Saint-Petersburg)
Tamm–Horsfall Protein (uromodulin) is named after Igor Tamm and Franc Horsfall Jr who described i... more Tamm–Horsfall Protein (uromodulin) is named after Igor Tamm and Franc Horsfall Jr who described it for the first time in 1952. It is a glycoprotein, secreted by the cells in the thick ascending limb of the loop of Henle. This protein will perform a number of important pathophysiological functions, including protection against uroinfections, especially caused by E. Сoli, and protection against formation of calcium concernments in the kidney. Igor Tamm (1922-1995) is an outstanding cytologist, virologist and biochemist. He is one of the pioneers in the study of viral replication. He was born in Estonia and died in the USA. In 1964 he was elected for a professorship in Rockefeller Institute for Medical Research, where has been working continuously. Since 1959, he became a head of the virology lab established by his mentor and co-author Franc Horsfall. In the course of studies on the natural inhibitor of viral replication, Tamm and Horsfall isolated and characterized biochemically a new...
[Treatment of Wegener's granulomatosis using plasmapheresis]
Vŭtreshni bolesti, 1983
A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made af... more A case with Wegener's granulomatosis in a young woman is described. The diagnosis was made after extirpation and histological investigation of granuloma tissue from the nasal concha and by needle renal biopsy. A successful treatment was carried out with plasmapheresis, hemodialysis and immune-suppressors, the acute paroxysm being coped as well as the developed acute renal insufficiency. After each plasmapheresis a considerable reduction of the circulating immune complexes was established. After a remission of 9 months the patient developed a stage of terminal chronic renal insufficiency and was subjected to chronic dialysis with good rehabilitation.