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D. Pulsipher

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Research paper thumbnail of Job Submission Description Language WG (JSDL-WG), 2003

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Research paper thumbnail of Job submission description language specification

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Research paper thumbnail of Job submission description language (jsdl) specification, version 1.0

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Research paper thumbnail of Suppression of acoustic noise in speech using two microphone adaptive noise cancellation

IEEE Transactions on Acoustics, Speech, and Signal Processing, 1980

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Research paper thumbnail of Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

Neurology, 2011

Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic general... more Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic generalized epilepsy (IGE). However, there are few studies examining IGE early in its course and the neurodevelopmental course of this region is not adequately defined. We examined the 2-year developmental course of the thalamus and frontal lobes in pediatric new-onset IGE (i.e., within 12 months of diagnosis). We performed whole-brain MRI in 22 patients with new-onset IGE and 36 age-matched healthy controls. MRI was repeated 24 months after baseline MRI. Quantitative volumetrics were used to examine thalamic and frontal lobe volumes. The IGE group showed significant differences in thalamic volume within 1 year of seizure onset (baseline) and went on to show thalamic volume loss at a significantly faster rate than healthy control children over the 2-year interval. The control group also showed a significantly greater increase in frontal white matter expansion than the IGE group. In contrast, frontal lobe gray matter volume differences were moderate at baseline and persisted over time, indicating similar developmental trajectories with differences early in the disease process that are maintained. Brain tissue abnormalities in thalamic and frontal regions can be identified very early in the course of IGE and an abnormal trajectory of growth continues over a 2-year interval.

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Research paper thumbnail of OGSA™ EMS Architecture Scenarios Version 1.0

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Research paper thumbnail of OGSA™ EMS Architecture Scenarios Version 1.0 (draft 017)

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Research paper thumbnail of Mechanism for managing execution environments for aggregated processes

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Research paper thumbnail of Mechanism for managing execution of interdependent aggregated processes

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Research paper thumbnail of Mechanism for managing parallel execution of processes in a distributed computing environment

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Research paper thumbnail of Hierarchically structured logging for computer work processing

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Research paper thumbnail of OGSA�� Basic Execution Service Version 1.0

Open Grid Forum, GFD, Aug 7, 2007

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Research paper thumbnail of Job submission description language (jsdl) specification, version 1.0

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Research paper thumbnail of Job Submission Description Language WG (JSDL-WG), 2003

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Research paper thumbnail of Job submission description language specification

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Research paper thumbnail of Job submission description language (jsdl) specification, version 1.0

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Suppression of acoustic noise in speech using two microphone adaptive noise cancellation

IEEE Transactions on Acoustics, Speech, and Signal Processing, 1980

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

Neurology, 2011

Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic general... more Quantitative MRI techniques have demonstrated thalamocortical abnormalities in idiopathic generalized epilepsy (IGE). However, there are few studies examining IGE early in its course and the neurodevelopmental course of this region is not adequately defined. We examined the 2-year developmental course of the thalamus and frontal lobes in pediatric new-onset IGE (i.e., within 12 months of diagnosis). We performed whole-brain MRI in 22 patients with new-onset IGE and 36 age-matched healthy controls. MRI was repeated 24 months after baseline MRI. Quantitative volumetrics were used to examine thalamic and frontal lobe volumes. The IGE group showed significant differences in thalamic volume within 1 year of seizure onset (baseline) and went on to show thalamic volume loss at a significantly faster rate than healthy control children over the 2-year interval. The control group also showed a significantly greater increase in frontal white matter expansion than the IGE group. In contrast, frontal lobe gray matter volume differences were moderate at baseline and persisted over time, indicating similar developmental trajectories with differences early in the disease process that are maintained. Brain tissue abnormalities in thalamic and frontal regions can be identified very early in the course of IGE and an abnormal trajectory of growth continues over a 2-year interval.

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Research paper thumbnail of OGSA™ EMS Architecture Scenarios Version 1.0

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Research paper thumbnail of OGSA™ EMS Architecture Scenarios Version 1.0 (draft 017)

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Research paper thumbnail of Mechanism for managing execution environments for aggregated processes

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Research paper thumbnail of Mechanism for managing execution of interdependent aggregated processes

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Research paper thumbnail of Mechanism for managing parallel execution of processes in a distributed computing environment

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Research paper thumbnail of Hierarchically structured logging for computer work processing

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Research paper thumbnail of OGSA�� Basic Execution Service Version 1.0

Open Grid Forum, GFD, Aug 7, 2007

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Research paper thumbnail of Job submission description language (jsdl) specification, version 1.0

Bookmarks Related papers MentionsView impact

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