DR HAMIZAH MOHD ZAKI - Academia.edu (original) (raw)
Papers by DR HAMIZAH MOHD ZAKI
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
![Research paper thumbnail of Crystal structure of 2-{[1-(2-methyl-5-nitro-1<i>H</i>-imidazol-1-yl)propan-2-yloxy]carbonyl}benzoic acid](https://attachments.academia-assets.com/111453759/thumbnails/1.jpg)
](Acta Crystallographica Section E-structure Reports Online, Nov 5, 2014
In the title compound, C 15 H 15 N 3 O 6 , the dihedral angle between the planes of the benzene a... more In the title compound, C 15 H 15 N 3 O 6 , the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10). An intramolecular C-HÁ Á ÁO hydrogen bond is observed. In the crystal, O-HÁ Á ÁN hydrogen bonds link the molecules into chains parallel to the c axis.
Crystal Growth & Design, May 26, 2023
ADVANCED MATERIALS AND RADIATION PHYSICS (AMRP-2015): 4th National Conference on Advanced Materials and Radiation Physics, 2015
Considerable attention has been drawn during the last two decades to prepare nanocomposites consi... more Considerable attention has been drawn during the last two decades to prepare nanocomposites consists of conducting polymer and noble metal due to their potential ability to generate a new class of material with novel optical, chemical, electronic or mechanical properties for various applications. In this work, an attempt has been made to synthesize nanocomposite of polyaniline (PANI) coated with gold nanoparticles (AuNPs) chemically with various types of surfactants such as polyvinylpyrrolidone (PVP), and sodium dodecyl sulphate (SDS) which act as stabilizing agents to help in stabilization of the PANI/Gold nanocomposites system. The synthesized nanocomposites were characterized by UV-Visible, field emission scanning electron microscope (FESEM) and particle size analyzer (PSA). The formation of finger like structure can be seen in the FESEM images when the AuNPs were incorporated into the polymer matrix. The EDX data showed that 18.66% and 12.67% of AuNPs atoms were present in the composite system thus proved the incorporation of AuNPs into the polymer matrix. A small red shift of the absorption peak in the UV-Vis of both PANI/AuNPs composites system may be due to the incorporation of AuNPs in the PANI matrix.
Crystal Growth & Design
Advances in Polymer Technology, 2013
ABSTRACT In the present work, we explore the opportunity to deposit zinc sulfide (ZnS)/polyanilin... more ABSTRACT In the present work, we explore the opportunity to deposit zinc sulfide (ZnS)/polyaniline (PANI) composite films through an electrochemical route. The structural and the optical characterization showed the interaction between ZnS nanoparticular and PANI. The structure of the PANI–ZnS composite films was characterized by scanning electron microscopy, atomic force microscopy, and UV–vis spectroscopy. Cyclic voltammetry was used to investigate the electrochemical behavior of the resulting material. The existence of Zn and S on PANI–ZnS composite films was proved by the EDX-mapping method. The conductivity measurements of PANI–ZnS composite films and PANI were accomplished by the four-probe technique. © 2013 Wiley Periodicals, Inc. Adv Polym Technol 2013, 32, 21373; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.21373
Faculty of Applied Sciences, 2021
Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility an... more Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility and bioavailability of drugs. In this study, the cocrystal formation screening was carried out for nicotinamide(NIC) as the API (Active Pharmaceutical Ingredient) with two coformers; cinnamic acid (CIN), and p-coumaric acid (COU) using recrystallization method with different solvents (methanol, ethanol, and acetonitrile) and molar ratios of NIC:CIN and NIC:COU of 1:1, 1:2 and 2:1. The NIC:CIN and NIC:COU mixtures were characterized using Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), and Fourier Transform Infrared (FTIR) to assess the formation of cocrystal. All characterization data for NIC:CIN mixtures showed that the use of different types of solvents and molar ratios have no significant effect on the formation of the cocrystal. The characterization data showed the formation of similar NIC:CIN cocrystal with no polymorphism with a melting temperature of 96-98 o C for all mixtures. The diffraction pattern of all NIC:CIN also showed similar new peaks at 2θ of 6.7°, 17.7°, 20.6°, 22.4°, and 25.1°. The DSC and PXRD data of NIC:CIN were supported by FTIR which revealed similar hydrogen bonding interaction for all NIC:CIN mixtures. The characterization of NIC:COU mixture revealed four different cocrystal forms with melting points of 118 °C, 152 °C, 160 °C, and 169 °C. The PXRD data of NIC:COU mixture also showed different diffraction patterns signifying distinct crystalline identities which supported with different FTIR spectrum validating the difference in hydrogen bonding interaction. It was observed that the use of different types of solvents did not give significant effects on the formation of NIC:CIN and NIC:COU cocrystals.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
In the title benzoylhydrazide derivative, C15H14N2O2, the dihedral angle between the planes of th... more In the title benzoylhydrazide derivative, C15H14N2O2, the dihedral angle between the planes of the two phenyl rings is 12.56 (9). The azomethine double bond adopts an E configuration stabilized by an N—H O hydrogen bond. In the crystal, the components are linked by C—H O inter-actions to form chains along the b axis.
Schiff base derived from N-phenyl-1,4-phenylenediamine (NPPD)have been synthesized and studied us... more Schiff base derived from N-phenyl-1,4-phenylenediamine (NPPD)have been synthesized and studied using X-ray photoelectron spectroscopy (XPS). The binding energies in XPS agree very well with elemental analysis of the studied compound. The results confirmed presence of C=N bond in Schiff base ligands and the presence of Cl 2p in (E)-N1-(4chlorobenzylidene)-N4-phenylbenzene-1,4-diamine (K2).
Journal of Molecular Liquids, 2021
Science Letters, 2021
Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility an... more Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility and bioavailability of drugs. In this study, the cocrystal formation screening was carried out for nicotinamide(NIC) as the API (Active Pharmaceutical Ingredient) with two coformers; cinnamic acid (CIN), and p-coumaric acid (COU) using recrystallization method with different solvents (methanol, ethanol, and acetonitrile) and molar ratios of NIC:CIN and NIC:COU of 1:1, 1:2 and 2:1. The NIC:CIN and NIC:COU mixtures were characterized using Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), and Fourier Transform Infrared (FTIR) to assess the formation of cocrystal. All characterization data for NIC:CIN mixtures showed that the use of different types of solvents and molar ratios have no significant effect on the formation of the cocrystal. The characterization data showed the formation of similar NIC:CIN cocrystal with no polymorphism with a melting temperature of 96–98 ...
Phytochemistry Letters, 2018
Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along w... more Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic techniques and the absolute configuration of 1 was established by single-crystal X-ray diffraction. Alkaloid 1 showed cytotoxic activity on human colon and lung cancer cell lines with IC 50 values ranging from 5.32 to 9.91 μM.
Applied Surface Science, 2019
et al., XPS and DFT investigations of corrosion inhibition of substituted benzylidene Schiff base... more et al., XPS and DFT investigations of corrosion inhibition of substituted benzylidene Schiff bases on mild steel in hydrochloric acid, Applied Surface Science,
Indonesian Journal of Chemistry, 2018
The interaction of Active Pharmaceutical Ingredient (API) with other compounds will affect drugs ... more The interaction of Active Pharmaceutical Ingredient (API) with other compounds will affect drugs stability, toxicity, modified dissolution profiles or may form a new compound with the different crystal structure. Acetaminophenol (APAP), the most common drug used widely (also known as Panadol) was mixed with Naringenin (NR) to glance for a new phase of interactions leading to new compound phase. The amide-acid supramolecular heterosynthon; N-H…O interaction between acid and the respective base were observed in the APAP-NR mixture blends. The interaction was prepared by the binary interaction from neat grinding and liquid-assisted grinding techniques at a different stoichiometry of binary mixture ratio of APAP-NR which were 1:1, 1:2 and 2:1 molar ratio. The interaction was estimated using Group Contribution Method (GCM) and physicochemical properties were characterized by Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), powder X-ray diffraction (PXRD) and Differenti...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Acta Crystallographica Section E-structure Reports Online, Nov 5, 2014
In the title compound, C 15 H 15 N 3 O 6 , the dihedral angle between the planes of the benzene a... more In the title compound, C 15 H 15 N 3 O 6 , the dihedral angle between the planes of the benzene and imidazole rings is 34.93 (10). An intramolecular C-HÁ Á ÁO hydrogen bond is observed. In the crystal, O-HÁ Á ÁN hydrogen bonds link the molecules into chains parallel to the c axis.
Crystal Growth & Design, May 26, 2023
ADVANCED MATERIALS AND RADIATION PHYSICS (AMRP-2015): 4th National Conference on Advanced Materials and Radiation Physics, 2015
Considerable attention has been drawn during the last two decades to prepare nanocomposites consi... more Considerable attention has been drawn during the last two decades to prepare nanocomposites consists of conducting polymer and noble metal due to their potential ability to generate a new class of material with novel optical, chemical, electronic or mechanical properties for various applications. In this work, an attempt has been made to synthesize nanocomposite of polyaniline (PANI) coated with gold nanoparticles (AuNPs) chemically with various types of surfactants such as polyvinylpyrrolidone (PVP), and sodium dodecyl sulphate (SDS) which act as stabilizing agents to help in stabilization of the PANI/Gold nanocomposites system. The synthesized nanocomposites were characterized by UV-Visible, field emission scanning electron microscope (FESEM) and particle size analyzer (PSA). The formation of finger like structure can be seen in the FESEM images when the AuNPs were incorporated into the polymer matrix. The EDX data showed that 18.66% and 12.67% of AuNPs atoms were present in the composite system thus proved the incorporation of AuNPs into the polymer matrix. A small red shift of the absorption peak in the UV-Vis of both PANI/AuNPs composites system may be due to the incorporation of AuNPs in the PANI matrix.
Crystal Growth & Design
Advances in Polymer Technology, 2013
ABSTRACT In the present work, we explore the opportunity to deposit zinc sulfide (ZnS)/polyanilin... more ABSTRACT In the present work, we explore the opportunity to deposit zinc sulfide (ZnS)/polyaniline (PANI) composite films through an electrochemical route. The structural and the optical characterization showed the interaction between ZnS nanoparticular and PANI. The structure of the PANI–ZnS composite films was characterized by scanning electron microscopy, atomic force microscopy, and UV–vis spectroscopy. Cyclic voltammetry was used to investigate the electrochemical behavior of the resulting material. The existence of Zn and S on PANI–ZnS composite films was proved by the EDX-mapping method. The conductivity measurements of PANI–ZnS composite films and PANI were accomplished by the four-probe technique. © 2013 Wiley Periodicals, Inc. Adv Polym Technol 2013, 32, 21373; View this article online at wileyonlinelibrary.com. DOI 10.1002/adv.21373
Faculty of Applied Sciences, 2021
Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility an... more Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility and bioavailability of drugs. In this study, the cocrystal formation screening was carried out for nicotinamide(NIC) as the API (Active Pharmaceutical Ingredient) with two coformers; cinnamic acid (CIN), and p-coumaric acid (COU) using recrystallization method with different solvents (methanol, ethanol, and acetonitrile) and molar ratios of NIC:CIN and NIC:COU of 1:1, 1:2 and 2:1. The NIC:CIN and NIC:COU mixtures were characterized using Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), and Fourier Transform Infrared (FTIR) to assess the formation of cocrystal. All characterization data for NIC:CIN mixtures showed that the use of different types of solvents and molar ratios have no significant effect on the formation of the cocrystal. The characterization data showed the formation of similar NIC:CIN cocrystal with no polymorphism with a melting temperature of 96-98 o C for all mixtures. The diffraction pattern of all NIC:CIN also showed similar new peaks at 2θ of 6.7°, 17.7°, 20.6°, 22.4°, and 25.1°. The DSC and PXRD data of NIC:CIN were supported by FTIR which revealed similar hydrogen bonding interaction for all NIC:CIN mixtures. The characterization of NIC:COU mixture revealed four different cocrystal forms with melting points of 118 °C, 152 °C, 160 °C, and 169 °C. The PXRD data of NIC:COU mixture also showed different diffraction patterns signifying distinct crystalline identities which supported with different FTIR spectrum validating the difference in hydrogen bonding interaction. It was observed that the use of different types of solvents did not give significant effects on the formation of NIC:CIN and NIC:COU cocrystals.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
In the title benzoylhydrazide derivative, C15H14N2O2, the dihedral angle between the planes of th... more In the title benzoylhydrazide derivative, C15H14N2O2, the dihedral angle between the planes of the two phenyl rings is 12.56 (9). The azomethine double bond adopts an E configuration stabilized by an N—H O hydrogen bond. In the crystal, the components are linked by C—H O inter-actions to form chains along the b axis.
Schiff base derived from N-phenyl-1,4-phenylenediamine (NPPD)have been synthesized and studied us... more Schiff base derived from N-phenyl-1,4-phenylenediamine (NPPD)have been synthesized and studied using X-ray photoelectron spectroscopy (XPS). The binding energies in XPS agree very well with elemental analysis of the studied compound. The results confirmed presence of C=N bond in Schiff base ligands and the presence of Cl 2p in (E)-N1-(4chlorobenzylidene)-N4-phenylbenzene-1,4-diamine (K2).
Journal of Molecular Liquids, 2021
Science Letters, 2021
Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility an... more Cocrystal plays an important role in the pharmaceutical industry to improve the low solubility and bioavailability of drugs. In this study, the cocrystal formation screening was carried out for nicotinamide(NIC) as the API (Active Pharmaceutical Ingredient) with two coformers; cinnamic acid (CIN), and p-coumaric acid (COU) using recrystallization method with different solvents (methanol, ethanol, and acetonitrile) and molar ratios of NIC:CIN and NIC:COU of 1:1, 1:2 and 2:1. The NIC:CIN and NIC:COU mixtures were characterized using Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), and Fourier Transform Infrared (FTIR) to assess the formation of cocrystal. All characterization data for NIC:CIN mixtures showed that the use of different types of solvents and molar ratios have no significant effect on the formation of the cocrystal. The characterization data showed the formation of similar NIC:CIN cocrystal with no polymorphism with a melting temperature of 96–98 ...
Phytochemistry Letters, 2018
Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along w... more Two new alkaloids, (−)-goniolanceolactam (1) and 2-acetyl-3-amino-1,4-naphthoquinone (2), along with two known naphthoquinone alkaloids, 2-acetyl-3-amino-5-hydroxy-1,4-naphthoquinone (3) and cleistopholine (4) were isolated from the cytotoxic, dichloromethane root extract of Goniothalamus lanceolatus (Annonaceae). The structures were elucidated by spectroscopic techniques and the absolute configuration of 1 was established by single-crystal X-ray diffraction. Alkaloid 1 showed cytotoxic activity on human colon and lung cancer cell lines with IC 50 values ranging from 5.32 to 9.91 μM.
Applied Surface Science, 2019
et al., XPS and DFT investigations of corrosion inhibition of substituted benzylidene Schiff base... more et al., XPS and DFT investigations of corrosion inhibition of substituted benzylidene Schiff bases on mild steel in hydrochloric acid, Applied Surface Science,
Indonesian Journal of Chemistry, 2018
The interaction of Active Pharmaceutical Ingredient (API) with other compounds will affect drugs ... more The interaction of Active Pharmaceutical Ingredient (API) with other compounds will affect drugs stability, toxicity, modified dissolution profiles or may form a new compound with the different crystal structure. Acetaminophenol (APAP), the most common drug used widely (also known as Panadol) was mixed with Naringenin (NR) to glance for a new phase of interactions leading to new compound phase. The amide-acid supramolecular heterosynthon; N-H…O interaction between acid and the respective base were observed in the APAP-NR mixture blends. The interaction was prepared by the binary interaction from neat grinding and liquid-assisted grinding techniques at a different stoichiometry of binary mixture ratio of APAP-NR which were 1:1, 1:2 and 2:1 molar ratio. The interaction was estimated using Group Contribution Method (GCM) and physicochemical properties were characterized by Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR), powder X-ray diffraction (PXRD) and Differenti...