Danilo Sirigu - Academia.edu (original) (raw)
Papers by Danilo Sirigu
Journal of ultrasound, 2009
The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal m... more The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal muscle of the right thigh. The patient had been treated with surgical procedures and with multiple sessions of transarterial chemoembolization, one of which was complicated by a right femoral artery hematoma at the catheter insertion site. It is unclear whether the muscle metastasis was caused by blood-borne spread or by tumor-cell seeding caused by the TACE procedure.
International Journal of Colorectal Disease, 2021
The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy ... more The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography. The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively. Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the a...
Giornale italiano di cardiologia, 2019
BACKGROUND The purpose of this study was to use hypnosis in patients with congenital heart diseas... more BACKGROUND The purpose of this study was to use hypnosis in patients with congenital heart disease undergoing transesophageal echocardiography (TEE). METHODS From January 2016 to July 2017, 50 adult patients undergoing TEE were randomly assigned to two groups: TEE in hypnosis (n = 23), TEE in sedation (n = 27). Vital parameters (heart rate [HR], blood pressure [BP], oxygen saturation [SO2] before, during and after the procedure) and drug administration were recorded. The State-Trait Anxiety Inventory was performed before and after TEE, the memory and experience of TEE through a structured interview were assessed. RESULTS All patients in the hypnosis group performed TEE without any sedation. As for anxiety before TEE, no significant differences were observed between groups; after TEE all patients were less anxious than at the beginning (p<0.001) with a greater decrease in patients of the hypnosis group (p<0.001). Before TEE, there were no significant differences also in HR, BP ...
Recenti progressi in medicina, 2010
Improvements in the ultrasound examination of bowel disease have registered in the last years the... more Improvements in the ultrasound examination of bowel disease have registered in the last years the introduction of new technologies regarding high frequency probes (US), highly sensitive color or power Doppler units (CD-US), and the development of new non-linear technologies that optimize detection of microbubbles contrast agents responses. Contrast-enhanced ultrasound (CE-US) most importantly increases the results in sonographic evaluation of Crohn disease inflammatory activity. CE-US has become an imaging modality routinely employed in the clinical practice for the evaluation of parenchymal organs due to the introduction of new generation microbubble contrast agents which persist in the bloodstream for several minutes after intravenous injection. The availability of high frequency dedicated contrast-specific US techniques provide accurate depiction of small bowel wall perfusion due to the extremely high sensitivity of non-linear signals produced by microbubble insonation. In Crohn&...
A Correction to this paper has been published: https://doi.org/10.1007/s00384-021-03862-5
Poster: "ECR 2012 / B-0057 / Non-invasive assessment of bowel wall fibrosis in Crohn’s disea... more Poster: "ECR 2012 / B-0057 / Non-invasive assessment of bowel wall fibrosis in Crohn’s disease: role of the qualitative elastographic imaging (IE) and correlation with baseline (US), colour Doppler (CD-US) and contrast-enhanced ultrasound (CE-US) patterns" by: "V. Migaleddu, G. Virgilio, D. Scanu, M. P. Dore, A. Porcu, M. Marzo, D. sirigu; Sassari/IT"
Journal of Advances in Medicine and Medical Research
International Journal of Colorectal Disease
Acute appendicitis (AA) is among the most common causes of lower abdominal pain and admissions to... more Acute appendicitis (AA) is among the most common causes of lower abdominal pain and admissions to the emergency department. Over the past 20 years, there has been a renewed interest in the conservative management of uncomplicated AA, and several studies demonstrated that an antibiotic-first strategy is a viable treatment option for uncomplicated AA. The aim of this prospective non-randomized controlled, multicenter trial is to compare antibiotic therapy and emergency appendectomy as treatment for patients with uncomplicated AA confirmed by US and/or CT or MRI scan. All adult patients in the age range 18 to 65 years with suspected AA, consecutively admitted to the Surgical Department of the 13 participating Italian Hospitals, will be invited to take part in the study. A multicenter prospective collected registry developed by surgeons, radiologists, and pathologists with expertise in the diagnosis and treatment of uncomplicated acute appendicitis represents the best research method to assess the long-term role of antibiotics in the management of the disease. Comparison will be made between surgical and antibiotic-first approaches to uncomplicated AA through the analysis of the primary outcome measure of complication-free treatment success rate based on 1-year follow-up. Quality of life, length of hospital stay, pain evaluation, and time to return to normal activity will be evaluated as secondary outcome measures. Clinicaltrials.gov ID: NCT03080103.
Journal of Ultrasound, 2017
Endoscopy remains the main technique in the diagnosis and treatment of Crohn&amp;amp;amp;... more Endoscopy remains the main technique in the diagnosis and treatment of Crohn&amp;amp;amp;amp;amp;amp;amp;#39;s disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.
Abdominal Imaging, 2011
The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment pl... more The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment planning and monitoring, is currently based on a sum of clinical data and imaging findings. Among the contrast enhanced cross-sectional imaging techniques (CE-US, CE-CT, CE-MR), CE-US is less invasive, more comfortable for the patient, and has significant diagnostic accuracy. In addition, it is a portable, easily repeatable, well tolerated, and ionizing radiation-free imaging modality. CE-US has been introduced as effective method in the quantitative and qualitative evaluation of CD inflammatory activity. CE-US might help in characterizing bowel-wall thickening by differentiating inflammatory neovascularisation, edema, and fibrosis. The recent chance to evaluate the bowel-wall stiffness by US elastography imaging could allow further assessment of fibrosis that characterizes the evolution of the inflammatory activity.
PURPOSE To check the usefulness of color Doppler and high sensitivity color Doppler Energy in the... more PURPOSE To check the usefulness of color Doppler and high sensitivity color Doppler Energy in the study of intracavernous vascularization and in detecting anatomical variants. METHOD AND MATERIALS Sequoia 512 imagegate (Siemens-Acuson) equipment was used with a high frequency probe (14 Mhz and Doppler 13 Mhz) to consecutively examine 33 patients for erectile deficit; an initial morphological study preceded the functional color Doppler study and color Doppler Energy after intracavernous injection of 10 mcg of alprostidil. Individuation of the cavernous artery or its anatomical variants was preliminary to placing the sample volume for velocytometric assessment. RESULTS Of 56 patients (aged 32-71) 12 patients (21.4%) were found to have anatomical variants of the cavernous artery (C.A.): 8 with double C.A. and 1 with triple C.A. In 3 cases shunts between C.A. and bulbar artery were identified and between cavernous artery and pudendal artery. CONCLUSION Individuation of anatomical varian...
The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal m... more The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal muscle of the right thigh. The patient had been treated with surgical procedures and with multiple sessions of transarterial chemoembolization, one of which was complicated by a right femoral artery hematoma at the catheter insertion site. It is unclear whether the muscle metastasis was caused by
Indian Journal of Dental Research, 2009
Imaging of soft tissue infections has traditionally been a challenging and difficult task. The co... more Imaging of soft tissue infections has traditionally been a challenging and difficult task. The concept of fascial spaces is based on the knowledge of anatomists that all spaces exist only potentially, until fascia is separated by pus, blood, drain or surgeon's finger. In case of odontogenic infections, fascial spaces may become involved when the infection spreads deeply into the soft tissue rather than exiting
Recenti progressi in medicina, 2010
Improvements in the ultrasound examination of bowel disease have registered in the last years the... more Improvements in the ultrasound examination of bowel disease have registered in the last years the introduction of new technologies regarding high frequency probes (US), highly sensitive color or power Doppler units (CD-US), and the development of new non-linear technologies that optimize detection of microbubbles contrast agents responses. Contrast-enhanced ultrasound (CE-US) most importantly increases the results in sonographic evaluation of Crohn disease inflammatory activity. CE-US has become an imaging modality routinely employed in the clinical practice for the evaluation of parenchymal organs due to the introduction of new generation microbubble contrast agents which persist in the bloodstream for several minutes after intravenous injection. The availability of high frequency dedicated contrast-specific US techniques provide accurate depiction of small bowel wall perfusion due to the extremely high sensitivity of non-linear signals produced by microbubble insonation. In Crohn&...
Journal of ultrasound, 2009
The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal m... more The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal muscle of the right thigh. The patient had been treated with surgical procedures and with multiple sessions of transarterial chemoembolization, one of which was complicated by a right femoral artery hematoma at the catheter insertion site. It is unclear whether the muscle metastasis was caused by blood-borne spread or by tumor-cell seeding caused by the TACE procedure.
International Journal of Colorectal Disease, 2021
The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy ... more The aim of this prospective multicenter study was to compare antibiotic therapy and appendectomy as treatment for patients with uncomplicated appendicitis confirmed by ultrasound and/or computed tomography. The study was conducted from January 2017 to January 2018. Data regarding all patients discharged from the participating centers with a diagnosis of uncomplicated appendicitis were collected prospectively. Of the 318 patients enrolled in the study, 27.4% underwent antibiotic-first therapy, and 72.6% underwent appendectomy. The matched group was composed of 87 patients in both study arms. Of the 87 patients available of 1-year follow-up in the antibiotic-first group, 64 (73.6%) did not require appendectomy. The complication-free treatment success in the antibiotic-first group was 64.4%. A statistically significant higher complication-free treatment success was found in the appendectomy group: 81.8% in the pre-matching sample and 83.9% in the post-matching sample. Patients in the a...
Giornale italiano di cardiologia, 2019
BACKGROUND The purpose of this study was to use hypnosis in patients with congenital heart diseas... more BACKGROUND The purpose of this study was to use hypnosis in patients with congenital heart disease undergoing transesophageal echocardiography (TEE). METHODS From January 2016 to July 2017, 50 adult patients undergoing TEE were randomly assigned to two groups: TEE in hypnosis (n = 23), TEE in sedation (n = 27). Vital parameters (heart rate [HR], blood pressure [BP], oxygen saturation [SO2] before, during and after the procedure) and drug administration were recorded. The State-Trait Anxiety Inventory was performed before and after TEE, the memory and experience of TEE through a structured interview were assessed. RESULTS All patients in the hypnosis group performed TEE without any sedation. As for anxiety before TEE, no significant differences were observed between groups; after TEE all patients were less anxious than at the beginning (p<0.001) with a greater decrease in patients of the hypnosis group (p<0.001). Before TEE, there were no significant differences also in HR, BP ...
Recenti progressi in medicina, 2010
Improvements in the ultrasound examination of bowel disease have registered in the last years the... more Improvements in the ultrasound examination of bowel disease have registered in the last years the introduction of new technologies regarding high frequency probes (US), highly sensitive color or power Doppler units (CD-US), and the development of new non-linear technologies that optimize detection of microbubbles contrast agents responses. Contrast-enhanced ultrasound (CE-US) most importantly increases the results in sonographic evaluation of Crohn disease inflammatory activity. CE-US has become an imaging modality routinely employed in the clinical practice for the evaluation of parenchymal organs due to the introduction of new generation microbubble contrast agents which persist in the bloodstream for several minutes after intravenous injection. The availability of high frequency dedicated contrast-specific US techniques provide accurate depiction of small bowel wall perfusion due to the extremely high sensitivity of non-linear signals produced by microbubble insonation. In Crohn&...
A Correction to this paper has been published: https://doi.org/10.1007/s00384-021-03862-5
Poster: "ECR 2012 / B-0057 / Non-invasive assessment of bowel wall fibrosis in Crohn’s disea... more Poster: "ECR 2012 / B-0057 / Non-invasive assessment of bowel wall fibrosis in Crohn’s disease: role of the qualitative elastographic imaging (IE) and correlation with baseline (US), colour Doppler (CD-US) and contrast-enhanced ultrasound (CE-US) patterns" by: "V. Migaleddu, G. Virgilio, D. Scanu, M. P. Dore, A. Porcu, M. Marzo, D. sirigu; Sassari/IT"
Journal of Advances in Medicine and Medical Research
International Journal of Colorectal Disease
Acute appendicitis (AA) is among the most common causes of lower abdominal pain and admissions to... more Acute appendicitis (AA) is among the most common causes of lower abdominal pain and admissions to the emergency department. Over the past 20 years, there has been a renewed interest in the conservative management of uncomplicated AA, and several studies demonstrated that an antibiotic-first strategy is a viable treatment option for uncomplicated AA. The aim of this prospective non-randomized controlled, multicenter trial is to compare antibiotic therapy and emergency appendectomy as treatment for patients with uncomplicated AA confirmed by US and/or CT or MRI scan. All adult patients in the age range 18 to 65 years with suspected AA, consecutively admitted to the Surgical Department of the 13 participating Italian Hospitals, will be invited to take part in the study. A multicenter prospective collected registry developed by surgeons, radiologists, and pathologists with expertise in the diagnosis and treatment of uncomplicated acute appendicitis represents the best research method to assess the long-term role of antibiotics in the management of the disease. Comparison will be made between surgical and antibiotic-first approaches to uncomplicated AA through the analysis of the primary outcome measure of complication-free treatment success rate based on 1-year follow-up. Quality of life, length of hospital stay, pain evaluation, and time to return to normal activity will be evaluated as secondary outcome measures. Clinicaltrials.gov ID: NCT03080103.
Journal of Ultrasound, 2017
Endoscopy remains the main technique in the diagnosis and treatment of Crohn&amp;amp;amp;... more Endoscopy remains the main technique in the diagnosis and treatment of Crohn&amp;amp;amp;amp;amp;amp;amp;#39;s disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.
Abdominal Imaging, 2011
The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment pl... more The evaluation of inflammatory activity in Crohn's disease (CD), a crucial aspect of treatment planning and monitoring, is currently based on a sum of clinical data and imaging findings. Among the contrast enhanced cross-sectional imaging techniques (CE-US, CE-CT, CE-MR), CE-US is less invasive, more comfortable for the patient, and has significant diagnostic accuracy. In addition, it is a portable, easily repeatable, well tolerated, and ionizing radiation-free imaging modality. CE-US has been introduced as effective method in the quantitative and qualitative evaluation of CD inflammatory activity. CE-US might help in characterizing bowel-wall thickening by differentiating inflammatory neovascularisation, edema, and fibrosis. The recent chance to evaluate the bowel-wall stiffness by US elastography imaging could allow further assessment of fibrosis that characterizes the evolution of the inflammatory activity.
PURPOSE To check the usefulness of color Doppler and high sensitivity color Doppler Energy in the... more PURPOSE To check the usefulness of color Doppler and high sensitivity color Doppler Energy in the study of intracavernous vascularization and in detecting anatomical variants. METHOD AND MATERIALS Sequoia 512 imagegate (Siemens-Acuson) equipment was used with a high frequency probe (14 Mhz and Doppler 13 Mhz) to consecutively examine 33 patients for erectile deficit; an initial morphological study preceded the functional color Doppler study and color Doppler Energy after intracavernous injection of 10 mcg of alprostidil. Individuation of the cavernous artery or its anatomical variants was preliminary to placing the sample volume for velocytometric assessment. RESULTS Of 56 patients (aged 32-71) 12 patients (21.4%) were found to have anatomical variants of the cavernous artery (C.A.): 8 with double C.A. and 1 with triple C.A. In 3 cases shunts between C.A. and bulbar artery were identified and between cavernous artery and pudendal artery. CONCLUSION Individuation of anatomical varian...
The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal m... more The authors describe a rare case of hepatocellular carcinoma that metastasized to the pectineal muscle of the right thigh. The patient had been treated with surgical procedures and with multiple sessions of transarterial chemoembolization, one of which was complicated by a right femoral artery hematoma at the catheter insertion site. It is unclear whether the muscle metastasis was caused by
Indian Journal of Dental Research, 2009
Imaging of soft tissue infections has traditionally been a challenging and difficult task. The co... more Imaging of soft tissue infections has traditionally been a challenging and difficult task. The concept of fascial spaces is based on the knowledge of anatomists that all spaces exist only potentially, until fascia is separated by pus, blood, drain or surgeon's finger. In case of odontogenic infections, fascial spaces may become involved when the infection spreads deeply into the soft tissue rather than exiting
Recenti progressi in medicina, 2010
Improvements in the ultrasound examination of bowel disease have registered in the last years the... more Improvements in the ultrasound examination of bowel disease have registered in the last years the introduction of new technologies regarding high frequency probes (US), highly sensitive color or power Doppler units (CD-US), and the development of new non-linear technologies that optimize detection of microbubbles contrast agents responses. Contrast-enhanced ultrasound (CE-US) most importantly increases the results in sonographic evaluation of Crohn disease inflammatory activity. CE-US has become an imaging modality routinely employed in the clinical practice for the evaluation of parenchymal organs due to the introduction of new generation microbubble contrast agents which persist in the bloodstream for several minutes after intravenous injection. The availability of high frequency dedicated contrast-specific US techniques provide accurate depiction of small bowel wall perfusion due to the extremely high sensitivity of non-linear signals produced by microbubble insonation. In Crohn&...