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Papers by Daniel Mason

Nature Communications, 2019

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistan... more The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibit...

Journal of controlled release : official journal of the Controlled Release Society, Jan 10, 2015

Gene therapy has the potential to serve as an adaptable platform technology for treating various ... more Gene therapy has the potential to serve as an adaptable platform technology for treating various diseases. Cardiovascular disease is a major cause of mortality in the developed world and genetic modification is steadily becoming a more plausible method to repair and regenerate heart tissue. Recently, new gene targets to treat cardiovascular disease have been identified and developed into therapies that have shown promise in animal models. Some of these therapies have advanced to clinical testing. Despite these recent successes, several barriers must be overcome for gene therapy to become a widely used treatment of cardiovascular diseases. In this review, we evaluate specific genetic targets that can be exploited to treat cardiovascular diseases, list the important delivery barriers for the gene carriers, assess the most promising methods of delivering the genetic information, and discuss the current status of clinical trials involving gene therapies targeted to the heart.

14th International Conference on Electronics, Communications and Computers, 2004. CONIELECOMP 2004., 2004

The complete follow-up of a product from its origin to its final use has been strongly developed ... more The complete follow-up of a product from its origin to its final use has been strongly developed in recent years. In wood industries, the implementation of ordinary identification systems presents implantation problems, mainly because of the extremely variable nature of the material and the particular features of the manufacturing process. In order to allow follow-up of products, new solutions have

PLoS ONE, 2014

Glycoside hydrolases catalyze the selective hydrolysis of glycosidic bonds in oligosaccharides, p... more Glycoside hydrolases catalyze the selective hydrolysis of glycosidic bonds in oligosaccharides, polysaccharides, and their conjugates. b-glucosidases occur in all domains of living organisms and constitute a major group among glycoside hydrolases. On the other hand, the benzoxazinoids occur in living systems and act as stable b-glucosides, such as 2-(2,4dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one)-b-D-gluco-pyranose, which hydrolyse to an aglycone DIMBOA. Here, we synthesized the library of novel 1,3-benzoxazine scaffold based aglycones by using 2-aminobenzyl alcohols and aldehydes from one-pot reaction in a chloroacetic acid catalytic system via aerobic oxidative synthesis. Among the synthesized benzoxazines, 4-(7-chloro-2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)phenol (compound 7) exhibit significant inhibition towards glucosidase compared to acarbose, with a IC 50 value of 11.5 mM. Based upon results generated by in silico target prediction algorithms (Naïve Bayesian classifier), these aglycones potentially target the additional sodium/glucose cotransporter 1 (where a log likelihood score of 2.70 was observed). Furthermore, the in vitro glucosidase activity was correlated with the in silico docking results, with a high docking score for the aglycones towards the substrate binding site of glycosidase. Evidently, the in vitro and in vivo experiments clearly suggest an anti-hyperglycemic effect via glucose uptake inhibition by 4-(7-chloro-2,4-dihydro-1H-benzo[d][1,3]oxazin-2-yl)phenol in the starved rat model. These synthetic aglycones could constitute a novel pharmacological approach for the treatment, or re-enforcement of existing treatments, of type 2 diabetes and associated secondary complications.

Wood Science and Technology, 2007

A method for evaluating the influence of the operating parameters of wood machining (planing, san... more A method for evaluating the influence of the operating parameters of wood machining (planing, sanding) on the quality of a finished surface was established. The influence of each of the operations involved was studied using different strategies. For the planing operation, three levels were established (Level 1, 2 and 3) by determining different values for each of the major process parameters (tool rotation speed, feed speed, depth of cut). For both, surface preparation and polishing, two levels were established with a fixed setup. Finally, as finishing products, two different transparent coatings were selected (water-borne and solventborne). The quantitative evaluation of the state of the surface was assessed by means of an artificial vision system for the determination of the pseudo-roughness of wood surfaces. A filtering method based on fast Fourier transforms was applied and it was possible to derive three criteria for evaluating the resulting profile.

Managing Leisure, 2006

Hosting sporting events has emerged as a means for cities to reposition themselves in an increasi... more Hosting sporting events has emerged as a means for cities to reposition themselves in an increasingly competitive global marketplace. Despite the widespread use of sporting events in urban develop-ment, the degree to which the local community fits into the plans of a city&amp;#x27;s pro-...

Journal of Management & Organization, 2010

The purpose of this paper was to examine ways that corporations can make a greater contribution t... more The purpose of this paper was to examine ways that corporations can make a greater contribution to civic and community development through strategic ties to a city's development agenda surrounding the hosting of sporting events. Using the perspective of Corporate Community Involvement (CCI), we draw upon data collected as part of a larger study on sporting events and community development to explore how cities and corporations can make socially responsible contributions to communities. The guiding principles of community involvement in decision-making, full public disclosure and transparency, and grassroots legacy planning underscore the importance of community-based strategies for CCI. We offer three related strategies: comprehensive social and community impact assessments, facilitation of local knowledge capital and providers, and cross-sectoral management event programming as ways for corporations to begin to engage in CCI activities related to events. These strategies offer ...

Holzforschung, 1991

An analysis of some chemical and physical parameters of the wood of Turkey oak, which have an inf... more An analysis of some chemical and physical parameters of the wood of Turkey oak, which have an influence on its bonding properties, was necessary for the Interpretation of the results of some previous mechanical tests on the glued joints.The wood pH is perfcctly compatible with the commonly used wood adhesives and wood wettability is good and thcre is no evidence of the presence of important quantities of non-polar extractives. There is no appreciable migration of the wood extractives to the surface, and no evidence of their deposition on the pit mcmbranes diminishing wood's microporosity. Moreover, the wood of turkey oak contains very little quantities of polyphcnols and practically no ellagitannins. Thus, even if the presence of a factor causing inactivation to gluing cannot be absolutely excluded, it is more probable that the gluing difficulties of this wood are of the same nature äs those of other oak species' wood with a comparable density (0.8-0.9 g/cm 3 at 12% MC).

Cancer, 1979

A symptomatic myelolipoma of the heterotopic adrenal gland was diagnosed as the cause of nephroti... more A symptomatic myelolipoma of the heterotopic adrenal gland was diagnosed as the cause of nephrotic syndrome and was surgically removed. Remission of the nephrotic syndrome promptly ensued. Ultrastructurally, the tumor consisted of well-differentiated cells resembling adrenal cortical cells, bone marrow cells in various stages of differentiation, and lipid cells. Some cells that contained fat were of adrenal cortical origin, but the derivation of most lipid cells and of bone marrow elements could not be deduced from the present ultrastructural findings.

Bioresource Technology, 2009

As biomass feedstock, wood and lactic acid biopolymers have been used as constituents of an innov... more As biomass feedstock, wood and lactic acid biopolymers have been used as constituents of an innovative biocomposite material possessing remarkable properties. Three different systems were made by soaking lactic acid oligomers into solid wood and then oven heating to induce in situ polymerisation, confirmed by Fourier transformed infrared spectroscopy (FTIR) and gel permeation chromatography (GPC) analysis. Combinations of treatment systems and heating durations, implying structural wood modification, led to different physical behaviours of the composites. The first obtained material was in the form of softened and easily bendable wood. Subjected to an extended heating period, this softened material could then regain its initial hardness. Another treatment parameter combination directly led to densified wood with improved properties. These two main composite materials are expected to be useable for bending, stamping or flooring industrial uses, depending on their physical condition.

Bioorganic & Medicinal Chemistry Letters, 2007

A 6-oxa-1-aza-bicyclo[3.2.1]octan-7-one system inhibits the proteolytic activity of several cyste... more A 6-oxa-1-aza-bicyclo[3.2.1]octan-7-one system inhibits the proteolytic activity of several cysteine proteases belonging to the papain family. In vitro mechanistic studies and in silico calculations suggest that the minimal p-overlap between the bridgehead nitrogen and the carbonyl leads to a considerable weakening of the urethane system, making it susceptible to nucleophilic attack from the active site thiol group. The resulting covalent adduct is slowly hydrolyzed, releasing the hydroxypiperidine product of the inhibitor. Synthesis and testing of a set of analogs led to variable protease subtype selectivities ranging from micromolar to nanomolar potencies.

Aquatic Botany, 1992

Abstract Seedlings and vegetative propagules of Nymphoides indica (L.) O. Kuntze, a species with ... more Abstract Seedlings and vegetative propagules of Nymphoides indica (L.) O. Kuntze, a species with floating leaves, were grown in a concrete tank at 17, 35, 75, 105 and 140 cm below the surface of the water. The total biomass, relative growth rate (RGR), net assimilation rate (NAR), specific leaf area (SLA), leaf area ratio (LAR) and leaf weight ratio (LWR) were measured or calculated for both seedlings and vegetative propagules. At the end of the experiment, the total biomass for seedlings and vegetative propagules was similar at all depths. Overall, RGR values were higher for seedlings (54.3–64.3 mg g−1 day−1) than for vegetative propagules (41.4–57.1 mg g−1 day−1). Before reaching maximum RGR, LAR and NAR values were generally higher for seedlings. After reaching maximum RGR, LAR values remained higher for seedlings, but NAR values became higher for vegetative propagules. Growth strategies for seedlings and vegetative propagules differed in shallow (17 and 35 cm) and deep (105 and 140 cm) water. Before maximum RGR were reached, LAR values of seedlings in shallow water (8.4–10.9 m2 kg−1) were higher than those in deep water (4.1–6.8 m2 kg−1). NAR values, on the other hand, were lower in shallow water (5.8–8.0 g m−2 day−1) than in deep water (10–13 g m−2 day−1). After reaching maximum RGR, LAR values were similar at all water depths, but NAR values remained lower in shallow water. Before maximum RGR were reached, LAR values of vegetative propagules were higher in shallow water (7.0–7.9 m2 kg−1) than in deep water (5.8–6.4 m2 kg−1). NAR values, however, were higher in deep water (4.4–6.8 m2 day−1). After reaching the maximum RGR, LAR values became higher in deep water and NAR values were highest in deep water and also at the shallowest water depth.

American Heart Journal, 1954