Daniel Teixeira - Academia.edu (original) (raw)
An open mind where the immovable has no place
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Constituindo a democracia principio basico de organizacao social e politica, adotado por grande p... more Constituindo a democracia principio basico de organizacao social e politica, adotado por grande parte das populacoes ao redor do globo, o conhecimento dos valores e modelos institucionais dos sistemas democraticos e de fundamental importância para as ciencias sociais. Tais objetos relacionam-se a aspectos cruciais da ordenacao social, envolvendo questoes de natureza etica, que demandam a tomada ou pressuposicao de decisoes morais e politicas a seu respeito. O contexto etico proprio das sociedades capitalistas contemporâneas fornece respostas com certo grau de homogeneidade sobre essas questoes, o que importa numa compreensao especifica do significado atribuido aos valores basicos da ideologia democratica — liberdade e igualdade —, e na adocao de um modelo institucional hegemonico para os sistemas politicos democraticos. Analisa-se o tratamento que se tem dado a esses temas, enfatizando o carater predominantemente etico da discussao, que se subordina muito mais a um julgamento interi...
Mutation research, 2012
Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached ... more Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached to histones H2A, H3, and H4, although the abundance of biotinylated histones is low. Biotinylation of both carboxylases and histones is catalyzed by holocarboxylase synthetase. Human biotin requirements are unknown. Recommendations for adequate intake of biotin are based on the typical intake of biotin in an apparently healthy population, which is only a crude estimate of the true intake due to analytical problems. Importantly, intake recommendations do not take into account possible effects of biotin deficiency on impairing genome stability. Recent studies suggest that biotin deficiency causes de-repression of long terminal repeats, thereby causing genome instability. While it was originally proposed that these effects are caused by loss of biotinylated histones, more recent evidence suggests a more immediate role of holocarboxylase synthetase in forming multiprotein complexes in chroma...
Constituindo a democracia principio basico de organizacao social e politica, adotado por grande p... more Constituindo a democracia principio basico de organizacao social e politica, adotado por grande parte das populacoes ao redor do globo, o conhecimento dos valores e modelos institucionais dos sistemas democraticos e de fundamental importância para as ciencias sociais. Tais objetos relacionam-se a aspectos cruciais da ordenacao social, envolvendo questoes de natureza etica, que demandam a tomada ou pressuposicao de decisoes morais e politicas a seu respeito. O contexto etico proprio das sociedades capitalistas contemporâneas fornece respostas com certo grau de homogeneidade sobre essas questoes, o que importa numa compreensao especifica do significado atribuido aos valores basicos da ideologia democratica — liberdade e igualdade —, e na adocao de um modelo institucional hegemonico para os sistemas politicos democraticos. Analisa-se o tratamento que se tem dado a esses temas, enfatizando o carater predominantemente etico da discussao, que se subordina muito mais a um julgamento interi...
Mutation research, 2012
Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached ... more Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached to histones H2A, H3, and H4, although the abundance of biotinylated histones is low. Biotinylation of both carboxylases and histones is catalyzed by holocarboxylase synthetase. Human biotin requirements are unknown. Recommendations for adequate intake of biotin are based on the typical intake of biotin in an apparently healthy population, which is only a crude estimate of the true intake due to analytical problems. Importantly, intake recommendations do not take into account possible effects of biotin deficiency on impairing genome stability. Recent studies suggest that biotin deficiency causes de-repression of long terminal repeats, thereby causing genome instability. While it was originally proposed that these effects are caused by loss of biotinylated histones, more recent evidence suggests a more immediate role of holocarboxylase synthetase in forming multiprotein complexes in chroma...