Danish Khan - Academia.edu (original) (raw)

Papers by Danish Khan

ACS Omega, 2022

Pore types and pore structure parameters are the important factors affecting the storage capacity... more Pore types and pore structure parameters are the important factors affecting the storage capacity of a shale oil reservoir. Pore morphology and mineralogical composition of shales have diverse effects on the upgrading of various phases of shale oil. To interpret the formation and distribution of different pore types and their structure parameters in the lacustrine calcareous shale, a combination of polarizing microscopy, X-ray diffraction, total organic carbon (TOC), field-emission scanning electron microscopy, and low-pressure nitrogen adsorption experiments were conducted on the Es3x shale of the Eocene Shahejie Formation in the Zhanhua Depression. The interpretations regarding pore types, pore structure parameters, and pore size distribution indicate that the pore morphology and pore size distribution in the lacustrine shale are very complicated and demonstrate strong heterogenic behavior. Inorganic pores (interparticle pores, intraparticle pores, intercrystalline pores, dissolution pores, and microfractures) are the most commonly distributed pore types in the studied shale. However, organic matter pores are poorly developed due to the lower thermal maturity of the Es3x shale. The Brunauer−Emmett−Teller specific surface and pore volume range from 0.026 to 1.282 m 2 /g (average 0.697 m 2 /g) and 0.003 to 0.008 cm 3 /g (average 0.005 cm 3 /g), respectively. The shape of the pores varies from slit-like to narrow slit. Different minerals develop different types of pores with various sizes extending from micropores (<2 nm), mesopores (2−50 nm), to macropores (>50 nm). The relationship between mineral components and pore parameters indicates that the carbonate minerals act as the main contributors to the formation and distribution of different pore types in the studied shale. Pore volume and the pore specific surface area did not show a good relationship with mineral composition and TOC due to disordered pores, but pore size shows a good relationship with mineral composition and TOC of the Es3x shale. The whole pore system description showed that the mesopores and macropores are abundantly distributed and are the main contributors to the pore system in the Es3x shale. A comprehensive understanding of the formation mechanism and structural features of various sized pores in a variety of different minerals can provide a good tool for the exploration and development of shale oil reservoirs.

Journal of Cell Biology, 2020

The heat shock response (HSR) is a gene expression program that protects cells from heat and prot... more The heat shock response (HSR) is a gene expression program that protects cells from heat and proteotoxic stressors. In this issue, Feder et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005165) show that subcellular relocalization of the cochaperone Sis1 drives the HSR by de-suppressing the transcription factor Hsf1.

2017 8th IEEE International Conference on Software Engineering and Service Science (ICSESS), 2017

Solar energy has the property of alternating, fluctuation and periodicity, and it has severe impa... more Solar energy has the property of alternating, fluctuation and periodicity, and it has severe impact on large scale photovoltaic (PV) grid-connected generation. This turn power utilities contrary to use PV power since the forecasting and overall assessment of the grid becomes very difficult. To develop a reliable algorithm that can minimize the errors associated with forecasting the nearby future PV power generation is particularly helpful for efficiently integration into the grid. PV power prediction can play a significant role in undertaking these challenges. This paper presents 3 days ahead power output forecasting of a PV system using a Theoretical Solar radiation and Elman Neural Network (ENN) software engineering technique by including the relations of PV power with solar radiation, temperature, humidity, and wind speed data. In the proposed method, the ENN is applied to have a significant effect on random PV power time-series data, and tackle the nonlinear fluctuations in a better approach.

2021 International Conference on Robotics and Automation in Industry (ICRAI), 2021

We propose the 3D sensing system using active stereo vision to get the 3D model of human body par... more We propose the 3D sensing system using active stereo vision to get the 3D model of human body parts and surgical tools. This article presents the 3D scanner based on active stereo vision utilized for image guided surgery. The proposed system comprises of a pair of cameras (stereo camera) and the projector to record images of the target object placed at a specific distance. The proposed approach also includes the pre-calibration of the stereo camera for removing the distortion from the image data using non-linear method. We have performed the camera calibration of stereo camera using undistorted image data to estimate camera parameters using chessboard target. This research uses NCC (normalized cross correlation) based stereo matching and this matching is reduced to single dimension by utilizing epipolar geometry. After estimating the matched points, DLT (direct linear transformation) is applied to render the 3D point clouds. The rendered 3D point clouds were further filtered to remove the background objects. This refinement stage includes removal of outliers, suppression of noise and smoothing. We tested the 3D scanning system using artificial skull and a paper box object for the demonstration of image guided surgery. The three dimensional sensing system using stereo vision and structured light was tested using the objects, skull and paper box objects. The three dimensional model (3D model) shows that the features are preserved. Post processing based filtering results in the refinement of the point clouds. To evaluate the proposed system, we used the paper box object and the 3D scans were captured. We found that the errors in the height and breadth were 9.4 μm and 23 μm respectively. Our system currently does not target real time applications, but the parallel processing and utilization of GPUs may reduce the processing time to meet the needs of real time surgical intervention.

International Journal of Molecular Sciences, 2021

The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents availab... more The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents available to clinicians is eroding our ability to effectively treat infections by these virulent pathogens. As the threat of fungal infection is escalating worldwide, this dwindling response capacity is fueling concerns of impending global health emergencies. These developments underscore the urgent need for new classes of anti-fungal drugs and, therefore, the identification of new targets. Phosphoinositide signaling does not immediately appear to offer attractive targets due to its evolutionary conservation across the Eukaryota. However, recent evidence argues otherwise. Herein, we discuss the evidence identifying Sec14-like phosphatidylinositol transfer proteins (PITPs) as unexplored portals through which phosphoinositide signaling in virulent fungi can be chemically disrupted with exquisite selectivity. Recent identification of lead compounds that target fungal Sec14 proteins, derived from s...

Current Research in Green and Sustainable Chemistry, 2021

Cell Reports, 2021

SUMMARY Pathological lipid accumulation is often associated with enhanced uptake of free fatty ac... more SUMMARY Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We find that SIRT6 deficiency enhances the expression of fatty acid transporters, leading to enhanced fatty acid uptake and lipid accumulation. Interestingly, the haploinsufficiency of SIRT6 is sufficient to induce the expression of fatty acid transporters and cause lipid accumulation in murine hearts. Mechanistically, SIRT6 depletion enhances the occupancy of the transcription factor PPARγ on the promoters of critical fatty acid transporters without modulating the acetylation of histone 3 at Lys 9 and Lys 56. Notably, the binding of SIRT6 to the DNA-binding domain of PPARγ is critical for regulating the expression of fatty acid transporters in cardiomyocytes. Our data suggest exploiting SIRT6 as a potential therapeutic target for protecting the heart from metabolic diseases.

The Minerals, Metals & Materials Series, 2017

Finite element simulation of heat treatment cycles in steel could be challenging when it involves... more Finite element simulation of heat treatment cycles in steel could be challenging when it involves phase transformation at the microscale. An ICME approach that can take into account the microstructure changes during the heat treatment and the corresponding changes in the macroscale properties could greatly help these simulations. Dual phase steel (DP steel) are potential alternate materials for gears with reduced distortion. Inter-critical annealing in DP steel involves phase transformation at the microscale and the finite element simulation of this heat treatment could be greatly improved by such an ICME approach. In the present work, phase field modeling implemented in the software package Micress is used to simulate the microstructure evolution during inter-critical annealing. Asymptotic Homogenization is used to predict the effective macroscale thermoelastic properties from the simulated microstructure. The macroscale effective flow curves are obtained by performing Virtual Testing on the phase field simulated microstructure using Finite Element Method. All the predicted effective properties are then passed on to the macro scale Finite Element simulation software Simufact Forming, where the heat treatment cycle for the inter-critical annealing is simulated. The thermal profiles from this simulation are extracted and passed on to microscale to repeat the process chain. All the simulation softwares are integrated together to implement a multi-scale simulation, aiming towards ICME approach.

Petroleum Science, 2019

The study of pore characteristics is of great importance in reservoir evaluation, especially in d... more The study of pore characteristics is of great importance in reservoir evaluation, especially in deeply buried sandstone. It controls the storage mechanism and reservoir fluid properties of the permeable horizons. The first member of Eocene Shahejie Formation (Es1) sandstone is classified as feldspathic litharenite and lithic arkose. The present research investigates the pore characteristics and reservoir features of the deeply buried sandstone reservoir of Es1 member of Shahejie Formation. The techniques including thin-section petrography, mercury injection capillary pressure (MICP), scanning electron microscopy and laser scanning confocal microscope images were used to demarcate the pores including primary intergranular pores and secondary intergranular, intragranular, dissolution and fracture pores. Mercury injection test and routine core analysis were led to demarcate the pore network characteristics of the studied reservoir. Pore size and pore throat size distribution are acquir...

The Journal of biological chemistry, Jan 13, 2018

Heart failure is an aging-associated disease, which is the leading cause of death world-wide. Sir... more Heart failure is an aging-associated disease, which is the leading cause of death world-wide. Sirtuin family members have been largely studied in the context of aging and aging-associated diseases. Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of sirtuins that are NAD+-dependent class III histone deacetylases. In this work, we studied the role of SIRT2 in regulating NFAT transcription factor and the development of cardiac hypertrophy. Confocal microscopy analysis indicated that SIRT2 is localized in the cytoplasm of cardiomyocytes and SIRT2 levels are reduced during pathological hypertrophy of the heart. SIRT2 deficient mice develops spontaneous pathological cardiac hypertrophy, remodelling, fibrosis and dysfunction in an age-dependent manner. Moreover, young SIRT2 deficient mice develops exacerbated agonist-induced hypertrophy. On contrast, SIRT2 overexpression attenuated agonist-induced cardiac hypertrophy in cardiomyocytes in a cell autonomous manner. Mechanistically, ...

AIP Conference Proceedings, 2017

The paper examines the impact of the humidity on the Solar panels which makes a space for the dra... more The paper examines the impact of the humidity on the Solar panels which makes a space for the drastic variation in the power generated and makes the device less efficient.. Humidity readily affects the efficiency of the solar cells and creates a minimal layer of water on its surface. It also decreases the efficiency by 10-20% of the total power output produced. Moreover, to handle this issue, all around characterized measures are required to be taken to guarantee the smooth working of the solar panels utilized in humid areas. In connection with this issue, Karachi, the biggest city of Pakistan which is located near the costal line touching Arabian Sea, was taken as a reference city to measure the humidity range. In Karachi, the average humidity lies between 25-70% (as per Pakistan Meteorological Department PMD), that indirectly leads in decreasing power acquired from a Solar Panel and develops various complexities for the solar system. The system on average experiences stability issues, such as those of power fluctuations etc., due to which, the whole solar system installed observes abnormal variations in acquired power. Silica Gel was used as a desiccant material in order to assure dryness over the solar panel. More than four experiments were conducted with the usage of water absorbent to improve the efficiency and to make system more power efficient.

With the increasing usage of AHSS grade steels in modern cars for vehicle light weighting and pas... more With the increasing usage of AHSS grade steels in modern cars for vehicle light weighting and passenger safety, it has become necessary for automotive industries to deeply study and accurately predict the response of these steels to enhance their designs for better performance and light weighting. Due to their complex multiphase nature, conventional continuum based approaches of modelling the materials are not suitable to capture the physical phenomena occurring at microscopic level. With the increase of the computing power of modern day computers, Representative Volume Element (RVE) based micromechanics approaches of modelling deformation of such materials, via real or synthetically generated microstructure with appropriate boundary conditions, have become one of the promising ways of tackling this problem. The present work focusses on modelling the deformation of Dual Phase Steels using 2D and 3D microstructure based micromechanics approach in order to study the deformation patter...

The Indian journal of medical research, 2012

Dengue virus (DV) infection has emerged as a major health problem in north India. Here, we report... more Dengue virus (DV) infection has emerged as a major health problem in north India. Here, we report the annual trend of dengue virus infection as seen in Lucknow, Uttar Pradesh, during 2008-2010. Blood samples from clinically suspected cases of dengue virus infection were collected and history was taken on structured clinical data sheet. All samples were tested for dengue IgM by antibody capture ELISA. Selected samples were tested by conventional RT-PCR for dengue virus RNA. Weather information was continuously recorded from website of world weather information service . There was a gradual increase in number of dengue fever cases with increased occurrence in 2010. Cases referred in January - December 2008 were 398 (54.5% anti DV IgM positive), in January - December 2009 were 599 (51.9% anti DV IgM positive) and in January - December 2010 were 1602 (64.9% anti DV IgM positive). Serotypes circulating in years 2008, 2009 and 2010 were DV-2 & DV-3, DV -1, 2 & 3 and DV-1 and DV-2 respecti...

Proceedings of the 6th International Conference on Pervasive Computing Technologies for Healthcare, 2012

We developed four mobile phone prototype applications informed by theoretical models of behavior ... more We developed four mobile phone prototype applications informed by theoretical models of behavior change to improve the snacking habits of low socioeconomic status (SES) families. Eight primary caregivers and 18 secondary caregivers from low SES backgrounds used the applications to evaluate their usability and usefulness. We found a schism between primary and secondary caregivers regarding whether the applications should be based on games, indicating a need to reconcile these differences to develop a system to support healthy family snacking. In addition, social context, understandable health abstractions, and sensitivity to health values are all important considerations when creating applications in a low SES context. This research contributes design implications for future applications intended to improve snacking habits in low SES families.

Proceedings of the 6th International Conference on Pervasive Computing Technologies for Healthcare, 2012

We conducted a study with eight low socioeconomic status caregivers, the "gatekeepers" to family ... more We conducted a study with eight low socioeconomic status caregivers, the "gatekeepers" to family and community health, to explore their technology perceptions and visualizations that can assist them in managing their families' health. We studied how to visualize the everyday health habits of a population that is at risk for chronic illness. Through semi-structured interviews and prototype design activities, we found that the caregivers wanted to use mobile technology to monitor a subset of their family members for at least one health metric. We inform future work with an analysis of the target population's needs in relation to longitudinal health visualizations with multiple family member data streams.

Biochemical Society Transactions, 2014

The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatid... more The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much of the progress in elucidating PITP functions has come from exploitation of genetically tractable model organisms, but the mechanisms for how PITPs execute their biological activities remain unclear. Structural and molecular dynamics approaches are filling in the details for how these proteins actually work as molecules. In the present paper, we discuss our recent work with Sec14-like PITPs and describe how PITPs integrate diverse territories of the lipid metabolome with phosphoinositide signalling.

2012 National Conference on Communications (NCC), 2012

Communication through fading channels with conventional signal constellation has a limitation tha... more Communication through fading channels with conventional signal constellation has a limitation that the nearby points may lead to wrong symbol detection even if any one dimension fades. This limitation can be overcome by phase rotation of symbols where each symbol is rotated by a rotation matrix. In the new constellation, each symbol attains unique real and imaginary components which imply

Clinical Epidemiology and Global Health, 2014

Aim: The sudden increase in number of cases of fever with rash at five sites in Uttar Pradesh, In... more Aim: The sudden increase in number of cases of fever with rash at five sites in Uttar Pradesh, India was surveyed to establish the aetiology and investigate the extent of the disease. Methods: We case defined, measles as a person with acute onset of fever, cough, coryza or conjunctivitis with maculopapular rash and a case of chickenpox as a person with acute onset of diffuse maculopapulovescicular rash. Blood samples were collected from clinically suspected cases and tested for anti-measles IgM/anti-VZV IgM and IgG antibody (depending on the clinical features) by ELISA. Detailed history was collected from each case including history of contact and immunization. Results: Confirmed measles outbreaks were identified at 2/5 sites. There was neither any death nor any serious complications due to measles. However, varicella outbreaks were confirmed in 3/5 sites with one mortality. Conclusion: Measles and chickenpox are still widespread in North India. Therefore, vaccination for varicella and better coverage of first dose and introduction of second dose opportunity for measles to susceptible population in affected areas is suggested.

PLoS ONE, 2013

Background: A public that is an informed partner in clinical research is important for ethical, m... more Background: A public that is an informed partner in clinical research is important for ethical, methodological, and operational reasons. There are indications that the public is unaware or misinformed, and not sufficiently engaged in clinical research but studies on the topic are lacking. PARTAKE-Public Awareness of Research for Therapeutic Advancements through Knowledge and Empowerment is a program aimed at increasing public awareness and partnership in clinical research. The PARTAKE Survey is a component of the program. Objective: To study public knowledge and perceptions of clinical research. Methods: A 40-item questionnaire combining multiple-choice and open-ended questions was administered to 175 Englishor Hindi-speaking individuals in 8 public locations representing various socioeconomic strata in New Delhi, India. Results: Interviewees were 18-84 old (mean: 39.6, SD616.6), 23.6% female, 68.6% employed, 7.3% illiterate, 26.3% had heard of research, 2.9% had participated and 58.9% expressed willingness to participate in clinical research. The following perceptions were reported (% true/% false/% not aware): 'research benefits society' (94.1%/3.5%/2.3%), 'the government protects against unethical clinical research' (56.7%/26.3%/16.9%), 'research hospitals provide better care' (67.2%/8.7%/ 23.9%), 'confidentiality is adequately protected' (54.1%/12.3%/33.5%), 'participation in research is voluntary' (85.3%/5.8%/ 8.7%); 'participants treated like 'guinea pigs'' (20.7%/53.2%/26.0%), and 'compensation for participation is adequate' (24.7%/ 12.9%/62.3%). Conclusions: Results suggest the Indian public is aware of some key features of clinical research (e.g., purpose, value, voluntary nature of participation), and supports clinical research in general but is unaware of other key features (e.g., compensation, confidentiality, protection of human participants) and exhibits some distrust in the conduct and reporting of clinical trials. Larger, cross-cultural surveys are required to inform educational programs addressing these issues.

ACS Omega, 2022

Pore types and pore structure parameters are the important factors affecting the storage capacity... more Pore types and pore structure parameters are the important factors affecting the storage capacity of a shale oil reservoir. Pore morphology and mineralogical composition of shales have diverse effects on the upgrading of various phases of shale oil. To interpret the formation and distribution of different pore types and their structure parameters in the lacustrine calcareous shale, a combination of polarizing microscopy, X-ray diffraction, total organic carbon (TOC), field-emission scanning electron microscopy, and low-pressure nitrogen adsorption experiments were conducted on the Es3x shale of the Eocene Shahejie Formation in the Zhanhua Depression. The interpretations regarding pore types, pore structure parameters, and pore size distribution indicate that the pore morphology and pore size distribution in the lacustrine shale are very complicated and demonstrate strong heterogenic behavior. Inorganic pores (interparticle pores, intraparticle pores, intercrystalline pores, dissolution pores, and microfractures) are the most commonly distributed pore types in the studied shale. However, organic matter pores are poorly developed due to the lower thermal maturity of the Es3x shale. The Brunauer−Emmett−Teller specific surface and pore volume range from 0.026 to 1.282 m 2 /g (average 0.697 m 2 /g) and 0.003 to 0.008 cm 3 /g (average 0.005 cm 3 /g), respectively. The shape of the pores varies from slit-like to narrow slit. Different minerals develop different types of pores with various sizes extending from micropores (<2 nm), mesopores (2−50 nm), to macropores (>50 nm). The relationship between mineral components and pore parameters indicates that the carbonate minerals act as the main contributors to the formation and distribution of different pore types in the studied shale. Pore volume and the pore specific surface area did not show a good relationship with mineral composition and TOC due to disordered pores, but pore size shows a good relationship with mineral composition and TOC of the Es3x shale. The whole pore system description showed that the mesopores and macropores are abundantly distributed and are the main contributors to the pore system in the Es3x shale. A comprehensive understanding of the formation mechanism and structural features of various sized pores in a variety of different minerals can provide a good tool for the exploration and development of shale oil reservoirs.

Journal of Cell Biology, 2020

The heat shock response (HSR) is a gene expression program that protects cells from heat and prot... more The heat shock response (HSR) is a gene expression program that protects cells from heat and proteotoxic stressors. In this issue, Feder et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005165) show that subcellular relocalization of the cochaperone Sis1 drives the HSR by de-suppressing the transcription factor Hsf1.

2017 8th IEEE International Conference on Software Engineering and Service Science (ICSESS), 2017

Solar energy has the property of alternating, fluctuation and periodicity, and it has severe impa... more Solar energy has the property of alternating, fluctuation and periodicity, and it has severe impact on large scale photovoltaic (PV) grid-connected generation. This turn power utilities contrary to use PV power since the forecasting and overall assessment of the grid becomes very difficult. To develop a reliable algorithm that can minimize the errors associated with forecasting the nearby future PV power generation is particularly helpful for efficiently integration into the grid. PV power prediction can play a significant role in undertaking these challenges. This paper presents 3 days ahead power output forecasting of a PV system using a Theoretical Solar radiation and Elman Neural Network (ENN) software engineering technique by including the relations of PV power with solar radiation, temperature, humidity, and wind speed data. In the proposed method, the ENN is applied to have a significant effect on random PV power time-series data, and tackle the nonlinear fluctuations in a better approach.

2021 International Conference on Robotics and Automation in Industry (ICRAI), 2021

We propose the 3D sensing system using active stereo vision to get the 3D model of human body par... more We propose the 3D sensing system using active stereo vision to get the 3D model of human body parts and surgical tools. This article presents the 3D scanner based on active stereo vision utilized for image guided surgery. The proposed system comprises of a pair of cameras (stereo camera) and the projector to record images of the target object placed at a specific distance. The proposed approach also includes the pre-calibration of the stereo camera for removing the distortion from the image data using non-linear method. We have performed the camera calibration of stereo camera using undistorted image data to estimate camera parameters using chessboard target. This research uses NCC (normalized cross correlation) based stereo matching and this matching is reduced to single dimension by utilizing epipolar geometry. After estimating the matched points, DLT (direct linear transformation) is applied to render the 3D point clouds. The rendered 3D point clouds were further filtered to remove the background objects. This refinement stage includes removal of outliers, suppression of noise and smoothing. We tested the 3D scanning system using artificial skull and a paper box object for the demonstration of image guided surgery. The three dimensional sensing system using stereo vision and structured light was tested using the objects, skull and paper box objects. The three dimensional model (3D model) shows that the features are preserved. Post processing based filtering results in the refinement of the point clouds. To evaluate the proposed system, we used the paper box object and the 3D scans were captured. We found that the errors in the height and breadth were 9.4 μm and 23 μm respectively. Our system currently does not target real time applications, but the parallel processing and utilization of GPUs may reduce the processing time to meet the needs of real time surgical intervention.

International Journal of Molecular Sciences, 2021

The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents availab... more The emergence of fungal “superbugs” resistant to the limited cohort of anti-fungal agents available to clinicians is eroding our ability to effectively treat infections by these virulent pathogens. As the threat of fungal infection is escalating worldwide, this dwindling response capacity is fueling concerns of impending global health emergencies. These developments underscore the urgent need for new classes of anti-fungal drugs and, therefore, the identification of new targets. Phosphoinositide signaling does not immediately appear to offer attractive targets due to its evolutionary conservation across the Eukaryota. However, recent evidence argues otherwise. Herein, we discuss the evidence identifying Sec14-like phosphatidylinositol transfer proteins (PITPs) as unexplored portals through which phosphoinositide signaling in virulent fungi can be chemically disrupted with exquisite selectivity. Recent identification of lead compounds that target fungal Sec14 proteins, derived from s...

Current Research in Green and Sustainable Chemistry, 2021

Cell Reports, 2021

SUMMARY Pathological lipid accumulation is often associated with enhanced uptake of free fatty ac... more SUMMARY Pathological lipid accumulation is often associated with enhanced uptake of free fatty acids via specific transporters in cardiomyocytes. Here, we identify SIRT6 as a critical transcriptional regulator of fatty acid transporters in cardiomyocytes. We find that SIRT6 deficiency enhances the expression of fatty acid transporters, leading to enhanced fatty acid uptake and lipid accumulation. Interestingly, the haploinsufficiency of SIRT6 is sufficient to induce the expression of fatty acid transporters and cause lipid accumulation in murine hearts. Mechanistically, SIRT6 depletion enhances the occupancy of the transcription factor PPARγ on the promoters of critical fatty acid transporters without modulating the acetylation of histone 3 at Lys 9 and Lys 56. Notably, the binding of SIRT6 to the DNA-binding domain of PPARγ is critical for regulating the expression of fatty acid transporters in cardiomyocytes. Our data suggest exploiting SIRT6 as a potential therapeutic target for protecting the heart from metabolic diseases.

The Minerals, Metals & Materials Series, 2017

Finite element simulation of heat treatment cycles in steel could be challenging when it involves... more Finite element simulation of heat treatment cycles in steel could be challenging when it involves phase transformation at the microscale. An ICME approach that can take into account the microstructure changes during the heat treatment and the corresponding changes in the macroscale properties could greatly help these simulations. Dual phase steel (DP steel) are potential alternate materials for gears with reduced distortion. Inter-critical annealing in DP steel involves phase transformation at the microscale and the finite element simulation of this heat treatment could be greatly improved by such an ICME approach. In the present work, phase field modeling implemented in the software package Micress is used to simulate the microstructure evolution during inter-critical annealing. Asymptotic Homogenization is used to predict the effective macroscale thermoelastic properties from the simulated microstructure. The macroscale effective flow curves are obtained by performing Virtual Testing on the phase field simulated microstructure using Finite Element Method. All the predicted effective properties are then passed on to the macro scale Finite Element simulation software Simufact Forming, where the heat treatment cycle for the inter-critical annealing is simulated. The thermal profiles from this simulation are extracted and passed on to microscale to repeat the process chain. All the simulation softwares are integrated together to implement a multi-scale simulation, aiming towards ICME approach.

Petroleum Science, 2019

The study of pore characteristics is of great importance in reservoir evaluation, especially in d... more The study of pore characteristics is of great importance in reservoir evaluation, especially in deeply buried sandstone. It controls the storage mechanism and reservoir fluid properties of the permeable horizons. The first member of Eocene Shahejie Formation (Es1) sandstone is classified as feldspathic litharenite and lithic arkose. The present research investigates the pore characteristics and reservoir features of the deeply buried sandstone reservoir of Es1 member of Shahejie Formation. The techniques including thin-section petrography, mercury injection capillary pressure (MICP), scanning electron microscopy and laser scanning confocal microscope images were used to demarcate the pores including primary intergranular pores and secondary intergranular, intragranular, dissolution and fracture pores. Mercury injection test and routine core analysis were led to demarcate the pore network characteristics of the studied reservoir. Pore size and pore throat size distribution are acquir...

The Journal of biological chemistry, Jan 13, 2018

Heart failure is an aging-associated disease, which is the leading cause of death world-wide. Sir... more Heart failure is an aging-associated disease, which is the leading cause of death world-wide. Sirtuin family members have been largely studied in the context of aging and aging-associated diseases. Sirtuin 2 (SIRT2) is a cytoplasmic protein in the family of sirtuins that are NAD+-dependent class III histone deacetylases. In this work, we studied the role of SIRT2 in regulating NFAT transcription factor and the development of cardiac hypertrophy. Confocal microscopy analysis indicated that SIRT2 is localized in the cytoplasm of cardiomyocytes and SIRT2 levels are reduced during pathological hypertrophy of the heart. SIRT2 deficient mice develops spontaneous pathological cardiac hypertrophy, remodelling, fibrosis and dysfunction in an age-dependent manner. Moreover, young SIRT2 deficient mice develops exacerbated agonist-induced hypertrophy. On contrast, SIRT2 overexpression attenuated agonist-induced cardiac hypertrophy in cardiomyocytes in a cell autonomous manner. Mechanistically, ...

AIP Conference Proceedings, 2017

The paper examines the impact of the humidity on the Solar panels which makes a space for the dra... more The paper examines the impact of the humidity on the Solar panels which makes a space for the drastic variation in the power generated and makes the device less efficient.. Humidity readily affects the efficiency of the solar cells and creates a minimal layer of water on its surface. It also decreases the efficiency by 10-20% of the total power output produced. Moreover, to handle this issue, all around characterized measures are required to be taken to guarantee the smooth working of the solar panels utilized in humid areas. In connection with this issue, Karachi, the biggest city of Pakistan which is located near the costal line touching Arabian Sea, was taken as a reference city to measure the humidity range. In Karachi, the average humidity lies between 25-70% (as per Pakistan Meteorological Department PMD), that indirectly leads in decreasing power acquired from a Solar Panel and develops various complexities for the solar system. The system on average experiences stability issues, such as those of power fluctuations etc., due to which, the whole solar system installed observes abnormal variations in acquired power. Silica Gel was used as a desiccant material in order to assure dryness over the solar panel. More than four experiments were conducted with the usage of water absorbent to improve the efficiency and to make system more power efficient.

With the increasing usage of AHSS grade steels in modern cars for vehicle light weighting and pas... more With the increasing usage of AHSS grade steels in modern cars for vehicle light weighting and passenger safety, it has become necessary for automotive industries to deeply study and accurately predict the response of these steels to enhance their designs for better performance and light weighting. Due to their complex multiphase nature, conventional continuum based approaches of modelling the materials are not suitable to capture the physical phenomena occurring at microscopic level. With the increase of the computing power of modern day computers, Representative Volume Element (RVE) based micromechanics approaches of modelling deformation of such materials, via real or synthetically generated microstructure with appropriate boundary conditions, have become one of the promising ways of tackling this problem. The present work focusses on modelling the deformation of Dual Phase Steels using 2D and 3D microstructure based micromechanics approach in order to study the deformation patter...

The Indian journal of medical research, 2012

Dengue virus (DV) infection has emerged as a major health problem in north India. Here, we report... more Dengue virus (DV) infection has emerged as a major health problem in north India. Here, we report the annual trend of dengue virus infection as seen in Lucknow, Uttar Pradesh, during 2008-2010. Blood samples from clinically suspected cases of dengue virus infection were collected and history was taken on structured clinical data sheet. All samples were tested for dengue IgM by antibody capture ELISA. Selected samples were tested by conventional RT-PCR for dengue virus RNA. Weather information was continuously recorded from website of world weather information service . There was a gradual increase in number of dengue fever cases with increased occurrence in 2010. Cases referred in January - December 2008 were 398 (54.5% anti DV IgM positive), in January - December 2009 were 599 (51.9% anti DV IgM positive) and in January - December 2010 were 1602 (64.9% anti DV IgM positive). Serotypes circulating in years 2008, 2009 and 2010 were DV-2 & DV-3, DV -1, 2 & 3 and DV-1 and DV-2 respecti...

Proceedings of the 6th International Conference on Pervasive Computing Technologies for Healthcare, 2012

We developed four mobile phone prototype applications informed by theoretical models of behavior ... more We developed four mobile phone prototype applications informed by theoretical models of behavior change to improve the snacking habits of low socioeconomic status (SES) families. Eight primary caregivers and 18 secondary caregivers from low SES backgrounds used the applications to evaluate their usability and usefulness. We found a schism between primary and secondary caregivers regarding whether the applications should be based on games, indicating a need to reconcile these differences to develop a system to support healthy family snacking. In addition, social context, understandable health abstractions, and sensitivity to health values are all important considerations when creating applications in a low SES context. This research contributes design implications for future applications intended to improve snacking habits in low SES families.

Proceedings of the 6th International Conference on Pervasive Computing Technologies for Healthcare, 2012

We conducted a study with eight low socioeconomic status caregivers, the "gatekeepers" to family ... more We conducted a study with eight low socioeconomic status caregivers, the "gatekeepers" to family and community health, to explore their technology perceptions and visualizations that can assist them in managing their families' health. We studied how to visualize the everyday health habits of a population that is at risk for chronic illness. Through semi-structured interviews and prototype design activities, we found that the caregivers wanted to use mobile technology to monitor a subset of their family members for at least one health metric. We inform future work with an analysis of the target population's needs in relation to longitudinal health visualizations with multiple family member data streams.

Biochemical Society Transactions, 2014

The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatid... more The physiological functions of phosphatidylinositol (PtdIns)-transfer proteins (PITPs)/phosphatidylcholine (PtdCho)-transfer proteins are poorly characterized, even though these proteins are conserved throughout the eukaryotic kingdom. Much of the progress in elucidating PITP functions has come from exploitation of genetically tractable model organisms, but the mechanisms for how PITPs execute their biological activities remain unclear. Structural and molecular dynamics approaches are filling in the details for how these proteins actually work as molecules. In the present paper, we discuss our recent work with Sec14-like PITPs and describe how PITPs integrate diverse territories of the lipid metabolome with phosphoinositide signalling.

2012 National Conference on Communications (NCC), 2012

Communication through fading channels with conventional signal constellation has a limitation tha... more Communication through fading channels with conventional signal constellation has a limitation that the nearby points may lead to wrong symbol detection even if any one dimension fades. This limitation can be overcome by phase rotation of symbols where each symbol is rotated by a rotation matrix. In the new constellation, each symbol attains unique real and imaginary components which imply

Clinical Epidemiology and Global Health, 2014

Aim: The sudden increase in number of cases of fever with rash at five sites in Uttar Pradesh, In... more Aim: The sudden increase in number of cases of fever with rash at five sites in Uttar Pradesh, India was surveyed to establish the aetiology and investigate the extent of the disease. Methods: We case defined, measles as a person with acute onset of fever, cough, coryza or conjunctivitis with maculopapular rash and a case of chickenpox as a person with acute onset of diffuse maculopapulovescicular rash. Blood samples were collected from clinically suspected cases and tested for anti-measles IgM/anti-VZV IgM and IgG antibody (depending on the clinical features) by ELISA. Detailed history was collected from each case including history of contact and immunization. Results: Confirmed measles outbreaks were identified at 2/5 sites. There was neither any death nor any serious complications due to measles. However, varicella outbreaks were confirmed in 3/5 sites with one mortality. Conclusion: Measles and chickenpox are still widespread in North India. Therefore, vaccination for varicella and better coverage of first dose and introduction of second dose opportunity for measles to susceptible population in affected areas is suggested.

PLoS ONE, 2013

Background: A public that is an informed partner in clinical research is important for ethical, m... more Background: A public that is an informed partner in clinical research is important for ethical, methodological, and operational reasons. There are indications that the public is unaware or misinformed, and not sufficiently engaged in clinical research but studies on the topic are lacking. PARTAKE-Public Awareness of Research for Therapeutic Advancements through Knowledge and Empowerment is a program aimed at increasing public awareness and partnership in clinical research. The PARTAKE Survey is a component of the program. Objective: To study public knowledge and perceptions of clinical research. Methods: A 40-item questionnaire combining multiple-choice and open-ended questions was administered to 175 Englishor Hindi-speaking individuals in 8 public locations representing various socioeconomic strata in New Delhi, India. Results: Interviewees were 18-84 old (mean: 39.6, SD616.6), 23.6% female, 68.6% employed, 7.3% illiterate, 26.3% had heard of research, 2.9% had participated and 58.9% expressed willingness to participate in clinical research. The following perceptions were reported (% true/% false/% not aware): 'research benefits society' (94.1%/3.5%/2.3%), 'the government protects against unethical clinical research' (56.7%/26.3%/16.9%), 'research hospitals provide better care' (67.2%/8.7%/ 23.9%), 'confidentiality is adequately protected' (54.1%/12.3%/33.5%), 'participation in research is voluntary' (85.3%/5.8%/ 8.7%); 'participants treated like 'guinea pigs'' (20.7%/53.2%/26.0%), and 'compensation for participation is adequate' (24.7%/ 12.9%/62.3%). Conclusions: Results suggest the Indian public is aware of some key features of clinical research (e.g., purpose, value, voluntary nature of participation), and supports clinical research in general but is unaware of other key features (e.g., compensation, confidentiality, protection of human participants) and exhibits some distrust in the conduct and reporting of clinical trials. Larger, cross-cultural surveys are required to inform educational programs addressing these issues.