Darrick Li - Academia.edu (original) (raw)

Papers by Darrick Li

Research paper thumbnail of Lack of Evidence for Increased Rates of Hepatocellular Carcinoma Following Treatment With Direct Acting Antivirals: A Systematic Review and Meta-Analysis

American Journal of Gastroenterology

Research paper thumbnail of S1411 Microangiopathic Hemolytic Anemia (MAHA) Is a Late and Fatal Complication of Metastatic Signet Ring Cell Gastrointestinal Carcinoma: A Systematic Review

American Journal of Gastroenterology

Research paper thumbnail of S1448 Impact of a Gastroenterology Hospitalist Model on Management of Bleeding Peptic Ulcer Disease

American Journal of Gastroenterology

Research paper thumbnail of Liver chemistries in glycogenic hepatopathy associated with type 1 diabetes mellitus: A systematic review and pooled analysis

Research paper thumbnail of S1773 Idiopathic Myointimal Hyperplasia of the Mesenteric Veins: A Rare Cause of Intestinal Ischemia

American Journal of Gastroenterology

Research paper thumbnail of Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis

Research paper thumbnail of Fr053 LOW VOLUME BOWEL PREPARATION IN HOSPITALIZED ADULT PATIENTS IS ASSOCIATED WITH REDUCTIONS IN LENGTH OF STAY

Research paper thumbnail of 1150 Intrahepatic cholestasis of pregnancy (IHCP) during the era of COVID-19

American Journal of Obstetrics and Gynecology

Research paper thumbnail of Sterile cerebrospinal fluid ascites presenting as high SAAG ascites: a case report

BMC Gastroenterology

Background Cerebrospinal fluid ascites is a rare complication of ventriculoperitoneal shunting an... more Background Cerebrospinal fluid ascites is a rare complication of ventriculoperitoneal shunting and is the result of infection and subsequent peritonitis in the majority of cases. Sterile cerebrospinal fluid ascites in which no known infectious etiology is identified, is even more unusual. Case Presentation A 26-year-old female with Loeys-Dietz syndrome and congenital hydrocephalus treated with a ventriculoperitoneal shunt, was evaluated after developing new-onset ascites of unclear etiology after abdominal surgery for repair of an aortic aneurysm requiring multiple therapeutic paracenteses. Her serum ascites albumin gradient (SAAG) was greater than 1.1, suggestive of a portal hypertensive etiology. Gram stain as well as multiple cultures of her ascites fluid were both negative. Extensive investigation including hepatic venous portal gradient measurement and liver biopsy revealed no evidence of hepatic disease or portal hypertension. She was ultimately found to have sterile cerebrosp...

Research paper thumbnail of Tu1657 OPPOSING FORCES: MIR-194 AS A PROTECTIVE MEDIATOR AND MIR-34A AS AN ENHANCER OF HEPATIC FIBROSIS IN NON-ALCOHOLIC AND ALCOHOL-RELATED LIVER DISEASES

Research paper thumbnail of Su1503 RANGE OF NORMAL LIVER STIFFNESS AND FACTORS ASSOCIATED WITH INCREASED STIFFNESS MEASUREMENTS IN APPARENTLY HEALTHY CHILDREN: AN INDIVIDUAL PATIENT DATA META-ANALYSIS

Research paper thumbnail of Correlations Between Clinical Activity Indices or Quality of Life Scores to Endoscopic Activity Scores Do not Vary According to Age at Diagnosis, Disease Location, and Disease Behavior in Inflammatory Bowel Disease

American Journal of Gastroenterology

Research paper thumbnail of No evidence for higher rates of hepatocellular carcinoma after direct-acting antiviral treatment: a meta-analysis

Hepatoma Research

Aim: Hepatitis C virus (HCV) is the leading cause of hepatocellular carcinoma (HCC) in the United... more Aim: Hepatitis C virus (HCV) is the leading cause of hepatocellular carcinoma (HCC) in the United States. Achieving sustained viral response with interferon (IFN) treatment reduces the risk from 3%-5% to 0.5%-1% annually. Several studies reported unexpectedly high rates of HCC after treatment with direct-acting antivirals (DAAs). The aim of our study was to compare HCC rates in DAA-, IFN-treated and untreated populations. Methods: A literature search was conducted using ScienceDirect, Ovid®, Web of Science and MEDLINE through January 2019. Studies were included if they measured rates of de novo or recurrent HCC (following curative treatment) in HCV-infected persons. We included 138 studies (n = 177,512). Simple pooling of data and meta-analysis were performed, using the random effects method. Results: Mean age was higher in the DAA-treated vs. IFN-treated group (58.4 years vs. 52.6 years; P = 0.0073), as were diabetes prevalence (34.5% vs. 11.7%; P ≤ 0.001) and incident cirrhosis (47.8% vs. 34.2%, P = 0.0017). The incidence rate of de novo HCC was 2.01/100 personyears (py) (95%CI: 1.38, 2.67) in the DAA group and 1.45/100py (95%CI: 0.98, 1.94) in the IFNtreated group. HCC recurred at 16.76/100py (95%CI: 10.75, 22.91) in the DAA-treated group vs.

Research paper thumbnail of Evaluation of model performance to predict survival after transjugular intrahepatic portosystemic shunt placement

PLOS ONE

Background/Aims The MELD score was developed to predict survival after transjugular intrahepatic ... more Background/Aims The MELD score was developed to predict survival after transjugular intrahepatic portosystemic shunt (TIPS) placement. Given changes in practice patterns and development of new prognostic tools in cirrhosis, we aimed to evaluate common models to predict mortality after TIPS placement. Methods Analysis of consecutive patients who underwent TIPS placement for ascites or bleeding. Performance to predict 90-day mortality was assessed by C statistic for six models (MELD, MELD-Na, CLIF-C ACLF, Child-Pugh, Platelet-Albumin-Bilirubin, and Emory score). Added predictive value to MELD score was assessed for univariate predictors of 90-day mortality. Stratified analysis by TIPS indication, emergent placement status, and TIPS stent type was performed. Results 413 patients were analyzed (248 with variceal bleeding, 165 with refractory ascites). 90-day mortality was 27% (113/413). Mean MELD score was 15 ± 7.9. MELD score best predicted mortality for all patients (c = 0.779), for variceal bleeding (c = 0.844), and for emergent TIPS (c = 0.817). CLIF-C ACLF score best predicted mortality for refractory ascites (c = 0.707). Addition of sodium to the MELD score did not improve predictive value across multiple strata. Addition of hemoglobin improved MELD score's predictive value in variceal bleeding. Addition of age improved MELD score's predictive value in refractory ascites.

Research paper thumbnail of Use of proton pump inhibitors in chronic liver diseases

Research paper thumbnail of The Incidence of Hepatocellular Carcinoma Is not Increased in Individuals with Chronic Hepatitis C After Treatment with Interferon-free Regimens: an ERCHIVES Study

Open Forum Infectious Diseases

Background Sustained virologic response (SVR) after interferon-based treatment for chronic hepati... more Background Sustained virologic response (SVR) after interferon-based treatment for chronic hepatitis C virus (HCV) infection has been strongly linked with decreased incidence of hepatocellular carcinoma (HCC). Surprisingly, several recent studies have reported higher rates of HCC in individuals treated with direct-acting antivirals (DAAs). However, making definitive conclusions has been challenging due to the heterogeneous populations and methodologies of these reports. As such, we sought to investigate whether DAA use is associated with increased rates of incident HCC. Methods Using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) database, we identified 17,836 patients without a prior diagnosis of HCC and divided them into 3 groups based on treatment: (a) pegylated interferon and ribavirin (IFN) (n = 3,534); (b) DAA-based therapy (n = 5,734); and (c) an untreated control group (n = 8,468). Predictors of HCC were identified using multivariate Cox proportional...

Research paper thumbnail of The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study

Hepatology (Baltimore, Md.), Jan 2, 2017

Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treate... more Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treated with direct-acting antivirals (DAAs). However, making definitive conclusions has been challenging due to the heterogeneous populations and methodologies of these reports. We investigated whether DAA use is associated with higher rates of incident HCC compared to treatment with interferon-based regimens. We performed a retrospective population-based cohort study using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) database. In a cohort of 17,836 persons, SVR was achieved by 66.6% and 96.2% of the IFN and DAA groups, respectively. Among all treated persons, the risk of HCC was not higher in the DAA group compared to the IFN group (HR 1.07; [95% CI: 0.55, 2.08]). Among persons with cirrhosis who achieved SVR, neither the HCC incidence rate nor HCC-free survival were significantly different in the DAA group compared to the IFN group (21.2 vs. 22.8 per 1000 person y...

Research paper thumbnail of Novel RNA Targets of the Spinal Muscular Atrophy Protein

Research paper thumbnail of Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes

Digestive diseases and sciences, Sep 3, 2016

Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's diseas... more Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey-Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correl...

Research paper thumbnail of Mischarging of M. barkeri tRNAPyl with alanine and serine in vitro

The Faseb Journal, Mar 1, 2006

Research paper thumbnail of Lack of Evidence for Increased Rates of Hepatocellular Carcinoma Following Treatment With Direct Acting Antivirals: A Systematic Review and Meta-Analysis

American Journal of Gastroenterology

Research paper thumbnail of S1411 Microangiopathic Hemolytic Anemia (MAHA) Is a Late and Fatal Complication of Metastatic Signet Ring Cell Gastrointestinal Carcinoma: A Systematic Review

American Journal of Gastroenterology

Research paper thumbnail of S1448 Impact of a Gastroenterology Hospitalist Model on Management of Bleeding Peptic Ulcer Disease

American Journal of Gastroenterology

Research paper thumbnail of Liver chemistries in glycogenic hepatopathy associated with type 1 diabetes mellitus: A systematic review and pooled analysis

Research paper thumbnail of S1773 Idiopathic Myointimal Hyperplasia of the Mesenteric Veins: A Rare Cause of Intestinal Ischemia

American Journal of Gastroenterology

Research paper thumbnail of Normal liver stiffness and influencing factors in healthy children: An individual participant data meta‐analysis

Research paper thumbnail of Fr053 LOW VOLUME BOWEL PREPARATION IN HOSPITALIZED ADULT PATIENTS IS ASSOCIATED WITH REDUCTIONS IN LENGTH OF STAY

Research paper thumbnail of 1150 Intrahepatic cholestasis of pregnancy (IHCP) during the era of COVID-19

American Journal of Obstetrics and Gynecology

Research paper thumbnail of Sterile cerebrospinal fluid ascites presenting as high SAAG ascites: a case report

BMC Gastroenterology

Background Cerebrospinal fluid ascites is a rare complication of ventriculoperitoneal shunting an... more Background Cerebrospinal fluid ascites is a rare complication of ventriculoperitoneal shunting and is the result of infection and subsequent peritonitis in the majority of cases. Sterile cerebrospinal fluid ascites in which no known infectious etiology is identified, is even more unusual. Case Presentation A 26-year-old female with Loeys-Dietz syndrome and congenital hydrocephalus treated with a ventriculoperitoneal shunt, was evaluated after developing new-onset ascites of unclear etiology after abdominal surgery for repair of an aortic aneurysm requiring multiple therapeutic paracenteses. Her serum ascites albumin gradient (SAAG) was greater than 1.1, suggestive of a portal hypertensive etiology. Gram stain as well as multiple cultures of her ascites fluid were both negative. Extensive investigation including hepatic venous portal gradient measurement and liver biopsy revealed no evidence of hepatic disease or portal hypertension. She was ultimately found to have sterile cerebrosp...

Research paper thumbnail of Tu1657 OPPOSING FORCES: MIR-194 AS A PROTECTIVE MEDIATOR AND MIR-34A AS AN ENHANCER OF HEPATIC FIBROSIS IN NON-ALCOHOLIC AND ALCOHOL-RELATED LIVER DISEASES

Research paper thumbnail of Su1503 RANGE OF NORMAL LIVER STIFFNESS AND FACTORS ASSOCIATED WITH INCREASED STIFFNESS MEASUREMENTS IN APPARENTLY HEALTHY CHILDREN: AN INDIVIDUAL PATIENT DATA META-ANALYSIS

Research paper thumbnail of Correlations Between Clinical Activity Indices or Quality of Life Scores to Endoscopic Activity Scores Do not Vary According to Age at Diagnosis, Disease Location, and Disease Behavior in Inflammatory Bowel Disease

American Journal of Gastroenterology

Research paper thumbnail of No evidence for higher rates of hepatocellular carcinoma after direct-acting antiviral treatment: a meta-analysis

Hepatoma Research

Aim: Hepatitis C virus (HCV) is the leading cause of hepatocellular carcinoma (HCC) in the United... more Aim: Hepatitis C virus (HCV) is the leading cause of hepatocellular carcinoma (HCC) in the United States. Achieving sustained viral response with interferon (IFN) treatment reduces the risk from 3%-5% to 0.5%-1% annually. Several studies reported unexpectedly high rates of HCC after treatment with direct-acting antivirals (DAAs). The aim of our study was to compare HCC rates in DAA-, IFN-treated and untreated populations. Methods: A literature search was conducted using ScienceDirect, Ovid®, Web of Science and MEDLINE through January 2019. Studies were included if they measured rates of de novo or recurrent HCC (following curative treatment) in HCV-infected persons. We included 138 studies (n = 177,512). Simple pooling of data and meta-analysis were performed, using the random effects method. Results: Mean age was higher in the DAA-treated vs. IFN-treated group (58.4 years vs. 52.6 years; P = 0.0073), as were diabetes prevalence (34.5% vs. 11.7%; P ≤ 0.001) and incident cirrhosis (47.8% vs. 34.2%, P = 0.0017). The incidence rate of de novo HCC was 2.01/100 personyears (py) (95%CI: 1.38, 2.67) in the DAA group and 1.45/100py (95%CI: 0.98, 1.94) in the IFNtreated group. HCC recurred at 16.76/100py (95%CI: 10.75, 22.91) in the DAA-treated group vs.

Research paper thumbnail of Evaluation of model performance to predict survival after transjugular intrahepatic portosystemic shunt placement

PLOS ONE

Background/Aims The MELD score was developed to predict survival after transjugular intrahepatic ... more Background/Aims The MELD score was developed to predict survival after transjugular intrahepatic portosystemic shunt (TIPS) placement. Given changes in practice patterns and development of new prognostic tools in cirrhosis, we aimed to evaluate common models to predict mortality after TIPS placement. Methods Analysis of consecutive patients who underwent TIPS placement for ascites or bleeding. Performance to predict 90-day mortality was assessed by C statistic for six models (MELD, MELD-Na, CLIF-C ACLF, Child-Pugh, Platelet-Albumin-Bilirubin, and Emory score). Added predictive value to MELD score was assessed for univariate predictors of 90-day mortality. Stratified analysis by TIPS indication, emergent placement status, and TIPS stent type was performed. Results 413 patients were analyzed (248 with variceal bleeding, 165 with refractory ascites). 90-day mortality was 27% (113/413). Mean MELD score was 15 ± 7.9. MELD score best predicted mortality for all patients (c = 0.779), for variceal bleeding (c = 0.844), and for emergent TIPS (c = 0.817). CLIF-C ACLF score best predicted mortality for refractory ascites (c = 0.707). Addition of sodium to the MELD score did not improve predictive value across multiple strata. Addition of hemoglobin improved MELD score's predictive value in variceal bleeding. Addition of age improved MELD score's predictive value in refractory ascites.

Research paper thumbnail of Use of proton pump inhibitors in chronic liver diseases

Research paper thumbnail of The Incidence of Hepatocellular Carcinoma Is not Increased in Individuals with Chronic Hepatitis C After Treatment with Interferon-free Regimens: an ERCHIVES Study

Open Forum Infectious Diseases

Background Sustained virologic response (SVR) after interferon-based treatment for chronic hepati... more Background Sustained virologic response (SVR) after interferon-based treatment for chronic hepatitis C virus (HCV) infection has been strongly linked with decreased incidence of hepatocellular carcinoma (HCC). Surprisingly, several recent studies have reported higher rates of HCC in individuals treated with direct-acting antivirals (DAAs). However, making definitive conclusions has been challenging due to the heterogeneous populations and methodologies of these reports. As such, we sought to investigate whether DAA use is associated with increased rates of incident HCC. Methods Using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) database, we identified 17,836 patients without a prior diagnosis of HCC and divided them into 3 groups based on treatment: (a) pegylated interferon and ribavirin (IFN) (n = 3,534); (b) DAA-based therapy (n = 5,734); and (c) an untreated control group (n = 8,468). Predictors of HCC were identified using multivariate Cox proportional...

Research paper thumbnail of The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study

Hepatology (Baltimore, Md.), Jan 2, 2017

Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treate... more Recent studies have reported higher rates of hepatocellular carcinoma (HCC) in individuals treated with direct-acting antivirals (DAAs). However, making definitive conclusions has been challenging due to the heterogeneous populations and methodologies of these reports. We investigated whether DAA use is associated with higher rates of incident HCC compared to treatment with interferon-based regimens. We performed a retrospective population-based cohort study using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) database. In a cohort of 17,836 persons, SVR was achieved by 66.6% and 96.2% of the IFN and DAA groups, respectively. Among all treated persons, the risk of HCC was not higher in the DAA group compared to the IFN group (HR 1.07; [95% CI: 0.55, 2.08]). Among persons with cirrhosis who achieved SVR, neither the HCC incidence rate nor HCC-free survival were significantly different in the DAA group compared to the IFN group (21.2 vs. 22.8 per 1000 person y...

Research paper thumbnail of Novel RNA Targets of the Spinal Muscular Atrophy Protein

Research paper thumbnail of Clinical Activity and Quality of Life Indices Are Valid Across Ulcerative Colitis But Not Crohn's Disease Phenotypes

Digestive diseases and sciences, Sep 3, 2016

Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's diseas... more Clinical activity and quality of life (QOL) indices assess disease activity in Crohn's disease (CD) and ulcerative colitis (UC). However, a paucity of data exists on the validity of these indices according to disease characteristics. To examine the correlation between QOL and clinical activity indices and endoscopic disease activity according to disease characteristics. We used a prospective registry to identify CD and UC patients ≥18 years old with available information on Short Inflammatory Bowel Disease Questionnaire scores (SIBDQ), Harvey-Bradshaw Index (HBI) and simple endoscopic scores for CD (SES-CD), and Simple Clinical Colitis Activity Index (SCCAI) and Mayo endoscopic score for UC. We used Spearman rank correlations to calculate correlations between indices and Fisher transformation to compare correlations across disease characteristics. Among 282 CD patients, we observed poor correlation between clinical activity and QOL indices to SES-CD with no differences in correl...

Research paper thumbnail of Mischarging of M. barkeri tRNAPyl with alanine and serine in vitro

The Faseb Journal, Mar 1, 2006