David Askin - Academia.edu (original) (raw)

Highly diastereoselective alkylations of chiral amide enolates: new routes to hydroxyethylene dipeptide isostere inhibitors of HIV-1 protease

J Org Chem, 1992

... RA; Sigal, IS; Huff, JR J. Med. Chem. 1991, 34, 1228-1230. (4) (a) Prepared from the unsubsti... more ... RA; Sigal, IS; Huff, JR J. Med. Chem. 1991, 34, 1228-1230. (4) (a) Prepared from the unsubstituted lactone4b in 95% diaetereo-selectivity via enolization with 2 equiv of LDA followed by alkylation with the corresponding benzylic iodides at -78 OC: Aakin, D.; Wallace, M.; Volante ...

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