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Papers by David Berry
Annals of the New York Academy of Sciences, May 1, 1979
~~~r ~b c b a i l l o r d ~ the U.S. Government's right t o , M ~p h L d y o . p d @ * . . retain... more ~~~r ~b c b a i l l o r d ~ the U.S. Government's right t o , M ~p h L d y o . p d @ * . . retain a nonexclusive, ro~altv-free license In and t o any copvright covering the article.
Proceedings of the National Academy of Sciences of the United States of America, Dec 1, 1981
Journal of Investigative Dermatology, 1975
Direct spectrofluorimetry was applied to intact erythrocytes (RBC) and plasma from 12 erythropoie... more Direct spectrofluorimetry was applied to intact erythrocytes (RBC) and plasma from 12 erythropoietic protoporphyria (EPP) patients, 9 lead in
The absorption, translocation and metabolism of 1,3-dichloropropene (a soil fumigant) in bush bea... more The absorption, translocation and metabolism of 1,3-dichloropropene (a soil fumigant) in bush beans, tomato and carrot was studied under growth chamber and greenhouse conditions using solution culture, vermiculite and sand. Absorption was monitored using gas chromatographic analysis and isotope techniques. Plants were shown to absorb a maximum amount of dichloropropene by 24 to 48 hr from solution culture and vermiculite. The plant absorbed and translocated 1,3-dichlorpropene-14C-U readily to aerial parts of the plant. Bush beans, tomatoes and carrots absorbed and translocated 3-chlorallyl alcohol-14C-U from solution culture and vermiculite. Levels of 3-chloroallyl alcohol reached maximum at 24 to 48 hr after inoculation The gas chromatographic analysis of plant materials showed that 1,3-dichloropropene and 3-chloroallyl alcohol were rapidly metabolized by the plant. The three plants metabolize 1,3-dichloropropene to 3-chloroallyl alcohol, part of which is converted to 3-choroacryli...
The incorporation of 3- C-,B-hydroxy-, B-methylglutaric acid (HMG) vii into carotenoids of excise... more The incorporation of 3- C-,B-hydroxy-, B-methylglutaric acid (HMG) vii into carotenoids of excised etiolated maize shoots, crude cell free extracts and soluble extracts (20, 000 x g) of maize was investigated. HMG was effectively incorporated into carotenoids of excised shoots, crude extracts and soluble extracts. The excised shoots, crude extracts and soluble extracts incorporated 2- 14 C-mevalonic acid (MVA) into carotenoids as well. The results indicated the presence of HMG-CoA reductase in the plant as well as an HMG activating enzyme. The soluble extract showed a pH optimum of 7. 0 for incorporation of HMG into carotenoids. Endogenous metabolites such as MVA in the soluble enzyme preparation decreased the amount of 3- 14 C-HMG incorporated into carotenoids. The conversion of HMG to MVA may be a regulatory site in carotenoid biosynthesis in the plant. Telone (a mixture of cis-1, 3-dichloropropene, trans-I, 3-dichloropropene and other halogenated hydrocarbons), 3-chloroallyl alco...
Journal of Lipid Research, 1982
The synthesis of 12-0-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stag... more The synthesis of 12-0-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stage promoter) is described. The preparation starts with phorbol-13-acetate-20-tritylether which is acylated by a carbodiimide method to yield its 12-retinoate. The latter is detritylated by acidic methanol to give RPA. Following an analogous procedure, the 4methyl-ether of RPA is prepared from 4-O-methylphorbol-13
Toxicology and Applied Pharmacology, 1979
ACS Symposium Series, 1985
... 1983; 51: 2420. 3. Palmer, Sushma and Bakshi, Kulbir, J. Natl Cancer Inst.. 1983; 70: 1153. 4... more ... 1983; 51: 2420. 3. Palmer, Sushma and Bakshi, Kulbir, J. Natl Cancer Inst.. 1983; 70: 1153. 4. Pascoe, Gary A., Sakai-Wong, Joanne, Soliven, Eva and Correia, Almira M., Biochem. Pharma.. 1983, 32: 3207. 5. Hendrich, S. and Bjeldanes, LF, Fd. Chem. Toxicol.. 1983; 21:479. ...
Carcinogenesis; a comprehensive survey, 1982
Cancer research, 1980
The effects of treating female mice with single topical doses of 2,3,7,8-tetrachlorodibenzo-p-dio... more The effects of treating female mice with single topical doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at various times before and after 7,12-dimethylbenz(a)anthracene (DMBA), benzo(a)pyrene, 3-methylcholanthrene (MCA), and (±)-trans-7/S,8«-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene were studied. TCDD, at doses of 1 /ig/mouse, was applied topically 3 days prior to, 5 min prior to, or 1 day after the initiator. The application of TCDD 5 min prior to or 1 day after initiation with DMBA, benzo(a)pyrene, or MCA had little or no effect on papilloma formation. In contrast, when TCDD was applied 3 days prior to initiation with these hydrocarbons, a marked reduction in papilloma formation was observed. TCDD, applied 3 days prior to, 5 min prior to, or 1 day after initiation with (±)-frans-7/?,8«-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene produced 81, 50, and 39% inhibition of papilloma formation after 20 weeks of pro motion. Similar effects were observed when higher initiating doses of DMBA and the diol-epoxide were utilized. In addition, single i.p. doses of TCDD (1 /xg/mouse) 3 days prior to initiation with DMBA or MCA were highly effective at inhibiting papilloma formation. Several congeners of TCDD, lacking, possessing similar, or possessing different inducing properties, were tested for their effects on tumor initiation by DMBA. 3,4,3',4'-Tetrachlorobiphenyl effectively inhibited tumor initiation by DMBA, whereas 2,7-dichlorodibenzo-p-dioxin and 2,4,5,2',4',5'-hexachlorobiphenyl had little or no effect on the tumor response. Topical application of TCDD at the doses utilized in the tumor experiments markedly induced epidermal aryl hydrocarbon hydroxylase (21-fold) 3 days after treatment. In addition, epi dermal uridine diphosphoglucuronyltransferase activities were stimulated 2-to 3-fold 3 days following TCDD treatment. TCDD treatment had little or no effect on epidermal epoxide hydrase or glutathione-S-transferase activities. The time course for induction of epidermal aryl hydrocarbon hydroxylase and uri dine diphosphoglucuronyltransferase correlated with the time course for the inhibitory effects of TCDD on tumor initiation with DMBA, benzo(a)pyrene, and MCA. INTRODUCTION Carcinogenic PAH3 require metabolic activation to highly
Toxicology and Applied Pharmacology, 1976
... BERRY, DL, ZACHARIAH, PK, NAMKUNG, MJ, AND JUCHAU, MR (1976). ... Bresnick andStevenson (1968... more ... BERRY, DL, ZACHARIAH, PK, NAMKUNG, MJ, AND JUCHAU, MR (1976). ... Bresnick andStevenson (1968) indicated that 17% of oral doses of 11C-labeled 3-methylcholanthrene was incorporated into fetal tissues but that injection into the amniotic sac was a better means to ...
Carcinogenesis, 1985
1-Nitropyrene (1-NO2Py), 3-nitrofluoranthene (3-NO2Ft), 3-aminofluoranthene (3-NH2Ft) and 8-nitro... more 1-Nitropyrene (1-NO2Py), 3-nitrofluoranthene (3-NO2Ft), 3-aminofluoranthene (3-NH2Ft) and 8-nitrofluoranthene (8-NO2Ft) were tested for mutagenicity in cultured Chinese hamster V79 cells. Mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) gene locus were quantified. 1-NO2Py had marginal direct-acting mutagenicity which was enhanced by a mixture of Aroclor 1254- and 1242-induced liver homogenates (S9) in the treatment medium. 1-NO2Py was more mutagenic with S9 activation than 3-NO2Ft, 3-NH2Ft or 8-NO2Ft. However, 8-NO2Ft, 3-NO2Ft and 3-NH2Ft were more mutagenic than 1-NO2Py when a post-microsomal liver supernatant (S100) was used for metabolic activation. The results of these investigations strongly support activation of some nitrated polycyclic aromatic hydrocarbons to proximate mutagens by a sequence of reductions and possible formation of polycyclic aromatic hydroxylamines.
Biochemical and Biophysical Research Communications, 1979
Analytical Methods, 2013
Three sets of soil samples were collected by the National Institute for Occupational Safety and H... more Three sets of soil samples were collected by the National Institute for Occupational Safety and Health and one set by South Dakota School of Mines & Technology from in and around the Slim Buttes Land Unit of the Sioux Ranger District of the Custer-Gallatin National Forest in the northwest of South Dakota. The rocks forming the Slim Buttes are sedimentary clays, sands and gravels including reworked volcanic ash-falls in which the zeolite mineral erionite has crystallized during diagenesis in a fibrous form or morphology similar to that of asbestos. The samples were prepared using the fluidized bed asbestos segregator (FBAS) and analyzed by phase contrast microscopy (PCM) or transmission electron microscopy to detect the presence of mineral fibers. FBAS-PCM results compared to semi-Electronic supplementary material The online version of this article (
Advances in Experimental Medicine and Biology, 1984
Sixty to eighty percent of all human cancers are associated with our environment and environmenta... more Sixty to eighty percent of all human cancers are associated with our environment and environmental agents. The environment is a complex mixture of chemical s that originate from industrial and technological development and, most importantly, natural sources. Many industrial chemicals, pesticides, insecticides and food additives have exhibited carcinogenic properties in various animal model systems, and occupational and drug exposure has led to human cancers. However, estimates attribute the majority of human cancers associated with the environment not to intentional or accidental chemical exposure, but to the vast number of naturally occurring chemicals in our environment (0011 and Peto, 1981). Carci nogenesi s encompasses many di fferent di seases, and the exact cause of a lesion is a multifactorial process including nature of exposure, duration, age, route of exposure and numerous environmental factors. Data from animal model s indicate that carcinogenesis is a multi-step process that involves genetic and epigenetic events. Boutwell (1974) proposed that complete carcinogenesis could be divided into initiation and promotion. Initiation is defined as an irreversible genetic event (mutational), and promotion is a time-and-dose-dependent process which is, to a certain degree, reversible. The genotoxic events could be a direct change in genetic material through attack by radiation or chemicals. The genotoxic change could result from a direct mutational lesion, faulty error-prone DNA repair, DNA polymerase error, or infidelity of DNA synthesis. The promotion process is termed "epigenetic" since no direct interaction of the promoter with the genetic material has been detected. The process involves conversion of the damaged cells into a dormant tumor cell followed by propagation of that cell into a viable growing tumor. The epigenetic events 91 M. Friedman (ed.
Regulatory Toxicology and Pharmacology, 2015
The United States Environmental Protection Agency (EPA) developed a quantitative exposure-respons... more The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO).
Annals of the New York Academy of Sciences, May 1, 1979
~~~r ~b c b a i l l o r d ~ the U.S. Government's right t o , M ~p h L d y o . p d @ * . . retain... more ~~~r ~b c b a i l l o r d ~ the U.S. Government's right t o , M ~p h L d y o . p d @ * . . retain a nonexclusive, ro~altv-free license In and t o any copvright covering the article.
Proceedings of the National Academy of Sciences of the United States of America, Dec 1, 1981
Journal of Investigative Dermatology, 1975
Direct spectrofluorimetry was applied to intact erythrocytes (RBC) and plasma from 12 erythropoie... more Direct spectrofluorimetry was applied to intact erythrocytes (RBC) and plasma from 12 erythropoietic protoporphyria (EPP) patients, 9 lead in
The absorption, translocation and metabolism of 1,3-dichloropropene (a soil fumigant) in bush bea... more The absorption, translocation and metabolism of 1,3-dichloropropene (a soil fumigant) in bush beans, tomato and carrot was studied under growth chamber and greenhouse conditions using solution culture, vermiculite and sand. Absorption was monitored using gas chromatographic analysis and isotope techniques. Plants were shown to absorb a maximum amount of dichloropropene by 24 to 48 hr from solution culture and vermiculite. The plant absorbed and translocated 1,3-dichlorpropene-14C-U readily to aerial parts of the plant. Bush beans, tomatoes and carrots absorbed and translocated 3-chlorallyl alcohol-14C-U from solution culture and vermiculite. Levels of 3-chloroallyl alcohol reached maximum at 24 to 48 hr after inoculation The gas chromatographic analysis of plant materials showed that 1,3-dichloropropene and 3-chloroallyl alcohol were rapidly metabolized by the plant. The three plants metabolize 1,3-dichloropropene to 3-chloroallyl alcohol, part of which is converted to 3-choroacryli...
The incorporation of 3- C-,B-hydroxy-, B-methylglutaric acid (HMG) vii into carotenoids of excise... more The incorporation of 3- C-,B-hydroxy-, B-methylglutaric acid (HMG) vii into carotenoids of excised etiolated maize shoots, crude cell free extracts and soluble extracts (20, 000 x g) of maize was investigated. HMG was effectively incorporated into carotenoids of excised shoots, crude extracts and soluble extracts. The excised shoots, crude extracts and soluble extracts incorporated 2- 14 C-mevalonic acid (MVA) into carotenoids as well. The results indicated the presence of HMG-CoA reductase in the plant as well as an HMG activating enzyme. The soluble extract showed a pH optimum of 7. 0 for incorporation of HMG into carotenoids. Endogenous metabolites such as MVA in the soluble enzyme preparation decreased the amount of 3- 14 C-HMG incorporated into carotenoids. The conversion of HMG to MVA may be a regulatory site in carotenoid biosynthesis in the plant. Telone (a mixture of cis-1, 3-dichloropropene, trans-I, 3-dichloropropene and other halogenated hydrocarbons), 3-chloroallyl alco...
Journal of Lipid Research, 1982
The synthesis of 12-0-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stag... more The synthesis of 12-0-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stage promoter) is described. The preparation starts with phorbol-13-acetate-20-tritylether which is acylated by a carbodiimide method to yield its 12-retinoate. The latter is detritylated by acidic methanol to give RPA. Following an analogous procedure, the 4methyl-ether of RPA is prepared from 4-O-methylphorbol-13
Toxicology and Applied Pharmacology, 1979
ACS Symposium Series, 1985
... 1983; 51: 2420. 3. Palmer, Sushma and Bakshi, Kulbir, J. Natl Cancer Inst.. 1983; 70: 1153. 4... more ... 1983; 51: 2420. 3. Palmer, Sushma and Bakshi, Kulbir, J. Natl Cancer Inst.. 1983; 70: 1153. 4. Pascoe, Gary A., Sakai-Wong, Joanne, Soliven, Eva and Correia, Almira M., Biochem. Pharma.. 1983, 32: 3207. 5. Hendrich, S. and Bjeldanes, LF, Fd. Chem. Toxicol.. 1983; 21:479. ...
Carcinogenesis; a comprehensive survey, 1982
Cancer research, 1980
The effects of treating female mice with single topical doses of 2,3,7,8-tetrachlorodibenzo-p-dio... more The effects of treating female mice with single topical doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at various times before and after 7,12-dimethylbenz(a)anthracene (DMBA), benzo(a)pyrene, 3-methylcholanthrene (MCA), and (±)-trans-7/S,8«-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene were studied. TCDD, at doses of 1 /ig/mouse, was applied topically 3 days prior to, 5 min prior to, or 1 day after the initiator. The application of TCDD 5 min prior to or 1 day after initiation with DMBA, benzo(a)pyrene, or MCA had little or no effect on papilloma formation. In contrast, when TCDD was applied 3 days prior to initiation with these hydrocarbons, a marked reduction in papilloma formation was observed. TCDD, applied 3 days prior to, 5 min prior to, or 1 day after initiation with (±)-frans-7/?,8«-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene produced 81, 50, and 39% inhibition of papilloma formation after 20 weeks of pro motion. Similar effects were observed when higher initiating doses of DMBA and the diol-epoxide were utilized. In addition, single i.p. doses of TCDD (1 /xg/mouse) 3 days prior to initiation with DMBA or MCA were highly effective at inhibiting papilloma formation. Several congeners of TCDD, lacking, possessing similar, or possessing different inducing properties, were tested for their effects on tumor initiation by DMBA. 3,4,3',4'-Tetrachlorobiphenyl effectively inhibited tumor initiation by DMBA, whereas 2,7-dichlorodibenzo-p-dioxin and 2,4,5,2',4',5'-hexachlorobiphenyl had little or no effect on the tumor response. Topical application of TCDD at the doses utilized in the tumor experiments markedly induced epidermal aryl hydrocarbon hydroxylase (21-fold) 3 days after treatment. In addition, epi dermal uridine diphosphoglucuronyltransferase activities were stimulated 2-to 3-fold 3 days following TCDD treatment. TCDD treatment had little or no effect on epidermal epoxide hydrase or glutathione-S-transferase activities. The time course for induction of epidermal aryl hydrocarbon hydroxylase and uri dine diphosphoglucuronyltransferase correlated with the time course for the inhibitory effects of TCDD on tumor initiation with DMBA, benzo(a)pyrene, and MCA. INTRODUCTION Carcinogenic PAH3 require metabolic activation to highly
Toxicology and Applied Pharmacology, 1976
... BERRY, DL, ZACHARIAH, PK, NAMKUNG, MJ, AND JUCHAU, MR (1976). ... Bresnick andStevenson (1968... more ... BERRY, DL, ZACHARIAH, PK, NAMKUNG, MJ, AND JUCHAU, MR (1976). ... Bresnick andStevenson (1968) indicated that 17% of oral doses of 11C-labeled 3-methylcholanthrene was incorporated into fetal tissues but that injection into the amniotic sac was a better means to ...
Carcinogenesis, 1985
1-Nitropyrene (1-NO2Py), 3-nitrofluoranthene (3-NO2Ft), 3-aminofluoranthene (3-NH2Ft) and 8-nitro... more 1-Nitropyrene (1-NO2Py), 3-nitrofluoranthene (3-NO2Ft), 3-aminofluoranthene (3-NH2Ft) and 8-nitrofluoranthene (8-NO2Ft) were tested for mutagenicity in cultured Chinese hamster V79 cells. Mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) gene locus were quantified. 1-NO2Py had marginal direct-acting mutagenicity which was enhanced by a mixture of Aroclor 1254- and 1242-induced liver homogenates (S9) in the treatment medium. 1-NO2Py was more mutagenic with S9 activation than 3-NO2Ft, 3-NH2Ft or 8-NO2Ft. However, 8-NO2Ft, 3-NO2Ft and 3-NH2Ft were more mutagenic than 1-NO2Py when a post-microsomal liver supernatant (S100) was used for metabolic activation. The results of these investigations strongly support activation of some nitrated polycyclic aromatic hydrocarbons to proximate mutagens by a sequence of reductions and possible formation of polycyclic aromatic hydroxylamines.
Biochemical and Biophysical Research Communications, 1979
Analytical Methods, 2013
Three sets of soil samples were collected by the National Institute for Occupational Safety and H... more Three sets of soil samples were collected by the National Institute for Occupational Safety and Health and one set by South Dakota School of Mines & Technology from in and around the Slim Buttes Land Unit of the Sioux Ranger District of the Custer-Gallatin National Forest in the northwest of South Dakota. The rocks forming the Slim Buttes are sedimentary clays, sands and gravels including reworked volcanic ash-falls in which the zeolite mineral erionite has crystallized during diagenesis in a fibrous form or morphology similar to that of asbestos. The samples were prepared using the fluidized bed asbestos segregator (FBAS) and analyzed by phase contrast microscopy (PCM) or transmission electron microscopy to detect the presence of mineral fibers. FBAS-PCM results compared to semi-Electronic supplementary material The online version of this article (
Advances in Experimental Medicine and Biology, 1984
Sixty to eighty percent of all human cancers are associated with our environment and environmenta... more Sixty to eighty percent of all human cancers are associated with our environment and environmental agents. The environment is a complex mixture of chemical s that originate from industrial and technological development and, most importantly, natural sources. Many industrial chemicals, pesticides, insecticides and food additives have exhibited carcinogenic properties in various animal model systems, and occupational and drug exposure has led to human cancers. However, estimates attribute the majority of human cancers associated with the environment not to intentional or accidental chemical exposure, but to the vast number of naturally occurring chemicals in our environment (0011 and Peto, 1981). Carci nogenesi s encompasses many di fferent di seases, and the exact cause of a lesion is a multifactorial process including nature of exposure, duration, age, route of exposure and numerous environmental factors. Data from animal model s indicate that carcinogenesis is a multi-step process that involves genetic and epigenetic events. Boutwell (1974) proposed that complete carcinogenesis could be divided into initiation and promotion. Initiation is defined as an irreversible genetic event (mutational), and promotion is a time-and-dose-dependent process which is, to a certain degree, reversible. The genotoxic events could be a direct change in genetic material through attack by radiation or chemicals. The genotoxic change could result from a direct mutational lesion, faulty error-prone DNA repair, DNA polymerase error, or infidelity of DNA synthesis. The promotion process is termed "epigenetic" since no direct interaction of the promoter with the genetic material has been detected. The process involves conversion of the damaged cells into a dormant tumor cell followed by propagation of that cell into a viable growing tumor. The epigenetic events 91 M. Friedman (ed.
Regulatory Toxicology and Pharmacology, 2015
The United States Environmental Protection Agency (EPA) developed a quantitative exposure-respons... more The United States Environmental Protection Agency (EPA) developed a quantitative exposure-response model for the non-cancer effects of Libby Amphibole Asbestos (LAA) (EPA, 2014). The model is based on the prevalence of localized pleural thickening (LPT) in workers exposed to LAA at a workplace in Marysville, Ohio (Lockey et al., 1984; Rohs et al., 2008). Recently, Lockey et al. (2015a) published a follow-up study of surviving Marysville workers. The data from this study increases the number of cases of LPT and extends the observation period for a number of workers, thereby providing a strengthened data set to define and constrain the optimal exposure-response model for non-cancer effects from inhalation exposure to LAA. The new data were combined with the previous data to update the exposure-response modeling for LPT. The results indicate that a bivariate model using cumulative exposure and time since first exposure is appropriate, and the benchmark concentration is similar to the findings previously reported by EPA (2014). In addition, the data were also used to develop initial exposure-response models for diffuse pleural thickening (DPT) and small interstitial opacities (SIO).