David Fulker - Academia.edu (original) (raw)

Papers by David Fulker

Research paper thumbnail of THE EXPLICIT NUMERICAL PREDICTION OF AN INTENSE HAILSTORM USING WSR-88D OBSERVATIONS: THE NEED FOR REAL TIME ACCESS TO LEVEL II DATA AND PLANS FOR A PROTOTYPE ACQUISITION SYSTEM

this document describes an effort to establish aprototype real time Level II acquisition test bed... more this document describes an effort to establish aprototype real time Level II acquisition test bed for 8radars in the southern Great Plains.

Research paper thumbnail of Components of an NSDL Architecture: Technical Scope and Functional Model

Computing Research Repository, 2002

We describe work leading toward specification of a technical architecture for the National Scienc... more We describe work leading toward specification of a technical architecture for the National Science, Mathematics, Engineering, and Technology Education Digital Library (NSDL). This includes a technical scope and a functional model, with some elaboration on the particularly rich set of library services that NSDL is expected eventually to encompass.

Research paper thumbnail of Exploring the genetic etiology of low general cognitive ability from 14 to 36 months

D. W. Fulker, 1985, 1988) multiple regression techniques suggest genetic etiology in low general ... more D. W. Fulker, 1985, 1988) multiple regression techniques suggest genetic etiology in low general cognitive ability groups. The stability of low general cognitive ability over time also appears to be primarily due to genetic factors. Although replication is necessary, these results suggest that the genetic etiology of low g during infancy and early childhood is at least as great as

Research paper thumbnail of A Supplement to Project CRAFT: A Real-Time Delivery System for Nexrad Level Via The Internet

Bulletin of The American Meteorological Society, 2007

Research paper thumbnail of Multipoint interval mapping of quantitative trait loci, using sib pairs

American journal of human genetics, 1995

The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all a... more The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.

Research paper thumbnail of The VisAD Java Class Library for Scientific Data and Visualization

ABSTRACT VisAD is a Java class library for interactive and collaborative visualization and analys... more ABSTRACT VisAD is a Java class library for interactive and collaborative visualization and analysis of numerical data. It is designed to support distributed computing and data sharing on the Internet through the use of distributed objects and a very general numerical data model. The data model integrates metadata for data organization, units, coordinate systems, sampling geometries and topoligies, missing data indicators, and error estimates. When data are combined in computations or visualizations, unit conversion, coordinate transforms and resampling are done implicitly as needed.

Research paper thumbnail of A diallel analysis of nicotine-induced hypothermia

Pharmacology Biochemistry and Behavior, 1984

The hypothermic responses of mice that occur after acute injection of nicotine show genetic influ... more The hypothermic responses of mice that occur after acute injection of nicotine show genetic influences. The body temperatures of mice of all five strains tested decreased after injection of either 0.75 or 1.5 mg/kg nicotine, but mice of the C3H strain were less affected than were those of the DBA, BALB, or C57BL strains. Mice of the A strain were the most sensitive to nicotine's effects. Genetic effects on nicotine-induced hypothermia were further examined using a five-by-five diallel cross. Additive genetic variance occurred at both nicotine doses. Substantial dominance variance, including directional dominance toward a large hypothermic response induced by injection of a low dose of nicotine (0.75 mg/kg), suggested that an intense response to a low drug dose is adaptive. The directional dominance was absent after treatment with a high dose (1.5 mg/kg) of the drug. Epistatic interactions occurring in crosses involving C57BL mice were pronounced.

Research paper thumbnail of Longitudinal Prediction of Specific Cognitive Abilities from Infant Novelty Preference

Child Development, 1991

A test of visual novelty preference, the Fagan Test of Infant Intelligence, was administered to a... more A test of visual novelty preference, the Fagan Test of Infant Intelligence, was administered to a group of 113 full-term infants from the Colorado Adoption Project at 5 and 7 months of age. The infants were followed longitudinally and the Bayley scales were administered at 12 and 24 months, the Sequenced Inventory of Communication Development at 24 and 36 months, and the Stanford-Binet and the Colorado Specific Cognitive Abilities Test at 36 months. 1 novelty preference score was obtained for each infant by averaging across the 2 test ages. Novelty preference correlated significantly with 36-month Binet IQ, the first unrotated principle component from the cognitive battery, and the 24-month Bayley MDI score. Novelty preference was also compared to specific abilities at all 3 follow-up ages; all of the specific abilities were significantly related to novelty preference, with the exceptions of 12- and 24-month Imitation and 36-month Perceptual Speed. Partial correlations suggest that novelty preference predicts language and memory independent of IQ. Overall, the results indicate that novelty preference during the first year of life not only predicts later IQ but may also reflect specific cognitive processes.

Research paper thumbnail of Digital library collaborations in a world community

Proceedings of the first ACM/IEEE-CS joint conference on Digital libraries - JCDL '01, 2001

Digital libraries and their user communities are increasingly internat ional in nature. However -... more Digital libraries and their user communities are increasingly internat ional in nature. However - though technological progress and global education have brought American and European communities closer - cross-cultural and other crosscutting issues impede the formation of &lquo;world community&rquo; on larger scales. The pertinent issues include: collaboration in the presence of language and cultural barriers, international copyrights, international revenue streams,

Research paper thumbnail of Increase in power through multivariate analyses

Behavior Genetics, 1998

Power to detect genetic and environmental influences increases not only with sample size but also... more Power to detect genetic and environmental influences increases not only with sample size but also with the number of measurements through longitudinal and/or multivariate designs, if those measurements correlate with each other. Power simulations are presented for uni-through quadrivariate cases, with differing genetic and environmental parameters. Even though subject attrition is a problem for most longitudinal studies, the gain in power available may more than make up for this shortcoming in many situations. In terms of planning studies to examine genetic and environmental influences, power calculations should not only consider sample size but number of measurements on particular phenotypes and their intercorrelations.

Research paper thumbnail of High-resolution mapping of quantitative trait loci in outbred mice

Research paper thumbnail of Real-time national GPS networks: Opportunities for atmospheric sensing

Earth, Planets and Space, 2000

Real-time national Global Positioning System (GPS) networks are being established in a number of ... more Real-time national Global Positioning System (GPS) networks are being established in a number of countries for atmospheric sensing. UCAR, in collaboration with participating universities, is developing one of these networks in the United States. The network, named "SuomiNet" to honor meteorological satellite pioneer Verner Suomi, is funded by the U.S. National Science Foundation. SuomiNet will exploit the recently-shown ability of groundbased GPS receivers to make thousands of accurate upper and lower atmospheric measurements per day. Phase delays induced in GPS signals by the ionosphere and neutral atmosphere can be measured with high precision simultaneously along up to a dozen GPS ray paths in the field of view. These delays can be converted into total electron content (TEC), and integrated water vapor (if surface pressure data or estimates are available), along each GPS ray path. The resulting continuous, accurate, all-weather, real-time upper and lower atmospheric data create a variety of opportunities for atmospheric research. In this letter we describe SuomiNet, its applications, and the opportunity to coordinate national real-time GPS networks to create a global network with larger scientific and operational potential.

Research paper thumbnail of A simple genetic basis for a complex psychological trait in laboratory mice

Research paper thumbnail of Genetic and environmental influences on cognition during childhood

Population Research and Policy Review, 1995

The basic methodology of behavior genetics is described in the context of the twin and sibling/ad... more The basic methodology of behavior genetics is described in the context of the twin and sibling/adoption design. Results of applying this model to cross-sectional data on cognitive development throughout the lifespan are presented. Results from a large longitudinal twin and adoption study of general intelligence are presented to illustrate the use of the basic behavior genetic model in studying the causes of continuity and change in development. A special model is presented for the study of abnormal behavior occurring at the extremes of ...

Research paper thumbnail of Personality dimensions in mothers and sons: Relationship to adolescent substance misuse

Personality and Individual Differences, 1997

The purpose of this study was to assess whether personality dimensions in mothers and in their so... more The purpose of this study was to assess whether personality dimensions in mothers and in their sons predict alcohol and/or substance misuse (ASM) in severely disturbed adolescent boys who were largely from father-absent homes. The sample consisted of 42 adolescent male treatment probands and their mothers. The youths mean age was 15.8 years. All were placed in a residential center and all had conduct disorder diagnosis by DSM III-R criteria. Of the total, 86% met DSM III-R criteria for substance dependence. Alcohol and substance use and criminality were assessed through direct interview, selfreport and family interview. Maternal and adolescent personality dimensions were assessed through an abbreviated version of Cloninger's Tri-Dimensional Personality Questionnaire (TPQ; Cloninger, 1987b). The results indicated that maternal novelty seeking (NS) predicted adolescent alcohol and drug symptoms, but was not significantly related to the mother's own ASM. Probands' NS predicted their own alcohol and drug dependence symptoms. In general, maternal ASM, maternal NS and proband NS all played some role in proband ASM. At the most severe level of adolescent drug dependence, the adolescent's own NS, when coupled with high maternal NS, rendered the youth most vulnerable to increased alcohol and drug dependent symptoms. The assessment of personality dimensions adds new perspectives to the study of families of adolescents with ASM. Maternal NS appears to contribute significantly to adolescent male ASM in largely father-absent homes. 0 1997

Research paper thumbnail of Linkage between sexual orientation and chromosome Xq28 in males but not in females

Research paper thumbnail of Quantitative trait locus analysis of contextual fear conditioning in mice

Research paper thumbnail of Altruism and aggression: The heritability of individual differences

Journal of Personality and Social Psychology, 1986

Five questionnaires measuring altruistic and aggressive tendencies were completed by 573 adult tw... more Five questionnaires measuring altruistic and aggressive tendencies were completed by 573 adult twin pairs of both sexes from the University of London Institute of Psychiatry Volunteer Twin Register. The questionnaires measured altruism, empathy, nurturanoe, aggressiveness, and assertiveness. The intraclass correlations for the five scales, respectively, were .53, .54, .49, .40, and .52 for 296 monozygotic pairs, and .25, .20, .14, .04, and .20 for 179 same-sex dizygotic pairs, resulting in broad heritability estimates of 56%, 68%, 70%, 72%, and 64%. Additional analyses, using maximum-likelihood modelfitting, revealed approximately 50% of the variance on each scale to be associated with genetic effects, virtually 0% with the twins' common environment, and the remaining 50% with each twins' specific environment and/or error associated with the tea Correcting for the unreliability in the tests raised the maximum-likelihood heritabilities to approximately 60%. Age and sex differences vase also found: altruism increased over the age span from 19 to 60, whereas aggressiveness decreased, and, at each age, women had higher scores than men on altruism and lower snores on aggressiveness.

Research paper thumbnail of Adoption results for self-reported personality: Evidence for nonadditive genetic effects?

Journal of Personality and Social Psychology, 1998

Twin studies consistently indicate moderate genetic influence on individual differences in person... more Twin studies consistently indicate moderate genetic influence on individual differences in personality as assessed using self-report questionnaires, with heritability estimates typically about 40%. In this first analysis of self-report personality data from the longitudinal Colorado Adoption Project, little evidence is found for additive genetic influence in parent-offspring and sibling adoption analyses based on a foundation sample of 245 adoptive families and 245 nonadoptive families with adopted and nonadopted children assessed yearly from 9 to 16 years. Although several factors might contribute to the discrepancy between twin and adoption results, we suggest that nonadditive genetic influence, which can be detected by twin studies but not by adoption studies, is a likely culprit. These findings have important implications for attempts to identify specific genes responsible for genetic influence on personality.

Research paper thumbnail of An Adoption Study of Depressive Symptoms in Middle Childhood

Journal of Child Psychology and Psychiatry, 1998

Several twin studies of children and adolescents have found significant heritability of depressiv... more Several twin studies of children and adolescents have found significant heritability of depressive symptoms. In contrast, the sole adoption study of biologically related and biologically unrelated adopted siblings found no evidence for genetic influence. The present study attempts to confirm these results in middle childhood using two adoption designs. The sample, from the Colorado Adoption Project, included 180 adopted children (77 with adoptive siblings) and their biological and adoptive mothers, and 227 nonadopted children (93 with biological siblings) and their mothers. Mothers reported their own neuroticism, and children's depressive symptoms were reported by the parents and by the children themselves. For both the sibling adoption and the parent-offspring designs heritability was negligible, shared environment modest, and non-shared environment substantial, irrespective of child gender. Although the power of the sibling data is low, the combined findings from the two designs suggest that genetic effects on depressive symptoms in childhood may be somewhat smaller than previously estimated in twin studies.

Research paper thumbnail of THE EXPLICIT NUMERICAL PREDICTION OF AN INTENSE HAILSTORM USING WSR-88D OBSERVATIONS: THE NEED FOR REAL TIME ACCESS TO LEVEL II DATA AND PLANS FOR A PROTOTYPE ACQUISITION SYSTEM

this document describes an effort to establish aprototype real time Level II acquisition test bed... more this document describes an effort to establish aprototype real time Level II acquisition test bed for 8radars in the southern Great Plains.

Research paper thumbnail of Components of an NSDL Architecture: Technical Scope and Functional Model

Computing Research Repository, 2002

We describe work leading toward specification of a technical architecture for the National Scienc... more We describe work leading toward specification of a technical architecture for the National Science, Mathematics, Engineering, and Technology Education Digital Library (NSDL). This includes a technical scope and a functional model, with some elaboration on the particularly rich set of library services that NSDL is expected eventually to encompass.

Research paper thumbnail of Exploring the genetic etiology of low general cognitive ability from 14 to 36 months

D. W. Fulker, 1985, 1988) multiple regression techniques suggest genetic etiology in low general ... more D. W. Fulker, 1985, 1988) multiple regression techniques suggest genetic etiology in low general cognitive ability groups. The stability of low general cognitive ability over time also appears to be primarily due to genetic factors. Although replication is necessary, these results suggest that the genetic etiology of low g during infancy and early childhood is at least as great as

Research paper thumbnail of A Supplement to Project CRAFT: A Real-Time Delivery System for Nexrad Level Via The Internet

Bulletin of The American Meteorological Society, 2007

Research paper thumbnail of Multipoint interval mapping of quantitative trait loci, using sib pairs

American journal of human genetics, 1995

The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all a... more The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.

Research paper thumbnail of The VisAD Java Class Library for Scientific Data and Visualization

ABSTRACT VisAD is a Java class library for interactive and collaborative visualization and analys... more ABSTRACT VisAD is a Java class library for interactive and collaborative visualization and analysis of numerical data. It is designed to support distributed computing and data sharing on the Internet through the use of distributed objects and a very general numerical data model. The data model integrates metadata for data organization, units, coordinate systems, sampling geometries and topoligies, missing data indicators, and error estimates. When data are combined in computations or visualizations, unit conversion, coordinate transforms and resampling are done implicitly as needed.

Research paper thumbnail of A diallel analysis of nicotine-induced hypothermia

Pharmacology Biochemistry and Behavior, 1984

The hypothermic responses of mice that occur after acute injection of nicotine show genetic influ... more The hypothermic responses of mice that occur after acute injection of nicotine show genetic influences. The body temperatures of mice of all five strains tested decreased after injection of either 0.75 or 1.5 mg/kg nicotine, but mice of the C3H strain were less affected than were those of the DBA, BALB, or C57BL strains. Mice of the A strain were the most sensitive to nicotine's effects. Genetic effects on nicotine-induced hypothermia were further examined using a five-by-five diallel cross. Additive genetic variance occurred at both nicotine doses. Substantial dominance variance, including directional dominance toward a large hypothermic response induced by injection of a low dose of nicotine (0.75 mg/kg), suggested that an intense response to a low drug dose is adaptive. The directional dominance was absent after treatment with a high dose (1.5 mg/kg) of the drug. Epistatic interactions occurring in crosses involving C57BL mice were pronounced.

Research paper thumbnail of Longitudinal Prediction of Specific Cognitive Abilities from Infant Novelty Preference

Child Development, 1991

A test of visual novelty preference, the Fagan Test of Infant Intelligence, was administered to a... more A test of visual novelty preference, the Fagan Test of Infant Intelligence, was administered to a group of 113 full-term infants from the Colorado Adoption Project at 5 and 7 months of age. The infants were followed longitudinally and the Bayley scales were administered at 12 and 24 months, the Sequenced Inventory of Communication Development at 24 and 36 months, and the Stanford-Binet and the Colorado Specific Cognitive Abilities Test at 36 months. 1 novelty preference score was obtained for each infant by averaging across the 2 test ages. Novelty preference correlated significantly with 36-month Binet IQ, the first unrotated principle component from the cognitive battery, and the 24-month Bayley MDI score. Novelty preference was also compared to specific abilities at all 3 follow-up ages; all of the specific abilities were significantly related to novelty preference, with the exceptions of 12- and 24-month Imitation and 36-month Perceptual Speed. Partial correlations suggest that novelty preference predicts language and memory independent of IQ. Overall, the results indicate that novelty preference during the first year of life not only predicts later IQ but may also reflect specific cognitive processes.

Research paper thumbnail of Digital library collaborations in a world community

Proceedings of the first ACM/IEEE-CS joint conference on Digital libraries - JCDL '01, 2001

Digital libraries and their user communities are increasingly internat ional in nature. However -... more Digital libraries and their user communities are increasingly internat ional in nature. However - though technological progress and global education have brought American and European communities closer - cross-cultural and other crosscutting issues impede the formation of &lquo;world community&rquo; on larger scales. The pertinent issues include: collaboration in the presence of language and cultural barriers, international copyrights, international revenue streams,

Research paper thumbnail of Increase in power through multivariate analyses

Behavior Genetics, 1998

Power to detect genetic and environmental influences increases not only with sample size but also... more Power to detect genetic and environmental influences increases not only with sample size but also with the number of measurements through longitudinal and/or multivariate designs, if those measurements correlate with each other. Power simulations are presented for uni-through quadrivariate cases, with differing genetic and environmental parameters. Even though subject attrition is a problem for most longitudinal studies, the gain in power available may more than make up for this shortcoming in many situations. In terms of planning studies to examine genetic and environmental influences, power calculations should not only consider sample size but number of measurements on particular phenotypes and their intercorrelations.

Research paper thumbnail of High-resolution mapping of quantitative trait loci in outbred mice

Research paper thumbnail of Real-time national GPS networks: Opportunities for atmospheric sensing

Earth, Planets and Space, 2000

Real-time national Global Positioning System (GPS) networks are being established in a number of ... more Real-time national Global Positioning System (GPS) networks are being established in a number of countries for atmospheric sensing. UCAR, in collaboration with participating universities, is developing one of these networks in the United States. The network, named "SuomiNet" to honor meteorological satellite pioneer Verner Suomi, is funded by the U.S. National Science Foundation. SuomiNet will exploit the recently-shown ability of groundbased GPS receivers to make thousands of accurate upper and lower atmospheric measurements per day. Phase delays induced in GPS signals by the ionosphere and neutral atmosphere can be measured with high precision simultaneously along up to a dozen GPS ray paths in the field of view. These delays can be converted into total electron content (TEC), and integrated water vapor (if surface pressure data or estimates are available), along each GPS ray path. The resulting continuous, accurate, all-weather, real-time upper and lower atmospheric data create a variety of opportunities for atmospheric research. In this letter we describe SuomiNet, its applications, and the opportunity to coordinate national real-time GPS networks to create a global network with larger scientific and operational potential.

Research paper thumbnail of A simple genetic basis for a complex psychological trait in laboratory mice

Research paper thumbnail of Genetic and environmental influences on cognition during childhood

Population Research and Policy Review, 1995

The basic methodology of behavior genetics is described in the context of the twin and sibling/ad... more The basic methodology of behavior genetics is described in the context of the twin and sibling/adoption design. Results of applying this model to cross-sectional data on cognitive development throughout the lifespan are presented. Results from a large longitudinal twin and adoption study of general intelligence are presented to illustrate the use of the basic behavior genetic model in studying the causes of continuity and change in development. A special model is presented for the study of abnormal behavior occurring at the extremes of ...

Research paper thumbnail of Personality dimensions in mothers and sons: Relationship to adolescent substance misuse

Personality and Individual Differences, 1997

The purpose of this study was to assess whether personality dimensions in mothers and in their so... more The purpose of this study was to assess whether personality dimensions in mothers and in their sons predict alcohol and/or substance misuse (ASM) in severely disturbed adolescent boys who were largely from father-absent homes. The sample consisted of 42 adolescent male treatment probands and their mothers. The youths mean age was 15.8 years. All were placed in a residential center and all had conduct disorder diagnosis by DSM III-R criteria. Of the total, 86% met DSM III-R criteria for substance dependence. Alcohol and substance use and criminality were assessed through direct interview, selfreport and family interview. Maternal and adolescent personality dimensions were assessed through an abbreviated version of Cloninger's Tri-Dimensional Personality Questionnaire (TPQ; Cloninger, 1987b). The results indicated that maternal novelty seeking (NS) predicted adolescent alcohol and drug symptoms, but was not significantly related to the mother's own ASM. Probands' NS predicted their own alcohol and drug dependence symptoms. In general, maternal ASM, maternal NS and proband NS all played some role in proband ASM. At the most severe level of adolescent drug dependence, the adolescent's own NS, when coupled with high maternal NS, rendered the youth most vulnerable to increased alcohol and drug dependent symptoms. The assessment of personality dimensions adds new perspectives to the study of families of adolescents with ASM. Maternal NS appears to contribute significantly to adolescent male ASM in largely father-absent homes. 0 1997

Research paper thumbnail of Linkage between sexual orientation and chromosome Xq28 in males but not in females

Research paper thumbnail of Quantitative trait locus analysis of contextual fear conditioning in mice

Research paper thumbnail of Altruism and aggression: The heritability of individual differences

Journal of Personality and Social Psychology, 1986

Five questionnaires measuring altruistic and aggressive tendencies were completed by 573 adult tw... more Five questionnaires measuring altruistic and aggressive tendencies were completed by 573 adult twin pairs of both sexes from the University of London Institute of Psychiatry Volunteer Twin Register. The questionnaires measured altruism, empathy, nurturanoe, aggressiveness, and assertiveness. The intraclass correlations for the five scales, respectively, were .53, .54, .49, .40, and .52 for 296 monozygotic pairs, and .25, .20, .14, .04, and .20 for 179 same-sex dizygotic pairs, resulting in broad heritability estimates of 56%, 68%, 70%, 72%, and 64%. Additional analyses, using maximum-likelihood modelfitting, revealed approximately 50% of the variance on each scale to be associated with genetic effects, virtually 0% with the twins' common environment, and the remaining 50% with each twins' specific environment and/or error associated with the tea Correcting for the unreliability in the tests raised the maximum-likelihood heritabilities to approximately 60%. Age and sex differences vase also found: altruism increased over the age span from 19 to 60, whereas aggressiveness decreased, and, at each age, women had higher scores than men on altruism and lower snores on aggressiveness.

Research paper thumbnail of Adoption results for self-reported personality: Evidence for nonadditive genetic effects?

Journal of Personality and Social Psychology, 1998

Twin studies consistently indicate moderate genetic influence on individual differences in person... more Twin studies consistently indicate moderate genetic influence on individual differences in personality as assessed using self-report questionnaires, with heritability estimates typically about 40%. In this first analysis of self-report personality data from the longitudinal Colorado Adoption Project, little evidence is found for additive genetic influence in parent-offspring and sibling adoption analyses based on a foundation sample of 245 adoptive families and 245 nonadoptive families with adopted and nonadopted children assessed yearly from 9 to 16 years. Although several factors might contribute to the discrepancy between twin and adoption results, we suggest that nonadditive genetic influence, which can be detected by twin studies but not by adoption studies, is a likely culprit. These findings have important implications for attempts to identify specific genes responsible for genetic influence on personality.

Research paper thumbnail of An Adoption Study of Depressive Symptoms in Middle Childhood

Journal of Child Psychology and Psychiatry, 1998

Several twin studies of children and adolescents have found significant heritability of depressiv... more Several twin studies of children and adolescents have found significant heritability of depressive symptoms. In contrast, the sole adoption study of biologically related and biologically unrelated adopted siblings found no evidence for genetic influence. The present study attempts to confirm these results in middle childhood using two adoption designs. The sample, from the Colorado Adoption Project, included 180 adopted children (77 with adoptive siblings) and their biological and adoptive mothers, and 227 nonadopted children (93 with biological siblings) and their mothers. Mothers reported their own neuroticism, and children's depressive symptoms were reported by the parents and by the children themselves. For both the sibling adoption and the parent-offspring designs heritability was negligible, shared environment modest, and non-shared environment substantial, irrespective of child gender. Although the power of the sibling data is low, the combined findings from the two designs suggest that genetic effects on depressive symptoms in childhood may be somewhat smaller than previously estimated in twin studies.