David Ouagne - Academia.edu (original) (raw)

Papers by David Ouagne

AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2014

Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electro... more Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electronic Health Records (EHRs) with clinical research and pharmacovigilance are limited to resolving lexical/syntactic data integration issues and do not address semantic barriers. This paper describes the collaboration between two European projects - EHR4CR and SALUS - in implementing ISO/IEC 11179-based metadata registries (MDRs) and semantically integrated cross-platform data access. A common "semantic MDR" provides a framework for bidirectional/cross-MDR mapping and federated queries are enabled using the newly-defined IHE Data Exchange (DEX) profile. In the pilot implementation, mappings for 178 EHR4CR and 199 SALUS metadata elements were persisted in the semantic MDR. The DEX profile was then used to access semantically equivalent data elements in SALUS or EHR4CR participating EHR systems. ISO/IEC 11179-based MDRs and DEX integration profile address the goal of developing pan-...

Studies in health technology and informatics, 2005

The diagnostic variability in pathology, widely reported in the literature, is partly due to the ... more The diagnostic variability in pathology, widely reported in the literature, is partly due to the use of different classification systems by pathologists. The descriptions of morphological characteristics on the same image within different classification systems can be considered as different points of view of pathologists. Our aim is to represent the points of view of the experts in pathology during image interpretation and to propose a method ological and technical solution in order to implement interoperability between these points of view. According to the hybrid ontology approach, we developed a system in three stages consisting in 1) the representation of the various points of view in local ontologies 2) the realization of a shared vocabulary and the development of a mapping tool used to allow the matching of local ontologies and shared vocabulary 3) the development of a transcoding algorithm for the translation of a case description from one point of view to another. A first e...

IRBM, 2015

Objectives: An important barrier to electronic healthcare information exchanges (HIE) is the lack... more Objectives: An important barrier to electronic healthcare information exchanges (HIE) is the lack of interoperability between information systems especially on the semantic level. In the scope of the ANR (Agence Nationale pour la Recherche) / TERSAN (Terminology and Data Elements Repositories for Healthcare Interoperability) project, we propose to set and use a semantic interoperability platform, based on semantic web technologies, in order to facilitate standardized healthcare information exchanges between heterogeneous Electronic Healthcare Records (EHRs) in different care settings. Material and methods: The platform is a standard-based expressive and scalable semantic interoperability framework. It includes centrally managed Common Data Elements bounded to international/national reference terminologies such as ICD10, CCAM, SNOMED CT, ICD-O, LOINC and PathLex. It offers semantic services such as dynamic mappings between reference and local terminologies. Results: A pilot implementation of semantic services was developed and evaluated within a HIE prototype in telepathology for remote expert advice. The semantic services developed for transcoding local terms into reference terms take into account the type of message and the exchange context defined within standard-based integration profiles. Conclusion: The TERSAN platform is an innovative semantic interoperability framework that (1) provides standard-based semantic services applicable to any HIE infrastructure and (2) preserves the use of local terminologies and local models by end users (health professional's priority).

Studies in health technology and informatics, 2010

This paper describes the building of an HL7-based Information Model Ontology (IMO) that can be ex... more This paper describes the building of an HL7-based Information Model Ontology (IMO) that can be exploited by a domain ontology in order to distribute querying over different clinical data repositories. We employed the Open Medical Development Framework (OMDF) based on a model driven development methodology. OMDF provides model transformation features to build an HL7-based information model that covers the conceptual scope of a target project. The resulting IMO is used to mediate between ontologically queries and information retrieval from semantically less defined Hospital Information Systems (HIS). In the context of the DebugIT project - which scope corresponds to the control of infectious diseases and antimicrobial resistances - Information Model Ontology is integrated to the DebugIT domain ontology in order to express queries.

Studies in health technology and informatics, 2006

For medical decisions, healthcare professionals need that all required information is both correc... more For medical decisions, healthcare professionals need that all required information is both correct and easily available. We address the issue of integrating anatomical pathology department to the healthcare enterprise. The pathology workflow from order to report, including specimen process and image acquisition was modeled. Corresponding integration profiles were addressed by expansion of the IHE (Integrating the Healthcare Enterprise) initiative. Implementation using respectively DICOM Structured Report (SR) and DICOM Slide-Coordinate Microscopy (SM) was tested. The two main integration profiles--pathology general workflow and pathology image workflow--rely on 13 transactions based on HL7 or DICOM standard. We propose a model of the case in anatomical pathology and of other information entities (orders, image folders and reports) and real-world objects (specimen, tissue samples, slides, etc). Cases representation in XML schemas, based on DICOM specification, allows producing DICOM ...

Studies in health technology and informatics, 2010

Building qualitative clinical decision support or monitoring based on information stored in clini... more Building qualitative clinical decision support or monitoring based on information stored in clinical information (or EHR) systems cannot be done without assessing and controlling information quality. Numerous works have introduced methods and measures to qualify and enhance data, information models and terminologies quality. This paper introduces an approach based on an Information Quality Triangle that aims at providing a generic framework to help in characterizing quality measures and methods in the context of the integration of EHR data in a clinical datawarehouse. We have successfully experimented the proposed approach at the HEGP hospital in France, as part of the DebugIT EU FP7 project.

Studies in health technology and informatics, 2012

A major barrier to repurposing routinely collected data for clinical research is the heterogeneit... more A major barrier to repurposing routinely collected data for clinical research is the heterogeneity of healthcare information systems. Electronic Healthcare Record for Clinical Research (EHR4CR) is a European platform designed to improve the efficiency of conducting clinical trials. In this paper, we propose an initial architecture of the EHR4CR Semantic Interoperability Framework. We used a model-driven engineering approach to build a reference HL7-based multidimensional model bound to a set of reference clinical terminologies acting as a global as view model. We then conducted an evaluation of its expressiveness for patient eligibility. The EHR4CR information model consists in one fact table dedicated to clinical statement and 4 dimensions. The EHR4CR terminology integrates reference terminologies used in patient care (e.g LOINC, ICD-10, SNOMED CT, etc). We used the Object Constraint Language (OCL) to represent patterns of eligibility criteria as constraints on the EHR4CR model to ...

Studies in health technology and informatics, 2009

Desiderata for interface terminologies (IT), designed to support interactions between humans and ... more Desiderata for interface terminologies (IT), designed to support interactions between humans and structured medical information, differ from desiderata for reference terminologies (RT). Terminology experts have recommended that IT be mapped to RT. The interface terminology of the Georges Pompidou European Hospital (GPEH-IT) contains more than 5,000 concepts, sometimes linked to ICD-10 but not yet to the SNOMED 3.5 VF, now available in France. Our objective was to use a formal characterization framework to compare GPEH-IT to SNOMED 3.5 VF and to define the functionalities of terminology services for managing both IT and RT and the mapping between them. We discuss the role of IT and RT in representing the meaning of clinical data.

AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2014

Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electro... more Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electronic Health Records (EHRs) with clinical research and pharmacovigilance are limited to resolving lexical/syntactic data integration issues and do not address semantic barriers. This paper describes the collaboration between two European projects - EHR4CR and SALUS - in implementing ISO/IEC 11179-based metadata registries (MDRs) and semantically integrated cross-platform data access. A common "semantic MDR" provides a framework for bidirectional/cross-MDR mapping and federated queries are enabled using the newly-defined IHE Data Exchange (DEX) profile. In the pilot implementation, mappings for 178 EHR4CR and 199 SALUS metadata elements were persisted in the semantic MDR. The DEX profile was then used to access semantically equivalent data elements in SALUS or EHR4CR participating EHR systems. ISO/IEC 11179-based MDRs and DEX integration profile address the goal of developing pan-...

AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2014

Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electro... more Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electronic Health Records (EHRs) with clinical research and pharmacovigilance are limited to resolving lexical/syntactic data integration issues and do not address semantic barriers. This paper describes the collaboration between two European projects - EHR4CR and SALUS - in implementing ISO/IEC 11179-based metadata registries (MDRs) and semantically integrated cross-platform data access. A common "semantic MDR" provides a framework for bidirectional/cross-MDR mapping and federated queries are enabled using the newly-defined IHE Data Exchange (DEX) profile. In the pilot implementation, mappings for 178 EHR4CR and 199 SALUS metadata elements were persisted in the semantic MDR. The DEX profile was then used to access semantically equivalent data elements in SALUS or EHR4CR participating EHR systems. ISO/IEC 11179-based MDRs and DEX integration profile address the goal of developing pan-...

Studies in health technology and informatics, 2005

The diagnostic variability in pathology, widely reported in the literature, is partly due to the ... more The diagnostic variability in pathology, widely reported in the literature, is partly due to the use of different classification systems by pathologists. The descriptions of morphological characteristics on the same image within different classification systems can be considered as different points of view of pathologists. Our aim is to represent the points of view of the experts in pathology during image interpretation and to propose a method ological and technical solution in order to implement interoperability between these points of view. According to the hybrid ontology approach, we developed a system in three stages consisting in 1) the representation of the various points of view in local ontologies 2) the realization of a shared vocabulary and the development of a mapping tool used to allow the matching of local ontologies and shared vocabulary 3) the development of a transcoding algorithm for the translation of a case description from one point of view to another. A first e...

IRBM, 2015

Objectives: An important barrier to electronic healthcare information exchanges (HIE) is the lack... more Objectives: An important barrier to electronic healthcare information exchanges (HIE) is the lack of interoperability between information systems especially on the semantic level. In the scope of the ANR (Agence Nationale pour la Recherche) / TERSAN (Terminology and Data Elements Repositories for Healthcare Interoperability) project, we propose to set and use a semantic interoperability platform, based on semantic web technologies, in order to facilitate standardized healthcare information exchanges between heterogeneous Electronic Healthcare Records (EHRs) in different care settings. Material and methods: The platform is a standard-based expressive and scalable semantic interoperability framework. It includes centrally managed Common Data Elements bounded to international/national reference terminologies such as ICD10, CCAM, SNOMED CT, ICD-O, LOINC and PathLex. It offers semantic services such as dynamic mappings between reference and local terminologies. Results: A pilot implementation of semantic services was developed and evaluated within a HIE prototype in telepathology for remote expert advice. The semantic services developed for transcoding local terms into reference terms take into account the type of message and the exchange context defined within standard-based integration profiles. Conclusion: The TERSAN platform is an innovative semantic interoperability framework that (1) provides standard-based semantic services applicable to any HIE infrastructure and (2) preserves the use of local terminologies and local models by end users (health professional's priority).

Studies in health technology and informatics, 2010

This paper describes the building of an HL7-based Information Model Ontology (IMO) that can be ex... more This paper describes the building of an HL7-based Information Model Ontology (IMO) that can be exploited by a domain ontology in order to distribute querying over different clinical data repositories. We employed the Open Medical Development Framework (OMDF) based on a model driven development methodology. OMDF provides model transformation features to build an HL7-based information model that covers the conceptual scope of a target project. The resulting IMO is used to mediate between ontologically queries and information retrieval from semantically less defined Hospital Information Systems (HIS). In the context of the DebugIT project - which scope corresponds to the control of infectious diseases and antimicrobial resistances - Information Model Ontology is integrated to the DebugIT domain ontology in order to express queries.

Studies in health technology and informatics, 2006

For medical decisions, healthcare professionals need that all required information is both correc... more For medical decisions, healthcare professionals need that all required information is both correct and easily available. We address the issue of integrating anatomical pathology department to the healthcare enterprise. The pathology workflow from order to report, including specimen process and image acquisition was modeled. Corresponding integration profiles were addressed by expansion of the IHE (Integrating the Healthcare Enterprise) initiative. Implementation using respectively DICOM Structured Report (SR) and DICOM Slide-Coordinate Microscopy (SM) was tested. The two main integration profiles--pathology general workflow and pathology image workflow--rely on 13 transactions based on HL7 or DICOM standard. We propose a model of the case in anatomical pathology and of other information entities (orders, image folders and reports) and real-world objects (specimen, tissue samples, slides, etc). Cases representation in XML schemas, based on DICOM specification, allows producing DICOM ...

Studies in health technology and informatics, 2010

Building qualitative clinical decision support or monitoring based on information stored in clini... more Building qualitative clinical decision support or monitoring based on information stored in clinical information (or EHR) systems cannot be done without assessing and controlling information quality. Numerous works have introduced methods and measures to qualify and enhance data, information models and terminologies quality. This paper introduces an approach based on an Information Quality Triangle that aims at providing a generic framework to help in characterizing quality measures and methods in the context of the integration of EHR data in a clinical datawarehouse. We have successfully experimented the proposed approach at the HEGP hospital in France, as part of the DebugIT EU FP7 project.

Studies in health technology and informatics, 2012

A major barrier to repurposing routinely collected data for clinical research is the heterogeneit... more A major barrier to repurposing routinely collected data for clinical research is the heterogeneity of healthcare information systems. Electronic Healthcare Record for Clinical Research (EHR4CR) is a European platform designed to improve the efficiency of conducting clinical trials. In this paper, we propose an initial architecture of the EHR4CR Semantic Interoperability Framework. We used a model-driven engineering approach to build a reference HL7-based multidimensional model bound to a set of reference clinical terminologies acting as a global as view model. We then conducted an evaluation of its expressiveness for patient eligibility. The EHR4CR information model consists in one fact table dedicated to clinical statement and 4 dimensions. The EHR4CR terminology integrates reference terminologies used in patient care (e.g LOINC, ICD-10, SNOMED CT, etc). We used the Object Constraint Language (OCL) to represent patterns of eligibility criteria as constraints on the EHR4CR model to ...

Studies in health technology and informatics, 2009

Desiderata for interface terminologies (IT), designed to support interactions between humans and ... more Desiderata for interface terminologies (IT), designed to support interactions between humans and structured medical information, differ from desiderata for reference terminologies (RT). Terminology experts have recommended that IT be mapped to RT. The interface terminology of the Georges Pompidou European Hospital (GPEH-IT) contains more than 5,000 concepts, sometimes linked to ICD-10 but not yet to the SNOMED 3.5 VF, now available in France. Our objective was to use a formal characterization framework to compare GPEH-IT to SNOMED 3.5 VF and to define the functionalities of terminology services for managing both IT and RT and the mapping between them. We discuss the role of IT and RT in representing the meaning of clinical data.

AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2014

Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electro... more Integration profiles collaboratively developed by CDISC and IHE for integrating data from Electronic Health Records (EHRs) with clinical research and pharmacovigilance are limited to resolving lexical/syntactic data integration issues and do not address semantic barriers. This paper describes the collaboration between two European projects - EHR4CR and SALUS - in implementing ISO/IEC 11179-based metadata registries (MDRs) and semantically integrated cross-platform data access. A common "semantic MDR" provides a framework for bidirectional/cross-MDR mapping and federated queries are enabled using the newly-defined IHE Data Exchange (DEX) profile. In the pilot implementation, mappings for 178 EHR4CR and 199 SALUS metadata elements were persisted in the semantic MDR. The DEX profile was then used to access semantically equivalent data elements in SALUS or EHR4CR participating EHR systems. ISO/IEC 11179-based MDRs and DEX integration profile address the goal of developing pan-...