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Papers by Gebiso Roba Debele

Frontiers in Psychiatry

IntroductionDespite the prevalence of post-traumatic disorder in internally displaced persons, wh... more IntroductionDespite the prevalence of post-traumatic disorder in internally displaced persons, which is well established, and the fact that respective international organizations are working on the issues, little attention is given in the context of sub-Saharan Africa, This study aims to review the available data about the prevalence and determinants of post-traumatic stress disorders among internally displaced people in sub-Saharan Africa.MethodsStudies published in the English language that have a clear outcome of interest and are available in full text were included. Six electronic databases were searched to identify published studies on the prevalence and determinants of posttraumatic stress disorder among IDPs in sub-Saharan Africa. This includes PubMed/MEDLINE, Scopus, EMBASE, PsychInfo, and the Web of Science. All relevant studies till June, 2023 were assessed. The review was done as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-2009) and ...

Risk Management and Healthcare Policy, May 1, 2021

Background: Cardiovascular disease (CVD) is a major cause of death and disability among people wi... more Background: Cardiovascular disease (CVD) is a major cause of death and disability among people with diabetes in the world and it is proving to be a major barrier to sustainable human development. Despite CVD continuing to devastate human survival, few studies in Ethiopia have focused on its prevalence which alone are insufficient to assess the risk of incident cardiovascular events. Therefore, we determined the incidence and predictors of cardiovascular disease among diabetic patients in a selected tertiary healthcare setting of Ethiopia. Methods: A retrospective cohort study using secondary data was conducted on 399 randomly selected diabetes patients. Data were entered using Epi-Data and analyzed using Stata version 14. Multivariable Weibull proportional hazards regression analysis was used to identify the predictors of CVDs (namely, coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD)) at 5% level of significance. Results: After a median follow-up of 5.9 years, the overall incidence rate of CVD per 100 person-years (PY) was 2.71 (95% CI=16.9-17.6). The multivariable Weibull proportional hazard regression analysis showed a significant association of chronic kidney disease (CKD); (adjusted hazard ratio (AHR) [95% CI]=2.53 [1.36-4.72]), systolic blood pressure (SBP)≥140; (AHR [95% CI]=4.30 [2.12-8.73]) and triglyceride (TG)≥200 mg/dL; (AHR [95% CI[=5.10 [2.02-12.89]) with risk of incident CVD. Conclusion: CVD is a public health problem among diabetic patients in Ethiopia. SBP≥140, chronic kidney disease, and high triglyceride were independent predictors of new CVD among diabetic patients. These findings emphasize the need of attention for CVD patients with CKD and hypertension (HTN) comorbidities and a longer follow-up period using a prospective study design to determine the long-term effects of predictors of CVD among diabetic patients.

Annals of medicine and surgery, May 3, 2023

Background: Intraventricular hemorrhage (IVH) is one of the medical issues that preterm infants a... more Background: Intraventricular hemorrhage (IVH) is one of the medical issues that preterm infants are susceptible to as a result of their difficulty adjusting to life outside the womb. It is bleeding into the ventricular system from the germinal matrix, a highly cellular and vascular tissue that is only seen in preterm newborns and ruptures easily. The study aims to assess the magnitude and associated factors of IVH in preterm neonates. Methods: A hospital-based cross-sectional study was conducted at Tibebe Ghion Specialized Hospital (TGSH) from 14 March 2022 to 15 August 2022. The neonatal referral form, the mother’s medical file, an in-person interview with the mother, and bedside cranial sonography were used to collect clinical data. After data were entered into Epi Info and exported to Scientific Program for Social Science (SPSS), analysis was carried out using binary and multivariable logistic regression. Results: The overall magnitude of IVH in preterm newborns among preterm neonates admitted to TGSH was 53 (27.04%) (95% CI: 20.9–32.2%). In the multivariable logistic regression analysis, a birth weight of between 1500 and 2000 g (OR: 0.38, 95% CI: 0.18–0.79) were negative, and those neonates with gestational age between 28 and 32 weeks (OR: 2.14, 95% CI: 1.04–4.41) were positively associated with the occurrence of IVH. Conclusion: The study discovered that the magnitude of IVH is slightly higher than that of prior studies done in different parts of the world, and those neonates delivered at early gestational ages and those with very low birth weight have a higher incidence of IVH. Both guardians and health providers should give more attention to those neonates born at an early gestational age and with small birth weight.

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Oct 1, 2021

Background: Chronic kidney disease (CKD) is one of the most common microvascular complications of... more Background: Chronic kidney disease (CKD) is one of the most common microvascular complications of diabetes mellitus (DM) and it is a major health burden worldwide. Despite the increasing trend of microvascular complications in developing countries, there is limited evidence on predictors of CKD among diabetic patients in Ethiopia. Therefore, this study was aimed to assess the incidence and predictors of CKD among DM patients. Methods: A retrospective follow-up study was conducted among type 1 and type 2 DM patients in Southwest Ethiopia. A total of 437 newly-diagnosed diabetes patients were selected using a simple random sampling technique. Data were extracted from patients' medical records. Cox proportional hazard model was fitted and a 95% confidence interval was used to select significant variables. Results: Overall, 15.56% of patients developed CKD, with an incidence rate of 2.29 per 1,000 person-month (PM) (95% CI=1.79-2.93). Female sex (AHR=0.51, 95% CI=0.27-0.94) was found to be a protective factor of CKD, while positive proteinuria (AHR=2.85, 95% CI=1.48-5.55), having hypertension (HTN) (AHR=2.31, 95% CI=1.03-5.56), and highdensity lipoprotein cholesterol (HDL-C) <40 mg/dL (AHR=3.19, 95% CI=1.73-5.98) were significant predictors of CKD. Conclusion: CKD among DM patients continues to be a significant public health problem in health-care settings of Ethiopia. The current study found being female was protective, while positive proteinuria, HTN, and HDL-C <40 mg/dL were risk factors for CKD. We recommend health professionals to give more attention to DM patients with the identified risk factors.

HIV/AIDS : Research and Palliative Care, Jul 1, 2022

Virological suppression for persons living with HIV (PLHIV) on antiretroviral therapy (ART) reach... more Virological suppression for persons living with HIV (PLHIV) on antiretroviral therapy (ART) reached 85% at the end of 2018, still falling short of the UNAIDS target of 95%. In Ethiopia, there were studies on treatment failure focusing on viral suppression and immunological failure of ART users, but none of them have addressed virological failure for second-line regimens. Objective: This study was aimed to estimate the incidence and predictors of virological failure among HIV patients who were switched to second-line ART at the selected public hospitals in Addis Ababa. Methods: An institutional-based retrospective follow-up study was conducted from September 2018 to January 2021 at public hospitals in Addis Ababa. The sample size was determined by using the Schoenfeld formula. Data entry were done by Epi Data version-4.6.0.0 and exported to R-software version-4.1.0 for analysis. Kaplan-Meier methods were used to compare the survival estimates. Cox proportional hazard model was used to identify predictors of virological failure and model adequacy was checked by using the Cox-Snell residuals plot. Results: Overall 44 (12.22%) HIV/AIDS patients developed virological failure with incidence density of 3.57/1000 Person-Month (PM) with 95% CI of [2.65-4.79]. Age >45 years (AHR=0.36, 95% CI: 0.12-0.99), CD4 count <100cell/mm 3 (AHR=3.02, 95% CI: 1.17-7.78), TB co-infection (AHR=2.48, 95% CI: 1.10-6.33), ATV/r-based second-line regimen (AHR=0.27, 95% CI: 0.11-0.70), and poor adherence at the start of second-line ART (AHR=6.18, 95% CI: 1.93-19.76) were the significant predictors of virological failure. Conclusion: A high incidence of virological failure was noticed. The rate of virological failure was higher for patients who had poor ART adherence, small CD4count, and TB co-infection. Therefore, targeted HIV care interventions shall be provided to young ages and efforts stepped up to improve adherence to ART, which helps to increase immunity and suppress viral replication. In addition, prevention and early detection of TB co-infection are crucial to the patients.

Research Square (Research Square), Nov 24, 2020

Background: Cardiovascular disease (CVD) is a major cause of death and disability among people wi... more Background: Cardiovascular disease (CVD) is a major cause of death and disability among people with diabetes in the world and it is being a major barrier to sustainable human development. Despite, CVDs have continued to devastate human survival, few studies in Ethiopia have focused on its prevalence which alone are insu cient to assess the risk of incident cardiovascular events. Therefore, we determined the incidence and predictors of cardiovascular disease among diabetic patients. Methods: A retrospective cohort study was conducted on 399 randomly selected diabetes patients. Data were entered using Epi-Data and analyzed using Stata version 14. Multivariable Weibull proportional hazards regression analysis was used to identify the predictors of CVDs (namely, coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD)) at 5% level of signi cance. Results: After a median follow-up of 5.9 years, the overall incidence rate of CVD per 100 person-years was 2.71 (95% CI: 16.9-17.6). The Multivariable survival analysis showed a signi cant association of CKD; (Adjusted Hazard Ratio (AHR) (95%CI) 2.53 [1.36, 4.72]), Systolic blood pressure (SBP) >/= 140; (AHR (95%CI) (4.30 [2.12, 8.73]) and triglyceride >/= 200 mg/dl; (AHR (95%CI) (5.10 [2.02, 12.89]) with risk of incident CVD. Conclusion: CVD is being a public health problem among diabetic patients in Ethiopia. SBP >/= 140, chronic kidney disease and high triglyceride were independent predictors of new CVD among diabetic patients. These ndings emphasize the need of attention for CVD patients with CKD and HTN comorbidities and longer follow up period using prospective study design to determine the long-term effects of predictors of CVD among diabetic patients.

BMC Women's Health

Following publication of the original article, in this article the author name 'Tegenu Balcha' wa... more Following publication of the original article, in this article the author name 'Tegenu Balcha' was incorrectly written as 'Taganu Balcha' The original article has been corrected.

BMC Women's Health

Background One of the most challenging problems in developing countries including Ethiopia is imp... more Background One of the most challenging problems in developing countries including Ethiopia is improving maternal health. About 303,000 mothers die globally, and one in every 180 is at risk from maternal causes. Developing regions account for 99% of maternal deaths. Maternal near miss (MNM) resulted in long-term consequences. A systematic review and meta-analysis was performed to assess the prevalence and predictors of maternal near miss in Ethiopia from January 2015 to March 2023. Methods A systematic review and meta-analysis cover both published and unpublished studies from different databases (PubMed, CINHAL, Scopus, Science Direct, and the Cochrane Library) to search for published studies whilst searches for unpublished studies were conducted using Google Scholar and Google searches. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Duplicated studies were removed using Endnote X8. The paper quality was also assessed based on the JB...

Research and Reports in Tropical Medicine

Background: Even though podoconiosis can cause physical, financial, and social impairments, it is... more Background: Even though podoconiosis can cause physical, financial, and social impairments, it is commonly overlooked by organizations, and one-fourth of the predicted worldwide burden will fall on Ethiopia. In spite of this, there are only a few attempts for prevention and control in certain areas in Ethiopia. Updated statistics on prevalence and contributing factors could make local efforts at prevention, control, and rehabilitation more effective. Thus, this study was aimed to assess the prevalence of podoconiosis and its associated factors among Ilu Aba Bor zone residents, South West Ethiopia. Methods: A community-based cross-sectional study was conducted on 491 participants from March 25 to April 25, 2022. Data were entered into Epi-Data version 4.6.0, then exported to SPSS version 25 for final analysis. In the bi-variable regression, variables with P-values less than 0.25 were included in the multivariable model. Finally, multivariable logistic regression was performed to identify factors associated with podoconiosis at a 5% level of significance. Results: In this study area, podoconiosis prevalence was found to be 5.7% [3.6-7.2]. In multivariable regression model, lower tertile wealth status [AOR=2.09; (95% CI (1.384, 5.343)], no formal education [AOR=2.23; (95% CI; 1.179-3.820)] and average distance to reach water source to home [AOR=2.061; (95% CI: 1.78-7.35)] were significantly associated podoconiosis. Conclusion and Recommendation: According to this study, one in every seventeen individuals had podoconiosis, which is a significant prevalence when compared to earlier studies. Podoconiosis was observed to be associated with factors like wealth status, educational attainment, and distance from water source. To address this public health issue, strong preventive and therapeutic treatments should be used.

PLOS ONE

Background Perinatal mental illnesses are predominant during gestation and continue for a year af... more Background Perinatal mental illnesses are predominant during gestation and continue for a year after delivery. According to the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), suicide is classified as a direct cause of death among the maternal population. The occurrence of suicidal behavior among perinatal women was considered the main contributor to the burden of the disorder. Hence, the current study will develop a protocol for a systematic review as well as a meta-analysis on estimating the prevalence and determinants of perinatal suicidal behavior in Sub-Saharan African countries. Methods PubMed/MEDLINE, Scopus, EMBASE, PsycINFO, and the Web of Science electronic databases will be searched for studies reporting primary data. The second search strategy will be done with Google Scholar, using a combination of the medical subject headings and keywords as the search terms. The studies will be classified into included, exclud...

Background Due to the rising number of diabetic patients, the burden of diabetic peripheral neuro... more Background Due to the rising number of diabetic patients, the burden of diabetic peripheral neuropathy (DPN) is clearly posing a major challenge to the long-term viability of the health-care system. Despite this, most DPN epidemiological research in eastern Africa, including Ethiopia, has so far been limited to survey studies. Thus, we determined the incidence of DPN and its predictors among diabetic patients in tertiary health-care setting of southwest Ethiopia. Methods A multicenter retrospective follow-up study was carried out on 567 randomly selected diabetic patients. Data were entered using Epi-Data v4.6 and analyzed using R v4.0.4. The survival curves were estimated using the Kaplan-Meier, and compared using Log-rank test between groups of categorical variables. The PHA were evaluated using the Schoenfeld residuals test. Multivariable Gompertz proportional hazard model was used to examine the predictors of DPN at 5% level of significance. Results Overall, of 567 DM patients 1...

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Background: With an increasing number of diabetes patients in developing countries, the burden of... more Background: With an increasing number of diabetes patients in developing countries, the burden of diabetes-related blindness is undoubtedly posing a massive challenge to the sustainable health care system due to the cost of care. Despite this fact, to date, most of the epidemiological research on diabetic retinopathy (DR) in eastern Africa, including Ethiopia, has been limited to survey studies. Thus, we determined the incidence of retinopathy and its predictors among diabetic patients in Jimma University Medical Center, Southwest Ethiopia. Methods: A retrospective follow-up study was conducted on 402 randomly selected diabetic patients of aged ≥15 years. A preliminary reviewed checklist was used to obtain information on the demographics, clinical and physiological attributes. Data were entered using EpiData version 4.6 and analyzed using Stata version 14. All variables at P-values less than 0.2 in bivariable analysis were exported to multivariable analysis. Multivariable accelerated failure time (AFT) regression analyses using Weibull distribution were used to examine the predictors of DR at a 5% level of significance. Results: Throughout a median follow-up period of 5.9 years, the cumulative incidence of DR was 20.15% (95%CI: 16.50-24.37) and the incidence rate was 36.9 per 1000 person years (PY) (95%CI: 29.7-45.9). Multivariable Weibull AFT regression analyses showed that type two diabetes mellitus (T2DM) (adjusted time ratio (ATR) 0.4095%CI: 0.20-0.78), hypertension (HTN) (ATR 0.54; 95%CI: [0.35, 0.82]), low high density lipoprotein cholesterol (HDL-C) (ATR 0.51; 95%CI: 0.36-0.73), and borderline high total cholesterol (TC) (ATR 0.63; 95%CI: 0.42-0.94) were a predictor of time to DR. Conclusion: The overall incidence of DR among patients with diabetes mellitus was estimated to be 20.15% and is becoming a public health burden in Ethiopia. Our results indicate that T2DM, HTN, low HDL-C and borderline high TC independently predicts an increased incidence/decreased survival time of retinopathy among diabetes patients. The low HDL-C, HTN, and high TC are modifiable risk factors that should be managed along with diabetes.

BMC Psychiatry

BackgroundType 2 diabetes mellitus is the most common health problem globally. Depression and anx... more BackgroundType 2 diabetes mellitus is the most common health problem globally. Depression and anxiety can exacerbate disease complications, make patients suffer more, and increase healthcare costs. Even though, depression and anxiety are common among type 2 diabetes mellitus patients, there have been limited studies conducted about the determinants of depression and anxiety in Ethiopia. Therefore, the purpose of this study was to assess the magnitude and determinants of depression and anxiety symptoms among Type 2 diabetes mellitus patients, attending out-patient treatment at Harari regional state government hospitals, Eastern Ethiopia.MethodAn institutional based cross-sectional study was conducted from March to April at Harari regional state government hospitals in eastern Ethiopia. A total of 421 participants were recruited using the systematic sampling technique. Data was collected by using Afan Oromo version of interviewer-administered structured and semi-structured questionnai...

Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ... more Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ceftriaxone is one of the threatening global issues of public health and many patients suffer due to harms arising from AMR because the infections caused by viruses, bacteria, fungi, protozoa and helminthes are no longer susceptible to the commonly available antibiotics. Objective: To evaluate the utilization pattern of ceftriaxone at Medical Ward in Bedele General Hospital, Bedele, South West Oromia, Ethiopia. Methodology: Patients' medical record cards (PMRCs) from the medical ward at Bedele General Hospital who took ceftriaxone between July 1 and December 30 of 2021 were the subject of a hospital-based retrospective cross-sectional study design and the selection of the medical record cards was done using a systemic random sample technique. Utilizing current Ethiopia's Standard Treatment Guideline for General Hospital and Drug Use Evaluation Criteria, the appropriateness of the...

Objectives The goal of the study was to evaluate the community of Mettu Town, South West Ethiopia... more Objectives The goal of the study was to evaluate the community of Mettu Town, South West Ethiopia's knowledge, attitudes, and use of complementary and alternative medicine. Methods A community-based descriptive cross-sectional study including 285 individuals in Mettu town 03 kebele was conducted. To choose the households, a standardized random sampling method was utilized and house to house interviews were used to gather the data. Results 143 people (48.9%) of the participants were female and 94.9% of the respondents used complementary and alternative medicine, and 89% were aware of it. Medical herbalism was the most often used system (50.6%), and a higher percentage of study participants thought alternative medicine was less expensive than modern medicine (30.8%) and more accessible (42.5%). Conclusion The majority of the Mettu town Community practiced Complementary and Alternative Medicine theraphy and the study participants in Mettu town have good knowledge but poor attitude ...

Annals of Medicine & Surgery

Frontiers in Psychiatry

BackgroundThe magnitude of mental health conditions in the general population was high in low-res... more BackgroundThe magnitude of mental health conditions in the general population was high in low-resource settings like Ethiopia. This was accompanied by little evidence on knowledge, attitudes, and related determinants in the general population. Therefore, the current survey is planned to assess the knowledge, attitude, and related factors of the community toward mental illness in Mattu, South West Ethiopia.ObjectivesOur study aimed to assess the knowledge, attitude, and related factors of the community toward mental illness in Mattu, South West Ethiopia.MethodsA community-based cross-sectional survey was conducted in South West Ethiopia, Mattu town from 1 April−20 June, 2022 using a systematic random sampling, a multistage stratified technique from 649 households, and employed an interviewer-administered pre-tested semi-structured English version questionnaire. Epi-data Version 3.1 and SPSS-V-23.3 were employed for data entry and analysis respectively. A statistically significant ass...

Journal of Health, Population and Nutrition

Background Despite currently available, scientifically proven treatments and national guideline, ... more Background Despite currently available, scientifically proven treatments and national guideline, the SAM recovery rate is still considerably behind expectations, and it continues to have a devastating impact on under-five children. Identifying predictors of time to recovery might help to reach the minimal criterion established by the WHO and the national Sphere which decreases child mortality. Therefore, the current study assessed time to recovery and its predictors among children aged 6–59 months admitted with SAM in the Healthcare Setting of Southwest Ethiopia, 2021. Methods An institutional-based multicenter retrospective follow-up study was conducted on 486 children aged 6 to 59 months admitted with SAM cases. Data were entered into Epi-Data version 4.6 and exported to Stata version 14 for further analysis. Cox–Snell residual plot was used to assess the final model’s overall goodness of fit. Finally, a significant predictor of time to recovery was identified using Weibull surviv...

Health Informatics Journal

Background Sound and reliable health information is needed to promote culture of evidence based d... more Background Sound and reliable health information is needed to promote culture of evidence based decision making. The aim of this study was to assess knowledge and attitudes of healthcare providers to use District health information system among public health facilities in South-West Ethiopia. Method Cross sectional quantitative study was conducted. A total of 264 participants were approached. Descriptive and analytical statistics was done. Result Overall 130 (49.2%) of respondents had good knowledge to use DHIS (95% CI: [43, 55.3]). 149 (56.4%) of respondents had favourable attitudes (95% CI: [53.2, 59.8]). Sufficient skills [AOR = 2.20, 95% CI: (1.16, 4.19)], older age [AOR = 1.92, 95% CI: (1.03, 3.59)] , resources [AOR = 2.56, 95% CI: (1.35, 4.86)], staffing [AOR = 2.85, 95% CI: (1.49, 5.48)] and high experiences [AOR = 4.66, 95% CI: (1.94, 5.78)] were variables associated with knowledge. Being trained [AOR = 3.59, 95% CI: (2.48, 5.42)], provision of feedback [AOR = 4.08, 95% CI: ...

Frontiers in Pharmacology

Background: Even though determining the time to anti-retroviral therapy (ART) adverse drug reacti... more Background: Even though determining the time to anti-retroviral therapy (ART) adverse drug reaction and its predictors is a crucial step to overcome the negative consequences of the adverse drug reaction, there is limited information regarding the time to ART adverse drug reaction and its predictors. Therefore, this study aimed to determine the time to first ART adverse drug reaction and its predictors among adult HIV/AIDS patients on first-line antiretroviral therapy in West Hararghe Zone, Eastern Ethiopia.Methods: An institution-based retrospective cohort study was conducted on 561 HIV/AIDS patients on first-line ART from September 2013–January 2019 at public hospitals in West Hararghe Zone, Eastern Ethiopia. Data were collected using checklists and document reviews, entered using Epi Info and analyzed in R software. A Cox proportional hazard model was fitted to identify predictors of the time to first ART adverse drug reaction. Model adequacy was checked using Cox Snell residuals...

Frontiers in Psychiatry

IntroductionDespite the prevalence of post-traumatic disorder in internally displaced persons, wh... more IntroductionDespite the prevalence of post-traumatic disorder in internally displaced persons, which is well established, and the fact that respective international organizations are working on the issues, little attention is given in the context of sub-Saharan Africa, This study aims to review the available data about the prevalence and determinants of post-traumatic stress disorders among internally displaced people in sub-Saharan Africa.MethodsStudies published in the English language that have a clear outcome of interest and are available in full text were included. Six electronic databases were searched to identify published studies on the prevalence and determinants of posttraumatic stress disorder among IDPs in sub-Saharan Africa. This includes PubMed/MEDLINE, Scopus, EMBASE, PsychInfo, and the Web of Science. All relevant studies till June, 2023 were assessed. The review was done as per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-2009) and ...

Risk Management and Healthcare Policy, May 1, 2021

Background: Cardiovascular disease (CVD) is a major cause of death and disability among people wi... more Background: Cardiovascular disease (CVD) is a major cause of death and disability among people with diabetes in the world and it is proving to be a major barrier to sustainable human development. Despite CVD continuing to devastate human survival, few studies in Ethiopia have focused on its prevalence which alone are insufficient to assess the risk of incident cardiovascular events. Therefore, we determined the incidence and predictors of cardiovascular disease among diabetic patients in a selected tertiary healthcare setting of Ethiopia. Methods: A retrospective cohort study using secondary data was conducted on 399 randomly selected diabetes patients. Data were entered using Epi-Data and analyzed using Stata version 14. Multivariable Weibull proportional hazards regression analysis was used to identify the predictors of CVDs (namely, coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD)) at 5% level of significance. Results: After a median follow-up of 5.9 years, the overall incidence rate of CVD per 100 person-years (PY) was 2.71 (95% CI=16.9-17.6). The multivariable Weibull proportional hazard regression analysis showed a significant association of chronic kidney disease (CKD); (adjusted hazard ratio (AHR) [95% CI]=2.53 [1.36-4.72]), systolic blood pressure (SBP)≥140; (AHR [95% CI]=4.30 [2.12-8.73]) and triglyceride (TG)≥200 mg/dL; (AHR [95% CI[=5.10 [2.02-12.89]) with risk of incident CVD. Conclusion: CVD is a public health problem among diabetic patients in Ethiopia. SBP≥140, chronic kidney disease, and high triglyceride were independent predictors of new CVD among diabetic patients. These findings emphasize the need of attention for CVD patients with CKD and hypertension (HTN) comorbidities and a longer follow-up period using a prospective study design to determine the long-term effects of predictors of CVD among diabetic patients.

Annals of medicine and surgery, May 3, 2023

Background: Intraventricular hemorrhage (IVH) is one of the medical issues that preterm infants a... more Background: Intraventricular hemorrhage (IVH) is one of the medical issues that preterm infants are susceptible to as a result of their difficulty adjusting to life outside the womb. It is bleeding into the ventricular system from the germinal matrix, a highly cellular and vascular tissue that is only seen in preterm newborns and ruptures easily. The study aims to assess the magnitude and associated factors of IVH in preterm neonates. Methods: A hospital-based cross-sectional study was conducted at Tibebe Ghion Specialized Hospital (TGSH) from 14 March 2022 to 15 August 2022. The neonatal referral form, the mother’s medical file, an in-person interview with the mother, and bedside cranial sonography were used to collect clinical data. After data were entered into Epi Info and exported to Scientific Program for Social Science (SPSS), analysis was carried out using binary and multivariable logistic regression. Results: The overall magnitude of IVH in preterm newborns among preterm neonates admitted to TGSH was 53 (27.04%) (95% CI: 20.9–32.2%). In the multivariable logistic regression analysis, a birth weight of between 1500 and 2000 g (OR: 0.38, 95% CI: 0.18–0.79) were negative, and those neonates with gestational age between 28 and 32 weeks (OR: 2.14, 95% CI: 1.04–4.41) were positively associated with the occurrence of IVH. Conclusion: The study discovered that the magnitude of IVH is slightly higher than that of prior studies done in different parts of the world, and those neonates delivered at early gestational ages and those with very low birth weight have a higher incidence of IVH. Both guardians and health providers should give more attention to those neonates born at an early gestational age and with small birth weight.

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Oct 1, 2021

Background: Chronic kidney disease (CKD) is one of the most common microvascular complications of... more Background: Chronic kidney disease (CKD) is one of the most common microvascular complications of diabetes mellitus (DM) and it is a major health burden worldwide. Despite the increasing trend of microvascular complications in developing countries, there is limited evidence on predictors of CKD among diabetic patients in Ethiopia. Therefore, this study was aimed to assess the incidence and predictors of CKD among DM patients. Methods: A retrospective follow-up study was conducted among type 1 and type 2 DM patients in Southwest Ethiopia. A total of 437 newly-diagnosed diabetes patients were selected using a simple random sampling technique. Data were extracted from patients' medical records. Cox proportional hazard model was fitted and a 95% confidence interval was used to select significant variables. Results: Overall, 15.56% of patients developed CKD, with an incidence rate of 2.29 per 1,000 person-month (PM) (95% CI=1.79-2.93). Female sex (AHR=0.51, 95% CI=0.27-0.94) was found to be a protective factor of CKD, while positive proteinuria (AHR=2.85, 95% CI=1.48-5.55), having hypertension (HTN) (AHR=2.31, 95% CI=1.03-5.56), and highdensity lipoprotein cholesterol (HDL-C) <40 mg/dL (AHR=3.19, 95% CI=1.73-5.98) were significant predictors of CKD. Conclusion: CKD among DM patients continues to be a significant public health problem in health-care settings of Ethiopia. The current study found being female was protective, while positive proteinuria, HTN, and HDL-C <40 mg/dL were risk factors for CKD. We recommend health professionals to give more attention to DM patients with the identified risk factors.

HIV/AIDS : Research and Palliative Care, Jul 1, 2022

Virological suppression for persons living with HIV (PLHIV) on antiretroviral therapy (ART) reach... more Virological suppression for persons living with HIV (PLHIV) on antiretroviral therapy (ART) reached 85% at the end of 2018, still falling short of the UNAIDS target of 95%. In Ethiopia, there were studies on treatment failure focusing on viral suppression and immunological failure of ART users, but none of them have addressed virological failure for second-line regimens. Objective: This study was aimed to estimate the incidence and predictors of virological failure among HIV patients who were switched to second-line ART at the selected public hospitals in Addis Ababa. Methods: An institutional-based retrospective follow-up study was conducted from September 2018 to January 2021 at public hospitals in Addis Ababa. The sample size was determined by using the Schoenfeld formula. Data entry were done by Epi Data version-4.6.0.0 and exported to R-software version-4.1.0 for analysis. Kaplan-Meier methods were used to compare the survival estimates. Cox proportional hazard model was used to identify predictors of virological failure and model adequacy was checked by using the Cox-Snell residuals plot. Results: Overall 44 (12.22%) HIV/AIDS patients developed virological failure with incidence density of 3.57/1000 Person-Month (PM) with 95% CI of [2.65-4.79]. Age >45 years (AHR=0.36, 95% CI: 0.12-0.99), CD4 count <100cell/mm 3 (AHR=3.02, 95% CI: 1.17-7.78), TB co-infection (AHR=2.48, 95% CI: 1.10-6.33), ATV/r-based second-line regimen (AHR=0.27, 95% CI: 0.11-0.70), and poor adherence at the start of second-line ART (AHR=6.18, 95% CI: 1.93-19.76) were the significant predictors of virological failure. Conclusion: A high incidence of virological failure was noticed. The rate of virological failure was higher for patients who had poor ART adherence, small CD4count, and TB co-infection. Therefore, targeted HIV care interventions shall be provided to young ages and efforts stepped up to improve adherence to ART, which helps to increase immunity and suppress viral replication. In addition, prevention and early detection of TB co-infection are crucial to the patients.

Research Square (Research Square), Nov 24, 2020

Background: Cardiovascular disease (CVD) is a major cause of death and disability among people wi... more Background: Cardiovascular disease (CVD) is a major cause of death and disability among people with diabetes in the world and it is being a major barrier to sustainable human development. Despite, CVDs have continued to devastate human survival, few studies in Ethiopia have focused on its prevalence which alone are insu cient to assess the risk of incident cardiovascular events. Therefore, we determined the incidence and predictors of cardiovascular disease among diabetic patients. Methods: A retrospective cohort study was conducted on 399 randomly selected diabetes patients. Data were entered using Epi-Data and analyzed using Stata version 14. Multivariable Weibull proportional hazards regression analysis was used to identify the predictors of CVDs (namely, coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD)) at 5% level of signi cance. Results: After a median follow-up of 5.9 years, the overall incidence rate of CVD per 100 person-years was 2.71 (95% CI: 16.9-17.6). The Multivariable survival analysis showed a signi cant association of CKD; (Adjusted Hazard Ratio (AHR) (95%CI) 2.53 [1.36, 4.72]), Systolic blood pressure (SBP) >/= 140; (AHR (95%CI) (4.30 [2.12, 8.73]) and triglyceride >/= 200 mg/dl; (AHR (95%CI) (5.10 [2.02, 12.89]) with risk of incident CVD. Conclusion: CVD is being a public health problem among diabetic patients in Ethiopia. SBP >/= 140, chronic kidney disease and high triglyceride were independent predictors of new CVD among diabetic patients. These ndings emphasize the need of attention for CVD patients with CKD and HTN comorbidities and longer follow up period using prospective study design to determine the long-term effects of predictors of CVD among diabetic patients.

BMC Women's Health

Following publication of the original article, in this article the author name 'Tegenu Balcha' wa... more Following publication of the original article, in this article the author name 'Tegenu Balcha' was incorrectly written as 'Taganu Balcha' The original article has been corrected.

BMC Women's Health

Background One of the most challenging problems in developing countries including Ethiopia is imp... more Background One of the most challenging problems in developing countries including Ethiopia is improving maternal health. About 303,000 mothers die globally, and one in every 180 is at risk from maternal causes. Developing regions account for 99% of maternal deaths. Maternal near miss (MNM) resulted in long-term consequences. A systematic review and meta-analysis was performed to assess the prevalence and predictors of maternal near miss in Ethiopia from January 2015 to March 2023. Methods A systematic review and meta-analysis cover both published and unpublished studies from different databases (PubMed, CINHAL, Scopus, Science Direct, and the Cochrane Library) to search for published studies whilst searches for unpublished studies were conducted using Google Scholar and Google searches. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Duplicated studies were removed using Endnote X8. The paper quality was also assessed based on the JB...

Research and Reports in Tropical Medicine

Background: Even though podoconiosis can cause physical, financial, and social impairments, it is... more Background: Even though podoconiosis can cause physical, financial, and social impairments, it is commonly overlooked by organizations, and one-fourth of the predicted worldwide burden will fall on Ethiopia. In spite of this, there are only a few attempts for prevention and control in certain areas in Ethiopia. Updated statistics on prevalence and contributing factors could make local efforts at prevention, control, and rehabilitation more effective. Thus, this study was aimed to assess the prevalence of podoconiosis and its associated factors among Ilu Aba Bor zone residents, South West Ethiopia. Methods: A community-based cross-sectional study was conducted on 491 participants from March 25 to April 25, 2022. Data were entered into Epi-Data version 4.6.0, then exported to SPSS version 25 for final analysis. In the bi-variable regression, variables with P-values less than 0.25 were included in the multivariable model. Finally, multivariable logistic regression was performed to identify factors associated with podoconiosis at a 5% level of significance. Results: In this study area, podoconiosis prevalence was found to be 5.7% [3.6-7.2]. In multivariable regression model, lower tertile wealth status [AOR=2.09; (95% CI (1.384, 5.343)], no formal education [AOR=2.23; (95% CI; 1.179-3.820)] and average distance to reach water source to home [AOR=2.061; (95% CI: 1.78-7.35)] were significantly associated podoconiosis. Conclusion and Recommendation: According to this study, one in every seventeen individuals had podoconiosis, which is a significant prevalence when compared to earlier studies. Podoconiosis was observed to be associated with factors like wealth status, educational attainment, and distance from water source. To address this public health issue, strong preventive and therapeutic treatments should be used.

PLOS ONE

Background Perinatal mental illnesses are predominant during gestation and continue for a year af... more Background Perinatal mental illnesses are predominant during gestation and continue for a year after delivery. According to the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), suicide is classified as a direct cause of death among the maternal population. The occurrence of suicidal behavior among perinatal women was considered the main contributor to the burden of the disorder. Hence, the current study will develop a protocol for a systematic review as well as a meta-analysis on estimating the prevalence and determinants of perinatal suicidal behavior in Sub-Saharan African countries. Methods PubMed/MEDLINE, Scopus, EMBASE, PsycINFO, and the Web of Science electronic databases will be searched for studies reporting primary data. The second search strategy will be done with Google Scholar, using a combination of the medical subject headings and keywords as the search terms. The studies will be classified into included, exclud...

Background Due to the rising number of diabetic patients, the burden of diabetic peripheral neuro... more Background Due to the rising number of diabetic patients, the burden of diabetic peripheral neuropathy (DPN) is clearly posing a major challenge to the long-term viability of the health-care system. Despite this, most DPN epidemiological research in eastern Africa, including Ethiopia, has so far been limited to survey studies. Thus, we determined the incidence of DPN and its predictors among diabetic patients in tertiary health-care setting of southwest Ethiopia. Methods A multicenter retrospective follow-up study was carried out on 567 randomly selected diabetic patients. Data were entered using Epi-Data v4.6 and analyzed using R v4.0.4. The survival curves were estimated using the Kaplan-Meier, and compared using Log-rank test between groups of categorical variables. The PHA were evaluated using the Schoenfeld residuals test. Multivariable Gompertz proportional hazard model was used to examine the predictors of DPN at 5% level of significance. Results Overall, of 567 DM patients 1...

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Background: With an increasing number of diabetes patients in developing countries, the burden of... more Background: With an increasing number of diabetes patients in developing countries, the burden of diabetes-related blindness is undoubtedly posing a massive challenge to the sustainable health care system due to the cost of care. Despite this fact, to date, most of the epidemiological research on diabetic retinopathy (DR) in eastern Africa, including Ethiopia, has been limited to survey studies. Thus, we determined the incidence of retinopathy and its predictors among diabetic patients in Jimma University Medical Center, Southwest Ethiopia. Methods: A retrospective follow-up study was conducted on 402 randomly selected diabetic patients of aged ≥15 years. A preliminary reviewed checklist was used to obtain information on the demographics, clinical and physiological attributes. Data were entered using EpiData version 4.6 and analyzed using Stata version 14. All variables at P-values less than 0.2 in bivariable analysis were exported to multivariable analysis. Multivariable accelerated failure time (AFT) regression analyses using Weibull distribution were used to examine the predictors of DR at a 5% level of significance. Results: Throughout a median follow-up period of 5.9 years, the cumulative incidence of DR was 20.15% (95%CI: 16.50-24.37) and the incidence rate was 36.9 per 1000 person years (PY) (95%CI: 29.7-45.9). Multivariable Weibull AFT regression analyses showed that type two diabetes mellitus (T2DM) (adjusted time ratio (ATR) 0.4095%CI: 0.20-0.78), hypertension (HTN) (ATR 0.54; 95%CI: [0.35, 0.82]), low high density lipoprotein cholesterol (HDL-C) (ATR 0.51; 95%CI: 0.36-0.73), and borderline high total cholesterol (TC) (ATR 0.63; 95%CI: 0.42-0.94) were a predictor of time to DR. Conclusion: The overall incidence of DR among patients with diabetes mellitus was estimated to be 20.15% and is becoming a public health burden in Ethiopia. Our results indicate that T2DM, HTN, low HDL-C and borderline high TC independently predicts an increased incidence/decreased survival time of retinopathy among diabetes patients. The low HDL-C, HTN, and high TC are modifiable risk factors that should be managed along with diabetes.

BMC Psychiatry

BackgroundType 2 diabetes mellitus is the most common health problem globally. Depression and anx... more BackgroundType 2 diabetes mellitus is the most common health problem globally. Depression and anxiety can exacerbate disease complications, make patients suffer more, and increase healthcare costs. Even though, depression and anxiety are common among type 2 diabetes mellitus patients, there have been limited studies conducted about the determinants of depression and anxiety in Ethiopia. Therefore, the purpose of this study was to assess the magnitude and determinants of depression and anxiety symptoms among Type 2 diabetes mellitus patients, attending out-patient treatment at Harari regional state government hospitals, Eastern Ethiopia.MethodAn institutional based cross-sectional study was conducted from March to April at Harari regional state government hospitals in eastern Ethiopia. A total of 421 participants were recruited using the systematic sampling technique. Data was collected by using Afan Oromo version of interviewer-administered structured and semi-structured questionnai...

Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ... more Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ceftriaxone is one of the threatening global issues of public health and many patients suffer due to harms arising from AMR because the infections caused by viruses, bacteria, fungi, protozoa and helminthes are no longer susceptible to the commonly available antibiotics. Objective: To evaluate the utilization pattern of ceftriaxone at Medical Ward in Bedele General Hospital, Bedele, South West Oromia, Ethiopia. Methodology: Patients' medical record cards (PMRCs) from the medical ward at Bedele General Hospital who took ceftriaxone between July 1 and December 30 of 2021 were the subject of a hospital-based retrospective cross-sectional study design and the selection of the medical record cards was done using a systemic random sample technique. Utilizing current Ethiopia's Standard Treatment Guideline for General Hospital and Drug Use Evaluation Criteria, the appropriateness of the...

Objectives The goal of the study was to evaluate the community of Mettu Town, South West Ethiopia... more Objectives The goal of the study was to evaluate the community of Mettu Town, South West Ethiopia's knowledge, attitudes, and use of complementary and alternative medicine. Methods A community-based descriptive cross-sectional study including 285 individuals in Mettu town 03 kebele was conducted. To choose the households, a standardized random sampling method was utilized and house to house interviews were used to gather the data. Results 143 people (48.9%) of the participants were female and 94.9% of the respondents used complementary and alternative medicine, and 89% were aware of it. Medical herbalism was the most often used system (50.6%), and a higher percentage of study participants thought alternative medicine was less expensive than modern medicine (30.8%) and more accessible (42.5%). Conclusion The majority of the Mettu town Community practiced Complementary and Alternative Medicine theraphy and the study participants in Mettu town have good knowledge but poor attitude ...

Annals of Medicine & Surgery

Frontiers in Psychiatry

BackgroundThe magnitude of mental health conditions in the general population was high in low-res... more BackgroundThe magnitude of mental health conditions in the general population was high in low-resource settings like Ethiopia. This was accompanied by little evidence on knowledge, attitudes, and related determinants in the general population. Therefore, the current survey is planned to assess the knowledge, attitude, and related factors of the community toward mental illness in Mattu, South West Ethiopia.ObjectivesOur study aimed to assess the knowledge, attitude, and related factors of the community toward mental illness in Mattu, South West Ethiopia.MethodsA community-based cross-sectional survey was conducted in South West Ethiopia, Mattu town from 1 April−20 June, 2022 using a systematic random sampling, a multistage stratified technique from 649 households, and employed an interviewer-administered pre-tested semi-structured English version questionnaire. Epi-data Version 3.1 and SPSS-V-23.3 were employed for data entry and analysis respectively. A statistically significant ass...

Journal of Health, Population and Nutrition

Background Despite currently available, scientifically proven treatments and national guideline, ... more Background Despite currently available, scientifically proven treatments and national guideline, the SAM recovery rate is still considerably behind expectations, and it continues to have a devastating impact on under-five children. Identifying predictors of time to recovery might help to reach the minimal criterion established by the WHO and the national Sphere which decreases child mortality. Therefore, the current study assessed time to recovery and its predictors among children aged 6–59 months admitted with SAM in the Healthcare Setting of Southwest Ethiopia, 2021. Methods An institutional-based multicenter retrospective follow-up study was conducted on 486 children aged 6 to 59 months admitted with SAM cases. Data were entered into Epi-Data version 4.6 and exported to Stata version 14 for further analysis. Cox–Snell residual plot was used to assess the final model’s overall goodness of fit. Finally, a significant predictor of time to recovery was identified using Weibull surviv...

Health Informatics Journal

Background Sound and reliable health information is needed to promote culture of evidence based d... more Background Sound and reliable health information is needed to promote culture of evidence based decision making. The aim of this study was to assess knowledge and attitudes of healthcare providers to use District health information system among public health facilities in South-West Ethiopia. Method Cross sectional quantitative study was conducted. A total of 264 participants were approached. Descriptive and analytical statistics was done. Result Overall 130 (49.2%) of respondents had good knowledge to use DHIS (95% CI: [43, 55.3]). 149 (56.4%) of respondents had favourable attitudes (95% CI: [53.2, 59.8]). Sufficient skills [AOR = 2.20, 95% CI: (1.16, 4.19)], older age [AOR = 1.92, 95% CI: (1.03, 3.59)] , resources [AOR = 2.56, 95% CI: (1.35, 4.86)], staffing [AOR = 2.85, 95% CI: (1.49, 5.48)] and high experiences [AOR = 4.66, 95% CI: (1.94, 5.78)] were variables associated with knowledge. Being trained [AOR = 3.59, 95% CI: (2.48, 5.42)], provision of feedback [AOR = 4.08, 95% CI: ...

Frontiers in Pharmacology

Background: Even though determining the time to anti-retroviral therapy (ART) adverse drug reacti... more Background: Even though determining the time to anti-retroviral therapy (ART) adverse drug reaction and its predictors is a crucial step to overcome the negative consequences of the adverse drug reaction, there is limited information regarding the time to ART adverse drug reaction and its predictors. Therefore, this study aimed to determine the time to first ART adverse drug reaction and its predictors among adult HIV/AIDS patients on first-line antiretroviral therapy in West Hararghe Zone, Eastern Ethiopia.Methods: An institution-based retrospective cohort study was conducted on 561 HIV/AIDS patients on first-line ART from September 2013–January 2019 at public hospitals in West Hararghe Zone, Eastern Ethiopia. Data were collected using checklists and document reviews, entered using Epi Info and analyzed in R software. A Cox proportional hazard model was fitted to identify predictors of the time to first ART adverse drug reaction. Model adequacy was checked using Cox Snell residuals...